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@LingjunLiResearch

Lingjun Li Research Group

Mass spectrometry-based research group at the University of Wisconsin-Madison studying neuropeptides, imaging, quantitative proteomics, and more!

Li Research Group · University of Wisconsin–Madison

Software and analysis code from the lab of Dr. Lingjun Li, School of Pharmacy and Department of Chemistry, UW–Madison.

The group develops mass spectrometry methods for neuropeptidomics, quantitative proteomics and glycomics, mass spectrometry imaging, ion mobility-MS, and capillary electrophoresis-MS. This organization hosts the lab's open-source tools and the code and data behind its publications.

🌐 lilabs.org · 🧰 Lab resources · 𝕏 @LiResearch · 🦋 @liresearch.bsky.social

Featured tools

Tool What it does Papers
cNPDB Comprehensive empirical crustacean neuropeptide database (web app) bioRxiv
EndoGenius Database searching optimized for neuropeptide identification from MS data J. Proteome Res. · bioRxiv (EndoGenius v2) · bioRxiv (DIA neuropeptidomics)
Hybrid EndoGenius Hybrid de novo sequencing + database searching for endogenous peptide discovery bioRxiv
MotifQuest Automated motif database creation to improve peptidomics database searching J. Am. Soc. Mass Spectrom.
HyPep Neuropeptide identification and discovery via sequence homology search J. Proteome Res.
MSIght Modular platform for confident untargeted MS imaging annotation J. Proteome Res.
MSI-Parser Analysis of single-cell MS imaging data Nat. Commun.

Other lab tools not hosted here (Metandem, PRESnovo) are listed on the resources page.

Using our code

Most repositories accompany a publication. If you use one, please cite the associated paper linked in its README. Questions about a specific tool are best raised as an issue in that repository.

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  1. EndoGenius EndoGenius Public

    EndoGenius is designed to identify neuropeptides in their endogenous form from mass spectra.

    Python 1 1

  2. MotifQuest MotifQuest Public

    MotifQuest is a program produced by the Lingjun Li Lab at the University of Wisconsin-Madison for identification of conserved endogenous peptide motifs.

    Python 1

  3. CNPDB CNPDB Public

    A comprehensive empirical crustacean neuropeptide database for in-depth, multidisciplinary neuropeptide research

    Python 2 3

  4. MSIght MSIght Public

    Forked from laurenfields/MSIght

    MSIght is a program produced by the Lingjun Li Lab at the University of Wisconsin-Madison for automated integration of H&E, MSI, and LC-MS/MS datasets

    Jupyter Notebook

  5. MSIparser MSIparser Public

    MSI-Parser is a program produced by the Lingjun Li Lab at the University of Wisconsin-Madison for definding regions of interest (ROI) for single cell mass spectrometry analysis, followed by average…

    Python 3 1

  6. HybridEndoGenius HybridEndoGenius Public

    Shell 2 2

Repositories

Showing 10 of 37 repositories

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