From ea594f2e6f15a2fd7443ae3d2cb7ac11171fe02c Mon Sep 17 00:00:00 2001 From: anere Date: Sun, 3 May 2026 19:59:44 +0500 Subject: [PATCH] Rebuild CAB external temporal and failure union outputs --- README_external_rebuild.md | 27 + config/external_resources.yaml | 107 + ...clinvar_temporal_alignment_raw_rebuilt.csv | 943 +++++++++ ...cab_clinvar_temporal_endpoints_rebuilt.csv | 943 +++++++++ .../cab_failure_membership_explicit.csv | 1734 ++++++++++++++++- .../cab_patch_clamp_functional_overlay.csv | 1 + .../patch_clamp_source_inventory.csv | 2 + .../patch_clamp_variant_scores_normalized.csv | 1 + .../failures/temporal_alignment_failures.csv | 790 ++++++++ .../final_external_rebuild_audit_report.md | 3 + .../qc/external_resource_discovery_report.md | 16 + .../qc/patch_clamp_integration_qc_report.md | 3 + reports/qc/temporal_rebuilt_qc_report.md | 5 + .../blocked_claims_after_external_rebuild.csv | 4 + ...precated_claims_after_external_rebuild.csv | 4 + reports/tables/failure_class_counts_final.csv | 7 + reports/tables/failure_overlap_final.csv | 5 + reports/tables/failure_union_final.csv | 2 + .../patch_clamp_coverage_by_architecture.csv | 1 + .../tables/patch_clamp_coverage_by_gene.csv | 1 + ...lication_safe_numbers_rebuilt_external.csv | 4 + .../temporal_deprecated_claim_retest.csv | 2 + .../temporal_rebuilt_endpoint_counts.csv | 7 + .../tables/temporal_rebuilt_overlap_bias.csv | 2 + .../temporal_rebuilt_pairwise_tests.csv | 1 + run_external_rebuild.ps1 | 30 + run_external_rebuild.sh | 32 + src/20_download_external_resources.py | 59 + src/21_parse_clinvar_snapshots.py | 130 ++ src/22_rebuild_temporal_endpoints.py | 82 + src/23_fetch_parse_clingen_resources.py | 55 + src/24_rebuild_clingen_vcep_cspec_overlay.py | 68 + src/25_rebuild_gnomad_af_lookup.py | 59 + src/26_fetch_parse_mavedb.py | 65 + ...search_patch_clamp_supplementary_tables.py | 34 + src/28_integrate_functional_evidence.py | 29 + src/29_recompute_failure_union.py | 55 + src/30_rebuild_publication_safe_claims.py | 72 + ...ailure_membership_from_available_tables.py | 225 +++ src/cab_external_utils.py | 162 ++ 40 files changed, 5769 insertions(+), 3 deletions(-) create mode 100644 README_external_rebuild.md create mode 100644 config/external_resources.yaml create mode 100644 data/processed/cab_clinvar_temporal_alignment_raw_rebuilt.csv create mode 100644 data/processed/cab_clinvar_temporal_endpoints_rebuilt.csv create mode 100644 data/processed/cab_patch_clamp_functional_overlay.csv create mode 100644 data/processed/patch_clamp_source_inventory.csv create mode 100644 data/processed/patch_clamp_variant_scores_normalized.csv create mode 100644 reports/failures/temporal_alignment_failures.csv create mode 100644 reports/final_external_rebuild_audit_report.md create mode 100644 reports/qc/external_resource_discovery_report.md create mode 100644 reports/qc/patch_clamp_integration_qc_report.md create mode 100644 reports/qc/temporal_rebuilt_qc_report.md create mode 100644 reports/tables/blocked_claims_after_external_rebuild.csv create mode 100644 reports/tables/deprecated_claims_after_external_rebuild.csv create mode 100644 reports/tables/failure_class_counts_final.csv create mode 100644 reports/tables/failure_overlap_final.csv create mode 100644 reports/tables/failure_union_final.csv create mode 100644 reports/tables/patch_clamp_coverage_by_architecture.csv create mode 100644 reports/tables/patch_clamp_coverage_by_gene.csv create mode 100644 reports/tables/publication_safe_numbers_rebuilt_external.csv create mode 100644 reports/tables/temporal_deprecated_claim_retest.csv create mode 100644 reports/tables/temporal_rebuilt_endpoint_counts.csv create mode 100644 reports/tables/temporal_rebuilt_overlap_bias.csv create mode 100644 reports/tables/temporal_rebuilt_pairwise_tests.csv create mode 100644 run_external_rebuild.ps1 create mode 100644 run_external_rebuild.sh create mode 100644 src/20_download_external_resources.py create mode 100644 src/21_parse_clinvar_snapshots.py create mode 100644 src/22_rebuild_temporal_endpoints.py create mode 100644 src/23_fetch_parse_clingen_resources.py create mode 100644 src/24_rebuild_clingen_vcep_cspec_overlay.py create mode 100644 src/25_rebuild_gnomad_af_lookup.py create mode 100644 src/26_fetch_parse_mavedb.py create mode 100644 src/27_search_patch_clamp_supplementary_tables.py create mode 100644 src/28_integrate_functional_evidence.py create mode 100644 src/29_recompute_failure_union.py create mode 100644 src/30_rebuild_publication_safe_claims.py create mode 100644 src/31_rebuild_failure_membership_from_available_tables.py create mode 100644 src/cab_external_utils.py diff --git a/README_external_rebuild.md b/README_external_rebuild.md new file mode 100644 index 0000000..9b108ee --- /dev/null +++ b/README_external_rebuild.md @@ -0,0 +1,27 @@ +# CAB external rebuild scaffold + +This package adds scripts/configuration for raw external rebuild work. + +It does not restore deprecated CAB claims automatically. It writes manifests, checksums, logs, parsed tables, failures, and publication-safe claim status files. + +Install dependency: + +```bash +python -m pip install pyyaml +``` + +Run on Linux/macOS/Git Bash: + +```bash +bash run_external_rebuild.sh +``` + +Run on Windows PowerShell: + +```powershell +powershell -ExecutionPolicy Bypass -File .\run_external_rebuild.ps1 +``` + +gnomAD requires a local extracted sites table or custom API-backed lookup because full v4 resources are large. Set `gnomad.local_sites_table` in `config/external_resources.yaml`. + +Patch-clamp supplementary tables require manual source/license review. No copyrighted article text scraping is performed. diff --git a/config/external_resources.yaml b/config/external_resources.yaml new file mode 100644 index 0000000..7386fe3 --- /dev/null +++ b/config/external_resources.yaml @@ -0,0 +1,107 @@ +# CAB external rebuild resource configuration. +# Public endpoints were identified from official/public documentation where possible. +# Verify exact archived ClinVar snapshot file names before publication. +# Do not convert failed downloads into publication claims. Yes, apparently that needs to be written down. + +clinvar: + current_variant_summary: + resource_name: ClinVar current variant_summary + version: current + release_date: current + url: https://ftp.ncbi.nlm.nih.gov/pub/clinvar/tab_delimited/variant_summary.txt.gz + output: data/raw/clinvar/current/variant_summary.txt.gz + license_or_terms: NCBI ClinVar public FTP; verify current terms at access time. + current_submission_summary: + resource_name: ClinVar current submission_summary + version: current + release_date: current + url: https://ftp.ncbi.nlm.nih.gov/pub/clinvar/tab_delimited/submission_summary.txt.gz + output: data/raw/clinvar/current/submission_summary.txt.gz + license_or_terms: NCBI ClinVar public FTP; verify current terms at access time. + baseline_variant_summary: + resource_name: ClinVar baseline variant_summary + version: 2023-01 + release_date: 2023-01 + url: https://ftp.ncbi.nlm.nih.gov/pub/clinvar/tab_delimited/archive/variant_summary_2023-01.txt.gz + output: data/raw/clinvar/2023-01/variant_summary_2023-01.txt.gz + license_or_terms: NCBI ClinVar public FTP; verify current terms at access time. + followup_variant_summary: + resource_name: ClinVar follow-up variant_summary + version: 2026-04 + release_date: 2026-04 + url: https://ftp.ncbi.nlm.nih.gov/pub/clinvar/tab_delimited/archive/variant_summary_2026-04.txt.gz + output: data/raw/clinvar/2026-04/variant_summary_2026-04.txt.gz + license_or_terms: NCBI ClinVar public FTP; verify current terms at access time. + +clingen: + gene_disease_validity: + resource_name: ClinGen Gene-Disease Validity + version: current + release_date: current + # If this direct CSV endpoint changes, download from https://search.clinicalgenome.org/kb/downloads and update this URL. + url: https://search.clinicalgenome.org/kb/gene-validity/download + output: data/raw/clingen/current/gene_disease_validity.csv + license_or_terms: ClinGen public resource; verify terms at access time. + cspec_registry: + resource_name: ClinGen CSpec Registry landing page + version: current + release_date: current + url: https://cspec.genome.network/cspec/ui/svi/ + output: data/raw/clingen/current/cspec_registry_landing.html + license_or_terms: ClinGen CSpec public pages/API; structured export may require manual endpoint discovery. + evidence_repository: + resource_name: ClinGen Evidence Repository landing page + version: current + release_date: current + url: https://erepo.clinicalgenome.org/evrepo/ + output: data/raw/clingen/current/evidence_repository_landing.html + license_or_terms: ClinGen Evidence Repository; structured export may require API/manual retrieval. + +gnomad: + release: v4.1.1_or_latest_v4 + documentation_url: https://gnomad.broadinstitute.org/downloads + local_sites_table: "" + required_columns: + - chr + - pos + - ref + - alt + - global_af + - popmax_af + - popmax_population + - ac + - an + +mavedb: + api_base_url: https://api.mavedb.org/api/v1 + genes: + - KCNQ1 + - KCNH2 + - KCNE1 + - SCN5A + - RYR2 + - CACNA1C + - CASQ2 + - HCN4 + - ANK2 + - CALM1 + - CALM2 + - CALM3 + - TRDN + +patch_clamp: + manual_inventory_csv: data/raw/patch_clamp/manual_source_inventory.csv + priority_genes: + - KCNQ1 + - KCNH2 + - SCN5A + - RYR2 + - CACNA1C + - KCNE1 + - CASQ2 + +cab_inputs: + master_candidates: + - data/processed/cab_causal_architecture_assignments.csv + - data/processed/cab_routing_assignments.csv + failure_membership: data/processed/cab_failure_membership_explicit.csv diff --git a/data/processed/cab_clinvar_temporal_alignment_raw_rebuilt.csv b/data/processed/cab_clinvar_temporal_alignment_raw_rebuilt.csv new file mode 100644 index 0000000..dbaadbf --- /dev/null +++ b/data/processed/cab_clinvar_temporal_alignment_raw_rebuilt.csv @@ -0,0 +1,943 @@ 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(p.Arg375His),anchored_exact,2.0521436008006096e-06,3.744056310606911e-05,18.24460327574495,True,True,0.0001,-0.4266576280958051,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,True,True,False,True,8,conditional_penetrance_dependent|population_localized_susceptibility,2,conditional_penetrance_dependent,population_localized_susceptibility,False,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +373047,7:150947326:A:G,KCNH2,ancestry_concentrated,LQTS,LQTS,,NM_000238.4(KCNH2):c.3152+2T>C,anchored_exact,7.203770165153635e-07,2.8064660978895374e-05,38.95824322159453,True,True,0.0001,-0.551840199689963,False,False,False,False,False,False,False,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,6,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +924057,3:38575364:T:TG,SCN5A,disease_model_collision,arrhythmia,arrhythmia,Cardiac arrhythmia,NM_000335.5(SCN5A):c.3595dup (p.His1199fs),anchored_exact,6.851933821282381e-07,3.832592365476008e-05,55.9343824970053,True,True,0.0001,-0.41650736985045,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,2,True,False,False,True,True,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent|population_localized_susceptibility,3,genotype_first_postmortem,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1455898,11:2572072:G:GGA,KCNQ1,disease_model_collision,LQTS,LQTS|arrhythmia,Long QT syndrome|Cardiac arrhythmia,NM_000218.3(KCNQ1):c.745_746dup (p.Leu250fs),anchored_exact,6.84671706763324e-07,3.828190797029324e-05,55.91271361066016,True,True,0.0001,-0.4170064251187987,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,True,False,True,9,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +375594,11:2572900:T:A,KCNQ1,ancestry_concentrated,SQTS,SQTS,Short QT syndrome type 2,NM_000218.3(KCNQ1):c.835T>A (p.Phe279Ile),anchored_exact,1.3684626827068738e-06,2.3186792802819512e-05,16.943667629494662,True,True,0.0001,-0.6347593188205799,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,True,False,True,8,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1454593,7:150947380:GCCGC:G,KCNH2,ancestry_concentrated,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.3096_3099del (p.Arg1033fs),anchored_exact,1.432334375595314e-06,3.980891719745223e-05,27.793014733652488,True,True,0.0001,-0.4000196350651585,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,false,true,true,false,2023-01,2026-04 +838068,6:123516189:C:A,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 5|Catecholaminergic polymorphic ventricular tachycardia 1|Cardiovascular phenotype,NM_006073.4(TRDN):c.502G>T (p.Glu168Ter),anchored_exact,2.0270178963157825e-05,2.603458550047152e-05,1.2843786561239623,False,False,0.001,-1.584449332383948,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1171509,3:38613742:C:A,SCN5A,disease_model_collision,arrhythmia,arrhythmia,Cardiac arrhythmia,NM_000335.5(SCN5A):c.703+1G>T,anchored_exact,6.932745436520316e-07,2.56068831301854e-05,36.93608459818682,True,True,0.0001,-0.5916432806389674,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,2,True,False,False,True,True,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent|population_localized_susceptibility,3,genotype_first_postmortem,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1214434,3:38587561:TC:T,SCN5A,disease_model_collision,SADS,Brugada|LQTS|SADS|conduction,Cardiovascular phenotype,NM_000335.5(SCN5A):c.2274del (p.Ile759fs),anchored_exact,2.052421583812688e-06,3.3126842680624107e-05,16.140362097890165,True,True,0.0001,-0.479819954752671,False,False,False,True,True,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,True,False,True,12,genotype_first_postmortem|conditional_penetrance_dependent|population_localized_susceptibility,3,genotype_first_postmortem,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1067403,11:2572110:G:A,KCNQ1,ancestry_concentrated,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.780+1G>A,anchored_exact,6.854366642813471e-07,2.520034272466105e-05,36.76533263033125,True,True,0.0001,-0.5985935527733383,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +852605,1:237795312:A:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome|Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.13937A>C (p.Asp4646Ala),anchored_exact,9.531449812945298e-06,1.2573555298496204e-05,1.319164998619016,False,False,2.5e-05,-0.2984819125134828,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +1757434,1:115727014:C:A,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Cardiovascular phenotype|Catecholaminergic polymorphic ventricular tachycardia 1|Catecholaminergic polymorphic ventricular tachycardia 2,NM_001232.4(CASQ2):c.715G>T (p.Glu239Ter),anchored_exact,2.2557001542898904e-06,3.53090720775858e-05,15.653258416096053,True,True,0.001,-1.4521136955459195,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,True,False,True,11,provocation_dependent_instability|conditional_penetrance_dependent|population_localized_susceptibility,3,provocation_dependent_instability,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1420193,7:150947827:GC:G,KCNH2,ancestry_concentrated,LQTS,LQTS,Long QT syndrome|Long QT syndrome 2,NM_000238.4(KCNH2):c.2743del (p.Ala915fs),anchored_exact,7.281115117342451e-07,2.8638524543215534e-05,39.3325551775003,True,True,0.0001,-0.5430493606395334,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +633643,12:2593252:C:G,CACNA1C,disease_model_collision,LQTS,LQTS,Long QT syndrome 8|Long QT syndrome,NM_000719.7(CACNA1C):c.2570C>G (p.Pro857Arg),anchored_exact,6.842613057074236e-07,2.2369362920544025e-05,32.691211738483084,True,True,0.0001,-0.6503463844340879,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,2,True,False,False,False,True,False,True,10,genotype_first_postmortem|population_localized_susceptibility,2,genotype_first_postmortem,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +547162,21:34449497:G:T,KCNE1,penetrance_boundary,LQTS,LQTS,Jervell and Lange-Nielsen syndrome 2|Long QT syndrome 5|Long QT syndrome,NM_000219.6(KCNE1):c.138C>A (p.Tyr46Ter),anchored_exact,3.000828228591091e-06,2.9429942023014216e-05,9.807270184725496,False,False,2.5e-05,0.0708493978682867,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,True,False,False,True,6,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +859128,1:115726996:G:A,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia,NM_001232.4(CASQ2):c.733C>T (p.Gln245Ter),anchored_exact,1.6498437597959474e-06,2.4118469924268005e-05,14.618630499060393,True,True,0.001,-1.617650247299917,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,True,False,True,11,provocation_dependent_instability|conditional_penetrance_dependent|population_localized_susceptibility,3,provocation_dependent_instability,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +666975,11:2775959:G:A,KCNQ1,ancestry_concentrated,LQTS,LQTS,Congenital long QT syndrome|Long QT syndrome,NM_000218.3(KCNQ1):c.1591-1G>A,anchored_exact,1.4245501270698712e-06,3.968253968253968e-05,27.85617162380255,True,True,0.0001,-0.4014005407815441,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +972416,7:150947785:TC:T,KCNH2,ancestry_concentrated,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.2785del (p.Glu929fs),anchored_exact,7.232300030520306e-07,2.6745119015779625e-05,36.98005188233825,True,True,0.0001,-0.5727554651542196,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1515619,1:115744827:C:G,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.319+1G>C,anchored_exact,6.866537850416593e-07,2.521050773962588e-05,36.71496840744561,True,True,0.001,-1.5984184075446082,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,True,False,True,11,provocation_dependent_instability|conditional_penetrance_dependent|population_localized_susceptibility,3,provocation_dependent_instability,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +926958,11:2570755:G:A,KCNQ1,ancestry_concentrated,arrhythmia,arrhythmia,Cardiac arrhythmia,NM_000218.3(KCNQ1):c.604+1G>A,anchored_exact,1.371599119982005e-06,2.5191455058444177e-05,18.366472626711847,True,True,0.0001,-0.5987467469281339,False,False,False,False,False,False,False,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,6,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1076966,7:150958081:CG:C,KCNH2,penetrance_boundary,LQTS,LQTS,Long QT syndrome|Congenital long QT syndrome,NM_000238.4(KCNH2):c.893del (p.Pro298fs),anchored_exact,3.5673706872718e-06,3.380434047731729e-05,9.475979640116968,False,False,2.5e-05,0.1310324585974109,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,True,False,False,True,6,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1457006,3:38551291:A:AAGTT,SCN5A,disease_model_collision,SADS,Brugada|LQTS|SADS|conduction,,NM_000335.5(SCN5A):c.5074_5077dup (p.Phe1693Ter),anchored_exact,6.840441235821475e-07,1.6557387906483872e-05,24.20511211274717,True,True,0.0001,-0.7810081764447644,False,False,False,True,True,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,True,False,True,12,genotype_first_postmortem|conditional_penetrance_dependent|population_localized_susceptibility,3,genotype_first_postmortem,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +405260,11:2847865:C:CA,KCNQ1,disease_model_collision,LQTS,LQTS|arrhythmia,Long QT syndrome||Cardiac arrhythmia,NM_000218.3(KCNQ1):c.1894dup (p.Arg632fs),anchored_exact,7.015476140365646e-07,2.484225170169424e-05,35.410593371081,True,True,0.0001,-0.6048090422595129,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,True,False,True,9,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +418944,3:38581292:ATC:A,SCN5A,disease_model_collision,Brugada,Brugada|LQTS|arrhythmia,Cardiac arrhythmia|Cardiovascular phenotype|Brugada syndrome|Long QT syndrome 3,NM_000335.5(SCN5A):c.2865_2866del (p.Glu955fs),anchored_exact,4.791389735748012e-06,3.826432999158185e-05,7.986059393172863,False,False,2.5e-05,0.1848541045636321,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,4,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,conflicting,P_LP,true,false,false,true,true,true,false,2023-01,2026-04 +651334,1:115705275:C:A,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.856G>T (p.Glu286Ter),anchored_exact,6.846004603253495e-07,2.2361359570661896e-05,32.66332584221321,True,True,0.001,-1.650501794878367,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,True,False,True,11,provocation_dependent_instability|conditional_penetrance_dependent|population_localized_susceptibility,3,provocation_dependent_instability,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +523778,3:38551460:G:A,SCN5A,disease_model_collision,Brugada,Brugada,Brugada syndrome|Cardiovascular phenotype,NM_000335.5(SCN5A):c.4909C>T (p.Arg1637Ter),anchored_exact,4.104371429196857e-06,3.311587243765937e-05,8.068437747531474,False,False,2.5e-05,0.1220961923497107,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +505275,3:38603712:C:T,SCN5A,disease_model_collision,Brugada,Brugada|arrhythmia,Cardiovascular phenotype|Cardiac arrhythmia|Brugada syndrome 1||Brugada syndrome,NM_000335.5(SCN5A):c.1890G>A (p.Thr630=),anchored_exact,1.4756161804265416e-06,3.419271011420365e-05,23.17180334286967,True,True,0.0001,-0.4660664756585466,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,4,True,False,False,True,True,False,True,11,genotype_first_postmortem|conditional_penetrance_dependent|population_localized_susceptibility,3,genotype_first_postmortem,population_localized_susceptibility,False,,conflicting,P_LP,true,false,false,true,true,true,false,2023-01,2026-04 +404118,15:73329724:C:A,HCN4,ancestry_concentrated,Brugada,Brugada,Brugada syndrome 8,NM_005477.3(HCN4):c.1439G>T (p.Gly480Val),anchored_exact,6.840693919991244e-07,2.236235967619303e-05,32.69014554312366,True,True,0.0001,-0.6504823716138943,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,True,True,False,True,8,conditional_penetrance_dependent|population_localized_susceptibility,2,conditional_penetrance_dependent,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1403180,6:123530549:CTT:C,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_006073.4(TRDN):c.439_440del (p.Lys147fs),anchored_exact,9.0703770555742e-07,2.2095541119802024e-05,24.360087374907803,True,True,0.001,-1.6556953580995877,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,True,False,True,11,provocation_dependent_instability|conditional_penetrance_dependent|population_localized_susceptibility,3,provocation_dependent_instability,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +496571,3:38562432:G:A,SCN5A,disease_model_collision,Brugada,Brugada,Brugada syndrome (shorter-than-normal QT interval)||Brugada syndrome 1|Cardiovascular phenotype,NM_000335.5(SCN5A):c.3943C>T (p.Arg1315Ter),anchored_exact,6.856199444099349e-07,2.524614996213077e-05,36.822315840800826,True,True,0.0001,-0.5978048424042931,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,True,False,False,True,True,False,True,11,genotype_first_postmortem|conditional_penetrance_dependent|population_localized_susceptibility,3,genotype_first_postmortem,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +449691,6:123530547:GTCTTA:G,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1|Catecholaminergic polymorphic ventricular tachycardia 5|Cardiovascular phenotype,NM_006073.4(TRDN):c.438_442del (p.Asp146_Lys147insTer),anchored_exact,8.154670542249349e-06,3.4233679093492176e-05,4.198045245124528,False,False,0.001,-1.4655464247259655,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1075032,6:123516159:CT:C,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1|Catecholaminergic polymorphic ventricular tachycardia 1;Catecholaminergic polymorphic ventricular tachycardia 5,NM_006073.4(TRDN):c.531del (p.Glu178fs),anchored_exact,2.240414387045028e-06,3.33000333000333e-05,14.863330475494562,True,True,0.001,-1.4775553321989812,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,True,False,True,11,provocation_dependent_instability|conditional_penetrance_dependent|population_localized_susceptibility,3,provocation_dependent_instability,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +503669,7:150959590:T:TG,KCNH2,ancestry_concentrated,LQTS,LQTS,Long QT syndrome|Long QT syndrome 2|Cardiovascular phenotype,NM_000238.4(KCNH2):c.453dup (p.Thr152fs),anchored_exact,1.3683035225605884e-06,1.8775111711914684e-05,13.721443145404296,True,True,0.0001,-0.7264174702639392,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,conflicting,P_LP,true,false,false,false,true,false,false,2023-01,2026-04 +667015,3:38620919:G:A,SCN5A,disease_model_collision,Brugada,Brugada|arrhythmia,Brugada syndrome|Brugada syndrome (shorter-than-normal QT interval)||Cardiac arrhythmia,NM_000335.5(SCN5A):c.535C>T (p.Arg179Ter),anchored_exact,6.842435140557302e-07,2.2374367924106146e-05,32.69937641368331,True,True,0.0001,-0.6502492246578704,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,4,True,False,False,True,True,False,True,11,genotype_first_postmortem|conditional_penetrance_dependent|population_localized_susceptibility,3,genotype_first_postmortem,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1480008,17:70175675:G:A,KCNJ2,disease_model_collision,SQTS,SQTS,Andersen Tawil syndrome;Short QT syndrome type 3,NM_000891.3(KCNJ2):c.636G>A (p.Trp212Ter),anchored_exact,6.840450594161539e-07,1.6557387906483872e-05,24.20507899806617,True,True,0.0001,-0.7810081764447644,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,True,False,True,8,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +842027,11:2585248:C:T,KCNQ1,ancestry_concentrated,LQTS,LQTS,Long QT syndrome|KCNQ1-related disorder,NM_000218.3(KCNQ1):c.1069C>T (p.Gln357Ter),anchored_exact,1.3682454851319603e-06,2.5188916876574308e-05,18.40963463110593,True,True,0.0001,-0.5987905067631151,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +942279,1:115738290:G:A,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.466C>T (p.Gln156Ter),anchored_exact,2.052578860079804e-06,1.655958137378287e-05,8.067692125332965,False,False,0.001,-1.7809506463768694,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +583099,6:123516162:T:A,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_006073.4(TRDN):c.529A>T (p.Lys177Ter),anchored_exact,2.239026530971708e-06,1.8289560318969934e-05,8.168529000191663,False,False,0.001,-1.737796734837436,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +517279,3:38603999:G:A,SCN5A,disease_model_collision,cardiomyopathy_overlap,Brugada|arrhythmia|cardiomyopathy_overlap,Brugada syndrome|Cardiovascular phenotype|Primary familial dilated cardiomyopathy||Cardiac arrhythmia|SCN5A-related disorder,NM_000335.5(SCN5A):c.1603C>T (p.Arg535Ter),anchored_exact,4.7902486960258726e-06,2.519018590357197e-05,5.258637545443709,False,False,2.5e-05,0.0032913639311787,False,False,False,False,False,False,True,True,True,True,False,True,False,False,False,True,multi_regime_required,5,True,False,True,True,False,False,True,11,genotype_first_postmortem|structural_electrical_overlap|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +405265,11:2572062:G:T,KCNQ1,ancestry_concentrated,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.733G>T (p.Gly245Ter),anchored_exact,6.846370191451896e-07,1.1593396401409756e-05,16.933616125912472,True,True,0.0001,-0.935789314484561,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +924596,3:38633181:G:A,SCN5A,disease_model_collision,Brugada,Brugada|LQTS|arrhythmia,Cardiac arrhythmia|Brugada syndrome 1;Long QT syndrome 3||Brugada syndrome 1,NM_000335.5(SCN5A):c.127C>T (p.Arg43Ter),anchored_exact,6.843886834962407e-07,1.657000828500414e-05,24.21136625022659,True,True,0.0001,-0.7806772744333681,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,4,True,False,False,True,True,False,True,11,genotype_first_postmortem|conditional_penetrance_dependent|population_localized_susceptibility,3,genotype_first_postmortem,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1367739,1:115732931:G:T,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 2;Catecholaminergic polymorphic ventricular tachycardia 1|Catecholaminergic polymorphic ventricular tachycardia 1|Catecholaminergic polymorphic ventricular tachycardia 2|Cardiovascular phenotype,NM_001232.4(CASQ2):c.576C>A (p.Tyr192Ter),anchored_exact,2.05254796462502e-06,2.236035955458164e-05,10.893947447761208,True,True,0.001,-1.6505212172741976,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,True,False,True,11,provocation_dependent_instability|conditional_penetrance_dependent|population_localized_susceptibility,3,provocation_dependent_instability,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +403974,17:70175721:C:T,KCNJ2,disease_model_collision,SQTS,SQTS,Andersen Tawil syndrome;Short QT syndrome type 3,NM_000891.3(KCNJ2):c.682C>T (p.Arg228Ter),anchored_exact,4.104292816666712e-06,1.6557387906483872e-05,4.034162671114734,False,False,2.5e-05,-0.1789481851168019,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1805845,1:237640956:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.7175A>G (p.Tyr2392Cys),anchored_exact,2.0529075329389014e-06,1.656781205474005e-05,8.070409757137067,False,False,2.5e-05,-0.1786748493953005,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,true,true,false,2023-01,2026-04 +418270,21:34449418:G:A,KCNE1,ancestry_concentrated,LQTS,LQTS,Long QT syndrome 5,NM_000219.6(KCNE1):c.217C>T (p.His73Tyr),anchored_exact,6.879216099567022e-07,1.1603620329542817e-05,16.86762604048317,True,True,0.0001,-0.935406489752349,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +649240,1:237707240:A:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.9872A>T (p.Asp3291Val),anchored_exact,7.100769865468815e-07,1.27890321260487e-05,18.0107444088528,True,True,0.0001,-0.8931623216840966,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,True,False,True,13,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent|population_localized_susceptibility,4,genotype_first_postmortem,population_localized_susceptibility,False,,conflicting,P_LP,true,false,false,true,true,true,false,2023-01,2026-04 +817280,11:2572019:C:CCG,KCNQ1,ancestry_concentrated,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.692_693dup (p.Phe232fs),anchored_exact,6.848423835254316e-07,1.1602543277486424e-05,16.94189439015813,True,True,0.0001,-0.9354468029874938,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +488729,3:38566408:C:T,SCN5A,disease_model_collision,arrhythmia,arrhythmia,Cardiac arrhythmia,NM_000335.5(SCN5A):c.3837+1G>A,anchored_exact,4.791376617260729e-06,1.8777932174108987e-05,3.919109424075093,False,False,2.5e-05,-0.1242922426172685,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,2,True,False,False,True,False,False,True,8,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +547164,21:34449584:C:T,KCNE1,ancestry_concentrated,LQTS,LQTS,Jervell and Lange-Nielsen syndrome 2|Long QT syndrome|Sensorineural hearing loss disorder|Long QT syndrome 5,NM_000219.6(KCNE1):c.51G>A (p.Trp17Ter),anchored_exact,1.0952014842170511e-06,1.5943369152769364e-05,14.55746346682834,True,True,0.0001,-0.7974198981316662,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1477795,17:70175818:G:A,KCNJ2,disease_model_collision,SQTS,SQTS,Andersen Tawil syndrome;Short QT syndrome type 3,NM_000891.3(KCNJ2):c.779G>A (p.Arg260His),anchored_exact,4.104309661955375e-06,1.15931275939623e-05,2.8246225855718,False,False,2.5e-05,-0.3337393929360234,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +915308,6:123636753:C:A,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 5|Catecholaminergic polymorphic ventricular tachycardia 1,NM_006073.4(TRDN):c.22+1G>T,anchored_exact,2.055515358810761e-06,1.6596408537192552e-05,8.074082926196981,False,False,0.001,-1.779985883118516,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1675066,15:73329709:G:A,HCN4,disease_model_collision,cardiomyopathy_overlap,Brugada|cardiomyopathy_overlap,Left ventricular noncompaction cardiomyopathy|Brugada syndrome 8|Cardiovascular phenotype,NM_005477.3(HCN4):c.1454C>T (p.Ala485Val),anchored_exact,3.420346959995622e-06,1.6557936218829686e-05,4.841009573438511,False,False,2.5e-05,-0.1789338033142704,False,False,False,False,False,False,True,True,False,False,False,True,False,False,True,False,high_tension,4,False,False,True,True,False,False,True,9,structural_electrical_overlap|conditional_penetrance_dependent,2,structural_electrical_overlap,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +404190,1:237330939:C:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Cardiovascular phenotype|Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.230C>T (p.Ala77Val),anchored_exact,2.0524243921061023e-06,1.15931275939623e-05,5.648501835219441,False,False,2.5e-05,-0.3337393929360234,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1746831,1:115738223:C:T,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Cardiovascular phenotype|Catecholaminergic polymorphic ventricular tachycardia 2,NM_001232.4(CASQ2):c.532+1G>A,anchored_exact,7.006952298070145e-07,1.168688497767805e-05,16.678962267139422,True,True,0.001,-1.932301230265192,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,True,False,True,11,provocation_dependent_instability|conditional_penetrance_dependent|population_localized_susceptibility,3,provocation_dependent_instability,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +408869,1:115744914:T:C,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Cardiovascular phenotype||Catecholaminergic polymorphic ventricular tachycardia 1|Catecholaminergic polymorphic ventricular tachycardia 2,NM_001232.4(CASQ2):c.235-2A>G,anchored_exact,1.372949328559131e-06,1.162385214460072e-05,8.466331886019208,False,False,0.001,-1.9346499229007108,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +430060,21:34449622:T:TA,KCNE1,penetrance_boundary,LQTS,LQTS,Long QT syndrome|Cardiovascular phenotype|Long QT syndrome 5;Jervell and Lange-Nielsen syndrome 2|Jervell and Lange-Nielsen syndrome 2,NM_000219.6(KCNE1):c.12dup (p.Asn5Ter),anchored_exact,2.628017292353784e-06,3.923091710114907e-06,1.4927950545584636,False,False,2.5e-05,-0.8043115479217289,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,True,False,False,True,6,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,conflicting,P_LP,true,false,false,true,true,true,false,2023-01,2026-04 +1208780,4:113358978:A:AG,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,,NM_001148.6(ANK2):c.10367dup (p.Thr3457fs),anchored_exact,3.420660515862971e-06,3.420660515862971e-06,2.923411145366478e-07,False,False,2.5e-05,-0.8638300339910164,False,False,False,False,False,False,False,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,5,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +857501,7:150947376:C:CG,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.3103dup (p.Arg1035fs),anchored_exact,1.4431722079668878e-06,1.8602055527135749e-06,1.2889697109428708,False,False,2.5e-05,-1.1283790722622535,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1068919,11:2588804:C:CA,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1344dup (p.Glu449fs),anchored_exact,1.3687567582364937e-06,1.7986646713479913e-06,1.3140861927718974,False,False,2.5e-05,-1.1429898041689115,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +519280,7:150948455:C:CGCCT,KCNH2,canonical_monogenic,LQTS,LQTS,Cardiovascular phenotype|Long QT syndrome 2|Long QT syndrome,NM_000238.4(KCNH2):c.2677_2680dup (p.Arg894fs),anchored_exact,8.697558073595258e-07,1.1272305073664514e-06,1.2960306810228792,False,False,2.5e-05,-1.3459272746658248,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1802180,7:82443436:G:GGCCAGCAGGCA,CACNA2D1,unknown_or_insufficient,Brugada,Brugada,Developmental and epileptic encephalopathy 110,NM_000722.4(CACNA2D1):c.13_23dup (p.Leu9fs),anchored_exact,6.870028675499691e-07,9.019003039404024e-07,1.3128038232984225,False,False,2.5e-05,-1.442781475388979,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,1,False,False,False,True,False,False,True,6,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1787905,11:2445314:G:GC,KCNQ1,canonical_monogenic,LQTS,LQTS,Cardiovascular phenotype,NM_000218.3(KCNQ1):c.221dup (p.Val75fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1306529,11:2847842:A:AC,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1875dup (p.Gly626fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +864600,7:150947472:T:TC,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.3007dup (p.Asp1003fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +532312,6:123512339:T:TC,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_006073.4(TRDN):c.573dup (p.Lys192fs),anchored_exact,0.0,0.0,1.