regulon-activity-scoring

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genecell / cytorete

Cell-type-resolved gene regulatory network inference from single-cell data.

bioinformatics transcription-factors computational-biology gene-expression scrna-seq single-cell motif-analysis gene-regulatory-network cistrome grn-inference piaso regulon regulon-activity-scoring

Updated Aug 24, 2026
Python

Qasim-Hussain-Code / alzheimer_cellular_vulnerability_sst_neurons_snRNA

Star

Single-nucleus transcriptomic profiling of cortical SST+ GABAergic interneurons in Alzheimer's disease to resolve selective metabolic vulnerability, modeling the pathogenic collapse of the PPARGC1A mitochondrial biogenesis regulon against SATB1-mediated cell-identity homeostasis.

differential-expression pathway-enrichment-analysis neurodegeneration gene-regulatory-networks gabaergic-neurons single-nucleus-rna-seq somatostatin-interneurons alzheimers-pathology selective-vulnerability mitochondrial-biogenesis ppargc1a-regulon satb1-chromatin transcriptional-collapse cortical-microcircuitry bioenergetic-failure snrna-seq-pipeline hypergeometric-ora regulon-activity-scoring

Updated Jun 25, 2026
Python

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