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County-Level Associations between Drinking Water PFAS Contamination and COVID-19 Mortality in the United States

This repository holds replication code for the following study:

Liddie, J.M., Bind, M.A., Karra, M., Sunderland, E.M. County-Level Associations between Drinking Water PFAS Contamination and COVID-19 Mortality in the United States. Journal of Exposure Science & Environmental Epidemiology (2024) DOI: 10.1038/s41370-024-00723-5 doi: 10.1038/s41370-024-00723-5

Files are numbered according to the order in which they are run for the main analyses, sensitivity analyses (including propensity score matching), and table/figure generation. Replication datasets and additional descriptions of the data are available on the Harvard Dataverse here[https://doi.org/10.7910/DVN/PN0RI5].

Contents

Modelling

  • 1_Modelling.R: primary models (including counties in the statewide sampling dataset and the Third Unregulated Contaminant Monitoring Rule) for the association between PFAS drinking water contamination and cumulative COVID-19 mortality
  • 2a_Modelling_matching.R: propensity score matched analyses (unadjusted and adjusted) as robustness/sensitivity analyses
  • 2b_Sensitivity_analyses.R: all other sensitivity analyses related to modeling choices, outcome measures, exposure measures, and confounding adjustments

Tables and figures

  • 3_Final tables and figures.RMD: all primary and supplemental figures and tables (excluding love plots)

Authors

  • Jahred Liddie, Department of Environmental Health, Harvard T.H. Chan School of Public Health
  • Marie-Abèle Bind, Biostatistics Center, Massachusetts General Hospital
  • Mahesh Karra, Frederick S. Pardee School of Global Studies, Boston University
  • Elsie M. Sunderland, Department of Environmental Health, Harvard T.H. Chan School of Public Health; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University

Contact

Jahred Liddie Harvard T.H. Chan School of Public Health Department of Environmental Health jliddie@g.harvard.edu

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