Hi, @PengNi
Thank you for developing these excellent computational tools. I read with great interest your paper, particularly the Discussion section where you address the strand-specific methylation model.
I am keen to apply this model to identify hemimethylated CpGs using HiFi reads, which contain the fp/fi/fn/rp/ri/rn tags. While the reported accuracy stands at a modest 0.85, I noted from Supplementary Fig. 21 that accuracy scales positively with increasing subread depth.
Would you consider making the strand-specific methylation model publicly available? Alternatively, I would greatly appreciate any suggestions or guidance you might have on implementing this analysis.
Hi, @PengNi
Thank you for developing these excellent computational tools. I read with great interest your paper, particularly the Discussion section where you address the strand-specific methylation model.
I am keen to apply this model to identify hemimethylated CpGs using HiFi reads, which contain the fp/fi/fn/rp/ri/rn tags. While the reported accuracy stands at a modest 0.85, I noted from Supplementary Fig. 21 that accuracy scales positively with increasing subread depth.
Would you consider making the strand-specific methylation model publicly available? Alternatively, I would greatly appreciate any suggestions or guidance you might have on implementing this analysis.