diff --git a/Include/internal/pycore_frame.h b/Include/internal/pycore_frame.h
index 8c410e9e208340..50908f2cb7a1d2 100644
--- a/Include/internal/pycore_frame.h
+++ b/Include/internal/pycore_frame.h
@@ -44,15 +44,16 @@ extern PyFrameObject* _PyFrame_New_NoTrack(PyCodeObject *code);
 /* other API */
 
 typedef enum _framestate {
-    FRAME_CREATED = -3,
-    FRAME_SUSPENDED = -2,
-    FRAME_SUSPENDED_YIELD_FROM = -1,
+    FRAME_CREATED = -4,
+    FRAME_SUSPENDED = -3,
+    FRAME_SUSPENDED_YIELD_FROM = -2,
+    FRAME_SUSPENDED_YIELD_FROM_LOCKED = -1,
     FRAME_EXECUTING = 0,
     FRAME_COMPLETED = 1,
     FRAME_CLEARED = 4
 } PyFrameState;
 
-#define FRAME_STATE_SUSPENDED(S) ((S) == FRAME_SUSPENDED || (S) == FRAME_SUSPENDED_YIELD_FROM)
+#define FRAME_STATE_SUSPENDED(S) ((S) >= FRAME_SUSPENDED && (S) <= FRAME_SUSPENDED_YIELD_FROM_LOCKED)
 #define FRAME_STATE_FINISHED(S) ((S) >= FRAME_COMPLETED)
 
 #ifdef __cplusplus
diff --git a/Include/internal/pycore_lock.h b/Include/internal/pycore_lock.h
index c4e007e744ce0f..e31d8b4e5c68c9 100644
--- a/Include/internal/pycore_lock.h
+++ b/Include/internal/pycore_lock.h
@@ -70,6 +70,9 @@ PyMutex_LockFlags(PyMutex *m, _PyLockFlags flags)
 // error messages) otherwise returns 0.
 extern int _PyMutex_TryUnlock(PyMutex *m);
 
+// Yield the processor to other threads (e.g., sched_yield).
+extern void _Py_yield(void);
+
 
 // PyEvent is a one-time event notification
 typedef struct {
diff --git a/Lib/test/support/threading_helper.py b/Lib/test/support/threading_helper.py
index 3e04c344a0d66f..cf87233f0e2e93 100644
--- a/Lib/test/support/threading_helper.py
+++ b/Lib/test/support/threading_helper.py
@@ -250,21 +250,32 @@ def requires_working_threading(*, module=False):
         return unittest.skipUnless(can_start_thread, msg)
 
 
-def run_concurrently(worker_func, nthreads, args=(), kwargs={}):
+def run_concurrently(worker_func, nthreads=None, args=(), kwargs={}):
     """
-    Run the worker function concurrently in multiple threads.
+    Run the worker function(s) concurrently in multiple threads.
+
+    If `worker_func` is a single callable, it is used for all threads.
+    If it is a list of callables, each callable is used for one thread.
     """
+    from collections.abc import Iterable
+
+    if nthreads is None:
+        nthreads = len(worker_func)
+    if not isinstance(worker_func, Iterable):
+        worker_func = [worker_func] * nthreads
+    assert len(worker_func) == nthreads
+
     barrier = threading.Barrier(nthreads)
 
-    def wrapper_func(*args, **kwargs):
+    def wrapper_func(func, *args, **kwargs):
         # Wait for all threads to reach this point before proceeding.
         barrier.wait()
-        worker_func(*args, **kwargs)
+        func(*args, **kwargs)
 
     with catch_threading_exception() as cm:
         workers = [
-            threading.Thread(target=wrapper_func, args=args, kwargs=kwargs)
-            for _ in range(nthreads)
+            threading.Thread(target=wrapper_func, args=(func, *args), kwargs=kwargs)
+            for func in worker_func
         ]
         with start_threads(workers):
             pass
diff --git a/Lib/test/test_free_threading/test_generators.py b/Lib/test/test_free_threading/test_generators.py
index 11f59301bcd51d..2b41e28896f5a8 100644
--- a/Lib/test/test_free_threading/test_generators.py
+++ b/Lib/test/test_free_threading/test_generators.py
@@ -1,4 +1,6 @@
 import concurrent.futures
+import itertools
+import threading
 import unittest
 from threading import Barrier
 from unittest import TestCase
@@ -120,3 +122,38 @@ def drive_generator(g):
 