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1074305,7:150947795:GC:G,KCNH2,disease_model_collision,LQTS,LQTS|arrhythmia,Long QT syndrome|Cardiac arrhythmia|Cardiovascular phenotype,NM_000238.4(KCNH2):c.2775del (p.Pro926fs),anchored_exact,7.97089897247866e-06,7.97089897247866e-06,1.2545634789706644e-07,False,False,2.5e-05,-0.496432703992366,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +917819,7:150947387:AC:A,KCNH2,disease_model_collision,LQTS,LQTS|arrhythmia,Long QT syndrome|Cardiac arrhythmia|Cardiovascular phenotype,NM_000238.4(KCNH2):c.3092del (p.Gly1031fs),anchored_exact,3.604154292403596e-06,4.655415458586356e-06,1.2916803192133486,False,False,2.5e-05,-0.7299815643170293,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +519537,11:2570664:GTGGTCCGCCTC:G,KCNQ1,penetrance_boundary,LQTS,LQTS,Cardiovascular phenotype|Long QT syndrome||Long QT syndrome 1,NM_000218.3(KCNQ1):c.524_534del (p.Leu175fs),anchored_exact,2.0543273721318167e-06,2.6979242171073577e-06,1.3132882034373443,False,False,2.5e-05,-0.9669102622072908,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,True,False,False,True,6,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +837649,7:150947472:TC:T,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.3007del (p.Asp1003fs),anchored_exact,1.404040829507322e-06,1.8277793212358715e-06,1.3017990510134867,False,False,2.5e-05,-1.136016249087652,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +656121,11:2572033:TC:T,KCNQ1,disease_model_collision,LQTS,LQTS|arrhythmia,Long QT syndrome||Cardiovascular phenotype|Cardiac arrhythmia,NM_000218.3(KCNQ1):c.706del (p.Ile235_Leu236insTer),anchored_exact,1.3692440403653143e-06,1.798784381514972e-06,1.3137059682429495,False,False,2.5e-05,-1.14296090065189,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +523933,11:2445114:TC:T,KCNQ1,canonical_monogenic,LQTS,LQTS,,NM_000218.3(KCNQ1):c.20del (p.Pro7fs),anchored_exact,1.0542451288603822e-06,1.1995470510335298e-06,1.1378254263358936,False,False,2.5e-05,-1.3189227212673351,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +449221,11:2445294:TCCCCGGCCGCG:T,KCNQ1,disease_model_collision,LQTS,LQTS|SQTS|arrhythmia,"Long QT syndrome|Cardiovascular phenotype|Short QT syndrome type 2;Atrial fibrillation, familial, 3;Beckwith-Wiedemann syndrome;Long QT syndrome 1;Jervell and Lange-Nielsen syndrome 1|Long QT syndrome 1|KCNQ1-related disorder",NM_000218.3(KCNQ1):c.200_210del (p.Pro67fs),anchored_exact,8.033277046838826e-07,9.895679744137304e-07,1.2318356964514732,False,False,2.5e-05,-1.40249437698272,False,False,False,False,False,False,True,False,True,True,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1332487,3:38581308:CAG:C,SCN5A,disease_model_collision,arrhythmia,arrhythmia,Cardiac arrhythmia,NM_000335.5(SCN5A):c.2849_2850del (p.Pro950fs),anchored_exact,6.857957974433533e-07,9.016856110813556e-07,1.314801431623534,False,False,2.5e-05,-1.4428848693261924,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,2,True,False,False,True,False,False,True,8,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +858435,7:150947652:CA:C,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome|Long QT syndrome 2|Cardiovascular phenotype,NM_000238.4(KCNH2):c.2918del (p.Leu973fs),anchored_exact,6.85348348858758e-07,9.000819074535783e-07,1.3133198549796452,False,False,2.5e-05,-1.4436579766365545,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +411734,12:2584592:GAGA:G,CACNA1C,disease_model_collision,LQTS,LQTS,Long QT syndrome|Cardiovascular phenotype,NM_000719.7(CACNA1C):c.2317_2319del (p.Lys773del),anchored_exact,6.845132973553145e-07,8.998033029979646e-07,1.3145149874508737,False,False,2.5e-05,-1.4437924256313794,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,2,True,False,False,False,False,False,True,8,genotype_first_postmortem,1,genotype_first_postmortem,genotype_first_postmortem,True,,conflicting,P_LP,true,false,false,false,true,false,false,2023-01,2026-04 +1327132,3:38557229:AC:A,SCN5A,disease_model_collision,SADS,Brugada|SADS,SUDDEN INFANT DEATH SYNDROME|Cardiovascular phenotype|Brugada syndrome 1,NM_000335.5(SCN5A):c.4296+1del,anchored_exact,6.843736954126432e-07,8.99647877820621e-07,1.314556022966598,False,False,2.5e-05,-1.4438674488359615,False,False,False,True,True,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1677487,6:123570976:CACGTGATTATCAGGGCA:C,TRDN,disease_model_collision,SADS,CPVT|SADS,,NM_006073.4(TRDN):c.162_178del (p.Ile54fs),anchored_exact,6.84147080675992e-07,8.994148407046376e-07,1.314650827955176,False,False,0.001,-3.0460399506762856,False,False,False,True,True,False,False,False,False,False,False,True,False,False,True,False,high_tension,4,True,False,False,False,False,False,True,7,genotype_first_postmortem,1,genotype_first_postmortem,genotype_first_postmortem,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +570614,4:113359097:ACAGT:A,ANK2,disease_model_collision,LQTS,LQTS,Long QT syndrome,NM_001148.6(ANK2):c.10483_10486del (p.Ser3495fs),anchored_exact,6.841218065194071e-07,8.993468942853699e-07,1.3146000772302235,False,False,2.5e-05,-1.4440127694247145,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +1342783,4:113358978:AG:A,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,,NM_001148.6(ANK2):c.10367del (p.Gly3456fs),anchored_exact,6.84114318239035e-07,8.993291004910337e-07,1.3145884568203765,False,False,2.5e-05,-1.4440213621303657,False,False,False,False,False,False,False,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,5,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +405341,7:150951697:AG:A,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.1695del (p.Cys566fs),anchored_exact,6.840890465030052e-07,8.992999848917603e-07,1.3145944594412535,False,False,2.5e-05,-1.4440354225547252,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +418689,7:150949032:CA:C,KCNH2,canonical_monogenic,LQTS,LQTS,,NM_000238.4(KCNH2):c.2415del (p.Phe805fs),anchored_exact,6.840675202005138e-07,8.992918975598614e-07,1.3146240047652844,False,False,2.5e-05,-1.4440393281473738,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +810745,7:150951021:TC:T,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.2044del (p.Glu682fs),anchored_exact,6.840656484121468e-07,8.992789581313703e-07,1.3146086864763482,False,False,2.5e-05,-1.444045577022557,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +503760,7:150948956:TGTAGGTCACA:T,KCNH2,canonical_monogenic,LQTS,LQTS,,NM_000238.4(KCNH2):c.2482_2491del (p.Cys828fs),anchored_exact,6.840478669335365e-07,8.992757233324281e-07,1.3146381301144725,False,False,2.5e-05,-1.4440471392273042,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1457672,11:2572978:TG:T,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome|Cardiovascular phenotype|Congenital long QT syndrome,NM_000218.3(KCNQ1):c.919del (p.Val307fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +635221,11:2445270:GC:G,KCNQ1,canonical_monogenic,LQTS,LQTS,,NM_000218.3(KCNQ1):c.176del (p.Pro59fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +405258,11:2445294:TC:T,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.200del (p.Pro67fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1382290,7:150974709:AC:A,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.307+1del,anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1070517,7:150958305:CT:C,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.669del (p.Leu225fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +653333,7:150947808:GC:G,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome||Cardiovascular phenotype,NM_000238.4(KCNH2):c.2762del (p.Gly921fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,true,false,2023-01,2026-04 +638156,7:150977867:TC:T,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome 2|Long QT syndrome,NM_000238.4(KCNH2):c.46del (p.Asp16fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +523705,7:150947425:TG:T,KCNH2,canonical_monogenic,LQTS,LQTS,Cardiovascular phenotype,NM_000238.4(KCNH2):c.3054del (p.Thr1019fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +418247,7:150947678:CG:C,KCNH2,canonical_monogenic,arrhythmia,arrhythmia,Cardiac arrhythmia,NM_000238.4(KCNH2):c.2892del (p.Gly965fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,False,True,2,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_low_signal,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1254662,3:38603785:GC:G,SCN5A,disease_model_collision,SADS,Brugada|LQTS|SADS|conduction,,NM_000335.5(SCN5A):c.1816del (p.Ala606fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,True,True,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1334090,12:2585484:AC:A,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,Timothy syndrome,NM_000719.7(CACNA1C):c.2451del (p.Ala818fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,4,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1455253,1:115705187:C:G,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Cardiovascular phenotype|Catecholaminergic polymorphic ventricular tachycardia 1|Catecholaminergic polymorphic ventricular tachycardia 2,NM_001232.4(CASQ2):c.939+5G>C,anchored_exact,3.47015940524244e-06,4.575293779613589e-06,1.3184678070505331,False,False,0.001,-2.33958101465353,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1425730,1:115702947:G:A,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.988C>T (p.Gln330Ter),anchored_exact,3.4213767620090325e-06,4.497138920218957e-06,1.314423671701846,False,False,0.001,-2.3470636965208613,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +427947,1:115725508:C:T,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 2|Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.783G>A (p.Trp261Ter),anchored_exact,2.738473082178839e-06,3.598442594045297e-06,1.3140323720654798,False,False,0.001,-2.443885421221095,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +654552,1:115738281:C:A,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.475G>T (p.Glu159Ter),anchored_exact,2.7365508786380734e-06,3.597652891253746e-06,1.314666796320421,False,False,0.001,-2.443980740569425,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +419715,7:150959571:C:T,KCNH2,penetrance_boundary,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.472+1G>A,anchored_exact,2.0523569951851703e-06,2.698021271199702e-06,1.3145963216598953,False,False,2.5e-05,-0.9668946393449596,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,True,False,False,True,6,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +463523,17:70175754:G:T,KCNJ2,disease_model_collision,SQTS,SQTS,Andersen Tawil syndrome;Short QT syndrome type 3,NM_000891.3(KCNJ2):c.715G>T (p.Glu239Ter),anchored_exact,2.052146408333356e-06,2.6978320221869704e-06,1.3146390026523511,False,False,2.5e-05,-0.9669251034059708,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +571947,15:73343471:G:A,HCN4,penetrance_boundary,Brugada,Brugada,Brugada syndrome 8||Cardiovascular phenotype,NM_005477.3(HCN4):c.1123C>T (p.Arg375Cys),anchored_exact,2.0521492158737845e-06,2.6978320221869704e-06,1.314637204098756,False,False,2.5e-05,-0.9669251034059708,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,True,False,False,True,6,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,conflicting,P_LP,true,false,false,true,true,true,false,2023-01,2026-04 +406420,3:38585690:C:A,SCN5A,disease_model_collision,Brugada,Brugada,Brugada syndrome 1,NM_000335.5(SCN5A):c.2787+1G>T,anchored_exact,1.5024444771643463e-06,2.0315788618282585e-06,1.3521820876073176,False,False,2.5e-05,-1.0901063232391948,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1033372,1:115726990:A:T,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 2,NM_001232.4(CASQ2):c.737+2T>A,anchored_exact,1.5389374252653512e-06,1.9958008350430693e-06,1.296869193904846,False,False,0.001,-2.6998828000012813,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +372376,7:150958430:G:T,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome|Cardiovascular phenotype,NM_000238.4(KCNH2):c.545C>A (p.Ser182Ter),anchored_exact,1.5324754535744223e-06,1.915719822144572e-06,1.2500817338343122,False,False,2.5e-05,-1.115608015721829,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +372313,12:2566466:G:A,CACNA1C,disease_model_collision,cardiomyopathy_overlap,LQTS|arrhythmia|cardiomyopathy_overlap,Hypertrophic cardiomyopathy 1|Long QT syndrome|Long QT syndrome 8|Cardiac arrhythmia|Timothy syndrome|Cardiovascular phenotype,NM_000719.7(CACNA1C):c.1553G>A (p.Arg518His),anchored_exact,1.385381180704965e-06,1.8129572051451725e-06,1.3086339859103944,False,False,2.5e-05,-1.139552455976783,False,False,False,False,False,False,True,True,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,True,True,False,False,True,11,genotype_first_postmortem|structural_electrical_overlap|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1739478,3:38557230:C:T,SCN5A,disease_model_collision,Brugada,Brugada,Cardiovascular phenotype|Brugada syndrome|Brugada syndrome 1,NM_000335.5(SCN5A):c.4296+1G>A,anchored_exact,1.3704318367760864e-06,1.8015648392193456e-06,1.3145962289239144,False,False,2.5e-05,-1.1422901114566184,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +488772,1:115768427:C:A,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1|Catecholaminergic polymorphic ventricular tachycardia 2,NM_001232.4(CASQ2):c.115G>T (p.Glu39Ter),anchored_exact,1.368531975749613e-06,1.7992245342257486e-06,1.3147111294415277,False,False,0.001,-2.744914635492492,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +463294,3:38606149:C:T,SCN5A,disease_model_collision,SADS,Brugada|LQTS|SADS|conduction,,NM_000335.5(SCN5A):c.1141-1G>A,anchored_exact,1.3687398969886353e-06,1.7989623585116103e-06,1.314319870524441,False,False,2.5e-05,-1.142917932409157,False,False,False,True,True,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +985692,4:113373351:C:T,ANK2,disease_model_collision,arrhythmia,arrhythmia,"Cardiac arrhythmia, ankyrin-B-related||Cardiovascular phenotype",NM_001148.6(ANK2):c.11761C>T (p.Gln3921Ter),anchored_exact,1.3681575022916638e-06,1.3681575022916638e-06,7.309094657709624e-07,False,False,2.5e-05,-1.261803912429194,False,False,False,False,False,False,False,False,False,False,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,5,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,conflicting,P_LP,true,false,false,true,true,true,false,2023-01,2026-04 +927383,7:150947870:G:A,KCNH2,canonical_monogenic,arrhythmia,arrhythmia,Cardiac arrhythmia|Cardiovascular phenotype,NM_000238.4(KCNH2):c.2701C>T (p.Gln901Ter),anchored_exact,7.256662341695911e-07,9.289001265161972e-07,1.2800648600031863,False,False,2.5e-05,-1.4299709866424328,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,False,True,2,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_low_signal,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1743359,3:38622399:C:G,SCN5A,disease_model_collision,SADS,Brugada|LQTS|SADS|conduction,Cardiovascular phenotype,NM_000335.5(SCN5A):c.482+1G>C,anchored_exact,6.915447588514272e-07,9.088017448993502e-07,1.3141614033014393,False,False,2.5e-05,-1.4394708564588885,False,False,False,True,True,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1072847,3:38609733:C:T,SCN5A,disease_model_collision,Brugada,Brugada|arrhythmia,Brugada syndrome|Cardiac arrhythmia,NM_000335.5(SCN5A):c.934+1G>A,anchored_exact,6.89303389994072e-07,9.06547630919076e-07,1.315164452857862,False,False,2.5e-05,-1.4405493813746684,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,4,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1208559,12:2448979:C:T,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,,NM_000719.7(CACNA1C):c.481C>T (p.Arg161Ter),anchored_exact,6.877020984541832e-07,9.03404389099884e-07,1.3136561273761245,False,False,2.5e-05,-1.442057812465226,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,4,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +573008,11:2572011:A:C,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.684-2A>C,anchored_exact,6.850675819169561e-07,8.997595842390913e-07,1.3133876052546227,False,False,2.5e-05,-1.443813527217629,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +519257,11:2572021:G:T,KCNQ1,canonical_monogenic,LQTS,LQTS,Cardiovascular phenotype,NM_000218.3(KCNQ1):c.692G>T (p.Arg231Leu),anchored_exact,6.8483018950621e-07,8.9957989618848e-07,1.3135804997974945,False,False,2.5e-05,-1.4439002674130756,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +519533,1:237441382:G:A,RYR2,disease_model_collision,cardiomyopathy_overlap,CPVT|arrhythmia|cardiomyopathy_overlap,Cardiovascular phenotype||Catecholaminergic polymorphic ventricular tachycardia 1|Cardiomyopathy,NM_001035.3(RYR2):c.1069G>A (p.Gly357Ser),anchored_exact,6.842332140486764e-07,8.995167795860064e-07,1.3146343183622424,False,False,2.5e-05,-1.44393073958564,False,False,False,False,False,True,True,True,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,True,True,False,False,True,13,genotype_first_postmortem|provocation_dependent_instability|structural_electrical_overlap|conditional_penetrance_dependent,4,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1784131,1:115768343:G:A,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Cardiovascular phenotype|Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.199C>T (p.Gln67Ter),anchored_exact,6.842023158879988e-07,8.995151613280442e-07,1.3146913211909823,False,False,0.001,-3.0459915122232477,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1527872,3:38557231:C:A,SCN5A,disease_model_collision,Brugada,Brugada,Brugada syndrome 1,NM_000335.5(SCN5A):c.4296G>T (p.Gly1432=),anchored_exact,6.842828442079563e-07,8.995119248295874e-07,1.314531875103312,False,False,2.5e-05,-1.4439330835103572,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1009997,1:237784136:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1|Paroxysmal familial ventricular fibrillation,NM_001035.3(RYR2):c.12424G>A (p.Ala4142Thr),anchored_exact,6.841424001357339e-07,8.993986620545503e-07,1.3146361740478818,False,False,2.5e-05,-1.4439877714961054,False,True,False,True,False,True,True,False,True,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,true,true,false,2023-01,2026-04 +1791538,11:2585278:C:T,KCNQ1,canonical_monogenic,LQTS,LQTS,Cardiovascular phenotype,NM_000218.3(KCNQ1):c.1099C>T (p.Gln367Ter),anchored_exact,6.841676758139885e-07,8.993096898820465e-07,1.3144575624016888,False,False,2.5e-05,-1.4440307357971842,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1415094,11:2777974:A:G,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1733-2A>G,anchored_exact,6.842163601605445e-07,8.992951324751659e-07,1.3143427583657852,False,False,2.5e-05,-1.4440377659145291,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +809661,4:113330289:C:T,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,Cardiovascular phenotype,NM_001148.6(ANK2):c.2944C>T (p.Arg982Ter),anchored_exact,6.840693919991244e-07,8.992935150146045e-07,1.3146227720607964,False,False,2.5e-05,-1.444038547031654,False,False,False,False,False,False,False,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,5,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +638351,17:70176216:G:T,KCNJ2,disease_model_collision,LQTS,LQTS|periodic_paralysis,Andersen Tawil syndrome,NM_000891.3(KCNJ2):c.1177G>T (p.Gly393Ter),anchored_exact,6.840750074564176e-07,8.992886626678298e-07,1.314604887272155,False,False,2.5e-05,-1.444040890374599,False,False,False,False,False,False,False,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,5,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +970883,15:73329725:C:T,HCN4,disease_model_collision,cardiomyopathy_overlap,Brugada|cardiomyopathy_overlap,Brugada syndrome 8|Left ventricular noncompaction cardiomyopathy|Cardiovascular phenotype|HCN4-related disorder,NM_005477.3(HCN4):c.1438G>A (p.Gly480Ser),anchored_exact,6.840675202005138e-07,8.992870452305412e-07,1.314616911427151,False,False,2.5e-05,-1.4440416714861042,False,False,False,False,False,False,True,True,False,False,False,True,False,False,True,False,high_tension,4,False,False,True,True,False,False,True,9,structural_electrical_overlap|conditional_penetrance_dependent,2,structural_electrical_overlap,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1504964,15:73329721:T:C,HCN4,canonical_monogenic,Brugada,Brugada,Brugada syndrome 8,NM_005477.3(HCN4):c.1442A>G (p.Tyr481Cys),anchored_exact,6.840656484121468e-07,8.992838103734187e-07,1.314615779706313,False,False,2.5e-05,-1.4440432337049,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,1,False,False,False,True,False,False,True,6,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1405357,7:150950951:C:T,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.2115G>A (p.Trp705Ter),anchored_exact,6.840506744739651e-07,8.992741059416839e-07,1.3146303700421835,False,False,2.5e-05,-1.4440479203275705,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +519476,17:70175958:A:G,KCNJ2,disease_model_collision,SQTS,SQTS|arrhythmia,Cardiovascular phenotype|Andersen Tawil syndrome;Short QT syndrome type 3|Cardiac arrhythmia,NM_000891.3(KCNJ2):c.919A>G (p.Met307Val),anchored_exact,6.840478669335365e-07,8.992741059416839e-07,1.3146357656770435,False,False,2.5e-05,-1.4440479203275705,False,False,False,False,False,False,True,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1076382,7:150958158:G:A,KCNH2,disease_model_collision,LQTS,LQTS|arrhythmia,Long QT syndrome|Long QT syndrome 2||Cardiac arrhythmia,NM_000238.4(KCNH2):c.817C>T (p.Arg273Ter),anchored_exact,8.45374281009174e-07,8.45374281009174e-07,1.1829066007303187e-06,False,False,2.5e-05,-1.4708909776059382,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1489978,11:2445447:C:A,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.349C>A (p.Pro117Thr),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +965523,11:2775960:C:T,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1591C>T (p.Gln531Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +933168,11:2445251:C:A,KCNQ1,disease_model_collision,LQTS,LQTS|arrhythmia,Long QT syndrome|Cardiac arrhythmia,NM_000218.3(KCNQ1):c.153C>A (p.Tyr51Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +869440,11:2570756:T:C,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.604+2T>C,anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +663623,11:2445149:G:A,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.51G>A (p.Trp17Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +637975,11:2776056:T:C,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.1685+2T>C,anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +488859,11:2445100:T:A,KCNQ1,canonical_monogenic,LQTS,LQTS,,NM_000218.3(KCNQ1):c.2T>A (p.Met1Lys),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +488698,11:2445222:G:T,KCNQ1,canonical_monogenic,LQTS,LQTS,,NM_000218.3(KCNQ1):c.124G>T (p.Glu42Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +431053,11:2445103:C:G,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.5C>G (p.Ala2Gly),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +375455,11:2445213:G:T,KCNQ1,disease_model_collision,LQTS,LQTS|SQTS|arrhythmia,"Jervell and Lange-Nielsen syndrome 1|Short QT syndrome type 2;Atrial fibrillation, familial, 3;Jervell and Lange-Nielsen syndrome 1;Long QT syndrome 1",NM_000218.3(KCNQ1):c.115G>T (p.Glu39Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,True,True,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1792370,7:150974768:G:A,KCNH2,canonical_monogenic,LQTS,LQTS,Cardiovascular phenotype,NM_000238.4(KCNH2):c.250C>T (p.Gln84Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1728012,7:150947344:G:A,KCNH2,canonical_monogenic,LQTS,LQTS,Cardiovascular phenotype,NM_000238.4(KCNH2):c.3136C>T (p.Gln1046Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1466419,7:150958504:T:C,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.473-2A>G,anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1197726,7:150974786:C:T,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome 2,NM_000238.4(KCNH2):c.232G>A (p.Ala78Thr),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1171507,7:150974942:C:A,KCNH2,canonical_monogenic,arrhythmia,arrhythmia,Cardiac arrhythmia,NM_000238.4(KCNH2):c.77-1G>T,anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,False,True,2,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_low_signal,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1066606,7:150977837:C:T,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.76+1G>A,anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +560686,7:150950166:A:T,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome 2,NM_000238.4(KCNH2):c.2398+2T>A,anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +373026,7:150947327:C:A,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.3152+1G>T,anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1684121,3:38613808:C:T,SCN5A,disease_model_collision,SADS,Brugada|LQTS|SADS|conduction,,NM_000335.5(SCN5A):c.638G>A (p.Gly213Asp),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,True,True,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,true,true,false,2023-01,2026-04 +1375303,3:38556559:C:T,SCN5A,disease_model_collision,SADS,Brugada|LQTS|SADS|conduction,,NM_000335.5(SCN5A):c.4316G>A (p.Trp1439Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,True,True,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +979202,3:38566558:C:A,SCN5A,disease_model_collision,Brugada,Brugada,Brugada syndrome 1,NM_000335.5(SCN5A):c.3688G>T (p.Glu1230Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +858096,3:38613824:C:A,SCN5A,disease_model_collision,SADS,Brugada|LQTS|SADS|conduction,,NM_000335.5(SCN5A):c.622G>T (p.Glu208Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,True,True,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +547163,21:34449585:C:T,KCNE1,canonical_monogenic,LQTS,LQTS,Jervell and Lange-Nielsen syndrome 2|Long QT syndrome 5,NM_000219.6(KCNE1):c.50G>A (p.Trp17Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1804987,1:237778753:C:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11863C>A (p.Gln3955Lys),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1678118,1:237042549:G:T,RYR2,disease_model_collision,SADS,CPVT|SADS,,NM_001035.3(RYR2):c.28G>T (p.Glu10Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,False,False,False,True,9,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1480581,1:237772077:G:T,RYR2,disease_model_collision,cardiomyopathy_overlap,CPVT|arrhythmia|cardiomyopathy_overlap,Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome|Catecholaminergic polymorphic ventricular tachycardia 1|Arrhythmogenic right ventricular dysplasia 2,NM_001035.3(RYR2):c.11623G>T (p.Val3875Leu),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,True,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,True,True,False,False,True,13,genotype_first_postmortem|provocation_dependent_instability|structural_electrical_overlap|conditional_penetrance_dependent,4,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1439521,1:237828428:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14638G>A (p.Val4880Ile),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1328938,1:237772075:C:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11621C>T (p.Thr3874Ile),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1035886,1:237772033:C:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia,NM_001035.3(RYR2):c.11579C>T (p.Thr3860Ile),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1021015,1:237784046:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1|Cardiovascular phenotype,NM_001035.3(RYR2):c.12334G>A (p.Asp4112Asn),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +869430,1:237783718:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12006G>A (p.Met4002Ile),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +656670,1:237772044:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11590A>G (p.Asn3864Asp),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +581079,1:237772078:T:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11624T>C (p.Val3875Ala),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +572162,1:237369568:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.344A>G (p.Tyr115Cys),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +463600,1:237042565:G:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.44G>C (p.Arg15Pro),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +404183,1:237772077:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1|Cardiovascular phenotype,NM_001035.3(RYR2):c.11623G>A (p.Val3875Ile),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1457736,1:115702920:C:T,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.1014+1G>A,anchored_exact,0.0,0.0,1.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1799347,6:123548540:C:T,TRDN,disease_model_collision,SADS,CPVT|SADS,Cardiovascular phenotype,NM_006073.4(TRDN):c.305G>A (p.Trp102Ter),anchored_exact,0.0,0.0,1.0,False,False,0.001,,False,False,False,True,True,False,False,False,False,False,False,True,False,False,True,False,high_tension,4,True,False,False,False,False,False,True,7,genotype_first_postmortem,1,genotype_first_postmortem,genotype_first_postmortem,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1517713,6:123548453:C:T,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1|Catecholaminergic polymorphic ventricular tachycardia 1;Catecholaminergic polymorphic ventricular tachycardia 5,NM_006073.4(TRDN):c.391+1G>A,anchored_exact,0.0,0.0,1.