The Personalilized Immunotherapy Research Lab (PIRL) is a multi-PI research group at the University of North Carolina - Chapel Hill. We work on identifying the determinants immune-mediated tumor clearance in a way that's fully personalized to each individual and their cancer. That high degree of personalization is manifested in algorithms for antigen identification across the spheres of genomics, proteomics, and machine learning for immunology.
Personalized Immunotherapy Research Lab @ UNC
Collective of researchers at UNC-CH who combine experimental and computational approaches to develop new immunotherapies and bring them into the clinic.
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Repositories
Showing 10 of 103 repositories
- oncoref Public
Curated cancer reference data: ontology, TMB, incidence/mortality, and expression. Bottom-of-stack for the openvax/PIRL libraries.
- trufflepig Public
Step-by-step RNA tumor analysis driven by pirlygenes gene sets — subsumes pirlygenes.analyze as many composable sub-commands with serializable intermediate state.
- tsarina Public
Tumor Specific Antigen discovery: personalized cancer immunotherapy targets from curated shared antigen data
- io-resistance-genie Public
[WIP / experiment] Living literature review of resistance to immune checkpoint inhibitors
- tcrsift Public
- exacto Public
Long-read toolkit for mutant proteoform prediction - somatic/germline DNA and RNA assembly, variant calling, integration, and translation
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