         g = gen()
         threading_helper.run_concurrently(drive_generator, self.NUM_THREADS, args=(g,))
+
+    def test_concurrent_gi_yieldfrom(self):
+        def gen_yield_from():
+            yield from itertools.count()
+
+        g = gen_yield_from()
+        next(g)  # Put in FRAME_SUSPENDED_YIELD_FROM state
+
+        def read_yieldfrom(gen):
+            for _ in range(10000):
+                self.assertIsNotNone(gen.gi_yieldfrom)
+
+        threading_helper.run_concurrently(read_yieldfrom, self.NUM_THREADS, args=(g,))
+
+    def test_gi_yieldfrom_close_race(self):
+        def gen_yield_from():
+            yield from itertools.count()
+
+        g = gen_yield_from()
+        next(g)
+
+        done = threading.Event()
+
+        def reader():
+            while not done.is_set():
+                g.gi_yieldfrom
+
+        def closer():
+            try:
+                g.close()
+            except ValueError:
+                pass
+            done.set()
+
+        threading_helper.run_concurrently([reader, closer])
diff --git a/Misc/NEWS.d/next/Core_and_Builtins/2026-01-27-17-49-43.gh-issue-120321.Vo7c9T.rst b/Misc/NEWS.d/next/Core_and_Builtins/2026-01-27-17-49-43.gh-issue-120321.Vo7c9T.rst
new file mode 100644
index 00000000000000..052ed07c123bcf
--- /dev/null
+++ b/Misc/NEWS.d/next/Core_and_Builtins/2026-01-27-17-49-43.gh-issue-120321.Vo7c9T.rst
@@ -0,0 +1,2 @@
+Made ``gi_yieldfrom`` thread-safe in the free-threading build
+by using a lightweight lock on the frame state.
diff --git a/Objects/genobject.c b/Objects/genobject.c
index fcdb9017a35f5b..cd23afca57e0fc 100644
--- a/Objects/genobject.c
+++ b/Objects/genobject.c
@@ -10,6 +10,7 @@
 #include "pycore_gc.h"            // _PyGC_CLEAR_FINALIZED()
 #include "pycore_genobject.h"     // _PyGen_SetStopIterationValue()
 #include "pycore_interpframe.h"   // _PyFrame_GetCode()
+#include "pycore_lock.h"          // _Py_yield()
 #include "pycore_modsupport.h"    // _PyArg_CheckPositional()
 #include "pycore_object.h"        // _PyObject_GC_UNTRACK()
 #include "pycore_opcode_utils.h"  // RESUME_AFTER_YIELD_FROM
@@ -44,6 +45,18 @@ static PyObject* async_gen_athrow_new(PyAsyncGenObject *, PyObject *);
     ((gen)->gi_frame_state = (state), true)
 #endif
 
+// Wait for any in-progress gi_yieldfrom read to complete.
+static inline void
+gen_yield_from_lock_wait(PyGenObject *gen, int8_t *frame_state)
+{
+#ifdef Py_GIL_DISABLED
+    while (*frame_state == FRAME_SUSPENDED_YIELD_FROM_LOCKED) {
+        _Py_yield();
+        *frame_state = _Py_atomic_load_int8_relaxed(&gen->gi_frame_state);
+    }
+#endif
+}
+
 
 static const char *NON_INIT_CORO_MSG = "can't send non-None value to a "
                                  "just-started coroutine";
@@ -318,6 +331,8 @@ gen_send_ex(PyGenObject *gen, PyObject *arg, PyObject **presult)
     *presult = NULL;
     int8_t frame_state = FT_ATOMIC_LOAD_INT8_RELAXED(gen->gi_frame_state);
     do {
+        gen_yield_from_lock_wait(gen, &frame_state);
+
         if (frame_state == FRAME_CREATED && arg && arg != Py_None) {
             const char *msg = "can't send non-None value to a "
                                 "just-started generator";
@@ -452,6 +467,8 @@ gen_close(PyObject *self, PyObject *args)
 