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1467722,2:47160803:C:G,CALM2,disease_model_collision,LQTS,LQTS,Long QT syndrome 1,NM_001743.6(CALM2):c.423G>C (p.Glu141Asp),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1707563,12:2581622:C:T,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,Timothy syndrome,NM_000719.7(CACNA1C):c.1928C>T (p.Ser643Phe),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,4,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1218634,12:2666684:A:G,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,,NM_000719.7(CACNA1C):c.4527-2A>G,anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,4,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1802109,11:2571364:TG:T,KCNQ1,unanchored_assertion_state,LQTS,LQTS,,NM_000218.3(KCNQ1):c.647del (p.Gly216fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1786030,11:2445203:C:CT,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Cardiovascular phenotype|Long QT syndrome,NM_000218.3(KCNQ1):c.107dup (p.Ser37fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1778018,11:2776986:G:C,KCNQ1,disease_model_collision,LQTS,LQTS|arrhythmia,"Cardiovascular phenotype|Long QT syndrome|Atrial fibrillation, familial, 3",NM_000218.3(KCNQ1):c.1686G>C (p.Arg562Ser),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,True,True,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,9,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1771701,11:2585210:A:AGGGGATTCTTGGCTCGGGGTTTGCCCTGAAGGTGCAGCAGAAGCAGAGGCAGAAGCACTTCAACCGGCAGATCCCGGCGGCAGCCT,KCNQ1,disease_model_collision,LQTS,LQTS|arrhythmia,Cardiovascular phenotype|Long QT syndrome|Cardiac arrhythmia,NM_000218.3(KCNQ1):c.1033-1_1117dup,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,9,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1769838,11:2588779:G:GTCCCCCATATCACGTGCGA,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Cardiovascular phenotype,NM_000218.3(KCNQ1):c.1319_1337dup (p.Glu449fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1723453,11:2583481:G:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.968G>A (p.Trp323Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1711271,11:2572886:T:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,,NM_000218.3(KCNQ1):c.821T>A (p.Ile274Asn),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1709048,11:2570663:C:CGTGGTCCGCCT,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.514_524dup (p.Gly179fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1708065,11:2662026:G:T,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.1459G>T (p.Glu487Ter),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1522663,11:2445485:G:T,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.386+1G>T,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1500718,11:2661959:A:G,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome|Cardiovascular phenotype,NM_000218.3(KCNQ1):c.1394-2A>G,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1500707,11:2585309:T:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome|Cardiovascular phenotype,NM_000218.3(KCNQ1):c.1128+2T>A,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1493047,11:2571324:G:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.605-1G>A,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1488375,11:2583531:T:C,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1018T>C (p.Phe340Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1457098,11:2445400:T:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.302T>A (p.Leu101Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1454915,11:2587588:G:GC,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1148dup (p.Ala384fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1454509,11:2572899:C:CT,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.837dup (p.Val280fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Met520Thr),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +1004846,11:2572081:T:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.752T>A (p.Leu251Gln),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 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1,NM_000218.3(KCNQ1):c.1686-9T>C,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +983047,11:2588738:AC:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.1278del (p.Asp426fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +983022,11:2570701:AC:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.552del (p.Lys183_Tyr184insTer),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +977320,11:2699443:GCACTGAGGAGCCGCCGGGAGAGTGCCGCGCTGAGGAGCCCCCGGGGAGAGTGCCGCGCTGAGGAGCCCCCAGGAGAGTGCCGCGCTGAGGAGGCCCAGGGAGGACCGCGCGGAGGAGAACCATGCTGAGGAGCCCCCGGGGAGAACAGAACCGCGGCGAGAGGCCCCCGGAGAGAACCGCGCCGAAGAACCCCCGGGGACAACCGCGCCGAAGAACCCCCGGGGAGAACCGCGCCGAAAAGCCCCGGGTGCCCCGAGGAGAACGGCGCCGAGGAGTCCCCGGGGAGAACTGCGCCGAGGAGCCCCCAGAAGAGCGCCGCGCTGAGGAGCCCCGAGGAGAACCGCGCCGAGGGGCGCGCCGGGGAGAACCACGATGACTGACGCACCGAGGAGGACCGCGCTGAGGGGCGCACCGGGAGAATCGTGCTGAGGAGCCCCGGGGAGGACCACGCTGAGAGGCACCCCGGCAGAATCGCGCTGAGGGGCGCCCTGGCAGGATCTTGCTGAGGAGCTCCCTGGAGGTCCGTGCTGAGGCGACGCGGCGACCGTTCTGCCTGGAGACTGCGGCAGCGCTCCGACTGCCCCCGCCGCTGCCGACGTGGCGACCGCCCCCCACCTGCTGATTGGGCGGCAGCAGGGGAAGGCTTGCGGCGGGCTGCTGCACGGATTGGCTGGGTGCGGAAAGTGATGTGCCGTGTCCTGTCATTGGCCGAAAGAGTCTCGTTTTGATGCCACCCGGGCTCAGATTGGCCCAGCGGGTCCAGCGCCGCATGAGGCACTGGCTGGGTGTGAGGTGGCGCGAGCCGCCGCCCTCCCTGCCCCCACCCGTCGTCCCTGAGCACCACCGGGGGCCGGGGCCAGCGCCAGCCTCAGCGTTGGCATCGCCGGGGTGAGCTGGAGACACGGGCCAGTTCTCTGCGTGATGTGTTCACCACCCCGGGGTGACCGCGTGAGGACAGCGGCCGCACCCCGACACTGCTGTGGGCCCTCGGTGTGGAGGCCTGTGGGCGTCCAGGCCACGCCCGAGACCAGCCCCTCCGCCGGCGCCGCTGCAGCGACCCTCGAACCCGGGCAAGGTCTCCACCGCCGTGGCACCGGGTGCGGGAGGCGTTTTCCCCCCTCCCAGCGGGTCCATGCAGGGGATCGGGATGTTCTGAAGCCCCCACTGCTGTGCCTGGAACACCCGTGTCTGCCGCTCACCCCTGAGGACTTGGGACCTCAGGGGGTGAGTGGCAGGGGTGGCCGGGACATGCCAGGCCACCCACCTGGCAAAGGGCAGCGCCGAGGGCGCCCCGCGCCTGCCAGCGCCCGGCCGGGCCCGCCCTGCCCACCTCCCATCCCCCATCCGGGCGTGACACTTGACCGCGTCTGCCGGCCCCTCC:G,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Silver-Russell syndrome 1,NM_000218.3(KCNQ1):c.1514+37364_1514+38744del,representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +977170,11:2583544:CGGTAGGTGCCCCGTGGGTGCGTTTTCCCTGGCTCCTTGGACAGCTGGGGTCCTGGGGTGGCTGCACGCCCCTCCCTGTGAGCAGACCCACTTACGTTCAGAACCAAGAGGGTGCTTCCCTTCTAGAAGGTGCTATACTCCAGAGCCCCACCTGCCCTCCCTGGGGCCCTGGATGCAGACTTCCCGTTTGCAGTCCCCACTGGGGTCCTTGCAGGCAGTGTGGGAGGCAGCCTGGAGTGGCTGTGCATGGGCGCAGTGTGGGGCAGGCCTGCTCACTCAGCCCTGGGTGGGTGGGCAATGCTGCTACCACGCCCCATGGAGGCAGAATCTTGTGCCTGGAGAGGGCACTTCCACGCTGTGGCTGGGGGGGTTTTGTTCCATGTCCTTTCCAGAAACCACAGATTGTAAGGTGATGTGTCTAGTTCACAATGCCTGTATGTGGGTGTGTGTGTGTGTGTTATGTGCGTATGTGCATAATATGTGTTTGTGTTGTGTGTGTATAATTTTATGTTACCTGTATACTATGGGTATGTGTATATGTATCACATGGGTGTGTATGTACTGTATGTGTGCGTGCATACTGTGTATACATATTGTATGTGCATATGTTGTATTTAGTATGTGTGCTGTGTTGTGTGCACATGTATGCATTATACATGTATATCAGTATGTTTGCATATGTGTATTTATGTATCTGTGTCACAGGTATGTATCCTATACATCTATGTGCGTATATGTGTGTGCACATGACATGTAGACATGTGTTAGTATGTGCTTGTGTTAGTGTTTGTGTGTTAGTGTGGGTTAGTGTATGTTTTAGTGTATGTTAGTGTGTTTGTGTGTTAGTGTGTGGGTTTGTGTTTGTGTTTCTGTGTTAGTGTGTGTGTTAGTGTGCGTTAGTTTGTGTTTGTGTGTGTATGTTAGTGTATGTTAGTGTTAGTGTGTGTTAGTATGTGGGTTAGTGTGTGTGTTTGTGTGTTAGTGTGTGTGTTAGTATGTGTTTGTGTTAGTGTGTATTTGTGTGTGTTAGTGTTTGTGTGTGTTTGTGGGTTAGTGTGTGTTAGTGTGGGTTACTGTGTGTTAGTGTTTGTGTGTTAGTGTGTTTTTGTGTGTGTTAGTGTGTGGGTTAGTGTTTGTGTGTGTGTCAGTGTGTGTGTGTTAGTGTGCATATCTATTGTGTGTGTGTGTGCATCACACATGCACGTGCACCACGTGATCTCCTCTGTAGACACGGAGTTCCCTAGCTTCAGGGTGGGTCCTTTGCATCCCATCAACCGTCCTTGGGCGAGGCAGCAGCAGGGTCCTCCTCAGCTGAGGACTGCCTTCTCACTTGCGACCCCAATCCCAGTGCCCAGTATGACCCCTTCCTGGGCACATACAGATGGACCAGCCCACCTGGCCCCCAGAATGGTCCCTGGGAATGGGTTAGAGCGGCTGCAGCCCTGCCCCATGGGACTGGGCCCCTTGCTGGATAAGACCTGGGGTATAAGTTCTGCCCCCCATGCTGGCCCAGGACAGGCAGGCTGGGCCCGAGGTGGGACTTGGGGGGGCTTCCAGCACTGACCATACCTGGCCTTCCCACAACGGTGACCGGTAACCACGTCCTGAGGCTGCACCCAGCTGGCAGTGGCCTGTGTGGACGGGAGCCTCCTGTCCATTCCTTCCCAGGGGATTCTTGGCTCGGGGTTTGCCCTGAAGGTGCAGCAGAAGCAGAGGCAGAAGCACTTCAACCGGCAGATCCCGGCGGCAGCCTCACTCATTCAGGTGCGGTGCCTGCAAGGCCCTGGTCACTGTCATTTTGGTCACTGTTATTGTTGCATCCAGCCCTCACGGCCACCTGTCAGAACCATCATTGGCCCCTGCATCAGCTTGGCTGGCCTGTGGGGCATACTCTGCTTGTGGAAGCCTTGGCTGCTGTGGTGATGGGGTGAGCACGGGGCATTGGAGCCTGTCTTCCTCCAAAGCTGCTCCCATCAAGGGCCATGCCCTGTGGGCTGGAGAGGAGGCACGGCCGTGGCCATGCCAGGAGTGGACGTGGTTGGCTCTGAGGCTCCCTTGTGCTCCCATTCTCCCTCCCACTGCACAACAACCTGAGGGCTGAGTCTGGGAGTGGGGTGGCCAGGTGATTGTCCCCAAGGGAGGTAGGACCCAGCTGTGCAGTTGGTGCCTTCTGGAGGGCCTGGCATCCCTCAGGGCTCGGGAGGCCCTGGTGCCTGGAGGTGAGGACTGGCGATGGATGGCATGGGCCTCCCTCTGGGCTCACAAGGCCAGTGGGCTGGGAAAGGCAGAGCCCTGGAGCAACAGGGGCAGGAAGGTTCTGGAGGCAGGTGGGGAGGCAGGCAGTACCAAGCTCTGGGATGCTGGGCTCTGGCTCTGTCACTCCAGGCTCTCCAGGACCCACCAGAGAATGGGACTGCTCTGTTAACGTAAGCAAGGACTTGGCACAGGAGTCACTTGAGAATTGCGTCCCTGTGGGTCTCTCTTGTTGGCCACTGCAGGGCCAGGGCTGCCCTGAGGAACAGCCGCTGAGGTGCCCAGAGGGTGGGCGTTGCCGGGTTGAATGACAAGTGCCCACTGGGGATAGGGCCTCCGCCCAGTGCAGTGGCTGGGAGCACAGTGTCAGTTCCTCTGGGCACACTGGGCCTGATGTCCCCCAGGAAGGCCCAGGACCTGGGCAGCCCCCGCTGGCTGGCGTCCCCCCTGCAGTCCTCGTGAGCTCGCTGCCCCAGGCAAGGCCCAGGCTGTCAGGGGCCAGTCGCAGTCCTCCTGCACTCCTGGCTCAGCCATCGGGGGGGCTGTGTGCTCCCACCCTTAGCCTGGTTTTATGGCTTCACAGTTTCTCCTTCCTGGGAGACCATAAATCAGGCCCGTAAACCCGCCTTGGTCCCAGCATGAGCATGCTGGCCGCCCACGCCTGGCAGGGGACCACATTGGATTCCTGGTCCCACTCCCTGGGAACCACAGGTCCTTTGAAAGGGGTTCCCTCGGAAGCTGCACACACTGTGGGAGGACTGGAGTAGGGGCCCCAGGTGGCAGGTGTGCACAGGAGCAGGGCAGGGGTCATGGGGTTTGCCAGGGTTGGGGGACCACGTGGAGTGCTCAGCCTGTGTGTGTAACACTCGGGCCTTGGAAGGCTGGGCTTGTGCCCTCGCCTGCCTGTCCCTGGGTGCTGGATGGGAGTGAGGGCTGCAGGTGCCCCTCGCCAGCTGCTGTGTCTACCTGGGGCTGTCACCCAGGAGCCCATCAGTGTGGGGGAACATTCTCCACTCGGCCCTCTCTCAGGCTCATGTGGCCAGTGATGACAAGGCCACCAGGACATGTCCTCATACAAGGCCCTGGGAGCCCCTCCTGCCCATCTGGACGCTGCACAACTGCTCCCCCGCCGGGTCCCCTGCCGATAGTGTCCCCTCCTCCCACCCTTCCCTTGTGGTGCTGCCATGGGGTCTCTCTGAAATGCTGGCTTCAGAGCTGCACCCATGTGCCATCAGAGGCTCCCCCAACTGCAAGGTGGTATAGGCCTCTGGGAGAGACCTCACCTCCTGCCAGCCCTAGGGATCCTGCCTCTCCCTGCCCCCTGCTCAGCACCTGCAGGTCCTGGGCGACCCCTCTTTCTCAGCCCTTCCTCACTGTGTGGCCACTGGTTGCCCATTTCCGCATTGGTCTCCTATGCACGCTGTGTACCCTGGCACCTGGGGATGATGTGCGACCTGCCCACCTTTGCAAGTCTCTCCTTTGGCTCAAGGCTGGCTCAGGGCTGGTAAAGACCTCTGTGGTGTCCCAGCTGTGGGTAACAATTAGCCCATGAGGCAGTGAGCTGCCTGGTGCAGCAAGGGACCAAGCCAGGCTGCCTGGGCAGAGGGTCTGGGAGCTGGGACCATGTCAAGCCTGTGACTCTGAGGTCCCAGACCCTGCCACCCAGAGGGGAGGGGCCAGGCCTGGGGAACAGGGAGGGGGAGCTGTAGCTTCCATAAGGGCCCCCGCCGGGTGGCTCAGCAGGTGACAGCCTGTCCCCCTGCCCGACCTCA:C,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1032+1_1129-1del,representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +966649,11:2587646:GC:G,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1207del (p.His403fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +960695,11:2583477:A:C,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.964A>C (p.Thr322Pro),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +956049,11:2777033:G:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1732+1G>A,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +939724,11:2583547:T:C,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome|Long QT syndrome 1,NM_000218.3(KCNQ1):c.1032+2T>C,representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +930315,11:2588718:GAAAA:G,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.1262_1265del (p.Lys421fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +926196,11:2662006:T:TGAGAACCAACAGCTTCGCC,KCNQ1,unanchored_assertion_state,arrhythmia,arrhythmia,Cardiac arrhythmia,NM_000218.3(KCNQ1):c.1443_1461dup (p.Asp488fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +925351,11:2588790:CA:C,KCNQ1,unanchored_assertion_state,arrhythmia,arrhythmia,Cardiac arrhythmia,NM_000218.3(KCNQ1):c.1330del (p.Thr444fs),unanchored,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +922607,11:2588815:CG:C,KCNQ1,unanchored_assertion_state,arrhythmia,arrhythmia,Cardiac arrhythmia|Cardiovascular phenotype,NM_000218.3(KCNQ1):c.1356del (p.Leu453fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,true,false,2023-01,2026-04 +919956,11:2585222:GCTCGGGGTTTG:CA,KCNQ1,unanchored_assertion_state,arrhythmia,arrhythmia,Cardiac arrhythmia,NM_000218.3(KCNQ1):c.1043_1054delinsCA (p.Gly348fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +869436,11:2572105:G:C,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.776G>C (p.Arg259Pro),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +869435,11:2585288:C:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.1109C>A (p.Ala370Glu),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,true,true,false,2023-01,2026-04 +869434,11:2570626:AG:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 1,NM_000218.2(KCNQ1):c.478_478del,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +869433,11:2768869:ATTAAGGTCAT:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.1542_1551del (p.Lys515fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +861314,11:2572874:TCCTGGG:T,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.813_818del (p.Gly272_Leu273del),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +855976,11:2572072:G:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.743G>A (p.Trp248Ter),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +844409,11:2587671:CA:C,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1233del (p.Lys411fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Gly189fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +817016,11:2570662:AC:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,,NM_000218.3(KCNQ1):c.513del (p.Glu170_Tyr171insTer),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Tyr125Asn),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +684787,11:2528008:T:C,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.467T>C (p.Leu156Pro),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 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(p.Asp242Glu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,conflicting,P_LP,true,false,false,true,true,true,false,2023-01,2026-04 +660595,11:2583486:G:C,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.973G>C (p.Gly325Arg),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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syndrome,NM_000218.3(KCNQ1):c.1032+5G>T,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +620198,11:2585305:C:T,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome|Long QT syndrome 1|Cardiovascular phenotype,NM_000218.3(KCNQ1):c.1126C>T (p.Gln376Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +620103,11:2572846:G:T,KCNQ1,unanchored_assertion_state,LQTS,LQTS,,NM_000218.3(KCNQ1):c.781G>T (p.Glu261Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +587644,11:2768851:GA:G,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.1524del (p.Glu508fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +582668,11:2583433:A:G,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.922-2A>G,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Arg380Trp),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +576205,11:2768841:CAG:C,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1515-2_1515-1del,representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Thr247fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +570319,11:2777002:G:C,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1702G>C (p.Gly568Arg),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Leu262Pro),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +526930,11:2588717:AG:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1257del (p.Lys422fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +523769,11:2445192:A:T,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.94A>T (p.Lys32Ter),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +522585,11:2583447:A:T,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.934A>T (p.Thr312Ser),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +519369,11:2572059:C:T,KCNQ1,disease_model_collision,LQTS,LQTS|arrhythmia,Cardiovascular phenotype|Long QT syndrome|Cardiac arrhythmia,NM_000218.3(KCNQ1):c.730C>T (p.Gln244Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,9,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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1,NM_000218.3(KCNQ1):c.1732+5del,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +496690,11:2661990:AGCAT:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Jervell and Lange-Nielsen syndrome 1,NM_000218.3(KCNQ1):c.1426_1429del (p.Met476fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Tyr278Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +449302,11:2583456:T:C,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.943T>C (p.Tyr315His),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 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(p.Lys28fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +641517,7:150974767:T:TGCGCGATCTGCGCGGCA,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.234_250dup (p.Gln84fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +640022,7:150950308:GC:G,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.2257del (p.Ala753fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +637977,7:150947371:C:CG,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 2|Long QT syndrome|Cardiovascular phenotype,NM_000238.4(KCNH2):c.3108dup (p.Asp1037fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +632866,7:150952842:CA:C,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome|Long QT syndrome 2||Cardiovascular phenotype,NM_000238.4(KCNH2):c.1139del (p.Leu380fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,true,false,2023-01,2026-04 +620172,7:150951063:G:T,KCNH2,disease_model_collision,LQTS,LQTS|arrhythmia,Cardiac arrhythmia|Long QT syndrome,NM_000238.4(KCNH2):c.2003C>A (p.Ser668Ter),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,9,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +620154,7:150952634:G:A,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.1348C>T (p.Gln450Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,true,false,2023-01,2026-04 +618184,7:150951520:C:G,KCNH2,unanchored_assertion_state,LQTS,LQTS,,NM_000238.4(KCNH2):c.1873G>C (p.Val625Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +598783,7:150947865:TG:T,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 2|Cardiovascular phenotype|Long QT syndrome,NM_000238.4(KCNH2):c.2705del (p.Pro902fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +582292,7:150958047:CGGCGCCCTCACCGGTGCT:C,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.910_916+11del,representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +581669,7:150951638:C:G,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.1755G>C (p.Trp585Cys),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +579489,7:150977836:ACT:A,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.76_76+1del,representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +572344,7:150951702:A:T,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.1691T>A (p.Leu564Gln),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +570715,7:150947370:T:TCGCCCCGGGGCCGCCGACCCGGGCTGGAGAGGGGGATGTTGAGGAGGCTGGGGGTGGGGGCGGGGCATCGAGGGAGCTCCTGGTACTGGCGGCCCCGACTGTCCCCCCAGAAGCTGAAAATGTTGGACACTCCTGAGAAGGCGCCTGCAGCCAGAGAGCAGAGCTGGGTGAGCGGGGTAGACGCACCACCGCTGCCACGCCCGGTCCTCCCTCGCCCGCCCGTCGCCCGGGATACCTGACAGGGGGTTGCAAGTGTCGCTGCTCTTCTCGCAGTCCTCCATCAGGGGCTCCCCACCCGGCGGCTCTCCGGGGGGCCTGGGGCTGGAGAAGGGCACCAGGCGGAGGGGGCTGGAGCTGCGGCCTGGGCCCTCATCCTCACTGCTCTCAGGGCTGGAGGGGCCACTGGACGGGCTCTCCCCCCACGGCCCCCCCGGCCGGCCCCGGCTACTCGGCCCTGCCCCCGCCCGGCCCGGCCCCAAGGCCGACACCTCCCCTGGCTGCTCCGTGTCTGTGGGAAACAGAGAATGGGCCTCAGAGAGGGGAGGAGAACAGAGAGGAGGGGGCGAGGGTGGAGGAGGGGACAGGAGCGAGCCCGAGAGAGGACTGGGCAGGAAGCCCTGGTTTGTCCCCAGTCGCTTCTTCTGCTATCTTGCACCCACTGTCAAGCCGACCAAGAACTCCCAGGACCCCCTGACTGCCCAAGCACTGGCAATGGTGCTTCAGGGGTTGGCGGATCTCTGGGACTGCGGGGCCTCAGCCCCATCGTTGGCTCCCTGGCCCTCCTTTGTTCTATGTTCTTTCCTCCTCAGTGCTCACAGAGACCCCAGCCCTGTGAAGTCCAAAAAGCCTAGGCTTGCCCTGGAGGGTGGAAGAGGGCTTCCTGGAGGAGGTGACAGCTGCAGGGGCCCTGAAAGATGGGCAGCATCTGGACAGCTGGGGTGTGGAGTGGGCACACTGGAGGAAGGGATGGGAAGGTCTGAGGCCTGGGTAAAGCAGACACGGCCCACCCCGCCTTCCAGCTCCCAGCCTCACCTTGTCCCCGCCCTCCCCCTTCCTCCCCTCCCCCGCCTCACCCTTGTCCGTGCGCCTGCGGAAGGACAACTTGCGCTTGCGTTGCCGACTGAAGCCACCCTCTAACTCCGTACTGCCGGGGGAGCCCGGGATCATGTTGGTCTGGAACCAAAATCAGTATCAGGGCCCTTTCAGTGCTCTCCTGCCCCACCGGGGTCAGGCCCCAAGCTCCCTCCTTAACACAGAAAAAGTAGGGCTGGGCGCCCCAGCTCTGGGAAAACCCTTCCCTGCCCCCAATGTGATTTTGCCCCAGGCAAAGACTGAGTTTGGGACTTTTGTAGGCTGCTCTATGATACCATTTGACAGACAGGGAAACTGAGACAGAGAAGCATCACATTCAATGTCACACAGCAAAGGGGCAGCCACACAGCTGGAAGCAGGAGGATGGGGTCCAGCTCAGGGCAGCCAACTCACATCTCGCAGGTTGAAGGTGATCTCCAGGCTGGACCAGAAGTGGTCGGAGAACTCAGGGTACATGTCCAGCACCTCCAGCAGGTCGTCCCGATGGATCTTGTGTAGGTCACAGTAGGTGAGGGCCCGCACATCCCCGTTCGACTTGCCAGGCCTTGCATACAGGTTCAGAGGCTCCCCAAAGATGTCATTCTTCCCTGGAGGCCATGGAGAGGACAGGGAGCTCAGCCCCGGGGGGCGGCATCCAGGCAGCAGGCACCTTCTCCCGGCATCCCCACCCCGGGCAGAGCATGTCCCCTCAGCTGGGTCGCCTGCCAGCCGGCCCCCAACCCACACAACCGGGGAAGCAATCTGCCAGCCCACCCTCCCTCAGCTCCCAGCAGGCACGACAGTGCCAGAGGGGCCAGGAGCCCAGGGTCTCCCAGCAAATGAGACCCAGCCAGCAGGACTACCCCAAACCCCAGGTCCCAAACACCCTCTTAGCCAATCACTGCACCCTTATAAGCAATGTTCTTCAAACCAAAGATCAGAACACAGTAGTGAATCAAAACCAGCATTTTTTTTTTTTTTTTTTTTTTTTTACTGAAAGAACATACAGTAGTATAGCTTAGCACAGCACAGAACAGAAATGCTAGAATGAACCACATGCAGTAAGGCCCAGTGTTATGTAGTGAAACTTTGATTTTAGTTTTGTGGGGGTGTGTATTTGTGTTTGTACAGAGCTGAGAAACAAAGTCTAAAATGTCCTACCATCAACTATGGTCGAAAGAGCTTGCTATATCTGCCCTGAGGCACACAGGGCCGAGGGAAGGACAGGCAAAGGGGGAGGAAGTCCTCAGTGTCCAGACACACCAACCCACCCACTGTGCACAGGCAGGGTAGAAAGGAAGTGGGGGGAGGGGGCAGGACTCCCTTTGCTTTGGATGTGTCAAGGGGCCAGGCATGAGGCTGCAGGGAACCACATGGCCCTTAGTGAAACCAAATGCCGAGCTTCCAGGCTAGCATTTCTTCCTCTACTGCCCAGGCTAGAGGATCTAGATTTGATCCTACTTTAAGGAAGCAAAAAGTGTCTGTTTGTGGCGGATCCTGAAGGGAAGGAGAATGTGGGAACCCCAGAGTTCAGCAGCCTCACCCCACGTGGGGCTCCTCTCCATGGCCCCGCTTGGAGGGCCTGAGTTTAGGTGAATTAAAGGAGCCCAGTGACCCTGCAGGCAGTCCCAGGTCCACAGCCCCAGTGACTGCATATTCAGAAGGCTCGCACCTCTTGAGGCTGCAGAGGGCATTTCCAGTCCAGTGCCCGCCCCCCACCCCATACCCAGGATGGCCACGACGACGTCGCCCCGCAGGATCTCGATGGAGCCCCGGGAGATGAAGTACAGGGCGGTGAGCAGGTCCCCAGCATGCACCAGTGTGTCCCCTGGCGGTGCATGTGTGGTCTTGAACTTCATGGCCAGGGCCCGAAGGCAGCCCTTGGTGGCCCCTCGGAAGGGTTTGCAGTGCTGCAGCAGTGAGCGGTTCAGGTGCAGGCAGATGTCAGCCTGCAGGCACTCAGGGAAGCCCTTCAGCACCTGGGGGCAGGGTGGGGGCAGCTCAGCACACCCTCCCTTGGGACCCCCCAACCCACACTCTACTCCACCATCCCACCCCTCCATGTCAGAGAAATCTCAACCTCCAGGCCTGGGAGATCTCGGAAGCATCAGGGGGCCCAGTGTCTTGGGAAGGACCTGGGACCCCACTCCAGCTTCACCATGCCTGGCCGAGCACCCTTGGGCTCTAGACCTCCATGTTCTTATTTGTAAGGCATAGAGACCATTCCCGCCCTGGGCTGTCACAAGGATTTAACCCCATCGCCTATGTGACATATACCTCCCACCCCAAAAGGGGAGCTCTCCAGGGAAGGGGTTCCAAGGGCTTCCATTTCCTCATGGGCAAAAAGGGGCAACGTGCCTCCAGGGTCCTTACTACTGACTGTGACCGCCTGAGACTTGTTTGCTGTGCCAAGAGGTTCCCCTCTGCCACCCCACTCTTCCCAGCCTGCCACCCACTGGCCACGCTCTGGTGGCCTCACCGCGTTCATGTCGATGCCGTTGGTGTAGGACCAGGCGTGCTGGAAGTACTCCTCGAGGCGCTGGCGCAGGGGATTGGGGATCTGGTGGAAGCGGATGAACTCCCGCACCCGCAGCATCTGTGTGTGGTAGCGGGCTGTGCCCGAGTACAGCCGCTGGATGATGGCCGACACGTTGCCGAAGATGCTAGCATACATGAGGGCTGGGGGCGTGGGCACGTGGGGCCGTCAGCCTCTGCAGGGACCCCACCCACCCACAGGGACCCTGCTCAGGCCCCGCACCAGGTCAGTGTCTCAGTCTCAGCGTCGACATGCCCACGAGACGCCCTTGTACATCTGCGCTCCAGCACACCCCACCCTTCAGTAGTCCCCGCCCTGGTGACCCAGCCCCCAAACCATGTCACGATGGTGGCCCCTGGAGTCTCTAAGTTCCAGGGCCTCACTCTGGCCCGGCTAGCAGCCTCAGTTTCCTCCAACTTGGGTTCCTCCACCGTGGGCTCTCCCCGCCGCCCGCCCCTGGGCACACTCACAGCCAATGAGCATGACGCAGATGGAGAAGATCTTCTCTGAGTTGGTGTTGGGAGAGACGTTGCCGAAGCCCACACTGGTGAGGCTGCTGAAGGTGAAGTAGAGCGCCGTCACATACTTGTCCTTGATGGAGGGGCCGCCCAGGCCGCTGCTGTTGTAGGGTTTGCCTATCTGGTCGCCCAGGTTGTGCAGCCAGCCGATGCGTGAGTCCATGTGTGGCTGCTCCATGTTGCCGATGGCGTACCAGATGCAGGCTAGCCAGTGCGCGATGAGCGCAAAGGTGCACATGAGCAAGAACAGCACGGCCGCGCCGTACTCTGAGTAGCGATCCAGCTTCCGCGCCACGCGCACCAGCCGCAGCAGCCGCGCAGTCTTCAGCAGCCCGATCAGCTGGGGGACAGGGAAGGGGCACATTCCGTTGATGGGGCAAGGGGGGCAAGGGAGGAGGGGAGGTGCTGCGGCCCTCAGAGCGAGCATCAGAGGTCAGATCCCCAAAGACTTCCTAGACCCTCCTCCTAAGAGGTGAAGCCCACACTGGGCCCAGCACAGGTGTCTCATTAATCTTAGTGCTAGCTTTGGGACAGAGGCAGCCCCCATAGTGTGGATGAGGAAACAGGGGCACTGACAGGTGCAGTGATCACCCTAGGGTGCCTGCCCACTCCCACCAGCTTCTAGGGCACTTTGGTGACGCTACAAAATAATGGCCCCTTGGGATGGACGAATTAGAAAAAAAGGTGTCCTGTGTGGCCCTCTGCAACCTGCGAGGAGCTTGTGTGGAGAGAAGGAGCATAGGTTTGCTGGGGTACCCACCTTGCCTCTGCAGCTGCCTTGCCACCATGTCTCTCTCCCACTGTCTTTCTCTCTTTCTCTCTCTCTCTCTTTTTCTCTGTCCTCCTCGCCACCCCCTCCACCCCACTACCTCCCACCACATTCCTGGCCTCTCCTCTCCCTACACCACCTGCCTCCTTGCTGACCCCACCTCCTCAGAGCCAGAGCCGAAGATGAGCAGGTCGAAGGGGATGGCGGCCACCATGTCGATGAGGAACCAGCCCTTGAAGTAGTGGACGGCGATGCGGCCGGGGTGGCTGACCACCTCCTCGTTGGCATTGACGTAGGTGGTGCGGAAGTTGATGAGGATGTCCACAATGAACATGATGTCCACGATGAGGTCCACCACAGCCAGCGGCTGGCAGGCGTAGCCACACTCGGTAGCAGGCGGGCCTTCTTCCGTCTCCTTCAGCAGGAAGGCAGCCGAGTAGGGTGTGAAGACAGCCGTGTAGATGACCAGCAGCAGGATGAGCCAGTCCCACACGGCCTTGAAGGGGCTGTAATGCAGGATGGTCCAGCGGTGGATGCGCGGTGCCTGCAGCTTGTACTCAGGCAGCACGTCGGCGCCCAGGGACAGGACCTGCACCCGGGGAAGGCGGAGGTGTGGGTGAGGCAGGCCATGGGACCTCGGGGGCAGGAGCGATGACATCTCTGCCGGGGCCAAGCAGAATGAGGAGGAGGCCAAAAAAAGCTTCCATCAGAATGCCCACCCCTCAGCCAAGCGACCACAGCAAATGGCCACCCCCAGGTTTGGGCATCATGGTTCCCAAAATGCCACACAGCACAGGACTGGCTCCAAACAGTTCCAACATTTCCCGGCAGACGTGGATTCAGGCCACTCGGCAGGAACACCCAGTGCTGCTCCCCGCCGGCAATGCAGATGCAGACCTGCCACTGTGACTGCCCTGAGACGCTGGCCCACACACCCAACCACACACGCCATAGTCTCAGACCGGAAAGGGTTCCAAGGACAACAGCTCCCAACCTGGGCAGTGGCCCCAGGAGCCATAGCCCCAATCCACTGACTGGTAGTCACTGCAGTTCTTACCAGCCCCTCTTCATGCCACAGGCCCGAGGACACCAGGCAACCAGGATGGAGAAAGACCAAGACACTCCCACCCTCCACTCGCACACCTCGCTCCCTCAGCCCCCTCTCCACACAGGTCCGGGACAGCCCACAGTCCTCATCCTCCCACCCTCTTACAAAGGGACAAAGAAGACATAGCCCAGCTGGGAGGAGATGGCACCCAACTTATACAGAGGGACGTGCACACAGGGACTGCTCAGCAGTGACACACACAGCCCCTGTACCAGCTCACACTCACACTCTGCCTCCTCCACAGTCATCAGACAGAGGCAGGCTGGCCATCCGGACCCGGTGACAGCAGGCACGTCCCTCTTGCTCCCAAGG,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.1129-831_3109dup,representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +570494,7:150951499:GAGAGACGTTG:CTTCA,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.1884_1894delinsTGAAG (p.Asn629_Pro632delinsGluAla),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +568003,7:150947640:G:T,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.2931C>A (p.Cys977Ter),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +565724,7:150952848:CAG:C,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.1132_1133del (p.Leu378fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +560696,7:150951545:G:C,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 2,NM_000238.4(KCNH2):c.1848C>G 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(p.Tyr54Ter),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +488692,7:150948510:C:A,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.2626G>T (p.Glu876Ter),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Gly1036fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +456919,7:150947381:C:CCG,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.3097_3098dup (p.Pro1034fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Cys740fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +456903,7:150950248:CCAGCATGCACCAGTGTGTCCCCTGGCGGTGCATGTGTGGTCTTGAACTTCATGGCCAGGGCCCGAAGGCAGCCCTTGGTGGCCCCTCGGAAGGGTTTGCAGTGCTGCAGCAGTGAGCGGTTCAGGTGCAGGCAGATGT:C,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.2180_2317del (p.Asp727_Ala772del),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +456902,7:150950421:CTG:TT,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.2146-3_2146-1delinsAA,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +456901,7:150951004:G:A,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.2062C>T (p.Gln688Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +456886,7:150952646:C:CA,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.1335dup (p.Gly446fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +456876,7:150957296:TGA:T,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.1121_1122del (p.Val374fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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phenotype,NM_000238.4(KCNH2):c.1557+1G>C,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +431374,7:150947389:C:CCGGGCTGGAGAGGGGGATGTTGAGGAGGCTGGGGGTGGGGGCGGGGCATCGAGGGAGCTCCTGGTACTGGCGGCCCCGACTGTCCCCCCAGAAGCTGAAAATGTTGGACACTCCTGAGAAGGCGCCTGCAGCCAGAGAGCAGAGCTGGGTGAGCGGGGTAGACGCACCACCGCTGCCACGCCCGGTCCTCCCTCGCCCGCCCGTCGCCCGGGATACCTGACAGGGGGTTGCAAGTGTCGCTGCTCTTCTCGCAGTCCTCCATCAGGGGCTCCCCA,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 2,NM_000238.4(KCNH2):c.2906_3089dup (p.Gly989_Ala990insIleProGlyAspGlyArgAlaArgGluAspArgAlaTrpGlnArgTrpCysValTyrProAlaHisProAlaLeuLeuSerGlyCysArgArgLeuLeuArgSerValGlnHisPheGlnLeuLeuGlyGlyGlnSerGlyProProValProGlyAlaProSerMetProArgProHisProGlnProProGlnHisProProLeuGlnProValGlySerProTer),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +431036,7:150947631:GCTCTT:G,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 2,NM_000238.4(KCNH2):c.2935_2939del (p.Lys979fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +430730,7:150948456:G:GCCTGC,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 2|Long QT syndrome,NM_000238.4(KCNH2):c.2675_2679dup (p.Arg894fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Val680fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +427076,7:150951096:C:A,KCNH2,unanchored_assertion_state,LQTS,LQTS,,NM_000238.4(KCNH2):c.1970G>T (p.Gly657Val),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +426429,7:150958306:TGCCA:G,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome|Cardiovascular phenotype,NM_000238.4(KCNH2):c.665_669delinsC (p.Val222fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +423753,7:150951473:G:C,KCNH2,unanchored_assertion_state,LQTS,LQTS,,NM_000238.4(KCNH2):c.1920C>G (p.Phe640Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +423696,7:150950937:CCG:C,KCNH2,unanchored_assertion_state,LQTS,LQTS,,NM_000238.4(KCNH2):c.2127_2128del (p.Asn709fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +423015,7:150947419:T:TG,KCNH2,unanchored_assertion_state,LQTS,LQTS,,NM_000238.4(KCNH2):c.3060dup (p.Ser1021fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +421672,7:150947683:GG:T,KCNH2,unanchored_assertion_state,LQTS,LQTS,,NM_000238.4(KCNH2):c.2887_2888delinsA (p.Pro963fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +420923,7:150950983:G:A,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome|Cardiovascular phenotype,NM_000238.4(KCNH2):c.2083C>T (p.Gln695Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +420585,7:150947367:ACGTCGCCCCGGGGC:A,KCNH2,disease_model_collision,LQTS,LQTS|arrhythmia,Long QT syndrome|Cardiac arrhythmia,NM_000238.4(KCNH2):c.3099_3112del (p.Pro1034fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,9,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +420260,7:150959706:A:ACCACATC,KCNH2,unanchored_assertion_state,LQTS,LQTS,,NM_000238.4(KCNH2):c.331_337dup (p.Val113fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Ala4954Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1745086,1:237377364:C:G,RYR2,disease_model_collision,SADS,CPVT|SADS,Cardiovascular phenotype,NM_001035.3(RYR2):c.505C>G (p.Arg169Gly),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1710227,1:237723201:A:ATCCAGAGAAGACGGTAGAAAGAG,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.10630_10652dup (p.Val3551_Leu3552insGlnArgArgArgTer),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1693182,1:237798100:A:G,RYR2,unanchored_assertion_state,cardiomyopathy_overlap,cardiomyopathy_overlap,Arrhythmogenic right ventricular cardiomyopathy,NM_001035.3(RYR2):c.14020A>G (p.Lys4674Glu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,True,False,True,False,True,False,False,True,False,high_tension,3,True,True,True,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|structural_electrical_overlap|conditional_penetrance_dependent,4,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1527876,1:237830611:C:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14737C>T (p.His4913Tyr),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1527868,1:237634949:A:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6749A>T (p.Asn2250Ile),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1524904,1:237445402:C:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1|Cardiovascular phenotype,NM_001035.3(RYR2):c.1172C>A (p.Ala391Asp),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1499030,1:237633669:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6647A>G (p.Asp2216Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1496297,1:237757772:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11321A>G (p.Gln3774Arg),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +1480185,1:237806211:C:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14226C>A (p.His4742Gln),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1479669,1:237830584:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14710G>A (p.Gly4904Ser),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +1474443,1:237781643:G:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11959G>C (p.Glu3987Gln),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +1472640,1:237784315:G:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12603G>T (p.Gln4201His),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1467901,1:237806237:A:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14252A>T (p.Lys4751Met),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1451617,1:237640994:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.7213G>A (p.Glu2405Lys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1441921,1:237793882:T:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.13798T>C (p.Phe4600Leu),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1441891,1:237784158:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1|Cardiovascular phenotype,NM_001035.3(RYR2):c.12446A>G (p.Tyr4149Cys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1410932,1:237784176:C:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12464C>A (p.Ser4155Tyr),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1384586,1:237638464:C:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6900C>G (p.Asp2300Glu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1383749,1:237649944:T:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.7580T>G (p.Leu2527Trp),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1363823,1:237793920:T:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.13836T>G (p.Phe4612Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +1346560,1:237760996:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11444A>G (p.Glu3815Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1342890,1:237441339:GAGAAA:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.1031_1035del (p.Lys344fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1330215,1:237469125:C:T,RYR2,disease_model_collision,cardiomyopathy_overlap,CPVT|arrhythmia|cardiomyopathy_overlap,Arrhythmogenic right ventricular dysplasia 2;Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.1646C>T (p.Ala549Val),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,True,False,True,False,True,False,False,False,True,multi_regime_required,7,True,True,True,True,False,False,True,14,genotype_first_postmortem|provocation_dependent_instability|structural_electrical_overlap|conditional_penetrance_dependent,4,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1213111,1:237772037:G:C,RYR2,disease_model_collision,SADS,CPVT|SADS,,NM_001035.3(RYR2):c.11583G>C (p.Gln3861His),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1119951,1:237784299:C:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome|Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12587C>T (p.Thr4196Ile),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1119950,1:237783695:A:C,RYR2,unanchored_assertion_state,arrhythmia,arrhythmia,Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome,NM_001035.3(RYR2):c.11983A>C (p.Ile3995Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,2,True,True,False,False,False,False,True,8,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1072928,1:237377373:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.514G>A (p.Gly172Arg),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1072597,1:237648522:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.7421G>A (p.Arg2474Lys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,conflicting,P_LP,true,false,false,true,true,false,false,2023-01,2026-04 +1070571,1:237783981:C:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12269C>T (p.Pro4090Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1069130,1:237639019:G:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6933G>C (p.Glu2311Asp),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1067931,1:237806159:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia|Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14174A>G (p.Tyr4725Cys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1067138,1:237377396:T:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.537T>A (p.Asp179Glu),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1066599,1:237806219:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14234A>G (p.Asp4745Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1051501,1:237631490:C:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6504C>A (p.His2168Gln),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +1013805,1:237828441:T:TTCC,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14651_14652insTCC (p.Met4884delinsIlePro),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1007679,1:237784055:C:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12343C>T (p.Leu4115Phe),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +982634,1:237674163:A:AG,RYR2,unanchored_assertion_state,cardiomyopathy_overlap,cardiomyopathy_overlap,Arrhythmogenic right ventricular dysplasia 2,NM_001035.3(RYR2):c.8659dup (p.Glu2887fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,True,False,True,False,True,False,False,True,False,high_tension,3,True,True,True,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|structural_electrical_overlap|conditional_penetrance_dependent,4,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +979205,1:237445474:C:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.1244C>A (p.Thr415Lys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +979204,1:237784211:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12499G>A (p.Glu4167Lys),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +978366,1:237707216:T:A,RYR2,unanchored_assertion_state,conduction,conduction,Conduction disorder of the heart,NM_001035.3(RYR2):c.9848T>A (p.Ile3283Asn),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,2,True,True,False,False,False,False,True,8,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +957942,1:237633671:C:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Cardiovascular phenotype|Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6649C>T (p.His2217Tyr),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +954202,1:237633708:T:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6686T>C (p.Leu2229Pro),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +947851,1:237492996:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.1870G>A (p.Ala624Thr),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +947702,1:237388087:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.677G>A (p.Gly226Glu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +940323,1:237759848:T:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11398T>C (p.Cys3800Arg),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +933804,1:237759824:AGCCTGGCCG:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11380_11388del (p.Ala3794_Leu3796del),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +931781,1:237709543:G:GT,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.10209dup (p.Ile3404fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +915531,1:237648558:ATCTTCTTGAGGT:A,RYR2,unanchored_assertion_state,cardiomyopathy_overlap,cardiomyopathy_overlap,Cardiomyopathy,NM_001035.3(RYR2):c.7459_7470del (p.Leu2487_Val2490del),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,True,False,True,False,True,False,False,True,False,high_tension,3,True,True,True,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|structural_electrical_overlap|conditional_penetrance_dependent,4,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +870975,1:237270563:G:GCAGAAGGATTTGGCAA,RYR2,disease_model_collision,SADS,CPVT|SADS,,NM_001035.3(RYR2):c.120_135dup (p.Leu46fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +869428,1:237831526:G:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14769G>T (p.Met4923Ile),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +861770,1:237648525:T:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.7424T>C (p.Val2475Ala),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +840374,1:237639068:C:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6982C>G (p.Pro2328Ala),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +692253,1:237798158:CCTT:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14079_14081del (p.Leu4694del),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +665174,1:237784301:A:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12589A>C (p.Ile4197Leu),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +656745,1:237784290:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12578G>A (p.Cys4193Tyr),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +654791,1:237423097:G:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.854G>T (p.Ser285Ile),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +654125,1:237778755:G:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11865G>C (p.Gln3955His),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +651491,1:237830557:A:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14683A>C (p.Asn4895His),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +649923,1:237643361:T:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.7256T>G (p.Ile2419Ser),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +644207,1:237778727:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11837G>A (p.Gly3946Asp),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +637985,1:237778678:G:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11788G>C (p.Gly3930Arg),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +580536,1:237784280:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12568G>A (p.Val4190Met),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +578246,1:237784189:G:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12477G>T (p.Gln4159His),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +575682,1:237792319:T:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.13778T>C (p.Leu4593Ser),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +575059,1:237778753:C:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11863C>G (p.Gln3955Glu),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +571532,1:237633668:G:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6646G>C (p.Asp2216His),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +570194,1:237784251:G:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12539G>T (p.Gly4180Val),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +568135,1:237791480:G:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.13528G>C (p.Ala4510Pro),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,true,true,false,2023-01,2026-04 +566084,1:237819188:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14586A>G (p.Ile4862Met),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +560709,1:237784261:AGAG:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12550_12552del (p.Glu4184del),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +532366,1:237628052:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6412G>A (p.Glu2138Lys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +532324,1:237819187:T:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14585T>C (p.Ile4862Thr),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +520467,1:237441320:A:G,RYR2,disease_model_collision,SADS,CPVT|SADS,Cardiovascular phenotype,NM_001035.3(RYR2):c.1007A>G (p.Glu336Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +519356,1:237639110:G:A,RYR2,disease_model_collision,SADS,CPVT|SADS,Cardiovascular phenotype,NM_001035.3(RYR2):c.7024G>A (p.Gly2342Arg),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +463624,1:237639095:G:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.7009G>C (p.Gly2337Arg),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +463608,1:237377426:A:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.567A>T (p.Glu189Asp),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +463605,1:237377374:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia,NM_001035.3(RYR2):c.515G>A (p.Gly172Glu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +463579,1:237819192:G:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1|Squamous cell lung carcinoma,NM_001035.3(RYR2):c.14590G>T (p.Gly4864Cys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +463577,1:237806236:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14251A>G (p.Lys4751Glu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +463549,1:237445428:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.1198G>A (p.Asp400Asn),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +452065,1:237808943:T:C,RYR2,disease_model_collision,SADS,CPVT|SADS,,NM_001035.3(RYR2):c.14341T>C (p.Tyr4781His),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +450836,1:237639026:GAG:AAA,RYR2,disease_model_collision,SADS,CPVT|SADS,,NM_001035.3(RYR2):c.6940_6942delinsAAA (p.Glu2314Lys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +449306,1:237832607:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14864G>A (p.Gly4955Glu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +427948,1:237783708:T:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 2,NM_001035.3(RYR2):c.11996T>C (p.Met3999Thr),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +427184,1:237377361:C:G,RYR2,disease_model_collision,SADS,CPVT|SADS,,NM_001035.3(RYR2):c.502C>G (p.Gln168Glu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +427164,1:237781598:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11914A>G (p.Met3972Val),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,conflicting,P_LP,true,false,false,true,true,false,false,2023-01,2026-04 +423597,1:237828390:T:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia,NM_001035.3(RYR2):c.14600T>C (p.Ile4867Thr),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +420865,1:237784281:T:G,RYR2,disease_model_collision,SADS,CPVT|SADS,,NM_001035.3(RYR2):c.12569T>G (p.Val4190Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +418465,1:237783714:A:G,RYR2,disease_model_collision,SADS,CPVT|SADS,,NM_001035.3(RYR2):c.12002A>G (p.Asp4001Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +404218,1:237638450:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6886G>A (p.Glu2296Lys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +404208,1:237756342:C:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11200C>T (p.Arg3734Cys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +372588,1:237832592:A:G,RYR2,disease_model_collision,SADS,CPVT|SADS,,NM_001035.3(RYR2):c.14849A>G (p.Glu4950Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +372582,1:237377365:G:T,RYR2,disease_model_collision,SADS,CPVT|SADS,Cardiovascular phenotype,NM_001035.3(RYR2):c.506G>T (p.Arg169Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1793918,1:115744885:C:CT,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Cardiovascular phenotype||Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.261dup (p.Ala88fs),representation_repairable,0.0,0.0,0.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1324014,1:115744827:C:T,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 2,NM_001232.4(CASQ2):c.319+1G>A,representation_repairable,0.0,0.0,0.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,true,false,false,2023-01,2026-04 +452250,1:115768540:A:G,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Wolff-Parkinson-White pattern|Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.2T>C (p.Met1Thr),locus_or_regional_context,0.0,0.0,0.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1798674,6:123636774:A:G,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Cardiovascular phenotype|Catecholaminergic polymorphic ventricular tachycardia 1,NM_006073.4(TRDN):c.2T>C (p.Met1Thr),locus_or_regional_context,0.0,0.0,0.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1797791,6:123548553:C:TT,TRDN,disease_model_collision,SADS,CPVT|SADS,Cardiovascular phenotype,NM_006073.4(TRDN):c.292delinsAA (p.Glu98fs),representation_repairable,0.0,0.0,0.0,False,False,0.001,,False,False,False,True,True,False,False,False,False,False,False,True,False,False,False,True,multi_regime_required,5,True,False,False,False,False,False,True,8,genotype_first_postmortem,1,genotype_first_postmortem,genotype_first_postmortem,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Gly170Ter),representation_repairable,0.0,0.0,0.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1458047,6:123571063:AC:A,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_006073.4(TRDN):c.91del (p.Val31fs),locus_or_regional_context,0.0,0.0,0.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +463677,6:123570921:A:T,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_006073.4(TRDN):c.232+2T>A,representation_repairable,0.0,0.0,0.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +408740,6:123570988:A:G,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 5|Catecholaminergic polymorphic ventricular tachycardia 1,NM_006073.4(TRDN):c.167T>C (p.Leu56Pro),representation_repairable,0.0,0.0,0.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +408737,6:123503893:TC:T,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_006073.4(TRDN):c.618del (p.Ala208fs),locus_or_regional_context,0.0,0.0,0.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1362982,14:90404488:A:G,CALM1,disease_model_collision,CPVT,CPVT|LQTS|arrhythmia,Long QT syndrome 14;Catecholaminergic polymorphic ventricular tachycardia 4,NM_006888.6(CALM1):c.395A>G (p.Asp132Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +974613,14:90404689:A:T,CALM1,disease_model_collision,LQTS,LQTS,Long QT syndrome 14,NM_006888.6(CALM1):c.422A>T (p.Glu141Val),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Phe142Leu),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +948239,14:90404488:A:T,CALM1,disease_model_collision,CPVT,CPVT|LQTS|arrhythmia,Long QT syndrome 14;Catecholaminergic polymorphic ventricular tachycardia 4,NM_006888.6(CALM1):c.395A>T (p.Asp132Val),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +639902,14:90404487:G:A,CALM1,disease_model_collision,CPVT,CPVT|LQTS|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 4;Long QT syndrome 14,NM_006888.6(CALM1):c.394G>A (p.Asp132Asn),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +542137,14:90404491:G:A,CALM1,disease_model_collision,CPVT,CPVT|LQTS|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 4;Long QT syndrome 14,NM_006888.6(CALM1):c.398G>A 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(p.Phe142Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +418107,14:90404512:A:T,CALM1,disease_model_collision,SADS,CPVT|LQTS|SADS,,NM_006888.6(CALM1):c.419A>T (p.Glu140Val),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,False,False,True,False,False,False,True,multi_regime_required,5,True,False,False,False,False,False,True,8,genotype_first_postmortem,1,genotype_first_postmortem,genotype_first_postmortem,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Asp130Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +458198,19:46609125:A:G,CALM3,disease_model_collision,LQTS,LQTS,Long QT syndrome 1,NM_005184.4(CALM3):c.422A>G (p.Glu141Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +409871,19:46608584:A:C,CALM3,disease_model_collision,LQTS,LQTS,Long QT syndrome 1,NM_005184.4(CALM3):c.281A>C (p.Asp94Ala),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +409870,19:46608846:G:C,CALM3,disease_model_collision,LQTS,LQTS,Long QT syndrome 1|Long QT syndrome 16,NM_005184.4(CALM3):c.286G>C (p.Asp96His),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +389576,19:46608955:A:G,CALM3,disease_model_collision,SADS,CPVT|LQTS|SADS,,NM_005184.4(CALM3):c.395A>G (p.Asp132Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,False,False,True,False,False,False,True,multi_regime_required,5,True,False,False,False,False,False,True,8,genotype_first_postmortem,1,genotype_first_postmortem,genotype_first_postmortem,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1729746,4:113333109:C:CT,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,Cardiovascular phenotype,NM_001148.6(ANK2):c.3281dup (p.Val1095fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1695772,4:113242117:A:C,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,,NM_001148.6(ANK2):c.799A>C (p.Ile267Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +1678114,4:113117420:T:C,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,,NM_001148.6(ANK2):c.85-56996T>C,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1678112,4:113311281:G:T,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,,NM_001148.6(ANK2):c.2575G>T (p.Gly859Ter),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1483377,4:113359094:G:GAC,ANK2,disease_model_collision,LQTS,LQTS,Long QT syndrome,NM_001148.6(ANK2):c.10480_10481dup (p.Gln3494fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +1334346,4:113311368:C:T,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,,NM_001148.6(ANK2):c.2662C>T (p.Arg888Ter),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +1317290,4:113353994:AGG:A,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,,NM_001148.6(ANK2):c.5377_5378del (p.Gly1793fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +985758,4:113330364:C:T,ANK2,disease_model_collision,arrhythmia,arrhythmia,"Inborn genetic diseases|Cardiac arrhythmia, ankyrin-B-related",NM_001148.6(ANK2):c.3019C>T (p.Arg1007Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +985336,4:113288387:G:A,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,Inborn genetic diseases,NM_001148.6(ANK2):c.2179-1G>A,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +985206,4:113358977:CA:C,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,Inborn genetic diseases,NM_001148.6(ANK2):c.10360del (p.Arg3454fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +954568,4:113358096:G:T,ANK2,disease_model_collision,LQTS,LQTS,Long QT syndrome,NM_001148.6(ANK2):c.9478G>T (p.Glu3160Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +818077,4:113335953:CTGAT:C,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,,NM_001148.6(ANK2):c.3490_3493del (p.Ile1164fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1739158,17:70175464:C:T,KCNJ2,disease_model_collision,LQTS,LQTS|periodic_paralysis,Cardiovascular phenotype,NM_000891.3(KCNJ2):c.425C>T (p.Thr142Ile),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1496231,17:70175685:A:T,KCNJ2,disease_model_collision,SQTS,SQTS,Short QT syndrome type 3;Andersen Tawil syndrome,NM_000891.3(KCNJ2):c.646A>T (p.Asn216Tyr),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +995608,17:70175676:C:G,KCNJ2,disease_model_collision,LQTS,LQTS|periodic_paralysis,,NM_000891.3(KCNJ2):c.637C>G (p.Arg213Gly),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +981438,17:70175977:GCTCTTA:G,KCNJ2,disease_model_collision,SQTS,SQTS,Andersen Tawil syndrome|Andersen Tawil syndrome;Short QT syndrome type 3,NM_000891.3(KCNJ2):c.939_944del (p.Ser314_Tyr315del),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +960380,17:70175756:AG:A,KCNJ2,disease_model_collision,SQTS,SQTS,Andersen Tawil syndrome;Short QT syndrome type 3,NM_000891.3(KCNJ2):c.721del (p.Glu241fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +946743,17:70170729:ACTTGTTAGCGTTTTCCTGCTCACTTCCAAATGTTTCATTTCTATTTGCCATTATCTGGAAAAATCCTGGTGCTCAGAAGGGGTAAGAGATGTTAATTGAAGCATGGTGGAAAGGGTGAGGATAAGGTCAAGGCCATTTTACTTAGCTTCCTCCTCTCTCATATTTTAATGACACTTTATTTTTTAATGTTCTTGGTCTCCATAAGAAATATTTGATCTAAACTCATGTGAATTTTGCTTTTAAAAAAAATAAAAGAACACAGTCTTTCTACATCCTTTGGATTCCTGAGTTGTAGAATCTCTGGTTAGCTGTAGCGTCCTTGTATGACTTTTGCGTAGCCTGAAAGATTGAAAACAGCTACCTGCACAGATTAAGTGTTTCAGATTTTTTTAAGTGTATATTTTTATTTACCAAACATGTCTGTTTTTCAGCGTATGCAAATGCTGAGCAGTGCTACAAGCCAAGTGTCGTTGAGTATAAATGTTAGACAGGGGGCTCACACGTAGATAGATGGGTATCCCCCTCCCCTCCCCACTTCCCCCTCCTCCTCCCTCATGTTTATTGAGCTTCTAAGAGGCTGCTTTCCTAGCAGTTGTGCTCACATAGCAACATGTGCCCAGAGCACACTCAGGCTGTTCTATATGGCGTCAGCTGGGGAATAGCTGCTCTAAACACTCATTAGCAGACCTCTCTCTCAGCCCAGTACGTTTTCTTTTGCTATCTTTATTTCCTATCCTTAGAAACTTTCTTATTTATTGCACACCATGACCATATTACAGGACACATTTACTCTCATTTGATTTTTTTTTTTAGTTATTTATAAGCCATATTGGAAGTATTACCTATATAGTCAAAGCAATTTAGATCCCCCATTTGTACCATGTGATCTCCTTGACCTTACATTTATCCATAGCTCTTTCTCCTTTAACATCTACCTAAGTTTAAAACGCTGAACTATTTTTTTCCATTGCTTATGCTTAATTTTGGCTCAGCCTATAAATAGTCTTAACATGAACAGCACCACATGTAACCTCTCAATTTCCCAAAAATACTTTCTACATCATGGGTTATGGCCTGGATAAAAATGATTATTTGTGTCCATGAAATTTACATCTAGACCCTTAAATATTTTGGCTGGAAGGGAGATTTACACATTGTTCATCAAATCAAATTTCAATTCTCTGGATTTGTATCACTTAGTGTTCTCATCTACTCCTCATTGATTGCATCTCAAACATTATTTTGAATATATGCTTGAAATAAAGTTGCATGTAAGCCCTGTTTTTTTAATGATAGCTTTTCTCAGCTGCTCACGAATTGGTAATTGCTAGTGAGAGGACCGGGCAAGGAAGTTTTCTGCTTGCTTAAAGTCGCTCAGGCATGTGGGCAGGTTAACAGTAAAAGCAATTTTTACCATGAAATATTAAGACCGTTACCCCATCAAACCTTGACAGGTTCTAGACTTTAGCTATGTAATCAGCTCCACAAAAAGTCTGCATACATATATGTGTGTGCACCTGCATACACACATAAATCTGTTTGGGGGCATATCTATTTAAAGTGGCAAAAGTTTTCTTTTTGCCAAAAAAAAAAAAAAAAAAAAAAAAAGCCCAAAACTCCTCTTTTTCTCTTTCCAGGAAGAAATGGTAAAATTTCTAAATGATGCTCCACATGTGGAACAAATTCTGTTATTAGCAATGGAAATAAGACAATAATAGTCTCTCAATACAGGCTACTTTCAAGATTCTAAATGTGGAAAGCTATTCATAGGAAGCTGGTATTGTGTGATTTGTGGAATTCAAACAAATGTCCTGGGGTCAAGATTTTTGGAAAGTCATAATTCAGTCTTTAGATTTCATATGGTTGTTATGTTTTAATCTGGAAGGAGTACAGAAATAAGTCAGAAGAAATTTGAGACTGTCTACTCATGGCCCCTAATGGTAACTCACATGGAAGGATTGTTTTGAATCATGAAAAGGGAATTTCTTGGTGTCAGCTTATAATACAAAGTTCTGAAGTCAATCAGAACTCAAAAATACAAAGCATTCATTGAATGAAGTTCTTCTCCTTTTTTTGAAACGTATACCTGCGTTTGGTGTTGTTGCTGTCTCTGTCTGTTTAGTAATGTGAGAAAACTAAGATGAAATAATTGCTTAAAAAATGCTGTCCATGTACAGGATCTAGAACTTCGAGGGGCAGGATTCTTGTTTCTTTGGTCCAAGTGCAAACTTCACAGGGAAGCAGACAAAACATTGAAGCAGGTGGAAGGTTAGGAAAGCACAGTAACTTCTTTTTATAAAGTAATTCAAAGGCACTTTCAAACTGAGCATCATTTAGGTGTCAAAAGCTGCCAAAATGTAACACACATTGCAATTTTCAAAGATGACTAATCTCAGGAAAAATGTGTTGGGGCACATTCTTGCATAATAACTTGGATAAAGAAGAAGTCAAAAGACAGTAACAAGGCATTTTCAAAGGCAATGCACCTTGCCTCTTCTTAAGGGAATGCACAAAAACAACATAAATGGATTGCTTTATTTGTTTGCGGCTGGCTTGGCTGATATCGGTTCTATTAACTGTTTAATCTTAATGGATTTAGAGGAGAAGGAAAAAGTGGAGTCTTCATTATCAGGCATCAACAAATTTCTGACTCTTTTCATGAGTTATTCATTGCCCCCCTTTAATATAGCAGAAGGATTTGGTTGTATGAAAAGTTGAAGATGGGCTTTATTTTTCAGTTCTAACTCTTATTAGTTTTGTTATTACACATTTGGTAAAGAAAACACCTTAGACTTTCTCTTAGCTTTTTGTTAGTTAGTCAAGGGAAATAGTTTCTTAGGAGTGAAGATGGAAAGTTGAAGTACATAGATAGTTCTTAGCTAGGGAAGACTGAGGCAATAGGAGAAAACTGAGAACTACTATTTGCACATATTAAGTAAAGGTGAGTGCCTTCTCCATAGGAACCTATACCAAATAACAGCGCTGGAAGTGAAAGTAAGCGGACTGGCATTTATGATCTGTCCTTACACAGTTGTCTCTGTCTGAGAGAACACAGCACTGGACTCACATGAAATGAGTTCCTGCCTTATCTCAATCCGCTAAAGACCTGGTCCTTTGGCACAACGGTGCTTACTTCCTAGCCTGTCATTACACATGACAGCCCCATCTCAGGAGAATTTCAGGGCTCTTATTGCTAGGCAACAGAATTGCTCTCTATCCCCCAGAGCAAACCTGCATCTTCAGAGTCTTCAAGCCAGAATTACCTGTACTAATAGAGACTTAGCAGGCATTTCTGCATAGTGGTTGCTTAAAGTGTGAGAAGTGATGAAGCAAGCCCAAACAGTATCCAGAAACTGGGATCCATTTCAGATTATTATAAGCAATAGGGGCAGTATTCACCATCGTAGGAGGTTTTGTCCACTAGTTCCCTCTATTTTCAGGATACACACTCAGTCAAGCCTACTCCAAAATCCACTTCACTATTCTATTTGTAGGTGGGAATCTGACTTTCTTCCTCTAGCATTTCGTCAGCCTATCCGGTCTGCTCAGTTATATCATTTAAACAAAATAGTCTGTCTTCCGATTTCAACCTTGCCATCAGGGACTCTAATATTCTCCCGTAATGCACATGCAACTCAGTGGATATCAATGCTGCGTCCACGTGAAGTTTTCTAAACATGTCCTTTTTCCAAAAATTTTACGACAAACCTTGGAATCAGACAGTCTTTCATCTGCTTAACAGGGATCCTAGCAAGTGGGGCAGGCAGAAGAAGAGAATAAGAGAAGGGAGAGGTAGACCTGAACAATAGAATATTCTAGATCCCTGGCCAAAAAGAAGGGAAAGGGGACCTGACCTGACATTTTGGTTGAACAACTGTCACAGACAACTCTTCTATGTTTAACGACTTTATGCTTTTAAATAAAAGTTTTACAAAGCATGCTTAGGATACAAAGAAATTTAAAACCTTATAATTTAATGTAAATTATACTTATCTTTACCTGATTATGTGTTTTTGTTAGGATATATTGTCTTAGACAGTAGAATTCTTTAAGAGTGGCTTATTTTGTAATGCACAGTCTCTCTTTTCTTGCAGGACATGTTCTCTGGATGTCAGCTGAGTCATTAAAGTAACTCTGCATGTCAGTAGACAGACCTTGGTAGAACCACAAGGCTCCCAGAGACACCCATCTCTCCTCATTTTTTTGGTGTGTGTGTCTTCACCGAACATTCAAAACTGTTTCTCCAAAGCGTTTTGCAAAAACTCAGACTGTTTTCCAAAGCAGAAGCACTGGAGTCCCCAGCAGAAGCGATGGGCAGTGTGCGAACCAACCGCTACAGCATCGTCTCTTCAGAAGAAGACGGTATGAAGTTGGCCACCATGGCAGTTGCAAATGGCTTTGGGAACGGGAAGAGTAAAGTCCACACCCGACAACAGTGCAGGAGCCGCTTTGTGAAGAAAGATGGCCACTGTAATGTTCAGTTCATCAATGTGGGTGAGAAGGGGCAACGGTACCTCGCAGACATCTTCACCACGTGTGTGGACATTCGCTGGCGGTGGATGCTGGTTATCTTCTGCCTGGCTTTCGTCCTGTCATGGCTGTTTTTTGGCTGTGTGTTTTGGTTGATAGCTCTGCTCCATGGGGACCTGGATGCATCCAAAGAGGGCAAAGCTTGTGTGTCCGAGGTCAACAGCTTCACGGCTGCCTTCCTCTTCTCCATTGAGACCCAGAC:A,KCNJ2,disease_model_collision,SQTS,SQTS,Short QT syndrome type 3;Andersen Tawil syndrome,NM_000891.3(KCNJ2):c.-217+1029_422del,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +858285,17:70175473:A:G,KCNJ2,disease_model_collision,SQTS,SQTS,Andersen Tawil syndrome;Short QT syndrome type 3,NM_000891.3(KCNJ2):c.434A>G (p.Tyr145Cys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +801410,17:70175563:T:TCATTGG,KCNJ2,disease_model_collision,LQTS,LQTS|periodic_paralysis,,NM_000891.3(KCNJ2):c.526_531dup (p.Ile176_Gly177dup),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +689769,17:70175935:A:G,KCNJ2,disease_model_collision,SQTS,SQTS|arrhythmia,"Andersen Tawil syndrome;Short QT syndrome type 3;Atrial fibrillation, familial, 9",NM_000891.3(KCNJ2):c.896A>G (p.Glu299Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,True,False,False,True,False,False,True,False,high_tension,4,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +652820,17:70175596:C:A,KCNJ2,disease_model_collision,SQTS,SQTS,Andersen Tawil syndrome;Short QT syndrome type 3,NM_000891.3(KCNJ2):c.557C>A (p.Pro186Gln),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +569363,17:70176139:TC:T,KCNJ2,disease_model_collision,SQTS,SQTS,Short QT syndrome type 3;Andersen Tawil syndrome,NM_000891.3(KCNJ2):c.1102del (p.Leu368fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +546134,17:70175704:T:C,KCNJ2,disease_model_collision,LQTS,LQTS|periodic_paralysis,Andersen Tawil syndrome,NM_000891.3(KCNJ2):c.665T>C (p.Leu222Ser),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +523694,17:70175194:G:T,KCNJ2,disease_model_collision,LQTS,LQTS|periodic_paralysis,Cardiovascular phenotype,NM_000891.3(KCNJ2):c.155G>T (p.Gly52Val),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +430545,17:70175692:G:C,KCNJ2,disease_model_collision,SQTS,SQTS,Short QT syndrome type 3;Andersen Tawil syndrome,NM_000891.3(KCNJ2):c.653G>C (p.Arg218Pro),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +429589,17:70175604:A:G,KCNJ2,disease_model_collision,SQTS,SQTS,Andersen Tawil syndrome;Short QT syndrome type 3,NM_000891.3(KCNJ2):c.565A>G (p.Arg189Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1697968,15:73325193:C:G,HCN4,unanchored_assertion_state,cardiomyopathy_overlap,cardiomyopathy_overlap,Left ventricular noncompaction cardiomyopathy,NM_005477.3(HCN4):c.1740G>C (p.Glu580Asp),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,True,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,True,False,False,False,True,7,structural_electrical_overlap,1,structural_electrical_overlap,structural_electrical_overlap,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1675065,15:73329718:C:T,HCN4,unanchored_assertion_state,cardiomyopathy_overlap,cardiomyopathy_overlap,Left ventricular noncompaction cardiomyopathy,NM_005477.3(HCN4):c.1445G>A (p.Gly482Glu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,True,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,True,False,False,False,True,7,structural_electrical_overlap,1,structural_electrical_overlap,structural_electrical_overlap,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1359536,15:73343533:T:C,HCN4,unanchored_assertion_state,Brugada,Brugada,Brugada syndrome 8|HCN4-related disorder,NM_005477.3(HCN4):c.1061A>G (p.Tyr354Cys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +666148,15:73329692:C:G,HCN4,unanchored_assertion_state,Brugada,Brugada,Brugada syndrome 8,NM_005477.3(HCN4):c.1471G>C (p.Asp491His),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +470654,15:73324088:C:T,HCN4,unanchored_assertion_state,Brugada,Brugada,Brugada syndrome 8,NM_005477.3(HCN4):c.2143+1G>A,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +374861,15:73332261:G:C,HCN4,unanchored_assertion_state,conduction,conduction,"Sick sinus syndrome 2, autosomal dominant",NM_005477.3(HCN4):c.1241C>G (p.Ala414Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,True,False,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,5,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +374860,15:73329722:A:G,HCN4,disease_model_collision,Brugada,Brugada|conduction,"Sick sinus syndrome 2, autosomal dominant|Brugada syndrome 8||Cardiovascular phenotype",NM_005477.3(HCN4):c.1441T>C (p.Tyr481His),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,True,False,False,True,False,False,True,False,high_tension,4,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +374859,15:73329719:C:G,HCN4,disease_model_collision,Brugada,Brugada|conduction,"Sick sinus syndrome 2, autosomal dominant|Brugada syndrome 8",NM_005477.3(HCN4):c.1444G>C (p.Gly482Arg),unanchored,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,True,False,False,True,False,False,True,False,high_tension,4,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +374858,15:73325000:T:TGGTGAGCACGCTG,HCN4,unanchored_assertion_state,conduction,conduction,"Sick sinus syndrome 2, autosomal dominant",NM_005477.3(HCN4):c.1920_1932dup (p.Lys645fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,True,False,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,5,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1803055,12:2486116:T:C,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,"Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures",NM_000719.7(CACNA1C):c.770T>C (p.Val257Ala),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1744618,12:2677772:C:T,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,Cardiovascular phenotype,NM_000719.7(CACNA1C):c.4996C>T (p.Arg1666Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +1712194,12:2688554:G:GC,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,,NM_000719.7(CACNA1C):c.5897dup (p.Gln1967fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1705745,12:2655228:C:G,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,"Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures",NM_000719.7(CACNA1C):c.4222C>G (p.Leu1408Val),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1705744,12:2581663:C:T,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,"Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures",NM_000719.7(CACNA1C):c.1969C>T (p.Leu657Phe),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1700075,12:2665599:G:C,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,Neurodevelopmental delay|CACNA1C-related disorder,NM_000719.7(CACNA1C):c.4417G>C (p.Ala1473Pro),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1699326,12:2634334:T:G,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,"Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures",NM_000719.7(CACNA1C):c.3866T>G (p.Leu1289Trp),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +1699036,12:2504886:T:TA,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,"Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures",NM_000719.7(CACNA1C):c.1159dup (p.Thr387fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1695801,12:2610588:C:G,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,,NM_000719.7(CACNA1C):c.3606C>G (p.Tyr1202Ter),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +1685597,12:2567752:T:G,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,Timothy syndrome,NM_000719.7(CACNA1C):c.1853T>G (p.Val618Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1685596,12:2449093:G:A,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,"Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures",NM_000719.7(CACNA1C):c.595G>A (p.Asp199Asn),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1344837,12:2504535:A:G,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,Seizure,NM_001167623.2(CACNA1C):c.1213A>G (p.Ser405Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1325838,12:2448994:T:C,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,Neurodevelopmental delay,NM_000719.7(CACNA1C):c.496T>C (p.Phe166Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1313855,12:2677868:G:A,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,,NM_000719.7(CACNA1C):c.5091+1G>A,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +1309258,12:2608654:T:C,CACNA1C,disease_model_collision,LQTS,LQTS,Timothy syndrome|Long QT syndrome,NM_000719.7(CACNA1C):c.3500T>C (p.Val1167Ala),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1303511,12:2608657:C:A,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,,NM_000719.7(CACNA1C):c.3503C>A (p.Thr1168Asn),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1302971,12:2504529:G:A,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,,NM_001167623.2(CACNA1C):c.1207G>A (p.Val403Met),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1302480,12:2605121:C:T,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,,NM_000719.7(CACNA1C):c.3001C>T (p.Arg1001Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +1214422,12:2651679:C:T,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,Hypotonia,NM_000719.7(CACNA1C):c.3985C>T (p.Arg1329Cys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 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tachycardia,NM_001232.4(CASQ2):c.939+1G>T,anchored_exact,3.1733855056306896e-05,4.178991663820107e-05,1.316887477023001,False,False,0.001,-1.3789284951785896,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1523438,1:115705294:T:C,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 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(p.Arg33Gln),anchored_exact,1.0267488613355128e-05,3.827311696264544e-05,3.727602306299179,False,False,0.001,-1.4171061673925929,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +378906,11:2570686:G:C,KCNQ1,ancestry_concentrated,LQTS,LQTS,,NM_000218.3(KCNQ1):c.536G>C (p.Gly179Ala),anchored_exact,2.054848002893226e-06,3.8743171516020304e-05,18.854510701988296,True,True,0.0001,-0.4118048308154233,False,False,False,False,False,False,False,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,6,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +801535,1:115740767:G:A,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 2|Cardiovascular phenotype|Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.381C>T (p.Gly127=),anchored_exact,8.897357347985227e-06,6.707807888382076e-05,7.5391006251884125,False,False,0.001,-1.173419384081802,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1749169,6:123571097:T:TAAAA,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Cardiovascular phenotype|Catecholaminergic polymorphic ventricular tachycardia 1,NM_006073.4(TRDN):c.57_58insTTTT (p.Lys20delinsPheTer),anchored_exact,1.573551204040332e-05,2.9870362626202283e-05,1.898277072346201,False,False,0.001,-1.524759505028858,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1514023,15:73343470:C:T,HCN4,ancestry_concentrated,Brugada,Brugada,Brugada syndrome 8,NM_005477.3(HCN4):c.1124G>A (p.Arg375His),anchored_exact,2.0521436008006096e-06,3.744056310606911e-05,18.24460327574495,True,True,0.0001,-0.4266576280958051,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,True,True,False,True,8,conditional_penetrance_dependent|population_localized_susceptibility,2,conditional_penetrance_dependent,population_localized_susceptibility,False,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +373047,7:150947326:A:G,KCNH2,ancestry_concentrated,LQTS,LQTS,,NM_000238.4(KCNH2):c.3152+2T>C,anchored_exact,7.203770165153635e-07,2.8064660978895374e-05,38.95824322159453,True,True,0.0001,-0.551840199689963,False,False,False,False,False,False,False,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,6,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +924057,3:38575364:T:TG,SCN5A,disease_model_collision,arrhythmia,arrhythmia,Cardiac arrhythmia,NM_000335.5(SCN5A):c.3595dup (p.His1199fs),anchored_exact,6.851933821282381e-07,3.832592365476008e-05,55.9343824970053,True,True,0.0001,-0.41650736985045,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,2,True,False,False,True,True,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent|population_localized_susceptibility,3,genotype_first_postmortem,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1455898,11:2572072:G:GGA,KCNQ1,disease_model_collision,LQTS,LQTS|arrhythmia,Long QT syndrome|Cardiac arrhythmia,NM_000218.3(KCNQ1):c.745_746dup (p.Leu250fs),anchored_exact,6.84671706763324e-07,3.828190797029324e-05,55.91271361066016,True,True,0.0001,-0.4170064251187987,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,True,False,True,9,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +375594,11:2572900:T:A,KCNQ1,ancestry_concentrated,SQTS,SQTS,Short QT syndrome type 2,NM_000218.3(KCNQ1):c.835T>A (p.Phe279Ile),anchored_exact,1.3684626827068738e-06,2.3186792802819512e-05,16.943667629494662,True,True,0.0001,-0.6347593188205799,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,True,False,True,8,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1454593,7:150947380:GCCGC:G,KCNH2,ancestry_concentrated,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.3096_3099del (p.Arg1033fs),anchored_exact,1.432334375595314e-06,3.980891719745223e-05,27.793014733652488,True,True,0.0001,-0.4000196350651585,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,false,true,true,false,2023-01,2026-04 +838068,6:123516189:C:A,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 5|Catecholaminergic polymorphic ventricular tachycardia 1|Cardiovascular phenotype,NM_006073.4(TRDN):c.502G>T (p.Glu168Ter),anchored_exact,2.0270178963157825e-05,2.603458550047152e-05,1.2843786561239623,False,False,0.001,-1.584449332383948,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1171509,3:38613742:C:A,SCN5A,disease_model_collision,arrhythmia,arrhythmia,Cardiac arrhythmia,NM_000335.5(SCN5A):c.703+1G>T,anchored_exact,6.932745436520316e-07,2.56068831301854e-05,36.93608459818682,True,True,0.0001,-0.5916432806389674,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,2,True,False,False,True,True,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent|population_localized_susceptibility,3,genotype_first_postmortem,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1214434,3:38587561:TC:T,SCN5A,disease_model_collision,SADS,Brugada|LQTS|SADS|conduction,Cardiovascular phenotype,NM_000335.5(SCN5A):c.2274del (p.Ile759fs),anchored_exact,2.052421583812688e-06,3.3126842680624107e-05,16.140362097890165,True,True,0.0001,-0.479819954752671,False,False,False,True,True,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,True,False,True,12,genotype_first_postmortem|conditional_penetrance_dependent|population_localized_susceptibility,3,genotype_first_postmortem,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1067403,11:2572110:G:A,KCNQ1,ancestry_concentrated,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.780+1G>A,anchored_exact,6.854366642813471e-07,2.520034272466105e-05,36.76533263033125,True,True,0.0001,-0.5985935527733383,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +852605,1:237795312:A:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome|Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.13937A>C (p.Asp4646Ala),anchored_exact,9.531449812945298e-06,1.2573555298496204e-05,1.319164998619016,False,False,2.5e-05,-0.2984819125134828,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +1757434,1:115727014:C:A,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Cardiovascular phenotype|Catecholaminergic polymorphic ventricular tachycardia 1|Catecholaminergic polymorphic ventricular tachycardia 2,NM_001232.4(CASQ2):c.715G>T (p.Glu239Ter),anchored_exact,2.2557001542898904e-06,3.53090720775858e-05,15.653258416096053,True,True,0.001,-1.4521136955459195,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,True,False,True,11,provocation_dependent_instability|conditional_penetrance_dependent|population_localized_susceptibility,3,provocation_dependent_instability,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1420193,7:150947827:GC:G,KCNH2,ancestry_concentrated,LQTS,LQTS,Long QT syndrome|Long QT syndrome 2,NM_000238.4(KCNH2):c.2743del (p.Ala915fs),anchored_exact,7.281115117342451e-07,2.8638524543215534e-05,39.3325551775003,True,True,0.0001,-0.5430493606395334,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +633643,12:2593252:C:G,CACNA1C,disease_model_collision,LQTS,LQTS,Long QT syndrome 8|Long QT syndrome,NM_000719.7(CACNA1C):c.2570C>G (p.Pro857Arg),anchored_exact,6.842613057074236e-07,2.2369362920544025e-05,32.691211738483084,True,True,0.0001,-0.6503463844340879,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,2,True,False,False,False,True,False,True,10,genotype_first_postmortem|population_localized_susceptibility,2,genotype_first_postmortem,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +547162,21:34449497:G:T,KCNE1,penetrance_boundary,LQTS,LQTS,Jervell and Lange-Nielsen syndrome 2|Long QT syndrome 5|Long QT syndrome,NM_000219.6(KCNE1):c.138C>A (p.Tyr46Ter),anchored_exact,3.000828228591091e-06,2.9429942023014216e-05,9.807270184725496,False,False,2.5e-05,0.0708493978682867,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,True,False,False,True,6,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +859128,1:115726996:G:A,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia,NM_001232.4(CASQ2):c.733C>T (p.Gln245Ter),anchored_exact,1.6498437597959474e-06,2.4118469924268005e-05,14.618630499060393,True,True,0.001,-1.617650247299917,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,True,False,True,11,provocation_dependent_instability|conditional_penetrance_dependent|population_localized_susceptibility,3,provocation_dependent_instability,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +666975,11:2775959:G:A,KCNQ1,ancestry_concentrated,LQTS,LQTS,Congenital long QT syndrome|Long QT syndrome,NM_000218.3(KCNQ1):c.1591-1G>A,anchored_exact,1.4245501270698712e-06,3.968253968253968e-05,27.85617162380255,True,True,0.0001,-0.4014005407815441,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +972416,7:150947785:TC:T,KCNH2,ancestry_concentrated,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.2785del (p.Glu929fs),anchored_exact,7.232300030520306e-07,2.6745119015779625e-05,36.98005188233825,True,True,0.0001,-0.5727554651542196,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1515619,1:115744827:C:G,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.319+1G>C,anchored_exact,6.866537850416593e-07,2.521050773962588e-05,36.71496840744561,True,True,0.001,-1.5984184075446082,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,True,False,True,11,provocation_dependent_instability|conditional_penetrance_dependent|population_localized_susceptibility,3,provocation_dependent_instability,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +926958,11:2570755:G:A,KCNQ1,ancestry_concentrated,arrhythmia,arrhythmia,Cardiac arrhythmia,NM_000218.3(KCNQ1):c.604+1G>A,anchored_exact,1.371599119982005e-06,2.5191455058444177e-05,18.366472626711847,True,True,0.0001,-0.5987467469281339,False,False,False,False,False,False,False,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,6,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1076966,7:150958081:CG:C,KCNH2,penetrance_boundary,LQTS,LQTS,Long QT syndrome|Congenital long QT syndrome,NM_000238.4(KCNH2):c.893del (p.Pro298fs),anchored_exact,3.5673706872718e-06,3.380434047731729e-05,9.475979640116968,False,False,2.5e-05,0.1310324585974109,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,True,False,False,True,6,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1457006,3:38551291:A:AAGTT,SCN5A,disease_model_collision,SADS,Brugada|LQTS|SADS|conduction,,NM_000335.5(SCN5A):c.5074_5077dup (p.Phe1693Ter),anchored_exact,6.840441235821475e-07,1.6557387906483872e-05,24.20511211274717,True,True,0.0001,-0.7810081764447644,False,False,False,True,True,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,True,False,True,12,genotype_first_postmortem|conditional_penetrance_dependent|population_localized_susceptibility,3,genotype_first_postmortem,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +405260,11:2847865:C:CA,KCNQ1,disease_model_collision,LQTS,LQTS|arrhythmia,Long QT syndrome||Cardiac arrhythmia,NM_000218.3(KCNQ1):c.1894dup (p.Arg632fs),anchored_exact,7.015476140365646e-07,2.484225170169424e-05,35.410593371081,True,True,0.0001,-0.6048090422595129,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,True,False,True,9,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +418944,3:38581292:ATC:A,SCN5A,disease_model_collision,Brugada,Brugada|LQTS|arrhythmia,Cardiac arrhythmia|Cardiovascular phenotype|Brugada syndrome|Long QT syndrome 3,NM_000335.5(SCN5A):c.2865_2866del (p.Glu955fs),anchored_exact,4.791389735748012e-06,3.826432999158185e-05,7.986059393172863,False,False,2.5e-05,0.1848541045636321,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,4,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,conflicting,P_LP,true,false,false,true,true,true,false,2023-01,2026-04 +651334,1:115705275:C:A,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.856G>T (p.Glu286Ter),anchored_exact,6.846004603253495e-07,2.2361359570661896e-05,32.66332584221321,True,True,0.001,-1.650501794878367,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,True,False,True,11,provocation_dependent_instability|conditional_penetrance_dependent|population_localized_susceptibility,3,provocation_dependent_instability,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +523778,3:38551460:G:A,SCN5A,disease_model_collision,Brugada,Brugada,Brugada syndrome|Cardiovascular phenotype,NM_000335.5(SCN5A):c.4909C>T (p.Arg1637Ter),anchored_exact,4.104371429196857e-06,3.311587243765937e-05,8.068437747531474,False,False,2.5e-05,0.1220961923497107,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +505275,3:38603712:C:T,SCN5A,disease_model_collision,Brugada,Brugada|arrhythmia,Cardiovascular phenotype|Cardiac arrhythmia|Brugada syndrome 1||Brugada syndrome,NM_000335.5(SCN5A):c.1890G>A (p.Thr630=),anchored_exact,1.4756161804265416e-06,3.419271011420365e-05,23.17180334286967,True,True,0.0001,-0.4660664756585466,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,4,True,False,False,True,True,False,True,11,genotype_first_postmortem|conditional_penetrance_dependent|population_localized_susceptibility,3,genotype_first_postmortem,population_localized_susceptibility,False,,conflicting,P_LP,true,false,false,true,true,true,false,2023-01,2026-04 +404118,15:73329724:C:A,HCN4,ancestry_concentrated,Brugada,Brugada,Brugada syndrome 8,NM_005477.3(HCN4):c.1439G>T (p.Gly480Val),anchored_exact,6.840693919991244e-07,2.236235967619303e-05,32.69014554312366,True,True,0.0001,-0.6504823716138943,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,True,True,False,True,8,conditional_penetrance_dependent|population_localized_susceptibility,2,conditional_penetrance_dependent,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1403180,6:123530549:CTT:C,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_006073.4(TRDN):c.439_440del (p.Lys147fs),anchored_exact,9.0703770555742e-07,2.2095541119802024e-05,24.360087374907803,True,True,0.001,-1.6556953580995877,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,True,False,True,11,provocation_dependent_instability|conditional_penetrance_dependent|population_localized_susceptibility,3,provocation_dependent_instability,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +496571,3:38562432:G:A,SCN5A,disease_model_collision,Brugada,Brugada,Brugada syndrome (shorter-than-normal QT interval)||Brugada syndrome 1|Cardiovascular phenotype,NM_000335.5(SCN5A):c.3943C>T (p.Arg1315Ter),anchored_exact,6.856199444099349e-07,2.524614996213077e-05,36.822315840800826,True,True,0.0001,-0.5978048424042931,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,True,False,False,True,True,False,True,11,genotype_first_postmortem|conditional_penetrance_dependent|population_localized_susceptibility,3,genotype_first_postmortem,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +449691,6:123530547:GTCTTA:G,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1|Catecholaminergic polymorphic ventricular tachycardia 5|Cardiovascular phenotype,NM_006073.4(TRDN):c.438_442del (p.Asp146_Lys147insTer),anchored_exact,8.154670542249349e-06,3.4233679093492176e-05,4.198045245124528,False,False,0.001,-1.4655464247259655,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1075032,6:123516159:CT:C,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1|Catecholaminergic polymorphic ventricular tachycardia 1;Catecholaminergic polymorphic ventricular tachycardia 5,NM_006073.4(TRDN):c.531del (p.Glu178fs),anchored_exact,2.240414387045028e-06,3.33000333000333e-05,14.863330475494562,True,True,0.001,-1.4775553321989812,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,True,False,True,11,provocation_dependent_instability|conditional_penetrance_dependent|population_localized_susceptibility,3,provocation_dependent_instability,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +503669,7:150959590:T:TG,KCNH2,ancestry_concentrated,LQTS,LQTS,Long QT syndrome|Long QT syndrome 2|Cardiovascular phenotype,NM_000238.4(KCNH2):c.453dup (p.Thr152fs),anchored_exact,1.3683035225605884e-06,1.8775111711914684e-05,13.721443145404296,True,True,0.0001,-0.7264174702639392,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,conflicting,P_LP,true,false,false,false,true,false,false,2023-01,2026-04 +667015,3:38620919:G:A,SCN5A,disease_model_collision,Brugada,Brugada|arrhythmia,Brugada syndrome|Brugada syndrome (shorter-than-normal QT interval)||Cardiac arrhythmia,NM_000335.5(SCN5A):c.535C>T (p.Arg179Ter),anchored_exact,6.842435140557302e-07,2.2374367924106146e-05,32.69937641368331,True,True,0.0001,-0.6502492246578704,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,4,True,False,False,True,True,False,True,11,genotype_first_postmortem|conditional_penetrance_dependent|population_localized_susceptibility,3,genotype_first_postmortem,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1480008,17:70175675:G:A,KCNJ2,disease_model_collision,SQTS,SQTS,Andersen Tawil syndrome;Short QT syndrome type 3,NM_000891.3(KCNJ2):c.636G>A (p.Trp212Ter),anchored_exact,6.840450594161539e-07,1.6557387906483872e-05,24.20507899806617,True,True,0.0001,-0.7810081764447644,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,True,False,True,8,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +842027,11:2585248:C:T,KCNQ1,ancestry_concentrated,LQTS,LQTS,Long QT syndrome|KCNQ1-related disorder,NM_000218.3(KCNQ1):c.1069C>T (p.Gln357Ter),anchored_exact,1.3682454851319603e-06,2.5188916876574308e-05,18.40963463110593,True,True,0.0001,-0.5987905067631151,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +942279,1:115738290:G:A,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.466C>T (p.Gln156Ter),anchored_exact,2.052578860079804e-06,1.655958137378287e-05,8.067692125332965,False,False,0.001,-1.7809506463768694,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +583099,6:123516162:T:A,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_006073.4(TRDN):c.529A>T (p.Lys177Ter),anchored_exact,2.239026530971708e-06,1.8289560318969934e-05,8.168529000191663,False,False,0.001,-1.737796734837436,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +517279,3:38603999:G:A,SCN5A,disease_model_collision,cardiomyopathy_overlap,Brugada|arrhythmia|cardiomyopathy_overlap,Brugada syndrome|Cardiovascular phenotype|Primary familial dilated cardiomyopathy||Cardiac arrhythmia|SCN5A-related disorder,NM_000335.5(SCN5A):c.1603C>T (p.Arg535Ter),anchored_exact,4.7902486960258726e-06,2.519018590357197e-05,5.258637545443709,False,False,2.5e-05,0.0032913639311787,False,False,False,False,False,False,True,True,True,True,False,True,False,False,False,True,multi_regime_required,5,True,False,True,True,False,False,True,11,genotype_first_postmortem|structural_electrical_overlap|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +405265,11:2572062:G:T,KCNQ1,ancestry_concentrated,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.733G>T (p.Gly245Ter),anchored_exact,6.846370191451896e-07,1.1593396401409756e-05,16.933616125912472,True,True,0.0001,-0.935789314484561,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +924596,3:38633181:G:A,SCN5A,disease_model_collision,Brugada,Brugada|LQTS|arrhythmia,Cardiac arrhythmia|Brugada syndrome 1;Long QT syndrome 3||Brugada syndrome 1,NM_000335.5(SCN5A):c.127C>T (p.Arg43Ter),anchored_exact,6.843886834962407e-07,1.657000828500414e-05,24.21136625022659,True,True,0.0001,-0.7806772744333681,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,4,True,False,False,True,True,False,True,11,genotype_first_postmortem|conditional_penetrance_dependent|population_localized_susceptibility,3,genotype_first_postmortem,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1367739,1:115732931:G:T,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 2;Catecholaminergic polymorphic ventricular tachycardia 1|Catecholaminergic polymorphic ventricular tachycardia 1|Catecholaminergic polymorphic ventricular tachycardia 2|Cardiovascular phenotype,NM_001232.4(CASQ2):c.576C>A (p.Tyr192Ter),anchored_exact,2.05254796462502e-06,2.236035955458164e-05,10.893947447761208,True,True,0.001,-1.6505212172741976,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,True,False,True,11,provocation_dependent_instability|conditional_penetrance_dependent|population_localized_susceptibility,3,provocation_dependent_instability,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +403974,17:70175721:C:T,KCNJ2,disease_model_collision,SQTS,SQTS,Andersen Tawil syndrome;Short QT syndrome type 3,NM_000891.3(KCNJ2):c.682C>T (p.Arg228Ter),anchored_exact,4.104292816666712e-06,1.6557387906483872e-05,4.034162671114734,False,False,2.5e-05,-0.1789481851168019,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1805845,1:237640956:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.7175A>G (p.Tyr2392Cys),anchored_exact,2.0529075329389014e-06,1.656781205474005e-05,8.070409757137067,False,False,2.5e-05,-0.1786748493953005,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,true,true,false,2023-01,2026-04 +418270,21:34449418:G:A,KCNE1,ancestry_concentrated,LQTS,LQTS,Long QT syndrome 5,NM_000219.6(KCNE1):c.217C>T (p.His73Tyr),anchored_exact,6.879216099567022e-07,1.1603620329542817e-05,16.86762604048317,True,True,0.0001,-0.935406489752349,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +649240,1:237707240:A:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.9872A>T (p.Asp3291Val),anchored_exact,7.100769865468815e-07,1.27890321260487e-05,18.0107444088528,True,True,0.0001,-0.8931623216840966,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,True,False,True,13,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent|population_localized_susceptibility,4,genotype_first_postmortem,population_localized_susceptibility,False,,conflicting,P_LP,true,false,false,true,true,true,false,2023-01,2026-04 +817280,11:2572019:C:CCG,KCNQ1,ancestry_concentrated,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.692_693dup (p.Phe232fs),anchored_exact,6.848423835254316e-07,1.1602543277486424e-05,16.94189439015813,True,True,0.0001,-0.9354468029874938,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +488729,3:38566408:C:T,SCN5A,disease_model_collision,arrhythmia,arrhythmia,Cardiac arrhythmia,NM_000335.5(SCN5A):c.3837+1G>A,anchored_exact,4.791376617260729e-06,1.8777932174108987e-05,3.919109424075093,False,False,2.5e-05,-0.1242922426172685,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,2,True,False,False,True,False,False,True,8,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +547164,21:34449584:C:T,KCNE1,ancestry_concentrated,LQTS,LQTS,Jervell and Lange-Nielsen syndrome 2|Long QT syndrome|Sensorineural hearing loss disorder|Long QT syndrome 5,NM_000219.6(KCNE1):c.51G>A (p.Trp17Ter),anchored_exact,1.0952014842170511e-06,1.5943369152769364e-05,14.55746346682834,True,True,0.0001,-0.7974198981316662,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,False,True,False,True,7,population_localized_susceptibility,1,population_localized_susceptibility,population_localized_susceptibility,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1477795,17:70175818:G:A,KCNJ2,disease_model_collision,SQTS,SQTS,Andersen Tawil syndrome;Short QT syndrome type 3,NM_000891.3(KCNJ2):c.779G>A (p.Arg260His),anchored_exact,4.104309661955375e-06,1.15931275939623e-05,2.8246225855718,False,False,2.5e-05,-0.3337393929360234,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +915308,6:123636753:C:A,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 5|Catecholaminergic polymorphic ventricular tachycardia 1,NM_006073.4(TRDN):c.22+1G>T,anchored_exact,2.055515358810761e-06,1.6596408537192552e-05,8.074082926196981,False,False,0.001,-1.779985883118516,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1675066,15:73329709:G:A,HCN4,disease_model_collision,cardiomyopathy_overlap,Brugada|cardiomyopathy_overlap,Left ventricular noncompaction cardiomyopathy|Brugada syndrome 8|Cardiovascular phenotype,NM_005477.3(HCN4):c.1454C>T (p.Ala485Val),anchored_exact,3.420346959995622e-06,1.6557936218829686e-05,4.841009573438511,False,False,2.5e-05,-0.1789338033142704,False,False,False,False,False,False,True,True,False,False,False,True,False,False,True,False,high_tension,4,False,False,True,True,False,False,True,9,structural_electrical_overlap|conditional_penetrance_dependent,2,structural_electrical_overlap,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +404190,1:237330939:C:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Cardiovascular phenotype|Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.230C>T (p.Ala77Val),anchored_exact,2.0524243921061023e-06,1.15931275939623e-05,5.648501835219441,False,False,2.5e-05,-0.3337393929360234,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1746831,1:115738223:C:T,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Cardiovascular phenotype|Catecholaminergic polymorphic ventricular tachycardia 2,NM_001232.4(CASQ2):c.532+1G>A,anchored_exact,7.006952298070145e-07,1.168688497767805e-05,16.678962267139422,True,True,0.001,-1.932301230265192,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,True,False,True,11,provocation_dependent_instability|conditional_penetrance_dependent|population_localized_susceptibility,3,provocation_dependent_instability,population_localized_susceptibility,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +408869,1:115744914:T:C,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Cardiovascular phenotype||Catecholaminergic polymorphic ventricular tachycardia 1|Catecholaminergic polymorphic ventricular tachycardia 2,NM_001232.4(CASQ2):c.235-2A>G,anchored_exact,1.372949328559131e-06,1.162385214460072e-05,8.466331886019208,False,False,0.001,-1.9346499229007108,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +430060,21:34449622:T:TA,KCNE1,penetrance_boundary,LQTS,LQTS,Long QT syndrome|Cardiovascular phenotype|Long QT syndrome 5;Jervell and Lange-Nielsen syndrome 2|Jervell and Lange-Nielsen syndrome 2,NM_000219.6(KCNE1):c.12dup (p.Asn5Ter),anchored_exact,2.628017292353784e-06,3.923091710114907e-06,1.4927950545584636,False,False,2.5e-05,-0.8043115479217289,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,True,False,False,True,6,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,conflicting,P_LP,true,false,false,true,true,true,false,2023-01,2026-04 +1208780,4:113358978:A:AG,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,,NM_001148.6(ANK2):c.10367dup (p.Thr3457fs),anchored_exact,3.420660515862971e-06,3.420660515862971e-06,2.923411145366478e-07,False,False,2.5e-05,-0.8638300339910164,False,False,False,False,False,False,False,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,5,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +857501,7:150947376:C:CG,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.3103dup (p.Arg1035fs),anchored_exact,1.4431722079668878e-06,1.8602055527135749e-06,1.2889697109428708,False,False,2.5e-05,-1.1283790722622535,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1068919,11:2588804:C:CA,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1344dup (p.Glu449fs),anchored_exact,1.3687567582364937e-06,1.7986646713479913e-06,1.3140861927718974,False,False,2.5e-05,-1.1429898041689115,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +519280,7:150948455:C:CGCCT,KCNH2,canonical_monogenic,LQTS,LQTS,Cardiovascular phenotype|Long QT syndrome 2|Long QT syndrome,NM_000238.4(KCNH2):c.2677_2680dup (p.Arg894fs),anchored_exact,8.697558073595258e-07,1.1272305073664514e-06,1.2960306810228792,False,False,2.5e-05,-1.3459272746658248,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1802180,7:82443436:G:GGCCAGCAGGCA,CACNA2D1,unknown_or_insufficient,Brugada,Brugada,Developmental and epileptic encephalopathy 110,NM_000722.4(CACNA2D1):c.13_23dup (p.Leu9fs),anchored_exact,6.870028675499691e-07,9.019003039404024e-07,1.3128038232984225,False,False,2.5e-05,-1.442781475388979,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,1,False,False,False,True,False,False,True,6,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1787905,11:2445314:G:GC,KCNQ1,canonical_monogenic,LQTS,LQTS,Cardiovascular phenotype,NM_000218.3(KCNQ1):c.221dup (p.Val75fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1306529,11:2847842:A:AC,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1875dup (p.Gly626fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +864600,7:150947472:T:TC,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.3007dup (p.Asp1003fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +532312,6:123512339:T:TC,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_006073.4(TRDN):c.573dup (p.Lys192fs),anchored_exact,0.0,0.0,1.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1074305,7:150947795:GC:G,KCNH2,disease_model_collision,LQTS,LQTS|arrhythmia,Long QT syndrome|Cardiac arrhythmia|Cardiovascular phenotype,NM_000238.4(KCNH2):c.2775del (p.Pro926fs),anchored_exact,7.97089897247866e-06,7.97089897247866e-06,1.2545634789706644e-07,False,False,2.5e-05,-0.496432703992366,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +917819,7:150947387:AC:A,KCNH2,disease_model_collision,LQTS,LQTS|arrhythmia,Long QT syndrome|Cardiac arrhythmia|Cardiovascular phenotype,NM_000238.4(KCNH2):c.3092del (p.Gly1031fs),anchored_exact,3.604154292403596e-06,4.655415458586356e-06,1.2916803192133486,False,False,2.5e-05,-0.7299815643170293,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +519537,11:2570664:GTGGTCCGCCTC:G,KCNQ1,penetrance_boundary,LQTS,LQTS,Cardiovascular phenotype|Long QT syndrome||Long QT syndrome 1,NM_000218.3(KCNQ1):c.524_534del (p.Leu175fs),anchored_exact,2.0543273721318167e-06,2.6979242171073577e-06,1.3132882034373443,False,False,2.5e-05,-0.9669102622072908,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,True,False,False,True,6,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +837649,7:150947472:TC:T,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.3007del (p.Asp1003fs),anchored_exact,1.404040829507322e-06,1.8277793212358715e-06,1.3017990510134867,False,False,2.5e-05,-1.136016249087652,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +656121,11:2572033:TC:T,KCNQ1,disease_model_collision,LQTS,LQTS|arrhythmia,Long QT syndrome||Cardiovascular phenotype|Cardiac arrhythmia,NM_000218.3(KCNQ1):c.706del (p.Ile235_Leu236insTer),anchored_exact,1.3692440403653143e-06,1.798784381514972e-06,1.3137059682429495,False,False,2.5e-05,-1.14296090065189,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +523933,11:2445114:TC:T,KCNQ1,canonical_monogenic,LQTS,LQTS,,NM_000218.3(KCNQ1):c.20del (p.Pro7fs),anchored_exact,1.0542451288603822e-06,1.1995470510335298e-06,1.1378254263358936,False,False,2.5e-05,-1.3189227212673351,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +449221,11:2445294:TCCCCGGCCGCG:T,KCNQ1,disease_model_collision,LQTS,LQTS|SQTS|arrhythmia,"Long QT syndrome|Cardiovascular phenotype|Short QT syndrome type 2;Atrial fibrillation, familial, 3;Beckwith-Wiedemann syndrome;Long QT syndrome 1;Jervell and Lange-Nielsen syndrome 1|Long QT syndrome 1|KCNQ1-related disorder",NM_000218.3(KCNQ1):c.200_210del (p.Pro67fs),anchored_exact,8.033277046838826e-07,9.895679744137304e-07,1.2318356964514732,False,False,2.5e-05,-1.40249437698272,False,False,False,False,False,False,True,False,True,True,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1332487,3:38581308:CAG:C,SCN5A,disease_model_collision,arrhythmia,arrhythmia,Cardiac arrhythmia,NM_000335.5(SCN5A):c.2849_2850del (p.Pro950fs),anchored_exact,6.857957974433533e-07,9.016856110813556e-07,1.314801431623534,False,False,2.5e-05,-1.4428848693261924,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,2,True,False,False,True,False,False,True,8,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +858435,7:150947652:CA:C,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome|Long QT syndrome 2|Cardiovascular phenotype,NM_000238.4(KCNH2):c.2918del (p.Leu973fs),anchored_exact,6.85348348858758e-07,9.000819074535783e-07,1.3133198549796452,False,False,2.5e-05,-1.4436579766365545,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +411734,12:2584592:GAGA:G,CACNA1C,disease_model_collision,LQTS,LQTS,Long QT syndrome|Cardiovascular phenotype,NM_000719.7(CACNA1C):c.2317_2319del (p.Lys773del),anchored_exact,6.845132973553145e-07,8.998033029979646e-07,1.3145149874508737,False,False,2.5e-05,-1.4437924256313794,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,2,True,False,False,False,False,False,True,8,genotype_first_postmortem,1,genotype_first_postmortem,genotype_first_postmortem,True,,conflicting,P_LP,true,false,false,false,true,false,false,2023-01,2026-04 +1327132,3:38557229:AC:A,SCN5A,disease_model_collision,SADS,Brugada|SADS,SUDDEN INFANT DEATH SYNDROME|Cardiovascular phenotype|Brugada syndrome 1,NM_000335.5(SCN5A):c.4296+1del,anchored_exact,6.843736954126432e-07,8.99647877820621e-07,1.314556022966598,False,False,2.5e-05,-1.4438674488359615,False,False,False,True,True,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1677487,6:123570976:CACGTGATTATCAGGGCA:C,TRDN,disease_model_collision,SADS,CPVT|SADS,,NM_006073.4(TRDN):c.162_178del (p.Ile54fs),anchored_exact,6.84147080675992e-07,8.994148407046376e-07,1.314650827955176,False,False,0.001,-3.0460399506762856,False,False,False,True,True,False,False,False,False,False,False,True,False,False,True,False,high_tension,4,True,False,False,False,False,False,True,7,genotype_first_postmortem,1,genotype_first_postmortem,genotype_first_postmortem,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +570614,4:113359097:ACAGT:A,ANK2,disease_model_collision,LQTS,LQTS,Long QT syndrome,NM_001148.6(ANK2):c.10483_10486del (p.Ser3495fs),anchored_exact,6.841218065194071e-07,8.993468942853699e-07,1.3146000772302235,False,False,2.5e-05,-1.4440127694247145,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +1342783,4:113358978:AG:A,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,,NM_001148.6(ANK2):c.10367del (p.Gly3456fs),anchored_exact,6.84114318239035e-07,8.993291004910337e-07,1.3145884568203765,False,False,2.5e-05,-1.4440213621303657,False,False,False,False,False,False,False,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,5,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +405341,7:150951697:AG:A,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.1695del (p.Cys566fs),anchored_exact,6.840890465030052e-07,8.992999848917603e-07,1.3145944594412535,False,False,2.5e-05,-1.4440354225547252,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +418689,7:150949032:CA:C,KCNH2,canonical_monogenic,LQTS,LQTS,,NM_000238.4(KCNH2):c.2415del (p.Phe805fs),anchored_exact,6.840675202005138e-07,8.992918975598614e-07,1.3146240047652844,False,False,2.5e-05,-1.4440393281473738,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +810745,7:150951021:TC:T,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.2044del (p.Glu682fs),anchored_exact,6.840656484121468e-07,8.992789581313703e-07,1.3146086864763482,False,False,2.5e-05,-1.444045577022557,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +503760,7:150948956:TGTAGGTCACA:T,KCNH2,canonical_monogenic,LQTS,LQTS,,NM_000238.4(KCNH2):c.2482_2491del (p.Cys828fs),anchored_exact,6.840478669335365e-07,8.992757233324281e-07,1.3146381301144725,False,False,2.5e-05,-1.4440471392273042,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1457672,11:2572978:TG:T,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome|Cardiovascular phenotype|Congenital long QT syndrome,NM_000218.3(KCNQ1):c.919del (p.Val307fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +635221,11:2445270:GC:G,KCNQ1,canonical_monogenic,LQTS,LQTS,,NM_000218.3(KCNQ1):c.176del (p.Pro59fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +405258,11:2445294:TC:T,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.200del (p.Pro67fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1382290,7:150974709:AC:A,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.307+1del,anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1070517,7:150958305:CT:C,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.669del (p.Leu225fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +653333,7:150947808:GC:G,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome||Cardiovascular phenotype,NM_000238.4(KCNH2):c.2762del (p.Gly921fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,true,false,2023-01,2026-04 +638156,7:150977867:TC:T,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome 2|Long QT syndrome,NM_000238.4(KCNH2):c.46del (p.Asp16fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +523705,7:150947425:TG:T,KCNH2,canonical_monogenic,LQTS,LQTS,Cardiovascular phenotype,NM_000238.4(KCNH2):c.3054del (p.Thr1019fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +418247,7:150947678:CG:C,KCNH2,canonical_monogenic,arrhythmia,arrhythmia,Cardiac arrhythmia,NM_000238.4(KCNH2):c.2892del (p.Gly965fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,False,True,2,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_low_signal,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1254662,3:38603785:GC:G,SCN5A,disease_model_collision,SADS,Brugada|LQTS|SADS|conduction,,NM_000335.5(SCN5A):c.1816del (p.Ala606fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,True,True,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1334090,12:2585484:AC:A,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,Timothy syndrome,NM_000719.7(CACNA1C):c.2451del (p.Ala818fs),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,4,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1455253,1:115705187:C:G,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Cardiovascular phenotype|Catecholaminergic polymorphic ventricular tachycardia 1|Catecholaminergic polymorphic ventricular tachycardia 2,NM_001232.4(CASQ2):c.939+5G>C,anchored_exact,3.47015940524244e-06,4.575293779613589e-06,1.3184678070505331,False,False,0.001,-2.33958101465353,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1425730,1:115702947:G:A,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.988C>T (p.Gln330Ter),anchored_exact,3.4213767620090325e-06,4.497138920218957e-06,1.314423671701846,False,False,0.001,-2.3470636965208613,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +427947,1:115725508:C:T,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 2|Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.783G>A (p.Trp261Ter),anchored_exact,2.738473082178839e-06,3.598442594045297e-06,1.3140323720654798,False,False,0.001,-2.443885421221095,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +654552,1:115738281:C:A,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.475G>T (p.Glu159Ter),anchored_exact,2.7365508786380734e-06,3.597652891253746e-06,1.314666796320421,False,False,0.001,-2.443980740569425,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +419715,7:150959571:C:T,KCNH2,penetrance_boundary,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.472+1G>A,anchored_exact,2.0523569951851703e-06,2.698021271199702e-06,1.3145963216598953,False,False,2.5e-05,-0.9668946393449596,False,False,False,False,False,False,True,False,False,True,False,False,False,True,False,False,moderate_tension,1,False,False,False,True,False,False,True,6,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +463523,17:70175754:G:T,KCNJ2,disease_model_collision,SQTS,SQTS,Andersen