Contributor submission Luc2

mite_data/data/MITE0000272.json

@@ -0,0 +1,68 @@
+{
+    "accession": "MITE0000272",
+    "status": "active",
+    "comment": " Luc2 might be involved in C-20 hydroxylation",
+    "changelog": [
+        {
+            "version": "1",
+            "date": "2026-03-26",
+            "contributors": [
+                "0000-0002-6077-7490"
+            ],
+            "reviewers": [
+                "0000-0002-9747-3423"
+            ],
+            "comment": "New entry."
+        }
+    ],
+    "enzyme": {
+        "name": "Luc2",
+        "description": "Cytochrome P450",
+        "references": [
+            "doi:10.1038/s41429-022-00529-3"
+        ],
+        "auxiliaryEnzymes": [
+            {
+                "name": "Luc6",
+                "description": "\u03b1/\u03b2 hydrolase",
+                "databaseIds": {
+                    "uniprot": "A0A6J4B4M6",
+                    "genpept": "BBQ09586.1"
+                }
+            }
+        ],
+        "databaseIds": {
+            "uniprot": "A0A6J4BC30",
+            "genpept": "BBQ09591.1"
+        }
+    },
+    "reactions": [
+        {
+            "tailoring": [
+                "Monooxygenation",
+                "Other"
+            ],
+            "description": " Luc2 oxidizes the C-20, but Luc3 is required for the full oxidation of the C-20 methyl group into the carboxylic acid",
+            "reactionSMARTS": "[#7:1](-[#6:21](-[#6:24]-[#8:26])-[#6:22]-[#6:23]-[#8:25])-[#6:2](=[#8:7])-[#6:3]-[#6:4](=[#8:8])-[#6:5](-[#6:9])=[#6:6]-[#6:10]=[#6:11]-[#6:12]=[#6:13]-[#6:14]=[#6:15](-[#6:20])-[#6:16]=[#6:17](-[#6:19])-[#6:18]>>[#7]1-[#6:24](-[#6]2-[#6:3](-[#8]-2)(-[#6:4](=[#8:8])-[#6:5](-[#6:9])=[#6:6]-[#6:10]=[#6:11]-[#6:12]=[#6:13]-[#6:14]=[#6:15](-[#6:20])-[#6:16]=[#6:17](-[#6]-[#8])-[#6:19])-[#6:2]-1=[#8:7])(-[#8])-[#6:25]-[#6]-[#8]",
+            "reactions": [
+                {
+                    "substrate": "CC(C)=C/C(C)=C/C=C/C=C/C=C(\\C)C(=O)CC(=O)NC(CO)CCO",
+                    "products": [
+                        "CC(=CC=CC=CC=C(C)C(=O)C12OC1C(O)(CCO)NC2=O)C=C(C)CO"
+                    ],
+                    "isIntermediate": false,
+                    "description": "oxidation-cyclisation sequence with invovlement of Luc2 and Luc6"
+                }
+            ],
+            "evidence": {
+                "evidenceCode": [
+                    "Knock-out studies"
+                ],
+                "references": [
+                    "doi:10.1038/s41429-022-00529-3",
+                    "doi:10.1016/j.chembiol.2013.07.004"
+                ]
+            }
+        }
+    ]
+}