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Preserve fixture provenance and native coordinates; add audited evidence (0.15.0) - #101

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iskandr merged 5 commits into
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fix/unresolved-fixtures-and-provenance
Sep 30, 2026
Merged

iskandr merged 5 commits into
mainfrom
fix/unresolved-fixtures-and-provenance

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@iskandr iskandr commented Sep 29, 2026 •

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Bundle subsetting now preserves the original headers, acquisition receipts and recorded selection outcomes. Historical retrieval cases now expose their native BAM coordinates and reference dictionaries, including the GRCh37/rCRS mitochondrial case, so callers can reject incompatible merges. New fusion requests use a versioned panel with explicit retained sides.

The comprehensive regression corpus includes the union of 51 vaccine variants, all 7,474 variant/BAM support cells, 12 annotated frameshifts, all 637 structural candidates, and four DNA-supported SNVs with zero alternate support in the 15 tested tumor RNA products. Low coverage, BTN3A3's separate blood-RNA observation and NR2F2's historical RNA support remain explicit. Independently recounted unsampled control BAMs are available in the local evidence delivery archive.

The larger balanced openvax-v3 read build is paused for disk space and remains an unpublished candidate. Its completion and disk-use improvements will follow in a separate PR. Completed source selections are checkpointed; the candidate permits 1,000,000 records per supplementary region and 2,000 supplementary regions per source. This PR does not change the published openvax-v1/v2 bundles or certify the unfinished v3 read archive.

Validation: 377 tests passed; Ruff, strict MkDocs and package builds passed. Real-bundle subsetting preserved every selected record, original header and receipt. All 140 independent control recounts passed, including 60 tumor-RNA negative checks. The committed overlap and coordinate regression fixtures run offline.

Review fixes: both control audits bind source URLs and BAM/index hashes to acquisition receipts; compact carry-forward preserves placed-unmapped records; packaged RNA-support statements follow the independent recount results.

Release: osteosarc 0.15.0. Python 3.9 support remains. The full v3 read archive is not part of this release.

@iskandr iskandr changed the title Fix fixture provenance, native coordinates and fusion sides; audit comprehensive evidence Preserve fixture provenance and native coordinates; add audited evidence (0.15.0) Sep 30, 2026
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iskandr marked this pull request as ready for review September 30, 2026 01:55
@iskandr
iskandr merged commit 60a25a4 into main Sep 30, 2026
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