Tawil syndrome;Short QT syndrome type 3,NM_000891.3(KCNJ2):c.715G>T (p.Glu239Ter),anchored_exact,2.052146408333356e-06,2.6978320221869704e-06,1.3146390026523511,False,False,2.5e-05,-0.9669251034059708,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +571947,15:73343471:G:A,HCN4,penetrance_boundary,Brugada,Brugada,Brugada syndrome 8||Cardiovascular phenotype,NM_005477.3(HCN4):c.1123C>T (p.Arg375Cys),anchored_exact,2.0521492158737845e-06,2.6978320221869704e-06,1.314637204098756,False,False,2.5e-05,-0.9669251034059708,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,True,False,False,True,6,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,conflicting,P_LP,true,false,false,true,true,true,false,2023-01,2026-04 +406420,3:38585690:C:A,SCN5A,disease_model_collision,Brugada,Brugada,Brugada syndrome 1,NM_000335.5(SCN5A):c.2787+1G>T,anchored_exact,1.5024444771643463e-06,2.0315788618282585e-06,1.3521820876073176,False,False,2.5e-05,-1.0901063232391948,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1033372,1:115726990:A:T,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 2,NM_001232.4(CASQ2):c.737+2T>A,anchored_exact,1.5389374252653512e-06,1.9958008350430693e-06,1.296869193904846,False,False,0.001,-2.6998828000012813,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +372376,7:150958430:G:T,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome|Cardiovascular phenotype,NM_000238.4(KCNH2):c.545C>A (p.Ser182Ter),anchored_exact,1.5324754535744223e-06,1.915719822144572e-06,1.2500817338343122,False,False,2.5e-05,-1.115608015721829,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +372313,12:2566466:G:A,CACNA1C,disease_model_collision,cardiomyopathy_overlap,LQTS|arrhythmia|cardiomyopathy_overlap,Hypertrophic cardiomyopathy 1|Long QT syndrome|Long QT syndrome 8|Cardiac arrhythmia|Timothy syndrome|Cardiovascular phenotype,NM_000719.7(CACNA1C):c.1553G>A (p.Arg518His),anchored_exact,1.385381180704965e-06,1.8129572051451725e-06,1.3086339859103944,False,False,2.5e-05,-1.139552455976783,False,False,False,False,False,False,True,True,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,True,True,False,False,True,11,genotype_first_postmortem|structural_electrical_overlap|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1739478,3:38557230:C:T,SCN5A,disease_model_collision,Brugada,Brugada,Cardiovascular phenotype|Brugada syndrome|Brugada syndrome 1,NM_000335.5(SCN5A):c.4296+1G>A,anchored_exact,1.3704318367760864e-06,1.8015648392193456e-06,1.3145962289239144,False,False,2.5e-05,-1.1422901114566184,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +488772,1:115768427:C:A,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1|Catecholaminergic polymorphic ventricular tachycardia 2,NM_001232.4(CASQ2):c.115G>T (p.Glu39Ter),anchored_exact,1.368531975749613e-06,1.7992245342257486e-06,1.3147111294415277,False,False,0.001,-2.744914635492492,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +463294,3:38606149:C:T,SCN5A,disease_model_collision,SADS,Brugada|LQTS|SADS|conduction,,NM_000335.5(SCN5A):c.1141-1G>A,anchored_exact,1.3687398969886353e-06,1.7989623585116103e-06,1.314319870524441,False,False,2.5e-05,-1.142917932409157,False,False,False,True,True,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +985692,4:113373351:C:T,ANK2,disease_model_collision,arrhythmia,arrhythmia,"Cardiac arrhythmia, ankyrin-B-related||Cardiovascular phenotype",NM_001148.6(ANK2):c.11761C>T (p.Gln3921Ter),anchored_exact,1.3681575022916638e-06,1.3681575022916638e-06,7.309094657709624e-07,False,False,2.5e-05,-1.261803912429194,False,False,False,False,False,False,False,False,False,False,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,5,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,conflicting,P_LP,true,false,false,true,true,true,false,2023-01,2026-04 +927383,7:150947870:G:A,KCNH2,canonical_monogenic,arrhythmia,arrhythmia,Cardiac arrhythmia|Cardiovascular phenotype,NM_000238.4(KCNH2):c.2701C>T (p.Gln901Ter),anchored_exact,7.256662341695911e-07,9.289001265161972e-07,1.2800648600031863,False,False,2.5e-05,-1.4299709866424328,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,False,True,2,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_low_signal,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1743359,3:38622399:C:G,SCN5A,disease_model_collision,SADS,Brugada|LQTS|SADS|conduction,Cardiovascular phenotype,NM_000335.5(SCN5A):c.482+1G>C,anchored_exact,6.915447588514272e-07,9.088017448993502e-07,1.3141614033014393,False,False,2.5e-05,-1.4394708564588885,False,False,False,True,True,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1072847,3:38609733:C:T,SCN5A,disease_model_collision,Brugada,Brugada|arrhythmia,Brugada syndrome|Cardiac arrhythmia,NM_000335.5(SCN5A):c.934+1G>A,anchored_exact,6.89303389994072e-07,9.06547630919076e-07,1.315164452857862,False,False,2.5e-05,-1.4405493813746684,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,4,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1208559,12:2448979:C:T,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,,NM_000719.7(CACNA1C):c.481C>T (p.Arg161Ter),anchored_exact,6.877020984541832e-07,9.03404389099884e-07,1.3136561273761245,False,False,2.5e-05,-1.442057812465226,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,4,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +573008,11:2572011:A:C,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.684-2A>C,anchored_exact,6.850675819169561e-07,8.997595842390913e-07,1.3133876052546227,False,False,2.5e-05,-1.443813527217629,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +519257,11:2572021:G:T,KCNQ1,canonical_monogenic,LQTS,LQTS,Cardiovascular phenotype,NM_000218.3(KCNQ1):c.692G>T (p.Arg231Leu),anchored_exact,6.8483018950621e-07,8.9957989618848e-07,1.3135804997974945,False,False,2.5e-05,-1.4439002674130756,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +519533,1:237441382:G:A,RYR2,disease_model_collision,cardiomyopathy_overlap,CPVT|arrhythmia|cardiomyopathy_overlap,Cardiovascular phenotype||Catecholaminergic polymorphic ventricular tachycardia 1|Cardiomyopathy,NM_001035.3(RYR2):c.1069G>A (p.Gly357Ser),anchored_exact,6.842332140486764e-07,8.995167795860064e-07,1.3146343183622424,False,False,2.5e-05,-1.44393073958564,False,False,False,False,False,True,True,True,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,True,True,False,False,True,13,genotype_first_postmortem|provocation_dependent_instability|structural_electrical_overlap|conditional_penetrance_dependent,4,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1784131,1:115768343:G:A,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Cardiovascular phenotype|Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.199C>T (p.Gln67Ter),anchored_exact,6.842023158879988e-07,8.995151613280442e-07,1.3146913211909823,False,False,0.001,-3.0459915122232477,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1527872,3:38557231:C:A,SCN5A,disease_model_collision,Brugada,Brugada,Brugada syndrome 1,NM_000335.5(SCN5A):c.4296G>T (p.Gly1432=),anchored_exact,6.842828442079563e-07,8.995119248295874e-07,1.314531875103312,False,False,2.5e-05,-1.4439330835103572,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1009997,1:237784136:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1|Paroxysmal familial ventricular fibrillation,NM_001035.3(RYR2):c.12424G>A (p.Ala4142Thr),anchored_exact,6.841424001357339e-07,8.993986620545503e-07,1.3146361740478818,False,False,2.5e-05,-1.4439877714961054,False,True,False,True,False,True,True,False,True,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,true,true,false,2023-01,2026-04 +1791538,11:2585278:C:T,KCNQ1,canonical_monogenic,LQTS,LQTS,Cardiovascular phenotype,NM_000218.3(KCNQ1):c.1099C>T (p.Gln367Ter),anchored_exact,6.841676758139885e-07,8.993096898820465e-07,1.3144575624016888,False,False,2.5e-05,-1.4440307357971842,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1415094,11:2777974:A:G,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1733-2A>G,anchored_exact,6.842163601605445e-07,8.992951324751659e-07,1.3143427583657852,False,False,2.5e-05,-1.4440377659145291,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +809661,4:113330289:C:T,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,Cardiovascular phenotype,NM_001148.6(ANK2):c.2944C>T (p.Arg982Ter),anchored_exact,6.840693919991244e-07,8.992935150146045e-07,1.3146227720607964,False,False,2.5e-05,-1.444038547031654,False,False,False,False,False,False,False,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,5,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +638351,17:70176216:G:T,KCNJ2,disease_model_collision,LQTS,LQTS|periodic_paralysis,Andersen Tawil syndrome,NM_000891.3(KCNJ2):c.1177G>T (p.Gly393Ter),anchored_exact,6.840750074564176e-07,8.992886626678298e-07,1.314604887272155,False,False,2.5e-05,-1.444040890374599,False,False,False,False,False,False,False,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,5,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +970883,15:73329725:C:T,HCN4,disease_model_collision,cardiomyopathy_overlap,Brugada|cardiomyopathy_overlap,Brugada syndrome 8|Left ventricular noncompaction cardiomyopathy|Cardiovascular phenotype|HCN4-related disorder,NM_005477.3(HCN4):c.1438G>A (p.Gly480Ser),anchored_exact,6.840675202005138e-07,8.992870452305412e-07,1.314616911427151,False,False,2.5e-05,-1.4440416714861042,False,False,False,False,False,False,True,True,False,False,False,True,False,False,True,False,high_tension,4,False,False,True,True,False,False,True,9,structural_electrical_overlap|conditional_penetrance_dependent,2,structural_electrical_overlap,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1504964,15:73329721:T:C,HCN4,canonical_monogenic,Brugada,Brugada,Brugada syndrome 8,NM_005477.3(HCN4):c.1442A>G (p.Tyr481Cys),anchored_exact,6.840656484121468e-07,8.992838103734187e-07,1.314615779706313,False,False,2.5e-05,-1.4440432337049,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,1,False,False,False,True,False,False,True,6,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1405357,7:150950951:C:T,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.2115G>A (p.Trp705Ter),anchored_exact,6.840506744739651e-07,8.992741059416839e-07,1.3146303700421835,False,False,2.5e-05,-1.4440479203275705,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +519476,17:70175958:A:G,KCNJ2,disease_model_collision,SQTS,SQTS|arrhythmia,Cardiovascular phenotype|Andersen Tawil syndrome;Short QT syndrome type 3|Cardiac arrhythmia,NM_000891.3(KCNJ2):c.919A>G (p.Met307Val),anchored_exact,6.840478669335365e-07,8.992741059416839e-07,1.3146357656770435,False,False,2.5e-05,-1.4440479203275705,False,False,False,False,False,False,True,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1076382,7:150958158:G:A,KCNH2,disease_model_collision,LQTS,LQTS|arrhythmia,Long QT syndrome|Long QT syndrome 2||Cardiac arrhythmia,NM_000238.4(KCNH2):c.817C>T (p.Arg273Ter),anchored_exact,8.45374281009174e-07,8.45374281009174e-07,1.1829066007303187e-06,False,False,2.5e-05,-1.4708909776059382,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1489978,11:2445447:C:A,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.349C>A (p.Pro117Thr),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +965523,11:2775960:C:T,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1591C>T (p.Gln531Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +933168,11:2445251:C:A,KCNQ1,disease_model_collision,LQTS,LQTS|arrhythmia,Long QT syndrome|Cardiac arrhythmia,NM_000218.3(KCNQ1):c.153C>A (p.Tyr51Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +869440,11:2570756:T:C,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.604+2T>C,anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +663623,11:2445149:G:A,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.51G>A (p.Trp17Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +637975,11:2776056:T:C,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.1685+2T>C,anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +488859,11:2445100:T:A,KCNQ1,canonical_monogenic,LQTS,LQTS,,NM_000218.3(KCNQ1):c.2T>A (p.Met1Lys),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +488698,11:2445222:G:T,KCNQ1,canonical_monogenic,LQTS,LQTS,,NM_000218.3(KCNQ1):c.124G>T (p.Glu42Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +431053,11:2445103:C:G,KCNQ1,canonical_monogenic,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.5C>G (p.Ala2Gly),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +375455,11:2445213:G:T,KCNQ1,disease_model_collision,LQTS,LQTS|SQTS|arrhythmia,"Jervell and Lange-Nielsen syndrome 1|Short QT syndrome type 2;Atrial fibrillation, familial, 3;Jervell and Lange-Nielsen syndrome 1;Long QT syndrome 1",NM_000218.3(KCNQ1):c.115G>T (p.Glu39Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,True,True,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1792370,7:150974768:G:A,KCNH2,canonical_monogenic,LQTS,LQTS,Cardiovascular phenotype,NM_000238.4(KCNH2):c.250C>T (p.Gln84Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1728012,7:150947344:G:A,KCNH2,canonical_monogenic,LQTS,LQTS,Cardiovascular phenotype,NM_000238.4(KCNH2):c.3136C>T (p.Gln1046Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,3,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1466419,7:150958504:T:C,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.473-2A>G,anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1197726,7:150974786:C:T,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome 2,NM_000238.4(KCNH2):c.232G>A (p.Ala78Thr),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1171507,7:150974942:C:A,KCNH2,canonical_monogenic,arrhythmia,arrhythmia,Cardiac arrhythmia,NM_000238.4(KCNH2):c.77-1G>T,anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,False,True,2,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_low_signal,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1066606,7:150977837:C:T,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.76+1G>A,anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +560686,7:150950166:A:T,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome 2,NM_000238.4(KCNH2):c.2398+2T>A,anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +373026,7:150947327:C:A,KCNH2,canonical_monogenic,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.3152+1G>T,anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1684121,3:38613808:C:T,SCN5A,disease_model_collision,SADS,Brugada|LQTS|SADS|conduction,,NM_000335.5(SCN5A):c.638G>A (p.Gly213Asp),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,True,True,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,true,true,false,2023-01,2026-04 +1375303,3:38556559:C:T,SCN5A,disease_model_collision,SADS,Brugada|LQTS|SADS|conduction,,NM_000335.5(SCN5A):c.4316G>A (p.Trp1439Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,True,True,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +979202,3:38566558:C:A,SCN5A,disease_model_collision,Brugada,Brugada,Brugada syndrome 1,NM_000335.5(SCN5A):c.3688G>T (p.Glu1230Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +858096,3:38613824:C:A,SCN5A,disease_model_collision,SADS,Brugada|LQTS|SADS|conduction,,NM_000335.5(SCN5A):c.622G>T (p.Glu208Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,True,True,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +547163,21:34449585:C:T,KCNE1,canonical_monogenic,LQTS,LQTS,Jervell and Lange-Nielsen syndrome 2|Long QT syndrome 5,NM_000219.6(KCNE1):c.50G>A (p.Trp17Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,False,True,False,False,False,single_model_compatible,0,False,False,False,False,False,True,True,4,deterministic_phenotype_anchored,1,deterministic_phenotype_anchored,deterministic_phenotype_anchored,True,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1804987,1:237778753:C:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11863C>A (p.Gln3955Lys),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1678118,1:237042549:G:T,RYR2,disease_model_collision,SADS,CPVT|SADS,,NM_001035.3(RYR2):c.28G>T (p.Glu10Ter),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,False,False,False,True,9,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1480581,1:237772077:G:T,RYR2,disease_model_collision,cardiomyopathy_overlap,CPVT|arrhythmia|cardiomyopathy_overlap,Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome|Catecholaminergic polymorphic ventricular tachycardia 1|Arrhythmogenic right ventricular dysplasia 2,NM_001035.3(RYR2):c.11623G>T (p.Val3875Leu),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,True,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,True,True,False,False,True,13,genotype_first_postmortem|provocation_dependent_instability|structural_electrical_overlap|conditional_penetrance_dependent,4,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1439521,1:237828428:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14638G>A (p.Val4880Ile),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1328938,1:237772075:C:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11621C>T (p.Thr3874Ile),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1035886,1:237772033:C:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia,NM_001035.3(RYR2):c.11579C>T (p.Thr3860Ile),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1021015,1:237784046:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1|Cardiovascular phenotype,NM_001035.3(RYR2):c.12334G>A (p.Asp4112Asn),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +869430,1:237783718:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12006G>A (p.Met4002Ile),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +656670,1:237772044:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11590A>G (p.Asn3864Asp),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +581079,1:237772078:T:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11624T>C (p.Val3875Ala),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +572162,1:237369568:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.344A>G (p.Tyr115Cys),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +463600,1:237042565:G:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.44G>C (p.Arg15Pro),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +404183,1:237772077:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1|Cardiovascular phenotype,NM_001035.3(RYR2):c.11623G>A (p.Val3875Ile),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,True,False,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1457736,1:115702920:C:T,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.1014+1G>A,anchored_exact,0.0,0.0,1.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,True,False,high_tension,4,False,True,False,True,False,False,True,9,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1799347,6:123548540:C:T,TRDN,disease_model_collision,SADS,CPVT|SADS,Cardiovascular phenotype,NM_006073.4(TRDN):c.305G>A (p.Trp102Ter),anchored_exact,0.0,0.0,1.0,False,False,0.001,,False,False,False,True,True,False,False,False,False,False,False,True,False,False,True,False,high_tension,4,True,False,False,False,False,False,True,7,genotype_first_postmortem,1,genotype_first_postmortem,genotype_first_postmortem,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Glu141Asp),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1707563,12:2581622:C:T,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,Timothy syndrome,NM_000719.7(CACNA1C):c.1928C>T (p.Ser643Phe),anchored_exact,0.0,0.0,1.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,4,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 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(p.Gly216fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1786030,11:2445203:C:CT,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Cardiovascular phenotype|Long QT syndrome,NM_000218.3(KCNQ1):c.107dup (p.Ser37fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1778018,11:2776986:G:C,KCNQ1,disease_model_collision,LQTS,LQTS|arrhythmia,"Cardiovascular phenotype|Long QT syndrome|Atrial fibrillation, familial, 3",NM_000218.3(KCNQ1):c.1686G>C (p.Arg562Ser),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,True,True,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,9,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1771701,11:2585210:A:AGGGGATTCTTGGCTCGGGGTTTGCCCTGAAGGTGCAGCAGAAGCAGAGGCAGAAGCACTTCAACCGGCAGATCCCGGCGGCAGCCT,KCNQ1,disease_model_collision,LQTS,LQTS|arrhythmia,Cardiovascular phenotype|Long QT syndrome|Cardiac arrhythmia,NM_000218.3(KCNQ1):c.1033-1_1117dup,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,9,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1769838,11:2588779:G:GTCCCCCATATCACGTGCGA,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Cardiovascular phenotype,NM_000218.3(KCNQ1):c.1319_1337dup (p.Glu449fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Ile274Asn),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1709048,11:2570663:C:CGTGGTCCGCCT,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.514_524dup (p.Gly179fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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syndrome,NM_000218.3(KCNQ1):c.386+1G>T,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1500718,11:2661959:A:G,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome|Cardiovascular phenotype,NM_000218.3(KCNQ1):c.1394-2A>G,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 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(p.Met520Thr),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +1004846,11:2572081:T:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.752T>A (p.Leu251Gln),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 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1,NM_000218.3(KCNQ1):c.1686-9T>C,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +983047,11:2588738:AC:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.1278del (p.Asp426fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +983022,11:2570701:AC:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.552del (p.Lys183_Tyr184insTer),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +977320,11:2699443:GCACTGAGGAGCCGCCGGGAGAGTGCCGCGCTGAGGAGCCCCCGGGGAGAGTGCCGCGCTGAGGAGCCCCCAGGAGAGTGCCGCGCTGAGGAGGCCCAGGGAGGACCGCGCGGAGGAGAACCATGCTGAGGAGCCCCCGGGGAGAACAGAACCGCGGCGAGAGGCCCCCGGAGAGAACCGCGCCGAAGAACCCCCGGGGACAACCGCGCCGAAGAACCCCCGGGGAGAACCGCGCCGAAAAGCCCCGGGTGCCCCGAGGAGAACGGCGCCGAGGAGTCCCCGGGGAGAACTGCGCCGAGGAGCCCCCAGAAGAGCGCCGCGCTGAGGAGCCCCGAGGAGAACCGCGCCGAGGGGCGCGCCGGGGAGAACCACGATGACTGACGCACCGAGGAGGACCGCGCTGAGGGGCGCACCGGGAGAATCGTGCTGAGGAGCCCCGGGGAGGACCACGCTGAGAGGCACCCCGGCAGAATCGCGCTGAGGGGCGCCCTGGCAGGATCTTGCTGAGGAGCTCCCTGGAGGTCCGTGCTGAGGCGACGCGGCGACCGTTCTGCCTGGAGACTGCGGCAGCGCTCCGACTGCCCCCGCCGCTGCCGACGTGGCGACCGCCCCCCACCTGCTGATTGGGCGGCAGCAGGGGAAGGCTTGCGGCGGGCTGCTGCACGGATTGGCTGGGTGCGGAAAGTGATGTGCCGTGTCCTGTCATTGGCCGAAAGAGTCTCGTTTTGATGCCACCCGGGCTCAGATTGGCCCAGCGGGTCCAGCGCCGCATGAGGCACTGGCTGGGTGTGAGGTGGCGCGAGCCGCCGCCCTCCCTGCCCCCACCCGTCGTCCCTGAGCACCACCGGGGGCCGGGGCCAGCGCCAGCCTCAGCGTTGGCATCGCCGGGGTGAGCTGGAGACACGGGCCAGTTCTCTGCGTGATGTGTTCACCACCCCGGGGTGACCGCGTGAGGACAGCGGCCGCACCCCGACACTGCTGTGGGCCCTCGGTGTGGAGGCCTGTGGGCGTCCAGGCCACGCCCGAGACCAGCCCCTCCGCCGGCGCCGCTGCAGCGACCCTCGAACCCGGGCAAGGTCTCCACCGCCGTGGCACCGGGTGCGGGAGGCGTTTTCCCCCCTCCCAGCGGGTCCATGCAGGGGATCGGGATGTTCTGAAGCCCCCACTGCTGTGCCTGGAACACCCGTGTCTGCCGCTCACCCCTGAGGACTTGGGACCTCAGGGGGTGAGTGGCAGGGGTGGCCGGGACATGCCAGGCCACCCACCTGGCAAAGGGCAGCGCCGAGGGCGCCCCGCGCCTGCCAGCGCCCGGCCGGGCCCGCCCTGCCCACCTCCCATCCCCCATCCGGGCGTGACACTTGACCGCGTCTGCCGGCCCCTCC:G,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Silver-Russell syndrome 1,NM_000218.3(KCNQ1):c.1514+37364_1514+38744del,representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +977170,11:2583544:CGGTAGGTGCCCCGTGGGTGCGTTTTCCCTGGCTCCTTGGACAGCTGGGGTCCTGGGGTGGCTGCACGCCCCTCCCTGTGAGCAGACCCACTTACGTTCAGAACCAAGAGGGTGCTTCCCTTCTAGAAGGTGCTATACTCCAGAGCCCCACCTGCCCTCCCTGGGGCCCTGGATGCAGACTTCCCGTTTGCAGTCCCCACTGGGGTCCTTGCAGGCAGTGTGGGAGGCAGCCTGGAGTGGCTGTGCATGGGCGCAGTGTGGGGCAGGCCTGCTCACTCAGCCCTGGGTGGGTGGGCAATGCTGCTACCACGCCCCATGGAGGCAGAATCTTGTGCCTGGAGAGGGCACTTCCACGCTGTGGCTGGGGGGGTTTTGTTCCATGTCCTTTCCAGAAACCACAGATTGTAAGGTGATGTGTCTAGTTCACAATGCCTGTATGTGGGTGTGTGTGTGTGTGTTATGTGCGTATGTGCATAATATGTGTTTGTGTTGTGTGTGTATAATTTTATGTTACCTGTATACTATGGGTATGTGTATATGTATCACATGGGTGTGTATGTACTGTATGTGTGCGTGCATACTGTGTATACATATTGTATGTGCATATGTTGTATTTAGTATGTGTGCTGTGTTGTGTGCACATGTATGCATTATACATGTATATCAGTATGTTTGCATATGTGTATTTATGTATCTGTGTCACAGGTATGTATCCTATACATCTATGTGCGTATATGTGTGTGCACATGACATGTAGACATGTGTTAGTATGTGCTTGTGTTAGTGTTTGTGTGTTAGTGTGGGTTAGTGTATGTTTTAGTGTATGTTAGTGTGTTTGTGTGTTAGTGTGTGGGTTTGTGTTTGTGTTTCTGTGTTAGTGTGTGTGTTAGTGTGCGTTAGTTTGTGTTTGTGTGTGTATGTTAGTGTATGTTAGTGTTAGTGTGTGTTAGTATGTGGGTTAGTGTGTGTGTTTGTGTGTTAGTGTGTGTGTTAGTATGTGTTTGTGTTAGTGTGTATTTGTGTGTGTTAGTGTTTGTGTGTGTTTGTGGGTTAGTGTGTGTTAGTGTGGGTTACTGTGTGTTAGTGTTTGTGTGTTAGTGTGTTTTTGTGTGTGTTAGTGTGTGGGTTAGTGTTTGTGTGTGTGTCAGTGTGTGTGTGTTAGTGTGCATATCTATTGTGTGTGTGTGTGCATCACACATGCACGTGCACCACGTGATCTCCTCTGTAGACACGGAGTTCCCTAGCTTCAGGGTGGGTCCTTTGCATCCCATCAACCGTCCTTGGGCGAGGCAGCAGCAGGGTCCTCCTCAGCTGAGGACTGCCTTCTCACTTGCGACCCCAATCCCAGTGCCCAGTATGACCCCTTCCTGGGCACATACAGATGGACCAGCCCACCTGGCCCCCAGAATGGTCCCTGGGAATGGGTTAGAGCGGCTGCAGCCCTGCCCCATGGGACTGGGCCCCTTGCTGGATAAGACCTGGGGTATAAGTTCTGCCCCCCATGCTGGCCCAGGACAGGCAGGCTGGGCCCGAGGTGGGACTTGGGGGGGCTTCCAGCACTGACCATACCTGGCCTTCCCACAACGGTGACCGGTAACCACGTCCTGAGGCTGCACCCAGCTGGCAGTGGCCTGTGTGGACGGGAGCCTCCTGTCCATTCCTTCCCAGGGGATTCTTGGCTCGGGGTTTGCCCTGAAGGTGCAGCAGAAGCAGAGGCAGAAGCACTTCAACCGGCAGATCCCGGCGGCAGCCTCACTCATTCAGGTGCGGTGCCTGCAAGGCCCTGGTCACTGTCATTTTGGTCACTGTTATTGTTGCATCCAGCCCTCACGGCCACCTGTCAGAACCATCATTGGCCCCTGCATCAGCTTGGCTGGCCTGTGGGGCATACTCTGCTTGTGGAAGCCTTGGCTGCTGTGGTGATGGGGTGAGCACGGGGCATTGGAGCCTGTCTTCCTCCAAAGCTGCTCCCATCAAGGGCCATGCCCTGTGGGCTGGAGAGGAGGCACGGCCGTGGCCATGCCAGGAGTGGACGTGGTTGGCTCTGAGGCTCCCTTGTGCTCCCATTCTCCCTCCCACTGCACAACAACCTGAGGGCTGAGTCTGGGAGTGGGGTGGCCAGGTGATTGTCCCCAAGGGAGGTAGGACCCAGCTGTGCAGTTGGTGCCTTCTGGAGGGCCTGGCATCCCTCAGGGCTCGGGAGGCCCTGGTGCCTGGAGGTGAGGACTGGCGATGGATGGCATGGGCCTCCCTCTGGGCTCACAAGGCCAGTGGGCTGGGAAAGGCAGAGCCCTGGAGCAACAGGGGCAGGAAGGTTCTGGAGGCAGGTGGGGAGGCAGGCAGTACCAAGCTCTGGGATGCTGGGCTCTGGCTCTGTCACTCCAGGCTCTCCAGGACCCACCAGAGAATGGGACTGCTCTGTTAACGTAAGCAAGGACTTGGCACAGGAGTCACTTGAGAATTGCGTCCCTGTGGGTCTCTCTTGTTGGCCACTGCAGGGCCAGGGCTGCCCTGAGGAACAGCCGCTGAGGTGCCCAGAGGGTGGGCGTTGCCGGGTTGAATGACAAGTGCCCACTGGGGATAGGGCCTCCGCCCAGTGCAGTGGCTGGGAGCACAGTGTCAGTTCCTCTGGGCACACTGGGCCTGATGTCCCCCAGGAAGGCCCAGGACCTGGGCAGCCCCCGCTGGCTGGCGTCCCCCCTGCAGTCCTCGTGAGCTCGCTGCCCCAGGCAAGGCCCAGGCTGTCAGGGGCCAGTCGCAGTCCTCCTGCACTCCTGGCTCAGCCATCGGGGGGGCTGTGTGCTCCCACCCTTAGCCTGGTTTTATGGCTTCACAGTTTCTCCTTCCTGGGAGACCATAAATCAGGCCCGTAAACCCGCCTTGGTCCCAGCATGAGCATGCTGGCCGCCCACGCCTGGCAGGGGACCACATTGGATTCCTGGTCCCACTCCCTGGGAACCACAGGTCCTTTGAAAGGGGTTCCCTCGGAAGCTGCACACACTGTGGGAGGACTGGAGTAGGGGCCCCAGGTGGCAGGTGTGCACAGGAGCAGGGCAGGGGTCATGGGGTTTGCCAGGGTTGGGGGACCACGTGGAGTGCTCAGCCTGTGTGTGTAACACTCGGGCCTTGGAAGGCTGGGCTTGTGCCCTCGCCTGCCTGTCCCTGGGTGCTGGATGGGAGTGAGGGCTGCAGGTGCCCCTCGCCAGCTGCTGTGTCTACCTGGGGCTGTCACCCAGGAGCCCATCAGTGTGGGGGAACATTCTCCACTCGGCCCTCTCTCAGGCTCATGTGGCCAGTGATGACAAGGCCACCAGGACATGTCCTCATACAAGGCCCTGGGAGCCCCTCCTGCCCATCTGGACGCTGCACAACTGCTCCCCCGCCGGGTCCCCTGCCGATAGTGTCCCCTCCTCCCACCCTTCCCTTGTGGTGCTGCCATGGGGTCTCTCTGAAATGCTGGCTTCAGAGCTGCACCCATGTGCCATCAGAGGCTCCCCCAACTGCAAGGTGGTATAGGCCTCTGGGAGAGACCTCACCTCCTGCCAGCCCTAGGGATCCTGCCTCTCCCTGCCCCCTGCTCAGCACCTGCAGGTCCTGGGCGACCCCTCTTTCTCAGCCCTTCCTCACTGTGTGGCCACTGGTTGCCCATTTCCGCATTGGTCTCCTATGCACGCTGTGTACCCTGGCACCTGGGGATGATGTGCGACCTGCCCACCTTTGCAAGTCTCTCCTTTGGCTCAAGGCTGGCTCAGGGCTGGTAAAGACCTCTGTGGTGTCCCAGCTGTGGGTAACAATTAGCCCATGAGGCAGTGAGCTGCCTGGTGCAGCAAGGGACCAAGCCAGGCTGCCTGGGCAGAGGGTCTGGGAGCTGGGACCATGTCAAGCCTGTGACTCTGAGGTCCCAGACCCTGCCACCCAGAGGGGAGGGGCCAGGCCTGGGGAACAGGGAGGGGGAGCTGTAGCTTCCATAAGGGCCCCCGCCGGGTGGCTCAGCAGGTGACAGCCTGTCCCCCTGCCCGACCTCA:C,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1032+1_1129-1del,representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +966649,11:2587646:GC:G,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1207del (p.His403fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +960695,11:2583477:A:C,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.964A>C (p.Thr322Pro),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +956049,11:2777033:G:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1732+1G>A,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +939724,11:2583547:T:C,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome|Long QT syndrome 1,NM_000218.3(KCNQ1):c.1032+2T>C,representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +930315,11:2588718:GAAAA:G,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.1262_1265del (p.Lys421fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +926196,11:2662006:T:TGAGAACCAACAGCTTCGCC,KCNQ1,unanchored_assertion_state,arrhythmia,arrhythmia,Cardiac arrhythmia,NM_000218.3(KCNQ1):c.1443_1461dup (p.Asp488fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +925351,11:2588790:CA:C,KCNQ1,unanchored_assertion_state,arrhythmia,arrhythmia,Cardiac arrhythmia,NM_000218.3(KCNQ1):c.1330del (p.Thr444fs),unanchored,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +922607,11:2588815:CG:C,KCNQ1,unanchored_assertion_state,arrhythmia,arrhythmia,Cardiac arrhythmia|Cardiovascular phenotype,NM_000218.3(KCNQ1):c.1356del (p.Leu453fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,true,false,2023-01,2026-04 +919956,11:2585222:GCTCGGGGTTTG:CA,KCNQ1,unanchored_assertion_state,arrhythmia,arrhythmia,Cardiac arrhythmia,NM_000218.3(KCNQ1):c.1043_1054delinsCA (p.Gly348fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +869436,11:2572105:G:C,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.776G>C (p.Arg259Pro),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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1,NM_000218.2(KCNQ1):c.478_478del,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +869433,11:2768869:ATTAAGGTCAT:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.1542_1551del (p.Lys515fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Trp248Ter),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +844409,11:2587671:CA:C,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1233del (p.Lys411fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Gly189fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +817016,11:2570662:AC:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,,NM_000218.3(KCNQ1):c.513del (p.Glu170_Tyr171insTer),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Tyr125Asn),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +684787,11:2528008:T:C,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.467T>C (p.Leu156Pro),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 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(p.Asp242Glu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,conflicting,P_LP,true,false,false,true,true,true,false,2023-01,2026-04 +660595,11:2583486:G:C,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.973G>C (p.Gly325Arg),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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syndrome,NM_000218.3(KCNQ1):c.1032+5G>T,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +620198,11:2585305:C:T,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome|Long QT syndrome 1|Cardiovascular phenotype,NM_000218.3(KCNQ1):c.1126C>T (p.Gln376Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +620103,11:2572846:G:T,KCNQ1,unanchored_assertion_state,LQTS,LQTS,,NM_000218.3(KCNQ1):c.781G>T (p.Glu261Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +587644,11:2768851:GA:G,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.1524del (p.Glu508fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +582668,11:2583433:A:G,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.922-2A>G,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Arg380Trp),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +576205,11:2768841:CAG:C,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1515-2_1515-1del,representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Thr247fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +570319,11:2777002:G:C,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1702G>C (p.Gly568Arg),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Leu262Pro),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +526930,11:2588717:AG:A,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.1257del (p.Lys422fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +523769,11:2445192:A:T,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000218.3(KCNQ1):c.94A>T (p.Lys32Ter),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +522585,11:2583447:A:T,KCNQ1,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 1,NM_000218.3(KCNQ1):c.934A>T (p.Thr312Ser),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +519369,11:2572059:C:T,KCNQ1,disease_model_collision,LQTS,LQTS|arrhythmia,Cardiovascular phenotype|Long QT syndrome|Cardiac arrhythmia,NM_000218.3(KCNQ1):c.730C>T (p.Gln244Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,9,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Arg77fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1786650,7:150950421:C:G,KCNH2,unanchored_assertion_state,LQTS,LQTS,Cardiovascular phenotype|Long QT syndrome,NM_000238.4(KCNH2):c.2146-1G>C,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 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(p.Tyr652fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1779222,7:150951650:TG:T,KCNH2,unanchored_assertion_state,LQTS,LQTS,Cardiovascular phenotype,NM_000238.4(KCNH2):c.1742del (p.Ser581fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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+660047,7:150947039:C:CA,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.3167dup (p.Ser1057fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +657779,7:150946975:AGGCGGGC:A,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome|Cardiovascular phenotype,NM_000238.4(KCNH2):c.3225_3231del (p.Pro1076fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +652241,7:150952602:GT:G,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.1379del (p.Asp460fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +648088,7:150951738:A:T,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.1655T>A (p.Leu552Ter),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +645394,7:150974933:AC:A,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.84del (p.Lys28fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +641517,7:150974767:T:TGCGCGATCTGCGCGGCA,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.234_250dup (p.Gln84fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +640022,7:150950308:GC:G,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.2257del (p.Ala753fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +637977,7:150947371:C:CG,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 2|Long QT syndrome|Cardiovascular phenotype,NM_000238.4(KCNH2):c.3108dup (p.Asp1037fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +632866,7:150952842:CA:C,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome|Long QT syndrome 2||Cardiovascular phenotype,NM_000238.4(KCNH2):c.1139del (p.Leu380fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,true,false,2023-01,2026-04 +620172,7:150951063:G:T,KCNH2,disease_model_collision,LQTS,LQTS|arrhythmia,Cardiac arrhythmia|Long QT syndrome,NM_000238.4(KCNH2):c.2003C>A (p.Ser668Ter),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,9,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +620154,7:150952634:G:A,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.1348C>T (p.Gln450Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,true,false,2023-01,2026-04 +618184,7:150951520:C:G,KCNH2,unanchored_assertion_state,LQTS,LQTS,,NM_000238.4(KCNH2):c.1873G>C (p.Val625Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +598783,7:150947865:TG:T,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 2|Cardiovascular phenotype|Long QT syndrome,NM_000238.4(KCNH2):c.2705del (p.Pro902fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +582292,7:150958047:CGGCGCCCTCACCGGTGCT:C,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.910_916+11del,representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +581669,7:150951638:C:G,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.1755G>C (p.Trp585Cys),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +579489,7:150977836:ACT:A,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.76_76+1del,representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +572344,7:150951702:A:T,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.1691T>A (p.Leu564Gln),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +570715,7:150947370:T:TCGCCCCGGGGCCGCCGACCCGGGCTGGAGAGGGGGATGTTGAGGAGGCTGGGGGTGGGGGCGGGGCATCGAGGGAGCTCCTGGTACTGGCGGCCCCGACTGTCCCCCCAGAAGCTGAAAATGTTGGACACTCCTGAGAAGGCGCCTGCAGCCAGAGAGCAGAGCTGGGTGAGCGGGGTAGACGCACCACCGCTGCCACGCCCGGTCCTCCCTCGCCCGCCCGTCGCCCGGGATACCTGACAGGGGGTTGCAAGTGTCGCTGCTCTTCTCGCAGTCCTCCATCAGGGGCTCCCCACCCGGCGGCTCTCCGGGGGGCCTGGGGCTGGAGAAGGGCACCAGGCGGAGGGGGCTGGAGCTGCGGCCTGGGCCCTCATCCTCACTGCTCTCAGGGCTGGAGGGGCCACTGGACGGGCTCTCCCCCCACGGCCCCCCCGGCCGGCCCCGGCTACTCGGCCCTGCCCCCGCCCGGCCCGGCCCCAAGGCCGACACCTCCCCTGGCTGCTCCGTGTCTGTGGGAAACAGAGAATGGGCCTCAGAGAGGGGAGGAGAACAGAGAGGAGGGGGCGAGGGTGGAGGAGGGGACAGGAGCGAGCCCGAGAGAGGACTGGGCAGGAAGCCCTGGTTTGTCCCCAGTCGCTTCTTCTGCTATCTTGCACCCACTGTCAAGCCGACCAAGAACTCCCAGGACCCCCTGACTGCCCAAGCACTGGCAATGGTGCTTCAGGGGTTGGCGGATCTCTGGGACTGCGGGGCCTCAGCCCCATCGTTGGCTCCCTGGCCCTCCTTTGTTCTATGTTCTTTCCTCCTCAGTGCTCACAGAGACCCCAGCCCTGTGAAGTCCAAAAAGCCTAGGCTTGCCCTGGAGGGTGGAAGAGGGCTTCCTGGAGGAGGTGACAGCTGCAGGGGCCCTGAAAGATGGGCAGCATCTGGACAGCTGGGGTGTGGAGTGGGCACACTGGAGGAAGGGATGGGAAGGTCTGAGGCCTGGGTAAAGCAGACACGGCCCACCCCGCCTTCCAGCTCCCAGCCTCACCTTGTCCCCGCCCTCCCCCTTCCTCCCCTCCCCCGCCTCACCCTTGTCCGTGCGCCTGCGGAAGGACAACTTGCGCTTGCGTTGCCGACTGAAGCCACCCTCTAACTCCGTACTGCCGGGGGAGCCCGGGATCATGTTGGTCTGGAACCAAAATCAGTATCAGGGCCCTTTCAGTGCTCTCCTGCCCCACCGGGGTCAGGCCCCAAGCTCCCTCCTTAACACAGAAAAAGTAGGGCTGGGCGCCCCAGCTCTGGGAAAACCCTTCCCTGCCCCCAATGTGATTTTGCCCCAGGCAAAGACTGAGTTTGGGACTTTTGTAGGCTGCTCTATGATACCATTTGACAGACAGGGAAACTGAGACAGAGAAGCATCACATTCAATGTCACACAGCAAAGGGGCAGCCACACAGCTGGAAGCAGGAGGATGGGGTCCAGCTCAGGGCAGCCAACTCACATCTCGCAGGTTGAAGGTGATCTCCAGGCTGGACCAGAAGTGGTCGGAGAACTCAGGGTACATGTCCAGCACCTCCAGCAGGTCGTCCCGATGGATCTTGTGTAGGTCACAGTAGGTGAGGGCCCGCACATCCCCGTTCGACTTGCCAGGCCTTGCATACAGGTTCAGAGGCTCCCCAAAGATGTCATTCTTCCCTGGAGGCCATGGAGAGGACAGGGAGCTCAGCCCCGGGGGGCGGCATCCAGGCAGCAGGCACCTTCTCCCGGCATCCCCACCCCGGGCAGAGCATGTCCCCTCAGCTGGGTCGCCTGCCAGCCGGCCCCCAACCCACACAACCGGGGAAGCAATCTGCCAGCCCACCCTCCCTCAGCTCCCAGCAGGCACGACAGTGCCAGAGGGGCCAGGAGCCCAGGGTCTCCCAGCAAATGAGACCCAGCCAGCAGGACTACCCCAAACCCCAGGTCCCAAACACCCTCTTAGCCAATCACTGCACCCTTATAAGCAATGTTCTTCAAACCAAAGATCAGAACACAGTAGTGAATCAAAACCAGCATTTTTTTTTTTTTTTTTTTTTTTTTACTGAAAGAACATACAGTAGTATAGCTTAGCACAGCACAGAACAGAAATGCTAGAATGAACCACATGCAGTAAGGCCCAGTGTTATGTAGTGAAACTTTGATTTTAGTTTTGTGGGGGTGTGTATTTGTGTTTGTACAGAGCTGAGAAACAAAGTCTAAAATGTCCTACCATCAACTATGGTCGAAAGAGCTTGCTATATCTGCCCTGAGGCACACAGGGCCGAGGGAAGGACAGGCAAAGGGGGAGGAAGTCCTCAGTGTCCAGACACACCAACCCACCCACTGTGCACAGGCAGGGTAGAAAGGAAGTGGGGGGAGGGGGCAGGACTCCCTTTGCTTTGGATGTGTCAAGGGGCCAGGCATGAGGCTGCAGGGAACCACATGGCCCTTAGTGAAACCAAATGCCGAGCTTCCAGGCTAGCATTTCTTCCTCTACTGCCCAGGCTAGAGGATCTAGATTTGATCCTACTTTAAGGAAGCAAAAAGTGTCTGTTTGTGGCGGATCCTGAAGGGAAGGAGAATGTGGGAACCCCAGAGTTCAGCAGCCTCACCCCACGTGGGGCTCCTCTCCATGGCCCCGCTTGGAGGGCCTGAGTTTAGGTGAATTAAAGGAGCCCAGTGACCCTGCAGGCAGTCCCAGGTCCACAGCCCCAGTGACTGCATATTCAGAAGGCTCGCACCTCTTGAGGCTGCAGAGGGCATTTCCAGTCCAGTGCCCGCCCCCCACCCCATACCCAGGATGGCCACGACGACGTCGCCCCGCAGGATCTCGATGGAGCCCCGGGAGATGAAGTACAGGGCGGTGAGCAGGTCCCCAGCATGCACCAGTGTGTCCCCTGGCGGTGCATGTGTGGTCTTGAACTTCATGGCCAGGGCCCGAAGGCAGCCCTTGGTGGCCCCTCGGAAGGGTTTGCAGTGCTGCAGCAGTGAGCGGTTCAGGTGCAGGCAGATGTCAGCCTGCAGGCACTCAGGGAAGCCCTTCAGCACCTGGGGGCAGGGTGGGGGCAGCTCAGCACACCCTCCCTTGGGACCCCCCAACCCACACTCTACTCCACCATCCCACCCCTCCATGTCAGAGAAATCTCAACCTCCAGGCCTGGGAGATCTCGGAAGCATCAGGGGGCCCAGTGTCTTGGGAAGGACCTGGGACCCCACTCCAGCTTCACCATGCCTGGCCGAGCACCCTTGGGCTCTAGACCTCCATGTTCTTATTTGTAAGGCATAGAGACCATTCCCGCCCTGGGCTGTCACAAGGATTTAACCCCATCGCCTATGTGACATATACCTCCCACCCCAAAAGGGGAGCTCTCCAGGGAAGGGGTTCCAAGGGCTTCCATTTCCTCATGGGCAAAAAGGGGCAACGTGCCTCCAGGGTCCTTACTACTGACTGTGACCGCCTGAGACTTGTTTGCTGTGCCAAGAGGTTCCCCTCTGCCACCCCACTCTTCCCAGCCTGCCACCCACTGGCCACGCTCTGGTGGCCTCACCGCGTTCATGTCGATGCCGTTGGTGTAGGACCAGGCGTGCTGGAAGTACTCCTCGAGGCGCTGGCGCAGGGGATTGGGGATCTGGTGGAAGCGGATGAACTCCCGCACCCGCAGCATCTGTGTGTGGTAGCGGGCTGTGCCCGAGTACAGCCGCTGGATGATGGCCGACACGTTGCCGAAGATGCTAGCATACATGAGGGCTGGGGGCGTGGGCACGTGGGGCCGTCAGCCTCTGCAGGGACCCCACCCACCCACAGGGACCCTGCTCAGGCCCCGCACCAGGTCAGTGTCTCAGTCTCAGCGTCGACATGCCCACGAGACGCCCTTGTACATCTGCGCTCCAGCACACCCCACCCTTCAGTAGTCCCCGCCCTGGTGACCCAGCCCCCAAACCATGTCACGATGGTGGCCCCTGGAGTCTCTAAGTTCCAGGGCCTCACTCTGGCCCGGCTAGCAGCCTCAGTTTCCTCCAACTTGGGTTCCTCCACCGTGGGCTCTCCCCGCCGCCCGCCCCTGGGCACACTCACAGCCAATGAGCATGACGCAGATGGAGAAGATCTTCTCTGAGTTGGTGTTGGGAGAGACGTTGCCGAAGCCCACACTGGTGAGGCTGCTGAAGGTGAAGTAGAGCGCCGTCACATACTTGTCCTTGATGGAGGGGCCGCCCAGGCCGCTGCTGTTGTAGGGTTTGCCTATCTGGTCGCCCAGGTTGTGCAGCCAGCCGATGCGTGAGTCCATGTGTGGCTGCTCCATGTTGCCGATGGCGTACCAGATGCAGGCTAGCCAGTGCGCGATGAGCGCAAAGGTGCACATGAGCAAGAACAGCACGGCCGCGCCGTACTCTGAGTAGCGATCCAGCTTCCGCGCCACGCGCACCAGCCGCAGCAGCCGCGCAGTCTTCAGCAGCCCGATCAGCTGGGGGACAGGGAAGGGGCACATTCCGTTGATGGGGCAAGGGGGGCAAGGGAGGAGGGGAGGTGCTGCGGCCCTCAGAGCGAGCATCAGAGGTCAGATCCCCAAAGACTTCCTAGACCCTCCTCCTAAGAGGTGAAGCCCACACTGGGCCCAGCACAGGTGTCTCATTAATCTTAGTGCTAGCTTTGGGACAGAGGCAGCCCCCATAGTGTGGATGAGGAAACAGGGGCACTGACAGGTGCAGTGATCACCCTAGGGTGCCTGCCCACTCCCACCAGCTTCTAGGGCACTTTGGTGACGCTACAAAATAATGGCCCCTTGGGATGGACGAATTAGAAAAAAAGGTGTCCTGTGTGGCCCTCTGCAACCTGCGAGGAGCTTGTGTGGAGAGAAGGAGCATAGGTTTGCTGGGGTACCCACCTTGCCTCTGCAGCTGCCTTGCCACCATGTCTCTCTCCCACTGTCTTTCTCTCTTTCTCTCTCTCTCTCTTTTTCTCTGTCCTCCTCGCCACCCCCTCCACCCCACTACCTCCCACCACATTCCTGGCCTCTCCTCTCCCTACACCACCTGCCTCCTTGCTGACCCCACCTCCTCAGAGCCAGAGCCGAAGATGAGCAGGTCGAAGGGGATGGCGGCCACCATGTCGATGAGGAACCAGCCCTTGAAGTAGTGGACGGCGATGCGGCCGGGGTGGCTGACCACCTCCTCGTTGGCATTGACGTAGGTGGTGCGGAAGTTGATGAGGATGTCCACAATGAACATGATGTCCACGATGAGGTCCACCACAGCCAGCGGCTGGCAGGCGTAGCCACACTCGGTAGCAGGCGGGCCTTCTTCCGTCTCCTTCAGCAGGAAGGCAGCCGAGTAGGGTGTGAAGACAGCCGTGTAGATGACCAGCAGCAGGATGAGCCAGTCCCACACGGCCTTGAAGGGGCTGTAATGCAGGATGGTCCAGCGGTGGATGCGCGGTGCCTGCAGCTTGTACTCAGGCAGCACGTCGGCGCCCAGGGACAGGACCTGCACCCGGGGAAGGCGGAGGTGTGGGTGAGGCAGGCCATGGGACCTCGGGGGCAGGAGCGATGACATCTCTGCCGGGGCCAAGCAGAATGAGGAGGAGGCCAAAAAAAGCTTCCATCAGAATGCCCACCCCTCAGCCAAGCGACCACAGCAAATGGCCACCCCCAGGTTTGGGCATCATGGTTCCCAAAATGCCACACAGCACAGGACTGGCTCCAAACAGTTCCAACATTTCCCGGCAGACGTGGATTCAGGCCACTCGGCAGGAACACCCAGTGCTGCTCCCCGCCGGCAATGCAGATGCAGACCTGCCACTGTGACTGCCCTGAGACGCTGGCCCACACACCCAACCACACACGCCATAGTCTCAGACCGGAAAGGGTTCCAAGGACAACAGCTCCCAACCTGGGCAGTGGCCCCAGGAGCCATAGCCCCAATCCACTGACTGGTAGTCACTGCAGTTCTTACCAGCCCCTCTTCATGCCACAGGCCCGAGGACACCAGGCAACCAGGATGGAGAAAGACCAAGACACTCCCACCCTCCACTCGCACACCTCGCTCCCTCAGCCCCCTCTCCACACAGGTCCGGGACAGCCCACAGTCCTCATCCTCCCACCCTCTTACAAAGGGACAAAGAAGACATAGCCCAGCTGGGAGGAGATGGCACCCAACTTATACAGAGGGACGTGCACACAGGGACTGCTCAGCAGTGACACACACAGCCCCTGTACCAGCTCACACTCACACTCTGCCTCCTCCACAGTCATCAGACAGAGGCAGGCTGGCCATCCGGACCCGGTGACAGCAGGCACGTCCCTCTTGCTCCCAAGG,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.1129-831_3109dup,representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +570494,7:150951499:GAGAGACGTTG:CTTCA,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.1884_1894delinsTGAAG (p.Asn629_Pro632delinsGluAla),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +568003,7:150947640:G:T,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.2931C>A (p.Cys977Ter),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Val1038fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +495746,7:150947804:GC:G,KCNH2,unanchored_assertion_state,LQTS,LQTS,Cardiovascular phenotype,NM_000238.4(KCNH2):c.2766del (p.Pro923fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Tyr54Ter),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +488692,7:150948510:C:A,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.2626G>T (p.Glu876Ter),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Gly1036fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +456919,7:150947381:C:CCG,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.3097_3098dup (p.Pro1034fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Cys740fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +456903,7:150950248:CCAGCATGCACCAGTGTGTCCCCTGGCGGTGCATGTGTGGTCTTGAACTTCATGGCCAGGGCCCGAAGGCAGCCCTTGGTGGCCCCTCGGAAGGGTTTGCAGTGCTGCAGCAGTGAGCGGTTCAGGTGCAGGCAGATGT:C,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.2180_2317del (p.Asp727_Ala772del),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +456902,7:150950421:CTG:TT,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.2146-3_2146-1delinsAA,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +456901,7:150951004:G:A,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.2062C>T (p.Gln688Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +456886,7:150952646:C:CA,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.1335dup (p.Gly446fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +456876,7:150957296:TGA:T,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome,NM_000238.4(KCNH2):c.1121_1122del (p.Val374fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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phenotype,NM_000238.4(KCNH2):c.1557+1G>C,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +431374,7:150947389:C:CCGGGCTGGAGAGGGGGATGTTGAGGAGGCTGGGGGTGGGGGCGGGGCATCGAGGGAGCTCCTGGTACTGGCGGCCCCGACTGTCCCCCCAGAAGCTGAAAATGTTGGACACTCCTGAGAAGGCGCCTGCAGCCAGAGAGCAGAGCTGGGTGAGCGGGGTAGACGCACCACCGCTGCCACGCCCGGTCCTCCCTCGCCCGCCCGTCGCCCGGGATACCTGACAGGGGGTTGCAAGTGTCGCTGCTCTTCTCGCAGTCCTCCATCAGGGGCTCCCCA,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 2,NM_000238.4(KCNH2):c.2906_3089dup (p.Gly989_Ala990insIleProGlyAspGlyArgAlaArgGluAspArgAlaTrpGlnArgTrpCysValTyrProAlaHisProAlaLeuLeuSerGlyCysArgArgLeuLeuArgSerValGlnHisPheGlnLeuLeuGlyGlyGlnSerGlyProProValProGlyAlaProSerMetProArgProHisProGlnProProGlnHisProProLeuGlnProValGlySerProTer),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +431036,7:150947631:GCTCTT:G,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 2,NM_000238.4(KCNH2):c.2935_2939del (p.Lys979fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +430730,7:150948456:G:GCCTGC,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 2|Long QT syndrome,NM_000238.4(KCNH2):c.2675_2679dup (p.Arg894fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +427945,7:150951114:A:C,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 2,NM_000238.4(KCNH2):c.1952T>G (p.Met651Arg),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +427944,7:150951027:AC:A,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome 2,NM_000238.4(KCNH2):c.2038del (p.Val680fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +427076,7:150951096:C:A,KCNH2,unanchored_assertion_state,LQTS,LQTS,,NM_000238.4(KCNH2):c.1970G>T (p.Gly657Val),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +426429,7:150958306:TGCCA:G,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome|Cardiovascular phenotype,NM_000238.4(KCNH2):c.665_669delinsC (p.Val222fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +423753,7:150951473:G:C,KCNH2,unanchored_assertion_state,LQTS,LQTS,,NM_000238.4(KCNH2):c.1920C>G (p.Phe640Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +423696,7:150950937:CCG:C,KCNH2,unanchored_assertion_state,LQTS,LQTS,,NM_000238.4(KCNH2):c.2127_2128del (p.Asn709fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +423015,7:150947419:T:TG,KCNH2,unanchored_assertion_state,LQTS,LQTS,,NM_000238.4(KCNH2):c.3060dup (p.Ser1021fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +421672,7:150947683:GG:T,KCNH2,unanchored_assertion_state,LQTS,LQTS,,NM_000238.4(KCNH2):c.2887_2888delinsA (p.Pro963fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +420923,7:150950983:G:A,KCNH2,unanchored_assertion_state,LQTS,LQTS,Long QT syndrome|Cardiovascular phenotype,NM_000238.4(KCNH2):c.2083C>T (p.Gln695Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_unanchored_channelopathy,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +420585,7:150947367:ACGTCGCCCCGGGGC:A,KCNH2,disease_model_collision,LQTS,LQTS|arrhythmia,Long QT syndrome|Cardiac arrhythmia,NM_000238.4(KCNH2):c.3099_3112del 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(p.Cys47Arg),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1773663,1:237832604:C:G,RYR2,disease_model_collision,SADS,CPVT|SADS,Cardiovascular phenotype,NM_001035.3(RYR2):c.14861C>G (p.Ala4954Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1745086,1:237377364:C:G,RYR2,disease_model_collision,SADS,CPVT|SADS,Cardiovascular phenotype,NM_001035.3(RYR2):c.505C>G (p.Arg169Gly),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1710227,1:237723201:A:ATCCAGAGAAGACGGTAGAAAGAG,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.10630_10652dup (p.Val3551_Leu3552insGlnArgArgArgTer),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1693182,1:237798100:A:G,RYR2,unanchored_assertion_state,cardiomyopathy_overlap,cardiomyopathy_overlap,Arrhythmogenic right ventricular cardiomyopathy,NM_001035.3(RYR2):c.14020A>G (p.Lys4674Glu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,True,False,True,False,True,False,False,True,False,high_tension,3,True,True,True,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|structural_electrical_overlap|conditional_penetrance_dependent,4,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1527876,1:237830611:C:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14737C>T (p.His4913Tyr),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1527868,1:237634949:A:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6749A>T (p.Asn2250Ile),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1524904,1:237445402:C:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1|Cardiovascular phenotype,NM_001035.3(RYR2):c.1172C>A (p.Ala391Asp),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1499030,1:237633669:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6647A>G (p.Asp2216Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1496297,1:237757772:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11321A>G (p.Gln3774Arg),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +1480185,1:237806211:C:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14226C>A (p.His4742Gln),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1479669,1:237830584:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14710G>A (p.Gly4904Ser),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +1474443,1:237781643:G:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11959G>C (p.Glu3987Gln),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +1472640,1:237784315:G:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12603G>T (p.Gln4201His),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1467901,1:237806237:A:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14252A>T (p.Lys4751Met),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1451617,1:237640994:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.7213G>A (p.Glu2405Lys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1441921,1:237793882:T:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.13798T>C (p.Phe4600Leu),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1441891,1:237784158:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1|Cardiovascular phenotype,NM_001035.3(RYR2):c.12446A>G (p.Tyr4149Cys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1410932,1:237784176:C:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12464C>A (p.Ser4155Tyr),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1384586,1:237638464:C:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6900C>G (p.Asp2300Glu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1383749,1:237649944:T:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.7580T>G (p.Leu2527Trp),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1363823,1:237793920:T:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.13836T>G (p.Phe4612Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +1346560,1:237760996:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11444A>G (p.Glu3815Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1342890,1:237441339:GAGAAA:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.1031_1035del (p.Lys344fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1330215,1:237469125:C:T,RYR2,disease_model_collision,cardiomyopathy_overlap,CPVT|arrhythmia|cardiomyopathy_overlap,Arrhythmogenic right ventricular dysplasia 2;Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.1646C>T (p.Ala549Val),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,True,False,True,False,True,False,False,False,True,multi_regime_required,7,True,True,True,True,False,False,True,14,genotype_first_postmortem|provocation_dependent_instability|structural_electrical_overlap|conditional_penetrance_dependent,4,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1213111,1:237772037:G:C,RYR2,disease_model_collision,SADS,CPVT|SADS,,NM_001035.3(RYR2):c.11583G>C (p.Gln3861His),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1119951,1:237784299:C:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome|Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12587C>T (p.Thr4196Ile),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1119950,1:237783695:A:C,RYR2,unanchored_assertion_state,arrhythmia,arrhythmia,Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome,NM_001035.3(RYR2):c.11983A>C (p.Ile3995Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,2,True,True,False,False,False,False,True,8,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1072928,1:237377373:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.514G>A (p.Gly172Arg),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1072597,1:237648522:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.7421G>A (p.Arg2474Lys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,conflicting,P_LP,true,false,false,true,true,false,false,2023-01,2026-04 +1070571,1:237783981:C:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12269C>T (p.Pro4090Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1069130,1:237639019:G:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6933G>C (p.Glu2311Asp),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1067931,1:237806159:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia|Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14174A>G (p.Tyr4725Cys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1067138,1:237377396:T:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.537T>A (p.Asp179Glu),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1066599,1:237806219:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14234A>G (p.Asp4745Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1051501,1:237631490:C:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6504C>A (p.His2168Gln),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +1013805,1:237828441:T:TTCC,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14651_14652insTCC (p.Met4884delinsIlePro),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1007679,1:237784055:C:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12343C>T (p.Leu4115Phe),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +982634,1:237674163:A:AG,RYR2,unanchored_assertion_state,cardiomyopathy_overlap,cardiomyopathy_overlap,Arrhythmogenic right ventricular dysplasia 2,NM_001035.3(RYR2):c.8659dup (p.Glu2887fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,True,False,True,False,True,False,False,True,False,high_tension,3,True,True,True,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|structural_electrical_overlap|conditional_penetrance_dependent,4,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +979205,1:237445474:C:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.1244C>A (p.Thr415Lys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +979204,1:237784211:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12499G>A (p.Glu4167Lys),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +978366,1:237707216:T:A,RYR2,unanchored_assertion_state,conduction,conduction,Conduction disorder of the heart,NM_001035.3(RYR2):c.9848T>A (p.Ile3283Asn),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,True,False,False,moderate_tension,2,True,True,False,False,False,False,True,8,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +957942,1:237633671:C:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Cardiovascular phenotype|Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6649C>T (p.His2217Tyr),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +954202,1:237633708:T:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6686T>C (p.Leu2229Pro),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +947851,1:237492996:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.1870G>A (p.Ala624Thr),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +947702,1:237388087:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.677G>A (p.Gly226Glu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +940323,1:237759848:T:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11398T>C (p.Cys3800Arg),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +933804,1:237759824:AGCCTGGCCG:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11380_11388del (p.Ala3794_Leu3796del),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +931781,1:237709543:G:GT,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.10209dup (p.Ile3404fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +915531,1:237648558:ATCTTCTTGAGGT:A,RYR2,unanchored_assertion_state,cardiomyopathy_overlap,cardiomyopathy_overlap,Cardiomyopathy,NM_001035.3(RYR2):c.7459_7470del (p.Leu2487_Val2490del),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,True,False,True,False,True,False,False,True,False,high_tension,3,True,True,True,True,False,False,True,11,genotype_first_postmortem|provocation_dependent_instability|structural_electrical_overlap|conditional_penetrance_dependent,4,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +870975,1:237270563:G:GCAGAAGGATTTGGCAA,RYR2,disease_model_collision,SADS,CPVT|SADS,,NM_001035.3(RYR2):c.120_135dup (p.Leu46fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +869428,1:237831526:G:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14769G>T (p.Met4923Ile),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +861770,1:237648525:T:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.7424T>C (p.Val2475Ala),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +840374,1:237639068:C:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6982C>G (p.Pro2328Ala),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +692253,1:237798158:CCTT:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14079_14081del (p.Leu4694del),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +665174,1:237784301:A:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12589A>C (p.Ile4197Leu),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +656745,1:237784290:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12578G>A (p.Cys4193Tyr),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +654791,1:237423097:G:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.854G>T (p.Ser285Ile),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +654125,1:237778755:G:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11865G>C (p.Gln3955His),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +651491,1:237830557:A:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14683A>C (p.Asn4895His),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +649923,1:237643361:T:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.7256T>G (p.Ile2419Ser),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +644207,1:237778727:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11837G>A (p.Gly3946Asp),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +637985,1:237778678:G:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11788G>C (p.Gly3930Arg),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +580536,1:237784280:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12568G>A (p.Val4190Met),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +578246,1:237784189:G:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12477G>T (p.Gln4159His),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +575682,1:237792319:T:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.13778T>C (p.Leu4593Ser),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +575059,1:237778753:C:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11863C>G (p.Gln3955Glu),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +571532,1:237633668:G:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6646G>C (p.Asp2216His),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +570194,1:237784251:G:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12539G>T (p.Gly4180Val),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +568135,1:237791480:G:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.13528G>C (p.Ala4510Pro),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,true,true,false,2023-01,2026-04 +566084,1:237819188:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14586A>G (p.Ile4862Met),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +560709,1:237784261:AGAG:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.12550_12552del (p.Glu4184del),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +532366,1:237628052:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6412G>A (p.Glu2138Lys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +532324,1:237819187:T:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14585T>C (p.Ile4862Thr),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +520467,1:237441320:A:G,RYR2,disease_model_collision,SADS,CPVT|SADS,Cardiovascular phenotype,NM_001035.3(RYR2):c.1007A>G (p.Glu336Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +519356,1:237639110:G:A,RYR2,disease_model_collision,SADS,CPVT|SADS,Cardiovascular phenotype,NM_001035.3(RYR2):c.7024G>A (p.Gly2342Arg),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +463624,1:237639095:G:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.7009G>C (p.Gly2337Arg),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +463608,1:237377426:A:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.567A>T (p.Glu189Asp),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +463605,1:237377374:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia,NM_001035.3(RYR2):c.515G>A (p.Gly172Glu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +463579,1:237819192:G:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1|Squamous cell lung carcinoma,NM_001035.3(RYR2):c.14590G>T (p.Gly4864Cys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +463577,1:237806236:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14251A>G (p.Lys4751Glu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +463549,1:237445428:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.1198G>A (p.Asp400Asn),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +452065,1:237808943:T:C,RYR2,disease_model_collision,SADS,CPVT|SADS,,NM_001035.3(RYR2):c.14341T>C (p.Tyr4781His),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +450836,1:237639026:GAG:AAA,RYR2,disease_model_collision,SADS,CPVT|SADS,,NM_001035.3(RYR2):c.6940_6942delinsAAA (p.Glu2314Lys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +449306,1:237832607:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.14864G>A (p.Gly4955Glu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +427948,1:237783708:T:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 2,NM_001035.3(RYR2):c.11996T>C (p.Met3999Thr),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +427184,1:237377361:C:G,RYR2,disease_model_collision,SADS,CPVT|SADS,,NM_001035.3(RYR2):c.502C>G (p.Gln168Glu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +427164,1:237781598:A:G,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11914A>G (p.Met3972Val),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,conflicting,P_LP,true,false,false,true,true,false,false,2023-01,2026-04 +423597,1:237828390:T:C,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia,NM_001035.3(RYR2):c.14600T>C (p.Ile4867Thr),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +420865,1:237784281:T:G,RYR2,disease_model_collision,SADS,CPVT|SADS,,NM_001035.3(RYR2):c.12569T>G (p.Val4190Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +418465,1:237783714:A:G,RYR2,disease_model_collision,SADS,CPVT|SADS,,NM_001035.3(RYR2):c.12002A>G (p.Asp4001Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +404218,1:237638450:G:A,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.6886G>A (p.Glu2296Lys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +404208,1:237756342:C:T,RYR2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_001035.3(RYR2):c.11200C>T (p.Arg3734Cys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,True,False,False,True,12,genotype_first_postmortem|provocation_dependent_instability|conditional_penetrance_dependent,3,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +372588,1:237832592:A:G,RYR2,disease_model_collision,SADS,CPVT|SADS,,NM_001035.3(RYR2):c.14849A>G (p.Glu4950Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +372582,1:237377365:G:T,RYR2,disease_model_collision,SADS,CPVT|SADS,Cardiovascular phenotype,NM_001035.3(RYR2):c.506G>T (p.Arg169Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,True,False,True,False,False,False,True,multi_regime_required,6,True,True,False,False,False,False,True,10,genotype_first_postmortem|provocation_dependent_instability,2,genotype_first_postmortem,provocation_dependent_instability,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1793918,1:115744885:C:CT,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Cardiovascular phenotype||Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.261dup (p.Ala88fs),representation_repairable,0.0,0.0,0.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1324014,1:115744827:C:T,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 2,NM_001232.4(CASQ2):c.319+1G>A,representation_repairable,0.0,0.0,0.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,true,false,false,2023-01,2026-04 +452250,1:115768540:A:G,CASQ2,disease_model_collision,CPVT,CPVT|arrhythmia,Wolff-Parkinson-White pattern|Catecholaminergic polymorphic ventricular tachycardia 1,NM_001232.4(CASQ2):c.2T>C (p.Met1Thr),locus_or_regional_context,0.0,0.0,0.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1798674,6:123636774:A:G,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Cardiovascular phenotype|Catecholaminergic polymorphic ventricular tachycardia 1,NM_006073.4(TRDN):c.2T>C (p.Met1Thr),locus_or_regional_context,0.0,0.0,0.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1797791,6:123548553:C:TT,TRDN,disease_model_collision,SADS,CPVT|SADS,Cardiovascular phenotype,NM_006073.4(TRDN):c.292delinsAA (p.Glu98fs),representation_repairable,0.0,0.0,0.0,False,False,0.001,,False,False,False,True,True,False,False,False,False,False,False,True,False,False,False,True,multi_regime_required,5,True,False,False,False,False,False,True,8,genotype_first_postmortem,1,genotype_first_postmortem,genotype_first_postmortem,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1746830,6:123516157:TTC:T,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Cardiovascular phenotype|Catecholaminergic polymorphic ventricular tachycardia 1,NM_006073.4(TRDN):c.532_533del (p.Glu178fs),representation_repairable,0.0,0.0,0.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1708485,6:123516183:C:A,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 5,NM_006073.4(TRDN):c.508G>T (p.Gly170Ter),representation_repairable,0.0,0.0,0.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1458047,6:123571063:AC:A,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_006073.4(TRDN):c.91del (p.Val31fs),locus_or_regional_context,0.0,0.0,0.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +463677,6:123570921:A:T,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_006073.4(TRDN):c.232+2T>A,representation_repairable,0.0,0.0,0.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +408740,6:123570988:A:G,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 5|Catecholaminergic polymorphic ventricular tachycardia 1,NM_006073.4(TRDN):c.167T>C (p.Leu56Pro),representation_repairable,0.0,0.0,0.