diff --git a/.yarn/versions/a3c9f4be.yml b/.yarn/versions/a3c9f4be.yml
new file mode 100644
index 0000000..90948e7
--- /dev/null
+++ b/.yarn/versions/a3c9f4be.yml
@@ -0,0 +1,2 @@
+releases:
+  "@nytimes/react-prosemirror": patch
diff --git a/src/hooks/__tests__/useEditorViewLayoutEffect.test.tsx b/src/hooks/__tests__/useEditorViewLayoutEffect.test.tsx
index 20ce83e..10d6ca2 100644
--- a/src/hooks/__tests__/useEditorViewLayoutEffect.test.tsx
+++ b/src/hooks/__tests__/useEditorViewLayoutEffect.test.tsx
@@ -1,12 +1,17 @@
 /* eslint-disable @typescript-eslint/no-empty-function */
 
 import { render } from "@testing-library/react";
-import type { EditorState } from "prosemirror-state";
-import type { EditorView } from "prosemirror-view";
+import { Schema } from "prosemirror-model";
+import { EditorState } from "prosemirror-state";
+import { EditorView } from "prosemirror-view";
 import React from "react";
 
 import { LayoutGroup } from "../../components/LayoutGroup.js";
 import { EditorContext } from "../../contexts/EditorContext.js";
+import {
+  setupProseMirrorView,
+  teardownProseMirrorView,
+} from "../../testing/setupProseMirrorView.js";
 import { useEditorEffect } from "../useEditorEffect.js";
 
 function TestComponent({
@@ -126,4 +131,101 @@ describe("useEditorViewLayoutEffect", () => {
 
     expect(effect).toHaveBeenCalledTimes(2);
   });
+
+  describe("with a real EditorView", () => {
+    const schema = new Schema({
+      nodes: {
+        text: {},
+        doc: { content: "text*" },
+      },
+    });
+
+    beforeAll(() => {
+      setupProseMirrorView();
+    });
+
+    afterAll(() => {
+      teardownProseMirrorView();
+    });
+
+    it("should not run the effect if the EditorView has been destroyed", () => {
+      const editorState = EditorState.create({ schema });
+      const mount = document.createElement("div");
+      document.body.appendChild(mount);
+      const editorView = new EditorView({ mount }, { state: editorState });
+
+      editorView.destroy();
+      expect(editorView.isDestroyed).toBe(true);
+
+      const effect = jest.fn();
+
+      render(
+        <LayoutGroup>
+          <EditorContext.Provider
+            value={{
+              editorView,
+              editorState,
+              registerEventListener: () => {},
+              unregisterEventListener: () => {},
+            }}
+          >
+            <TestComponent effect={effect} />
+          </EditorContext.Provider>
+        </LayoutGroup>
+      );
+
+      expect(effect).not.toHaveBeenCalled();
+
+      document.body.removeChild(mount);
+    });
+
+    it("should not re-run the effect after the EditorView is destroyed between renders", () => {
+      const editorState = EditorState.create({ schema });
+      const mount = document.createElement("div");
+      document.body.appendChild(mount);
+      const editorView = new EditorView({ mount }, { state: editorState });
+
+      const effect = jest.fn();
+
+      const { rerender } = render(
+        <LayoutGroup>
+          <EditorContext.Provider
+            value={{
+              editorView,
+              editorState,
+              registerEventListener: () => {},
+              unregisterEventListener: () => {},
+            }}
+          >
+            <TestComponent effect={effect} dependencies={["one"]} />
+          </EditorContext.Provider>
+        </LayoutGroup>
+      );
+
+      expect(effect).toHaveBeenCalledTimes(1);
+      expect(effect).toHaveBeenCalledWith(editorView);
+
+      editorView.destroy();
+      expect(editorView.isDestroyed).toBe(true);
+
+      rerender(
+        <LayoutGroup>
+          <EditorContext.Provider
+            value={{
+              editorView,
+              editorState,
+              registerEventListener: () => {},
+              unregisterEventListener: () => {},
+            }}
+          >
+            <TestComponent effect={effect} dependencies={["two"]} />
+          </EditorContext.Provider>
+        </LayoutGroup>
+      );
+
+      expect(effect).toHaveBeenCalledTimes(1);
+
+      document.body.removeChild(mount);
+    });
+  });
 });
diff --git a/src/hooks/useEditorEffect.ts b/src/hooks/useEditorEffect.ts
index 007d61d..4c2e177 100644
--- a/src/hooks/useEditorEffect.ts
+++ b/src/hooks/useEditorEffect.ts
@@ -34,7 +34,7 @@ export function useEditorEffect(
   // be defined inline and run on every re-render.
   useLayoutGroupEffect(
     () => {
-      if (editorView) {
+      if (editorView && !editorView.isDestroyed) {
         return effect(editorView);
       }
     },