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hh-health-AI/README.md

HH Health AI — healthcare investing, biomedical evidence and AI. Evidence to assumptions to valuation to human judgment.

Explore the flagship   ·   Workflows   ·   Research projects   ·   Sustainable finance work

Better evidence. Explicit assumptions. Falsifiable investment views.
AI should make research more inspectable—not make judgment less accountable.

About me

I build open-source tools for healthcare investing, biotech research and AI-assisted fundamental analysis. My work connects biomedical evidence and public datasets to the questions that matter for an investment thesis: what changes, how it changes the model, and what would prove the thesis wrong.

  • Research: Biotech, pharmaceuticals, medtech, life sciences tools and healthcare services.
  • Evidence: Clinical trials, regulatory catalysts, utilization, reimbursement, provider economics and company filings.
  • Methods: DCF, risk-adjusted NPV, scenarios, catalyst analysis and evidence-to-valuation workflows.

Start here: Healthcare Equity Research Platform

The flagship integration point for healthcare equity research.

A synthesis layer and 12 modular evidence pipelines connect clinical and regulatory developments, patient populations, commercial adoption, reimbursement, financial disclosures and valuation.

Core value: Turn a source-backed observation into an explicit model assumption and a testable investment view.

Clinical evidence → Probability & demand → Commercial assumptions → DCF / rNPV → Investment thesis

Explore the modules →

The platform brings together ClinicalTrials.gov, FDA, CMS, SEC EDGAR and other primary-source research workflows. It is the canonical integration point; the standalone project repositories below remain available during migration.

Research workflow

Discover → underwrite → decide and communicate → monitor and learn.

The workflow below comes from the Healthcare Equity Research Platform. It shows how evidence engines, valuation, thesis development and ongoing review connect.

flowchart TD
    subgraph DISC["1 · Discover"]
        ST["screen-themes"] --> IN["initiate<br/>scoping → memo → sub-sector layers"]
    end
    subgraph ENG["Evidence engines (co-installed plugins)"]
        E1["cms-reimbursement"]
        E2["clinical-catalysts"]
        E3["provider-adoption"]
        E4["procedure-exposure"]
    end
    FIN[("Financial layer<br/>filings & transcripts · Quartr / EDGAR")]
    subgraph UW["2 · Underwrite"]
        MV["model-valuation<br/>economic unit → formula → scenarios"] <--> TH["thesis<br/>variant perception · steel-man · pre-mortem"]
        ME["meetings-experts<br/>1-on-1s · expert calls, MNPI-safe"] --> TH
        INTL["international<br/>HTA · Japan · China · UK"] --> MV
        ESG["esg-stewardship"] --> TH
    end
    IN --> MV
    ENG -->|EVIDENCE BRIEFS| IV
    FIN --> IV
    LEDGER[("evidence ledger<br/>briefs from all five plugins")] --> IV
    EA["evidence-assembler agent<br/>runs the engines end-to-end for a ticker"] -.-> IV
    MV --> IV["investable-view capstone<br/>6 layers → scenario matrix → price-implied<br/>→ falsifiable underwriting statement"]
    TH --> IV
    subgraph DEC["3 · Decide & communicate"]
        CO["comms-compliance<br/>IC memo · MNPI scrub · disclosures"]
        PO["portfolio<br/>sizing · catalyst concentration · pairs"]
    end
    IV --> CO
    IV --> PO
    subgraph MON["4 · Monitor & learn"]
        EARN["earnings<br/>preview → live triage → post-print"] --> SD["sell-discipline<br/>scorecards · watchlists · post-mortems"]
    end
    PO --> EARN
    IV -->|falsifiers & early signals| SD
    SD -->|lessons → base rates & thresholds| TH

    classDef skill fill:#dbeafe,stroke:#2563eb,color:#111827
    classDef data fill:#dcfce7,stroke:#16a34a,color:#111827
    classDef agent fill:#fef3c7,stroke:#d97706,color:#111827,stroke-dasharray:5 5
    classDef brief fill:#fce7f3,stroke:#db2777,color:#111827
    classDef note fill:#f3f4f6,stroke:#6b7280,color:#111827
    classDef ext fill:#ede9fe,stroke:#7c3aed,color:#111827
    class ST,IN,MV,TH,ME,INTL,ESG,CO,PO,EARN,SD skill
    class FIN,LEDGER data
    class EA agent
    class IV brief
    class E1,E2,E3,E4 ext
Loading

