diff --git a/modules/local/fitness/run_mutscan/environment.yml b/modules/local/fitness/run_mutscan/environment.yml
index 9765c04..aeaf45d 100644
--- a/modules/local/fitness/run_mutscan/environment.yml
+++ b/modules/local/fitness/run_mutscan/environment.yml
@@ -2,6 +2,6 @@ channels:
   - conda-forge
   - bioconda
 dependencies:
-  - bioconda::bioconductor-biostrings=2.74.0
+  - bioconda::bioconductor-biostrings=2.78.0
   - bioconda::bioconductor-mutscan=1.0.0
-  - conda-forge::r-base=4.4.1
+  - conda-forge::r-base=4.5.3
diff --git a/nextflow.config b/nextflow.config
index f8086e2..64944d7 100644
--- a/nextflow.config
+++ b/nextflow.config
@@ -189,7 +189,7 @@ includeConfig params.custom_config_base && (!System.getenv('NXF_OFFLINE') || !pa
 
 
 // Load nf-core/deepmutscan custom profiles from different institutions.
-// includeConfig params.custom_config_base && (!System.getenv('NXF_OFFLINE') || !params.custom_config_base.startsWith('http')) ? "${params.custom_config_base}/pipeline/deepmutscan.config" : "/dev/null"
+includeConfig params.custom_config_base && (!System.getenv('NXF_OFFLINE') || !params.custom_config_base.startsWith('http')) ? "${params.custom_config_base}/pipeline/deepmutscan.config" : "/dev/null"
 
 // Set default registry for Apptainer, Docker, Podman, Charliecloud and Singularity independent of -profile
 // Will not be used unless Apptainer / Docker / Podman / Charliecloud / Singularity are enabled