diff --git a/.github/renovate.json5 b/.github/renovate.json5
index 8bbfe2bf9..e90f793b9 100644
--- a/.github/renovate.json5
+++ b/.github/renovate.json5
@@ -56,13 +56,6 @@
       "matchUpdateTypes": ["patch"],
       "schedule": ["before 8am every weekday"]
     },
-    {
-      // jiter >= 0.13 bumps PyO3 to 0.28, which drops PyPy 3.10 support.
-      // Our openai-latest test matrix still includes PyPy 3.10, so pin
-      // jiter to the 0.11.x line until PyPy 3.10 is removed from the matrix.
-      "matchPackageNames": ["jiter"],
-      "allowedVersions": "<0.12"
-    },
     {
       // pydantic 2.13 bumps PyO3 to 0.28 (via pydantic-core), which drops
       // PyPy 3.10 support. Our openai-latest test matrix still includes
diff --git a/docs-requirements.txt b/docs-requirements.txt
index 1ea3ccedd..c22538e92 100644
--- a/docs-requirements.txt
+++ b/docs-requirements.txt
@@ -14,7 +14,7 @@ claude-agent-sdk>=0.2.152
 google-genai>=2.22.0
 langchain>=1.3.18
 llama-index-core>=0.14.24
-openai>=2.54.0
+openai>=3.13.0
 openai-agents>=0.22.2
 smolagents>=1.26.0
 weaviate-client>=4.22.0
diff --git a/instrumentation/opentelemetry-instrumentation-genai-openai-agents/tests/requirements.latest.txt b/instrumentation/opentelemetry-instrumentation-genai-openai-agents/tests/requirements.latest.txt
index 5d24bf1e5..d64df072e 100644
--- a/instrumentation/opentelemetry-instrumentation-genai-openai-agents/tests/requirements.latest.txt
+++ b/instrumentation/opentelemetry-instrumentation-genai-openai-agents/tests/requirements.latest.txt
@@ -38,7 +38,7 @@
 # the newest supported version of external dependencies.
 
 openai-agents~=0.22.2
-openai==3.1.0
+openai==3.13.0
 pydantic>=2.12.5,<3
 httpx==0.28.1
 Deprecated==1.3.1
diff --git a/instrumentation/opentelemetry-instrumentation-genai-openai/examples/embeddings/requirements.txt b/instrumentation/opentelemetry-instrumentation-genai-openai/examples/embeddings/requirements.txt
index f77afa8dc..811f9cae4 100644
--- a/instrumentation/opentelemetry-instrumentation-genai-openai/examples/embeddings/requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-genai-openai/examples/embeddings/requirements.txt
@@ -1,4 +1,4 @@
-openai~=2.54.0
+openai~=3.13.0
 
 opentelemetry-sdk~=1.43.0
 opentelemetry-exporter-otlp-proto-grpc~=1.43.0
diff --git a/instrumentation/opentelemetry-instrumentation-genai-openai/examples/manual/requirements.txt b/instrumentation/opentelemetry-instrumentation-genai-openai/examples/manual/requirements.txt
index 171c07080..3f264d018 100644
--- a/instrumentation/opentelemetry-instrumentation-genai-openai/examples/manual/requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-genai-openai/examples/manual/requirements.txt
@@ -1,4 +1,4 @@
-openai~=2.54.0
+openai~=3.13.0
 
 opentelemetry-sdk~=1.43.0
 opentelemetry-exporter-otlp-proto-grpc~=1.43.0
diff --git a/instrumentation/opentelemetry-instrumentation-genai-openai/examples/zero-code/requirements.txt b/instrumentation/opentelemetry-instrumentation-genai-openai/examples/zero-code/requirements.txt
index 8d080fe7e..11a4d7a66 100644
--- a/instrumentation/opentelemetry-instrumentation-genai-openai/examples/zero-code/requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-genai-openai/examples/zero-code/requirements.txt
@@ -1,4 +1,4 @@
-openai~=2.54.0
+openai~=3.13.0
 
 opentelemetry-sdk~=1.43.0
 opentelemetry-exporter-otlp-proto-grpc~=1.43.0
diff --git a/instrumentation/opentelemetry-instrumentation-genai-openai/tests/requirements.latest.txt b/instrumentation/opentelemetry-instrumentation-genai-openai/tests/requirements.latest.txt
index ae2756dde..84ecd1e6a 100644
--- a/instrumentation/opentelemetry-instrumentation-genai-openai/tests/requirements.latest.txt
+++ b/instrumentation/opentelemetry-instrumentation-genai-openai/tests/requirements.latest.txt
@@ -37,12 +37,10 @@
 # This variant of the requirements aims to test the system using
 # the newest supported version of external dependencies.
 
-openai==3.1.0
+openai==3.13.0
 # older pydantic is required for PyPy < 3.11
 pydantic==2.12.5
 httpx2==2.12.0
-# older jiter is required for PyPy < 3.11
-jiter==0.11.1
 Deprecated==1.3.1
 importlib-metadata==9.0.1
 packaging==26.3
@@ -50,4 +48,4 @@ wrapt==2.2.2
 # test with the latest version of opentelemetry-api, sdk, semantic conventions, and instrumentation
 
 -e instrumentation/opentelemetry-instrumentation-genai-openai
--e util/opentelemetry-util-genai
\ No newline at end of file
+-e util/opentelemetry-util-genai
diff --git a/instrumentation/opentelemetry-instrumentation-genai-openai/tests/requirements.v2.txt b/instrumentation/opentelemetry-instrumentation-genai-openai/tests/requirements.v2.txt
index bc309e1a4..f5c158899 100644
--- a/instrumentation/opentelemetry-instrumentation-genai-openai/tests/requirements.v2.txt
+++ b/instrumentation/opentelemetry-instrumentation-genai-openai/tests/requirements.v2.txt
@@ -43,8 +43,6 @@ openai==2.54.0
 pydantic==2.12.5
 httpx==0.28.1
 opentelemetry-instrumentation-httpx==0.64b0
-# older jiter is required for PyPy < 3.11
-jiter==0.11.1
 Deprecated==1.3.1
 importlib-metadata==9.0.1
 packaging==26.3