Blue = skills · green = data sources and stores · amber (dashed) = agents · pink = evidence outputs · violet = suite handoffs.

Explore the source workflow and implementation →

Reproduced from the project's workflow documentation on 24 September 2026. Labels and connections are preserved; this profile copy does not automatically sync with future repository changes.

Selected research projects

From trial results to underwriting assumptions.

Organize trial readouts and regulatory events around approval probability, label, timing and clinical differentiation.

Clinical trials FDA catalysts

Integrated module →

Understand the economics of market access.

Connect coverage and payment evidence to access, pricing assumptions and healthcare business economics.

Coverage Payment Market access

Integrated module →

Test demand against observable evidence.

Use prescribing, utilization and launch proxies to challenge commercial assumptions and revenue trajectories.

Utilization Launch tracking

Integrated module →

Bring financial discipline to the healthcare thesis.

Examine company filings, accounting signals and insider activity alongside the scientific and commercial evidence.

SEC EDGAR Financial forensics

Integrated module →

Explore all 12 evidence modules
Research layer Integrated module
Clinical and regulatory clinical-catalysts
Publications, guidelines and expert signals evidence-catalysts
Safety signals fda-safety-signals
Prescription utilization rx-utilization
Epidemiology and patient populations epi-demand
Coverage and reimbursement cms-reimbursement
Provider adoption provider-adoption
Provider economics provider-economics
Procedure and coding exposure procedure-exposure
Patents, exclusivity and loss of exclusivity ip-exclusivity
International access global-access
Company filings and accounting sec-forensics

Tools and research craft

Python for public-data tooling; Markdown for agent instructions; Git for versioned research; GitHub for open collaboration.

Domain expertise: Biotech · Pharma · Medtech · Life Sciences Tools · Managed Care · Healthcare Services · Digital Health

Research methods: DCF · rNPV · Scenario Analysis · Catalyst Research · Evidence Synthesis

Research principles

Primary sources first. Important numbers should retain their source, vintage and limitations.

Evidence is not the conclusion. Observations, assumptions, calculations and investment judgment should remain distinguishable.

Models must be challengeable. A thesis needs explicit sensitivities, disconfirming evidence and a clear account of what would change the view.

Human judgment stays in the loop. These AI agents, skills and research workflows are designed to support institutional-quality due diligence—not to replace analyst accountability or imply independent certification.

Connect

Working on healthcare investing, biomedical data or AI-enabled research? Project issues and pull requests are welcome.

Start a project discussion   ·   Explore my sustainable finance work


Research and educational tools—not medical advice or investment recommendations.
Public project capabilities vary; inspect each repository's documentation and limitations.

Pinned Loading

  1. healthcare-equity healthcare-equity Public

    Synthesis engine for buy-side healthcare equity research.

    Python 49 5

  2. clinical-catalysts clinical-catalysts Public

    Science, trials, and FDA evidence engine for buy-side healthcare equity research. Answers: does the science work, will FDA/EMA allow it, when is the binary event, and who else is coming.

    Shell 1

  3. cms-reimbursement cms-reimbursement Public

    Access-and-payment evidence engine for buy-side healthcare equity research.

    Shell 1

  4. epi-demand epi-demand Public

    Epidemiology and end-market demand.

    Python 1

  5. evidence-catalysts evidence-catalysts Public

    Guidelines, conferences and literature velocity.

    Python 1

  6. global-access global-access Public

    International HTA, pricing and approvals.

    Python 1