diff --git a/CHANGELOG.md b/CHANGELOG.md
index 32dc3f3136..1e0404e123 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -4,6 +4,9 @@ This project adheres to [Semantic Versioning](https://semver.org/).
 
 ## [UNRELEASED]
 
+### Fixed
+- [#3805](https://github.com/plotly/dash/pull/3805) Fix FastAPI POST routes deadlock caused by middleware consuming request body. Fixes [#3801](https://github.com/plotly/dash/issues/3801).
+
 ## [4.2.0] - 2026-06-01 - *The Freedom Update*
 
 This release marks a major milestone for Dash, bringing unprecedented flexibility to how you build and deploy your applications.
diff --git a/dash/backends/_fastapi.py b/dash/backends/_fastapi.py
index 027b94bed4..0516b5edcb 100644
--- a/dash/backends/_fastapi.py
+++ b/dash/backends/_fastapi.py
@@ -223,7 +223,19 @@ async def __call__(self, scope: Scope, receive: Receive, send: Send) -> None:
             await self.app(scope, receive, send)
             return
 
-        # HTTP/WebSocket request handling
+        # Non-Dash routes pass through to avoid consuming body stream
+        path = scope["path"]
+        prefix = self.dash_app.config.routes_pathname_prefix
+        dash_prefix = prefix.rstrip("/") + "/_dash-"
+        if (
+            not path.startswith(dash_prefix)
+            and path != prefix
+            and path != prefix.rstrip("/")
+        ):
+            await self.app(scope, receive, send)
+            return
+
+        # HTTP request handling
         request = Request(scope, receive=receive)
         token = set_current_request(request)
 
diff --git a/tests/backend_tests/test_preconfig_backends.py b/tests/backend_tests/test_preconfig_backends.py
index eec832070a..5f912415ab 100644
--- a/tests/backend_tests/test_preconfig_backends.py
+++ b/tests/backend_tests/test_preconfig_backends.py
@@ -291,3 +291,46 @@ def test_silence_routes_logging(backend, expected_loggers):
         assert (
             logger.level == logging.ERROR
         ), f"Logger {logger_name} should be set to ERROR level for {backend} backend"
+
+
+def test_fastapi_custom_post_route(dash_duo):
+    """Test that user-defined POST routes work with FastAPI backend.
+
+    Regression test for https://github.com/plotly/dash/issues/3801
+    The DashMiddleware was consuming the request body for all routes,
+    causing POST requests to user-defined routes to hang.
+    """
+    from fastapi import FastAPI, Request
+    from fastapi.responses import JSONResponse
+    import requests
+
+    fastapi_app = FastAPI()
+
+    @fastapi_app.get("/api/echo")
+    async def echo_get():
+        return JSONResponse({"method": "GET", "ok": True})
+
+    @fastapi_app.post("/api/echo")
+    async def echo_post(request: Request):
+        body = await request.json()
+        return JSONResponse({"echo": body})
+
+    app = Dash(__name__, server=fastapi_app)
+    app.layout = html.Div("Dash is running")
+
+    dash_duo.start_server(app)
+
+    # Test GET request
+    url = dash_duo.server_url
+    resp = requests.get(f"{url}/api/echo", timeout=5)
+    assert resp.status_code == 200
+    assert resp.json() == {"method": "GET", "ok": True}
+
+    # Test POST request - this was hanging before the fix
+    resp = requests.post(
+        f"{url}/api/echo",
+        json={"hello": "world"},
+        timeout=5,
+    )
+    assert resp.status_code == 200
+    assert resp.json() == {"echo": {"hello": "world"}}