     int8_t frame_state = FT_ATOMIC_LOAD_INT8_RELAXED(gen->gi_frame_state);
     do {
+        gen_yield_from_lock_wait(gen, &frame_state);
+
         if (frame_state == FRAME_CREATED) {
             // && (1) to avoid -Wunreachable-code warning on Clang
             if (!_Py_GEN_TRY_SET_FRAME_STATE(gen, frame_state, FRAME_CLEARED) && (1)) {
@@ -614,6 +631,8 @@ _gen_throw(PyGenObject *gen, int close_on_genexit,
 {
     int8_t frame_state = FT_ATOMIC_LOAD_INT8_RELAXED(gen->gi_frame_state);
     do {
+        gen_yield_from_lock_wait(gen, &frame_state);
+
         if (frame_state == FRAME_EXECUTING) {
             gen_raise_already_executing_error(gen);
             return NULL;
@@ -876,12 +895,25 @@ static PyObject *
 gen_getyieldfrom(PyObject *self, void *Py_UNUSED(ignored))
 {
     PyGenObject *gen = _PyGen_CAST(self);
-    int8_t frame_state = FT_ATOMIC_LOAD_INT8_RELAXED(gen->gi_frame_state);
+#ifdef Py_GIL_DISABLED
+    int8_t frame_state = _Py_atomic_load_int8_relaxed(&gen->gi_frame_state);
+    do {
+        gen_yield_from_lock_wait(gen, &frame_state);
+        if (frame_state != FRAME_SUSPENDED_YIELD_FROM) {
+            Py_RETURN_NONE;
+        }
+    } while (!_Py_GEN_TRY_SET_FRAME_STATE(gen, frame_state, FRAME_SUSPENDED_YIELD_FROM_LOCKED));
+
+    PyObject *result = PyStackRef_AsPyObjectNew(_PyFrame_StackPeek(&gen->gi_iframe));
+    _Py_atomic_store_int8_release(&gen->gi_frame_state, FRAME_SUSPENDED_YIELD_FROM);
+    return result;
+#else
+    int8_t frame_state = gen->gi_frame_state;
     if (frame_state != FRAME_SUSPENDED_YIELD_FROM) {
         Py_RETURN_NONE;
     }
-    // TODO: still not thread-safe with free threading
     return PyStackRef_AsPyObjectNew(_PyFrame_StackPeek(&gen->gi_iframe));
+#endif
 }
 
 
diff --git a/Python/ceval.c b/Python/ceval.c
index 04ae7b4d86f9d0..c59f20bbf1e803 100644
--- a/Python/ceval.c
+++ b/Python/ceval.c
@@ -3391,7 +3391,9 @@ _PyEval_GetAwaitable(PyObject *iterable, int oparg)
     else if (PyCoro_CheckExact(iter)) {
         PyCoroObject *coro = (PyCoroObject *)iter;
         int8_t frame_state = FT_ATOMIC_LOAD_INT8_RELAXED(coro->cr_frame_state);
-        if (frame_state == FRAME_SUSPENDED_YIELD_FROM) {
+        if (frame_state == FRAME_SUSPENDED_YIELD_FROM ||
+            frame_state == FRAME_SUSPENDED_YIELD_FROM_LOCKED)
+        {
             /* `iter` is a coroutine object that is being awaited. */
             Py_CLEAR(iter);
             _PyErr_SetString(PyThreadState_GET(), PyExc_RuntimeError,
diff --git a/Python/ceval_macros.h b/Python/ceval_macros.h
index 1cbeb18d02c082..b127812b4bf703 100644
--- a/Python/ceval_macros.h
+++ b/Python/ceval_macros.h
@@ -522,19 +522,22 @@ gen_try_set_executing(PyGenObject *gen)
 #ifdef Py_GIL_DISABLED
     if (!_PyObject_IsUniquelyReferenced((PyObject *)gen)) {
         int8_t frame_state = _Py_atomic_load_int8_relaxed(&gen->gi_frame_state);
-        while (frame_state < FRAME_EXECUTING) {
+        while (frame_state < FRAME_SUSPENDED_YIELD_FROM_LOCKED) {
             if (_Py_atomic_compare_exchange_int8(&gen->gi_frame_state,
                                                  &frame_state,
                                                  FRAME_EXECUTING)) {
                 return true;
             }
         }
+        // NB: We return false for FRAME_SUSPENDED_YIELD_FROM_LOCKED as well.
+        // That case is rare enough that we can just handle it in the deopt.
         return false;
     }
 #endif
     // Use faster non-atomic modifications in the GIL-enabled build and when
     // the object is uniquely referenced in the free-threaded build.
     if (gen->gi_frame_state < FRAME_EXECUTING) {
+        assert(gen->gi_frame_state != FRAME_SUSPENDED_YIELD_FROM_LOCKED);
         gen->gi_frame_state = FRAME_EXECUTING;
         return true;
     }
diff --git a/Python/lock.c b/Python/lock.c
index 12b5ebc89aeec7..ad97bfd93c8495 100644
--- a/Python/lock.c
+++ b/Python/lock.c
@@ -40,7 +40,7 @@ struct mutex_entry {
     int handed_off;
 };
 
-static void
+void
 _Py_yield(void)
 {
 #ifdef MS_WINDOWS