diff --git a/lib/ch/connection.ex b/lib/ch/connection.ex
index b53394a..da7201c 100644
--- a/lib/ch/connection.ex
+++ b/lib/ch/connection.ex
@@ -7,6 +7,8 @@ defmodule Ch.Connection do
 
   @user_agent "ch/" <> Mix.Project.config()[:version]
 
+  @server_display_name_key :server_display_name
+
   @typep conn :: HTTP.t()
 
   @impl true
@@ -25,6 +27,12 @@ defmodule Ch.Connection do
         |> maybe_put_private(:username, opts[:username])
         |> maybe_put_private(:password, opts[:password])
         |> maybe_put_private(:settings, opts[:settings])
+        |> HTTP.put_private(:reconnect_opts, %{
+          scheme: scheme,
+          address: address,
+          port: port,
+          mint_opts: mint_opts
+        })
 
       handshake = Query.build("select 1, version()")
       params = DBConnection.Query.encode(handshake, _params = [], _opts = [])
@@ -364,9 +372,11 @@ defmodule Ch.Connection do
           | {:error, Error.t(), conn}
           | {:disconnect, Mint.Types.error(), conn}
   defp request(conn, method, path, headers, body, opts) do
-    with {:ok, conn, _ref} <- send_request(conn, method, path, headers, body) do
-      receive_full_response(conn, timeout(conn, opts))
-    end
+    with_retry_if_stale_connection(conn, fn conn ->
+      with {:ok, conn, _ref} <- send_request(conn, method, path, headers, body) do
+        receive_full_response(conn, timeout(conn, opts))
+      end
+    end)
   end
 
   @spec request_chunked(conn, binary, binary, Mint.Types.headers(), Enumerable.t(), Keyword.t()) ::
@@ -374,9 +384,11 @@ defmodule Ch.Connection do
           | {:error, Error.t(), conn}
           | {:disconnect, Mint.Types.error(), conn}
   def request_chunked(conn, method, path, headers, stream, opts) do
-    with {:ok, conn, ref} <- send_request(conn, method, path, headers, :stream),
-         {:ok, conn} <- stream_body(conn, ref, stream),
-         do: receive_full_response(conn, timeout(conn, opts))
+    with_retry_if_stale_connection(conn, fn conn ->
+      with {:ok, conn, ref} <- send_request(conn, method, path, headers, :stream),
+           {:ok, conn} <- stream_body(conn, ref, stream),
+           do: receive_full_response(conn, timeout(conn, opts))
+    end)
   end
 
   @spec stream_body(conn, Mint.Types.request_ref(), Enumerable.t()) ::
@@ -405,6 +417,56 @@ defmodule Ch.Connection do
     end
   end
 
+  defp with_retry_if_stale_connection(conn, fun) do
+    case fun.(conn) do
+      {:disconnect, reason, conn} ->
+        if reconnectable_error?(reason) do
+          case reconnect(conn) do
+            {:ok, new_conn} ->
+              fun.(new_conn)
+
+            {:error, reason} ->
+              {:disconnect, reason, conn}
+          end
+        else
+          {:disconnect, reason, conn}
+        end
+
+      other ->
+        other
+    end
+  end
+
+  defp reconnectable_error?(%Mint.TransportError{reason: :closed}), do: true
+  defp reconnectable_error?(%Mint.TransportError{reason: :econnreset}), do: true
+  defp reconnectable_error?(_), do: false
+
+  @spec reconnect(conn) :: {:ok, conn} | {:error, Mint.Types.error()}
+  defp reconnect(conn) do
+    %{scheme: scheme, address: address, port: port, mint_opts: mint_opts} =
+      HTTP.get_private(conn, :reconnect_opts)
+
+    {:ok, _closed_conn} = HTTP.close(conn)
+
+    case HTTP.connect(scheme, address, port, mint_opts) do
+      {:ok, new_conn} ->
+        new_conn =
+          new_conn
+          |> HTTP.put_private(:timeout, HTTP.get_private(conn, :timeout))
+          |> maybe_put_private(:database, HTTP.get_private(conn, :database))
+          |> maybe_put_private(:username, HTTP.get_private(conn, :username))
+          |> maybe_put_private(:password, HTTP.get_private(conn, :password))
+          |> maybe_put_private(:settings, HTTP.get_private(conn, :settings))
+          |> HTTP.put_private(:reconnect_opts, HTTP.get_private(conn, :reconnect_opts))
+          |> maybe_put_private(@server_display_name_key, HTTP.get_private(conn, @server_display_name_key))
+
+        {:ok, new_conn}
+
+      {:error, _reason} = error ->
+        error
+    end
+  end
+
   @spec receive_full_response(conn, timeout) ::
           {:ok, conn, [response]}
           | {:error, Error.t(), conn}
@@ -499,8 +561,6 @@ defmodule Ch.Connection do
     "/?" <> URI.encode_query(settings ++ query_params)
   end
 
-  @server_display_name_key :server_display_name
-
   @spec ensure_same_server(conn, Mint.Types.headers()) :: conn
   defp ensure_same_server(conn, headers) do
     expected_name = HTTP.get_private(conn, @server_display_name_key)