diff --git a/README.md b/README.md
index d223435..1700581 100644
--- a/README.md
+++ b/README.md
@@ -68,9 +68,21 @@ const options = {
 const formData = serialize(
   object,
   options, // optional
-  existingFormData, // optional
-  keyPrefix, // optional
+  existingFormData, // optional: allows you to send an existing FormData instance to be used
+  keyPrefix, // optional: prefix all keys with this value
 );
 
 console.log(formData);
 ```
+
+## Usage in Node.js
+
+```js
+const FormData = require('form-data');
+
+const object = { foo: [1, 2, 3] };
+
+const formData = serialize(object, undefined, new FormData());
+
+console.log(formData);
+```
diff --git a/package-lock.json b/package-lock.json
index b174b8f..28a3096 100644
--- a/package-lock.json
+++ b/package-lock.json
@@ -9,6 +9,7 @@
       "version": "4.4.1",
       "license": "MIT",
       "devDependencies": {
+        "form-data": "^4.0.0",
         "jest": "^27.4.7",
         "prettier": "^2.5.1",
         "pretty-quick": "^3.1.3",
@@ -1794,9 +1795,9 @@
       }
     },
     "node_modules/form-data": {
-      "version": "3.0.1",
-      "resolved": "https://registry.npmjs.org/form-data/-/form-data-3.0.1.tgz",
-      "integrity": "sha512-RHkBKtLWUVwd7SqRIvCZMEvAMoGUp0XU+seQiZejj0COz3RI3hWP4sCv3gZWWLjJTd7rGwcsF5eKZGii0r/hbg==",
+      "version": "4.0.0",
+      "resolved": "https://registry.npmjs.org/form-data/-/form-data-4.0.0.tgz",
+      "integrity": "sha512-ETEklSGi5t0QMZuiXoA/Q6vcnxcLQP5vdugSpuAyi6SVGi2clPPp+xgEhuMaHC+zGgn31Kd235W35f7Hykkaww==",
       "dev": true,
       "dependencies": {
         "asynckit": "^0.4.0",
@@ -2871,6 +2872,20 @@
         }
       }
     },
+    "node_modules/jsdom/node_modules/form-data": {
+      "version": "3.0.1",
+      "resolved": "https://registry.npmjs.org/form-data/-/form-data-3.0.1.tgz",
+      "integrity": "sha512-RHkBKtLWUVwd7SqRIvCZMEvAMoGUp0XU+seQiZejj0COz3RI3hWP4sCv3gZWWLjJTd7rGwcsF5eKZGii0r/hbg==",
+      "dev": true,
+      "dependencies": {
+        "asynckit": "^0.4.0",
+        "combined-stream": "^1.0.8",
+        "mime-types": "^2.1.12"
+      },
+      "engines": {
+        "node": ">= 6"
+      }
+    },
     "node_modules/jsesc": {
       "version": "2.5.2",
       "resolved": "https://registry.npmjs.org/jsesc/-/jsesc-2.5.2.tgz",
@@ -5500,9 +5515,9 @@
       }
     },
     "form-data": {
-      "version": "3.0.1",
-      "resolved": "https://registry.npmjs.org/form-data/-/form-data-3.0.1.tgz",
-      "integrity": "sha512-RHkBKtLWUVwd7SqRIvCZMEvAMoGUp0XU+seQiZejj0COz3RI3hWP4sCv3gZWWLjJTd7rGwcsF5eKZGii0r/hbg==",
+      "version": "4.0.0",
+      "resolved": "https://registry.npmjs.org/form-data/-/form-data-4.0.0.tgz",
+      "integrity": "sha512-ETEklSGi5t0QMZuiXoA/Q6vcnxcLQP5vdugSpuAyi6SVGi2clPPp+xgEhuMaHC+zGgn31Kd235W35f7Hykkaww==",
       "dev": true,
       "requires": {
         "asynckit": "^0.4.0",
@@ -6323,6 +6338,19 @@
         "whatwg-url": "^8.5.0",
         "ws": "^7.4.6",
         "xml-name-validator": "^3.0.0"
+      },
+      "dependencies": {
+        "form-data": {
+          "version": "3.0.1",
+          "resolved": "https://registry.npmjs.org/form-data/-/form-data-3.0.1.tgz",
+          "integrity": "sha512-RHkBKtLWUVwd7SqRIvCZMEvAMoGUp0XU+seQiZejj0COz3RI3hWP4sCv3gZWWLjJTd7rGwcsF5eKZGii0r/hbg==",
+          "dev": true,
+          "requires": {
+            "asynckit": "^0.4.0",
+            "combined-stream": "^1.0.8",
+            "mime-types": "^2.1.12"
+          }
+        }
       }
     },
     "jsesc": {
diff --git a/package.json b/package.json
index 1b25f65..f034009 100644
--- a/package.json
+++ b/package.json
@@ -27,6 +27,7 @@
     "testEnvironment": "jsdom"
   },
   "devDependencies": {
+    "form-data": "^4.0.0",
     "jest": "^27.4.7",
     "prettier": "^2.5.1",
     "pretty-quick": "^3.1.3",
diff --git a/src/index.js b/src/index.js
index d3a9deb..7147c64 100644
--- a/src/index.js
+++ b/src/index.js
@@ -24,6 +24,7 @@ function isDate(value) {
 
 function isReactNativeBlob(value) {
   return (
+    typeof FormData !== 'undefined' &&
     typeof new FormData().getParts === 'function' &&
     isObject(value) &&
     !isUndefined(value.uri)
@@ -54,7 +55,9 @@ function initCfg(value) {
 
 function serialize(obj, cfg, fd, pre) {
   cfg = cfg || {};
-  fd = fd || new FormData();
+  if (typeof FormData !== 'undefined' && !fd) {
+    fd = new FormData();
+  }
 
   cfg.indices = initCfg(cfg.indices);
   cfg.nullsAsUndefineds = initCfg(cfg.nullsAsUndefineds);
diff --git a/src/index.node.test.js b/src/index.node.test.js
new file mode 100644
index 0000000..7bd2a4f
--- /dev/null
+++ b/src/index.node.test.js
@@ -0,0 +1,26 @@
+/**
+ * @jest-environment node
+ */
+
+const FormData = require('form-data');
+
+const { serialize } = require('.');
+
+const formDataAppend = FormData.prototype.append;
+
+beforeEach(() => {
+  FormData.prototype.append = jest.fn(formDataAppend);
+});
+
+test('works in nodejs', () => {
+  const formData = new FormData();
+  serialize(
+    {
+      foo: 'bar',
+    },
+    null,
+    formData,
+  );
+
+  expect(formData.append).toHaveBeenCalledWith('foo', 'bar');
+});