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Curate Leddy TAP1-negative control arms - #720

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iskandr merged 1 commit into
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fix/thp1-control-knockout-absence
Oct 19, 2026
Merged

iskandr merged 1 commit into
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fix/thp1-control-knockout-absence

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@iskandr

@iskandr iskandr commented Oct 19, 2026 •

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Summary

Record source-backed absence of TAP1 knockout on the two parental wild-type THP-1 arms and two primary human monocyte-derived macrophage arms in PMID 39438697. The paper's Figure 5 and acknowledgements distinguish the parental WT line from the TAP1 knockout line and describe the primary hMDM experiment. The authors' conditions table names the four THP-1 WT/KO × mock/H37Rv runs explicitly.

The four condition_knockout_genes: "none" claims remove only PMID 39438697's four known engineering_drift_audit errors. The global baseline falls 59→55 findings, 43→39 errors, across 10→9 studies; warnings remain 16. Arm identities, infection states and observed data are unchanged. All four arms retain their prior unengineered verdict and expression-anchor tiers. Bump to 1.82.11.

Dependency

PR #717 is merged and published as Hitlist 1.82.10. This PR is based on main.

Verification

  • ./format.sh and ./lint.sh pass.
  • All 22 engineering-drift tests pass, including exact baseline equality.
  • ./test.sh was attempted but its memory preflight refused at 1.00 GB free versus the required 2.5 GB. Final-head CI passes lint, the five-version unit matrix, corpus integration and coverage.

Refs #593.

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Coverage Report for CI Build 39316566296

Warning

No base build found for commit 24809ac on fix/python-310-314-support.
Coverage changes can't be calculated without a base build.
If a base build is processing, this comment will update automatically when it completes.

Coverage: 88.839%

Details

  • Patch coverage: No coverable lines changed in this PR.

Uncovered Changes

No uncovered changes found.

Coverage Regressions

Requires a base build to compare against. How to fix this →


Coverage Stats

Coverage Status
Relevant Lines: 13977
Covered Lines: 12417
Line Coverage: 88.84%
Coverage Strength: 0.89 hits per line

💛 - Coveralls

@iskandr
iskandr changed the base branch from fix/python-310-314-support to main October 19, 2026 21:04
@iskandr
iskandr marked this pull request as ready for review October 19, 2026 21:05
@iskandr
iskandr merged commit 7d84da3 into main Oct 19, 2026
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2 participants