Analysis and figure-regeneration code for a two-cohort early-onset Alzheimer's disease transcriptomic study with matched-null testing and cross-layer evaluation.
Human kidney healthy & injured cell-state atlas (Lake et al. Nature 2023) — computational reproduction: sn/scRNA-seq · Visium · Slide-seq · KPMP niches. Colab-ready notebook for multi-omics & spatial figure reanalysis.
Reproducible R analysis code for fibroblast FLRT2–UNC5C signalling in human obese HFpEF (single-nucleus + orthogonal-bulk, CellChat)
Single-nucleus transcriptomic profiling of cortical SST+ GABAergic interneurons in Alzheimer's disease to resolve selective metabolic vulnerability, modeling the pathogenic collapse of the PPARGC1A mitochondrial biogenesis regulon against SATB1-mediated cell-identity homeostasis.
Analysis notebooks supporting snPATHO-Seq for single-nucleus RNA profiling of archival FFPE tissue.
Kidney papilla Visium + snRNA-seq reproduction (Canela et al. Nat Commun 2023): label transfer · stone vs control spatial DE · mineralization ROI. GEO GSE206306/GSE231569 · RunPod/Colab ready.
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