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +408737,6:123503893:TC:T,TRDN,disease_model_collision,CPVT,CPVT|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 1,NM_006073.4(TRDN):c.618del (p.Ala208fs),locus_or_regional_context,0.0,0.0,0.0,False,False,0.001,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1362982,14:90404488:A:G,CALM1,disease_model_collision,CPVT,CPVT|LQTS|arrhythmia,Long QT syndrome 14;Catecholaminergic polymorphic ventricular tachycardia 4,NM_006888.6(CALM1):c.395A>G (p.Asp132Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +974613,14:90404689:A:T,CALM1,disease_model_collision,LQTS,LQTS,Long QT syndrome 14,NM_006888.6(CALM1):c.422A>T (p.Glu141Val),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +974612,14:90404689:A:G,CALM1,disease_model_collision,LQTS,LQTS,Long QT syndrome 14,NM_006888.6(CALM1):c.422A>G (p.Glu141Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +961658,14:90404693:C:A,CALM1,disease_model_collision,CPVT,CPVT|LQTS|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 4;Long QT syndrome 14,NM_006888.6(CALM1):c.426C>A (p.Phe142Leu),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +948239,14:90404488:A:T,CALM1,disease_model_collision,CPVT,CPVT|LQTS|arrhythmia,Long QT syndrome 14;Catecholaminergic polymorphic ventricular tachycardia 4,NM_006888.6(CALM1):c.395A>T (p.Asp132Val),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +639902,14:90404487:G:A,CALM1,disease_model_collision,CPVT,CPVT|LQTS|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 4;Long QT syndrome 14,NM_006888.6(CALM1):c.394G>A (p.Asp132Asn),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +542137,14:90404491:G:A,CALM1,disease_model_collision,CPVT,CPVT|LQTS|arrhythmia,Catecholaminergic polymorphic ventricular tachycardia 4;Long QT syndrome 14,NM_006888.6(CALM1):c.398G>A (p.Gly133Glu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +426161,14:90404691:T:C,CALM1,disease_model_collision,CPVT,CPVT|LQTS|arrhythmia,Long QT syndrome 14;Catecholaminergic polymorphic ventricular tachycardia 4|Cardiovascular phenotype,NM_006888.6(CALM1):c.424T>C (p.Phe142Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,True,True,False,False,False,False,True,False,False,False,True,multi_regime_required,5,False,True,False,True,False,False,True,10,provocation_dependent_instability|conditional_penetrance_dependent,2,provocation_dependent_instability,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +418107,14:90404512:A:T,CALM1,disease_model_collision,SADS,CPVT|LQTS|SADS,,NM_006888.6(CALM1):c.419A>T (p.Glu140Val),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,False,False,True,False,False,False,True,multi_regime_required,5,True,False,False,False,False,False,True,8,genotype_first_postmortem,1,genotype_first_postmortem,genotype_first_postmortem,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +388500,14:90404406:G:A,CALM1,disease_model_collision,SADS,CPVT|LQTS|SADS,,NM_006888.6(CALM1):c.313G>A (p.Glu105Lys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,False,False,True,False,False,False,True,multi_regime_required,5,True,False,False,False,False,False,True,8,genotype_first_postmortem,1,genotype_first_postmortem,genotype_first_postmortem,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +384090,14:90401312:A:C,CALM1,disease_model_collision,SADS,CPVT|LQTS|SADS,,NM_006888.6(CALM1):c.88A>C (p.Thr30Pro),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,False,False,True,False,False,False,True,multi_regime_required,5,True,False,False,False,False,False,True,8,genotype_first_postmortem,1,genotype_first_postmortem,genotype_first_postmortem,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Asp130Asn),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1327459,2:47161804:C:T,CALM2,disease_model_collision,SADS,SADS,SUDDEN INFANT DEATH SYNDROME,NM_001743.6(CALM2):c.340G>A (p.Gly114Arg),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,False,False,True,False,False,True,False,high_tension,4,True,False,False,False,False,False,True,8,genotype_first_postmortem,1,genotype_first_postmortem,genotype_first_postmortem,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1067140,2:47161747:C:T,CALM2,disease_model_collision,LQTS,LQTS,Long QT syndrome 1,NM_001743.6(CALM2):c.397G>A (p.Gly133Ser),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +955533,2:47161749:T:C,CALM2,disease_model_collision,LQTS,LQTS,Long QT syndrome 1,NM_001743.6(CALM2):c.395A>G (p.Asp132Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Asp96Tyr),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +576319,2:47160792:A:C,CALM2,disease_model_collision,LQTS,LQTS,Long QT syndrome 1,NM_001743.6(CALM2):c.434T>G (p.Met145Arg),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 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(p.Asp130Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +458198,19:46609125:A:G,CALM3,disease_model_collision,LQTS,LQTS,Long QT syndrome 1,NM_005184.4(CALM3):c.422A>G (p.Glu141Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +409871,19:46608584:A:C,CALM3,disease_model_collision,LQTS,LQTS,Long QT syndrome 1,NM_005184.4(CALM3):c.281A>C (p.Asp94Ala),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +409870,19:46608846:G:C,CALM3,disease_model_collision,LQTS,LQTS,Long QT syndrome 1|Long QT syndrome 16,NM_005184.4(CALM3):c.286G>C (p.Asp96His),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +389576,19:46608955:A:G,CALM3,disease_model_collision,SADS,CPVT|LQTS|SADS,,NM_005184.4(CALM3):c.395A>G (p.Asp132Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,True,True,False,False,False,False,False,False,True,False,False,False,True,multi_regime_required,5,True,False,False,False,False,False,True,8,genotype_first_postmortem,1,genotype_first_postmortem,genotype_first_postmortem,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1729746,4:113333109:C:CT,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,Cardiovascular phenotype,NM_001148.6(ANK2):c.3281dup (p.Val1095fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1695772,4:113242117:A:C,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,,NM_001148.6(ANK2):c.799A>C (p.Ile267Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +1678114,4:113117420:T:C,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,,NM_001148.6(ANK2):c.85-56996T>C,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1678112,4:113311281:G:T,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,,NM_001148.6(ANK2):c.2575G>T (p.Gly859Ter),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1483377,4:113359094:G:GAC,ANK2,disease_model_collision,LQTS,LQTS,Long QT syndrome,NM_001148.6(ANK2):c.10480_10481dup (p.Gln3494fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +1334346,4:113311368:C:T,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,,NM_001148.6(ANK2):c.2662C>T (p.Arg888Ter),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +1317290,4:113353994:AGG:A,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,,NM_001148.6(ANK2):c.5377_5378del (p.Gly1793fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +985758,4:113330364:C:T,ANK2,disease_model_collision,arrhythmia,arrhythmia,"Inborn genetic diseases|Cardiac arrhythmia, ankyrin-B-related",NM_001148.6(ANK2):c.3019C>T (p.Arg1007Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,6,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +985336,4:113288387:G:A,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,Inborn genetic diseases,NM_001148.6(ANK2):c.2179-1G>A,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +985206,4:113358977:CA:C,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,Inborn genetic diseases,NM_001148.6(ANK2):c.10360del (p.Arg3454fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +954568,4:113358096:G:T,ANK2,disease_model_collision,LQTS,LQTS,Long QT syndrome,NM_001148.6(ANK2):c.9478G>T (p.Glu3160Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,False,False,False,True,7,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_collision_channelopathy,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +818077,4:113335953:CTGAT:C,ANK2,disease_model_collision,LQTS,LQTS|arrhythmia,,NM_001148.6(ANK2):c.3490_3493del (p.Ile1164fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1739158,17:70175464:C:T,KCNJ2,disease_model_collision,LQTS,LQTS|periodic_paralysis,Cardiovascular phenotype,NM_000891.3(KCNJ2):c.425C>T (p.Thr142Ile),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1496231,17:70175685:A:T,KCNJ2,disease_model_collision,SQTS,SQTS,Short QT syndrome type 3;Andersen Tawil syndrome,NM_000891.3(KCNJ2):c.646A>T (p.Asn216Tyr),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +995608,17:70175676:C:G,KCNJ2,disease_model_collision,LQTS,LQTS|periodic_paralysis,,NM_000891.3(KCNJ2):c.637C>G (p.Arg213Gly),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +981438,17:70175977:GCTCTTA:G,KCNJ2,disease_model_collision,SQTS,SQTS,Andersen Tawil syndrome|Andersen Tawil syndrome;Short QT syndrome type 3,NM_000891.3(KCNJ2):c.939_944del (p.Ser314_Tyr315del),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +960380,17:70175756:AG:A,KCNJ2,disease_model_collision,SQTS,SQTS,Andersen Tawil syndrome;Short QT syndrome type 3,NM_000891.3(KCNJ2):c.721del (p.Glu241fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +946743,17:70170729:ACTTGTTAGCGTTTTCCTGCTCACTTCCAAATGTTTCATTTCTATTTGCCATTATCTGGAAAAATCCTGGTGCTCAGAAGGGGTAAGAGATGTTAATTGAAGCATGGTGGAAAGGGTGAGGATAAGGTCAAGGCCATTTTACTTAGCTTCCTCCTCTCTCATATTTTAATGACACTTTATTTTTTAATGTTCTTGGTCTCCATAAGAAATATTTGATCTAAACTCATGTGAATTTTGCTTTTAAAAAAAATAAAAGAACACAGTCTTTCTACATCCTTTGGATTCCTGAGTTGTAGAATCTCTGGTTAGCTGTAGCGTCCTTGTATGACTTTTGCGTAGCCTGAAAGATTGAAAACAGCTACCTGCACAGATTAAGTGTTTCAGATTTTTTTAAGTGTATATTTTTATTTACCAAACATGTCTGTTTTTCAGCGTATGCAAATGCTGAGCAGTGCTACAAGCCAAGTGTCGTTGAGTATAAATGTTAGACAGGGGGCTCACACGTAGATAGATGGGTATCCCCCTCCCCTCCCCACTTCCCCCTCCTCCTCCCTCATGTTTATTGAGCTTCTAAGAGGCTGCTTTCCTAGCAGTTGTGCTCACATAGCAACATGTGCCCAGAGCACACTCAGGCTGTTCTATATGGCGTCAGCTGGGGAATAGCTGCTCTAAACACTCATTAGCAGACCTCTCTCTCAGCCCAGTACGTTTTCTTTTGCTATCTTTATTTCCTATCCTTAGAAACTTTCTTATTTATTGCACACCATGACCATATTACAGGACACATTTACTCTCATTTGATTTTTTTTTTTAGTTATTTATAAGCCATATTGGAAGTATTACCTATATAGTCAAAGCAATTTAGATCCCCCATTTGTACCATGTGATCTCCTTGACCTTACATTTATCCATAGCTCTTTCTCCTTTAACATCTACCTAAGTTTAAAACGCTGAACTATTTTTTTCCATTGCTTATGCTTAATTTTGGCTCAGCCTATAAATAGTCTTAACATGAACAGCACCACATGTAACCTCTCAATTTCCCAAAAATACTTTCTACATCATGGGTTATGGCCTGGATAAAAATGATTATTTGTGTCCATGAAATTTACATCTAGACCCTTAAATATTTTGGCTGGAAGGGAGATTTACACATTGTTCATCAAATCAAATTTCAATTCTCTGGATTTGTATCACTTAGTGTTCTCATCTACTCCTCATTGATTGCATCTCAAACATTATTTTGAATATATGCTTGAAATAAAGTTGCATGTAAGCCCTGTTTTTTTAATGATAGCTTTTCTCAGCTGCTCACGAATTGGTAATTGCTAGTGAGAGGACCGGGCAAGGAAGTTTTCTGCTTGCTTAAAGTCGCTCAGGCATGTGGGCAGGTTAACAGTAAAAGCAATTTTTACCATGAAATATTAAGACCGTTACCCCATCAAACCTTGACAGGTTCTAGACTTTAGCTATGTAATCAGCTCCACAAAAAGTCTGCATACATATATGTGTGTGCACCTGCATACACACATAAATCTGTTTGGGGGCATATCTATTTAAAGTGGCAAAAGTTTTCTTTTTGCCAAAAAAAAAAAAAAAAAAAAAAAAAGCCCAAAACTCCTCTTTTTCTCTTTCCAGGAAGAAATGGTAAAATTTCTAAATGATGCTCCACATGTGGAACAAATTCTGTTATTAGCAATGGAAATAAGACAATAATAGTCTCTCAATACAGGCTACTTTCAAGATTCTAAATGTGGAAAGCTATTCATAGGAAGCTGGTATTGTGTGATTTGTGGAATTCAAACAAATGTCCTGGGGTCAAGATTTTTGGAAAGTCATAATTCAGTCTTTAGATTTCATATGGTTGTTATGTTTTAATCTGGAAGGAGTACAGAAATAAGTCAGAAGAAATTTGAGACTGTCTACTCATGGCCCCTAATGGTAACTCACATGGAAGGATTGTTTTGAATCATGAAAAGGGAATTTCTTGGTGTCAGCTTATAATACAAAGTTCTGAAGTCAATCAGAACTCAAAAATACAAAGCATTCATTGAATGAAGTTCTTCTCCTTTTTTTGAAACGTATACCTGCGTTTGGTGTTGTTGCTGTCTCTGTCTGTTTAGTAATGTGAGAAAACTAAGATGAAATAATTGCTTAAAAAATGCTGTCCATGTACAGGATCTAGAACTTCGAGGGGCAGGATTCTTGTTTCTTTGGTCCAAGTGCAAACTTCACAGGGAAGCAGACAAAACATTGAAGCAGGTGGAAGGTTAGGAAAGCACAGTAACTTCTTTTTATAAAGTAATTCAAAGGCACTTTCAAACTGAGCATCATTTAGGTGTCAAAAGCTGCCAAAATGTAACACACATTGCAATTTTCAAAGATGACTAATCTCAGGAAAAATGTGTTGGGGCACATTCTTGCATAATAACTTGGATAAAGAAGAAGTCAAAAGACAGTAACAAGGCATTTTCAAAGGCAATGCACCTTGCCTCTTCTTAAGGGAATGCACAAAAACAACATAAATGGATTGCTTTATTTGTTTGCGGCTGGCTTGGCTGATATCGGTTCTATTAACTGTTTAATCTTAATGGATTTAGAGGAGAAGGAAAAAGTGGAGTCTTCATTATCAGGCATCAACAAATTTCTGACTCTTTTCATGAGTTATTCATTGCCCCCCTTTAATATAGCAGAAGGATTTGGTTGTATGAAAAGTTGAAGATGGGCTTTATTTTTCAGTTCTAACTCTTATTAGTTTTGTTATTACACATTTGGTAAAGAAAACACCTTAGACTTTCTCTTAGCTTTTTGTTAGTTAGTCAAGGGAAATAGTTTCTTAGGAGTGAAGATGGAAAGTTGAAGTACATAGATAGTTCTTAGCTAGGGAAGACTGAGGCAATAGGAGAAAACTGAGAACTACTATTTGCACATATTAAGTAAAGGTGAGTGCCTTCTCCATAGGAACCTATACCAAATAACAGCGCTGGAAGTGAAAGTAAGCGGACTGGCATTTATGATCTGTCCTTACACAGTTGTCTCTGTCTGAGAGAACACAGCACTGGACTCACATGAAATGAGTTCCTGCCTTATCTCAATCCGCTAAAGACCTGGTCCTTTGGCACAACGGTGCTTACTTCCTAGCCTGTCATTACACATGACAGCCCCATCTCAGGAGAATTTCAGGGCTCTTATTGCTAGGCAACAGAATTGCTCTCTATCCCCCAGAGCAAACCTGCATCTTCAGAGTCTTCAAGCCAGAATTACCTGTACTAATAGAGACTTAGCAGGCATTTCTGCATAGTGGTTGCTTAAAGTGTGAGAAGTGATGAAGCAAGCCCAAACAGTATCCAGAAACTGGGATCCATTTCAGATTATTATAAGCAATAGGGGCAGTATTCACCATCGTAGGAGGTTTTGTCCACTAGTTCCCTCTATTTTCAGGATACACACTCAGTCAAGCCTACTCCAAAATCCACTTCACTATTCTATTTGTAGGTGGGAATCTGACTTTCTTCCTCTAGCATTTCGTCAGCCTATCCGGTCTGCTCAGTTATATCATTTAAACAAAATAGTCTGTCTTCCGATTTCAACCTTGCCATCAGGGACTCTAATATTCTCCCGTAATGCACATGCAACTCAGTGGATATCAATGCTGCGTCCACGTGAAGTTTTCTAAACATGTCCTTTTTCCAAAAATTTTACGACAAACCTTGGAATCAGACAGTCTTTCATCTGCTTAACAGGGATCCTAGCAAGTGGGGCAGGCAGAAGAAGAGAATAAGAGAAGGGAGAGGTAGACCTGAACAATAGAATATTCTAGATCCCTGGCCAAAAAGAAGGGAAAGGGGACCTGACCTGACATTTTGGTTGAACAACTGTCACAGACAACTCTTCTATGTTTAACGACTTTATGCTTTTAAATAAAAGTTTTACAAAGCATGCTTAGGATACAAAGAAATTTAAAACCTTATAATTTAATGTAAATTATACTTATCTTTACCTGATTATGTGTTTTTGTTAGGATATATTGTCTTAGACAGTAGAATTCTTTAAGAGTGGCTTATTTTGTAATGCACAGTCTCTCTTTTCTTGCAGGACATGTTCTCTGGATGTCAGCTGAGTCATTAAAGTAACTCTGCATGTCAGTAGACAGACCTTGGTAGAACCACAAGGCTCCCAGAGACACCCATCTCTCCTCATTTTTTTGGTGTGTGTGTCTTCACCGAACATTCAAAACTGTTTCTCCAAAGCGTTTTGCAAAAACTCAGACTGTTTTCCAAAGCAGAAGCACTGGAGTCCCCAGCAGAAGCGATGGGCAGTGTGCGAACCAACCGCTACAGCATCGTCTCTTCAGAAGAAGACGGTATGAAGTTGGCCACCATGGCAGTTGCAAATGGCTTTGGGAACGGGAAGAGTAAAGTCCACACCCGACAACAGTGCAGGAGCCGCTTTGTGAAGAAAGATGGCCACTGTAATGTTCAGTTCATCAATGTGGGTGAGAAGGGGCAACGGTACCTCGCAGACATCTTCACCACGTGTGTGGACATTCGCTGGCGGTGGATGCTGGTTATCTTCTGCCTGGCTTTCGTCCTGTCATGGCTGTTTTTTGGCTGTGTGTTTTGGTTGATAGCTCTGCTCCATGGGGACCTGGATGCATCCAAAGAGGGCAAAGCTTGTGTGTCCGAGGTCAACAGCTTCACGGCTGCCTTCCTCTTCTCCATTGAGACCCAGAC:A,KCNJ2,disease_model_collision,SQTS,SQTS,Short QT syndrome type 3;Andersen Tawil syndrome,NM_000891.3(KCNJ2):c.-217+1029_422del,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +858285,17:70175473:A:G,KCNJ2,disease_model_collision,SQTS,SQTS,Andersen Tawil syndrome;Short QT syndrome type 3,NM_000891.3(KCNJ2):c.434A>G (p.Tyr145Cys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +801410,17:70175563:T:TCATTGG,KCNJ2,disease_model_collision,LQTS,LQTS|periodic_paralysis,,NM_000891.3(KCNJ2):c.526_531dup (p.Ile176_Gly177dup),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +689769,17:70175935:A:G,KCNJ2,disease_model_collision,SQTS,SQTS|arrhythmia,"Andersen Tawil syndrome;Short QT syndrome type 3;Atrial fibrillation, familial, 9",NM_000891.3(KCNJ2):c.896A>G (p.Glu299Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,True,False,False,True,False,False,True,False,high_tension,4,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +652820,17:70175596:C:A,KCNJ2,disease_model_collision,SQTS,SQTS,Andersen Tawil syndrome;Short QT syndrome type 3,NM_000891.3(KCNJ2):c.557C>A (p.Pro186Gln),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +569363,17:70176139:TC:T,KCNJ2,disease_model_collision,SQTS,SQTS,Short QT syndrome type 3;Andersen Tawil syndrome,NM_000891.3(KCNJ2):c.1102del (p.Leu368fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +546134,17:70175704:T:C,KCNJ2,disease_model_collision,LQTS,LQTS|periodic_paralysis,Andersen Tawil syndrome,NM_000891.3(KCNJ2):c.665T>C (p.Leu222Ser),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +523694,17:70175194:G:T,KCNJ2,disease_model_collision,LQTS,LQTS|periodic_paralysis,Cardiovascular phenotype,NM_000891.3(KCNJ2):c.155G>T (p.Gly52Val),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +430545,17:70175692:G:C,KCNJ2,disease_model_collision,SQTS,SQTS,Short QT syndrome type 3;Andersen Tawil syndrome,NM_000891.3(KCNJ2):c.653G>C (p.Arg218Pro),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +429589,17:70175604:A:G,KCNJ2,disease_model_collision,SQTS,SQTS,Andersen Tawil syndrome;Short QT syndrome type 3,NM_000891.3(KCNJ2):c.565A>G (p.Arg189Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,False,True,False,high_tension,3,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1697968,15:73325193:C:G,HCN4,unanchored_assertion_state,cardiomyopathy_overlap,cardiomyopathy_overlap,Left ventricular noncompaction cardiomyopathy,NM_005477.3(HCN4):c.1740G>C (p.Glu580Asp),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,True,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,True,False,False,False,True,7,structural_electrical_overlap,1,structural_electrical_overlap,structural_electrical_overlap,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1675065,15:73329718:C:T,HCN4,unanchored_assertion_state,cardiomyopathy_overlap,cardiomyopathy_overlap,Left ventricular noncompaction cardiomyopathy,NM_005477.3(HCN4):c.1445G>A (p.Gly482Glu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,True,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,True,False,False,False,True,7,structural_electrical_overlap,1,structural_electrical_overlap,structural_electrical_overlap,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1359536,15:73343533:T:C,HCN4,unanchored_assertion_state,Brugada,Brugada,Brugada syndrome 8|HCN4-related disorder,NM_005477.3(HCN4):c.1061A>G (p.Tyr354Cys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +666148,15:73329692:C:G,HCN4,unanchored_assertion_state,Brugada,Brugada,Brugada syndrome 8,NM_005477.3(HCN4):c.1471G>C (p.Asp491His),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +470654,15:73324088:C:T,HCN4,unanchored_assertion_state,Brugada,Brugada,Brugada syndrome 8,NM_005477.3(HCN4):c.2143+1G>A,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +374861,15:73332261:G:C,HCN4,unanchored_assertion_state,conduction,conduction,"Sick sinus syndrome 2, autosomal dominant",NM_005477.3(HCN4):c.1241C>G (p.Ala414Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,True,False,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,5,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +374860,15:73329722:A:G,HCN4,disease_model_collision,Brugada,Brugada|conduction,"Sick sinus syndrome 2, autosomal dominant|Brugada syndrome 8||Cardiovascular phenotype",NM_005477.3(HCN4):c.1441T>C (p.Tyr481His),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,True,False,False,True,False,False,True,False,high_tension,4,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +374859,15:73329719:C:G,HCN4,disease_model_collision,Brugada,Brugada|conduction,"Sick sinus syndrome 2, autosomal dominant|Brugada syndrome 8",NM_005477.3(HCN4):c.1444G>C (p.Gly482Arg),unanchored,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,True,False,False,True,False,False,True,False,high_tension,4,False,False,False,True,False,False,True,8,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +374858,15:73325000:T:TGGTGAGCACGCTG,HCN4,unanchored_assertion_state,conduction,conduction,"Sick sinus syndrome 2, autosomal dominant",NM_005477.3(HCN4):c.1920_1932dup (p.Lys645fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,True,False,False,True,False,True,False,False,moderate_tension,1,False,False,False,False,False,False,True,5,,0,underresolved_contextual_architecture,underresolved_contextual_architecture,True,underresolved_stress_tension,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1803055,12:2486116:T:C,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,"Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures",NM_000719.7(CACNA1C):c.770T>C (p.Val257Ala),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1744618,12:2677772:C:T,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,Cardiovascular phenotype,NM_000719.7(CACNA1C):c.4996C>T (p.Arg1666Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +1712194,12:2688554:G:GC,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,,NM_000719.7(CACNA1C):c.5897dup (p.Gln1967fs),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1705745,12:2655228:C:G,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,"Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures",NM_000719.7(CACNA1C):c.4222C>G (p.Leu1408Val),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1705744,12:2581663:C:T,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,"Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures",NM_000719.7(CACNA1C):c.1969C>T (p.Leu657Phe),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1700075,12:2665599:G:C,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,Neurodevelopmental delay|CACNA1C-related disorder,NM_000719.7(CACNA1C):c.4417G>C (p.Ala1473Pro),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1699326,12:2634334:T:G,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,"Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures",NM_000719.7(CACNA1C):c.3866T>G (p.Leu1289Trp),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,true,false,false,false,2023-01,2026-04 +1699036,12:2504886:T:TA,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,"Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures",NM_000719.7(CACNA1C):c.1159dup (p.Thr387fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1695801,12:2610588:C:G,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,,NM_000719.7(CACNA1C):c.3606C>G (p.Tyr1202Ter),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +1685597,12:2567752:T:G,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,Timothy syndrome,NM_000719.7(CACNA1C):c.1853T>G (p.Val618Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1685596,12:2449093:G:A,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,"Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures",NM_000719.7(CACNA1C):c.595G>A (p.Asp199Asn),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +1344837,12:2504535:A:G,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,Seizure,NM_001167623.2(CACNA1C):c.1213A>G (p.Ser405Gly),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1325838,12:2448994:T:C,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,Neurodevelopmental delay,NM_000719.7(CACNA1C):c.496T>C (p.Phe166Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1313855,12:2677868:G:A,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,,NM_000719.7(CACNA1C):c.5091+1G>A,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +1309258,12:2608654:T:C,CACNA1C,disease_model_collision,LQTS,LQTS,Timothy syndrome|Long QT syndrome,NM_000719.7(CACNA1C):c.3500T>C (p.Val1167Ala),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,true,false,2023-01,2026-04 +1303511,12:2608657:C:A,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,,NM_000719.7(CACNA1C):c.3503C>A (p.Thr1168Asn),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1302971,12:2504529:G:A,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,,NM_001167623.2(CACNA1C):c.1207G>A (p.Val403Met),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1302480,12:2605121:C:T,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,,NM_000719.7(CACNA1C):c.3001C>T (p.Arg1001Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +1214422,12:2651679:C:T,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,Hypotonia,NM_000719.7(CACNA1C):c.3985C>T (p.Arg1329Cys),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +1164022,12:2653847:G:T,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,Timothy syndrome,NM_000719.7(CACNA1C):c.4087G>T (p.Val1363Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +981247,12:2581667:T:C,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,Intellectual disability,NM_000719.7(CACNA1C):c.1973T>C (p.Leu658Pro),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +978295,12:2512849:G:C,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,,NM_000719.7(CACNA1C):c.1255G>C (p.Gly419Arg),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +978276,12:2053592:TC:T,CACNA1C,disease_model_collision,conduction,conduction,Conduction disorder of the heart,NM_000719.7(CACNA1C):c.32del (p.Pro11fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,False,False,False,True,False,True,False,False,True,False,high_tension,3,True,False,False,True,False,False,True,9,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +973262,12:2457671:T:C,CACNA1C,disease_model_collision,Brugada,Brugada,Timothy syndrome;Brugada syndrome 3,NM_000719.7(CACNA1C):c.722T>C (p.Val241Ala),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,4,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +802809,12:2493386:G:A,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,Timothy syndrome,NM_000719.7(CACNA1C):c.1113G>A (p.Trp371Ter),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +633648,12:2665607:C:G,CACNA1C,disease_model_collision,LQTS,LQTS,Long QT syndrome 8,NM_000719.7(CACNA1C):c.4425C>G (p.Ile1475Met),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +633647,12:2567644:C:A,CACNA1C,disease_model_collision,LQTS,LQTS,Long QT syndrome 8,NM_000719.7(CACNA1C):c.1745C>A (p.Ala582Asp),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,True,False,high_tension,3,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +522828,12:2653847:G:C,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,CACNA1C-related disorder,NM_000719.7(CACNA1C):c.4087G>C (p.Val1363Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +521136,12:2566522:A:G,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,Timothy syndrome|Cardiovascular phenotype,NM_000719.7(CACNA1C):c.1609A>G (p.Asn537Asp),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,true,true,false,2023-01,2026-04 +450908,12:2605097:G:C,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,,NM_000719.7(CACNA1C):c.2977G>C (p.Val993Leu),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,VUS,P_LP,true,false,false,false,false,false,false,2023-01,2026-04 +450063,12:2653847:G:A,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,"Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures|CACNA1C-related disorder",NM_000719.7(CACNA1C):c.4087G>A (p.Val1363Met),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,true,false,false,false,2023-01,2026-04 +432248,12:2610700:G:GA,CACNA1C,disease_model_collision,Brugada,Brugada|LQTS,,NM_000719.7(CACNA1C):c.3717+1_3717+2insA,locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,True,False,True,False,False,False,True,multi_regime_required,5,True,False,False,True,False,False,True,10,genotype_first_postmortem|conditional_penetrance_dependent,2,genotype_first_postmortem,conditional_penetrance_dependent,False,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1802181,7:82084801:C:T,CACNA2D1,unanchored_assertion_state,Brugada,Brugada,Developmental and epileptic encephalopathy 110,NM_000722.4(CACNA2D1):c.626G>A (p.Gly209Asp),locus_or_regional_context,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 +1802179,7:82060485:T:TGTTC,CACNA2D1,unanchored_assertion_state,Brugada,Brugada,Developmental and epileptic encephalopathy 110,NM_000722.4(CACNA2D1):c.818_821dup (p.Ser275fs),representation_repairable,0.0,0.0,0.0,False,False,2.5e-05,,False,False,False,False,False,False,True,False,False,False,False,True,False,True,False,False,moderate_tension,2,False,False,False,True,False,False,True,7,conditional_penetrance_dependent,1,conditional_penetrance_dependent,conditional_penetrance_dependent,True,,P_LP,P_LP,false,false,false,false,false,false,false,2023-01,2026-04 diff --git a/data/processed/cab_failure_membership_explicit.csv b/data/processed/cab_failure_membership_explicit.csv index c17cc6c..8c87ccc 100644 --- a/data/processed/cab_failure_membership_explicit.csv +++ b/data/processed/cab_failure_membership_explicit.csv @@ -1,4 +1,1732 @@ assertion_id,variation_id,gene,condition_label_normalized,primary_regime,causal_architecture,clinical_inference_environment,failure_A_disease_model_transfer,failure_B_population_frequency,failure_C_phenotype_environment,failure_any_union,failure_class_count_per_assertion,failure_rule_source,failure_rule_notes -row_1,,,,,,,False,False,False,False,0,src/repair_cab_audit_package.py conservative field rules,Rules frozen in reports/qc/failure_rule_definitions.md -row_2,,,,,,,False,False,False,False,0,src/repair_cab_audit_package.py conservative field rules,Rules frozen in reports/qc/failure_rule_definitions.md -row_3,,,,,,,False,False,False,False,0,src/repair_cab_audit_package.py conservative field rules,Rules frozen in reports/qc/failure_rule_definitions.md +row_1,440850,SCN5A,,disease_model_collision,,SADS,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_2,1325231,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_3,4535537,KCNH2,,penetrance_boundary,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_4,3774534,CACNB2,,ancestry_concentrated,,Brugada,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_5,1074440,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_6,2565185,CASQ2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_7,1027323,KCNH2,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_8,2635811,TRDN,,disease_model_collision,,SADS,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_9,3076015,KCNH2,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_10,1766367,CASQ2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_11,1395670,KCNQ1,,disease_model_collision,,LQTS,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_12,2682850,TRDN,,disease_model_collision,,SADS,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_13,1427034,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_14,3075756,SCN5A,,disease_model_collision,,Brugada,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_15,1070395,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_16,427946,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_17,871731,KCNQ1,,disease_model_collision,,LQTS,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_18,2051520,TRDN,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_19,2632714,CACNA1C,,disease_model_collision,,Brugada,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_20,519365,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_21,1523438,CASQ2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_22,4756593,SCN5A,,disease_model_collision,,arrhythmia,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_23,862119,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_24,378906,KCNQ1,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_25,2744490,KCNQ1,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_26,4081881,ANK2,,disease_model_collision,,LQTS,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_27,801535,CASQ2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_28,1749169,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_29,1514023,HCN4,,ancestry_concentrated,,Brugada,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_30,373047,KCNH2,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_31,924057,SCN5A,,disease_model_collision,,arrhythmia,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_32,1455898,KCNQ1,,disease_model_collision,,LQTS,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_33,2452890,SCN5A,,disease_model_collision,,SADS,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_34,3673082,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_35,375594,KCNQ1,,ancestry_concentrated,,SQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_36,1454593,KCNH2,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_37,3023363,ANK2,,disease_model_collision,,LQTS,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_38,2980846,TRDN,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_39,3076018,KCNH2,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_40,3720989,KCNQ1,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_41,838068,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_42,4055971,CACNA1C,,disease_model_collision,,LQTS,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_43,440848,SCN5A,,disease_model_collision,,SADS,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_44,3381030,KCNH2,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_45,1171509,SCN5A,,disease_model_collision,,arrhythmia,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_46,2754396,SCN5A,,disease_model_collision,,SADS,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_47,1214434,SCN5A,,disease_model_collision,,SADS,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_48,1067403,KCNQ1,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_49,2830594,KCNQ1,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_50,852605,RYR2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_51,1757434,CASQ2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_52,1420193,KCNH2,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_53,633643,CACNA1C,,disease_model_collision,,LQTS,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_54,3906496,ANK2,,disease_model_collision,,LQTS,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_55,547162,KCNE1,,penetrance_boundary,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_56,859128,CASQ2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_57,666975,KCNQ1,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_58,4614938,SCN5A,,disease_model_collision,,SADS,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_59,972416,KCNH2,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_60,2914884,CASQ2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_61,1515619,CASQ2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_62,926958,KCNQ1,,ancestry_concentrated,,arrhythmia,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_63,2101362,ANK2,,disease_model_collision,,LQTS,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_64,3019374,CASQ2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_65,1076966,KCNH2,,penetrance_boundary,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_66,2664649,ANK2,,disease_model_collision,,LQTS,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_67,1457006,SCN5A,,disease_model_collision,,SADS,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_68,405260,KCNQ1,,disease_model_collision,,LQTS,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_69,418944,SCN5A,,disease_model_collision,,Brugada,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_70,651334,CASQ2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_71,4778592,CASQ2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_72,523778,SCN5A,,disease_model_collision,,Brugada,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_73,505275,SCN5A,,disease_model_collision,,Brugada,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_74,404118,HCN4,,ancestry_concentrated,,Brugada,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_75,3780742,TRDN,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_76,1403180,TRDN,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_77,496571,SCN5A,,disease_model_collision,,Brugada,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_78,2440963,KCNQ1,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_79,3255050,RYR2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_80,2440959,KCNQ1,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_81,2899907,KCNQ1,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_82,449691,TRDN,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_83,4278327,ANK2,,disease_model_collision,,arrhythmia,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_84,3359793,ANK2,,disease_model_collision,,LQTS,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_85,1075032,TRDN,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_86,503669,KCNH2,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_87,667015,SCN5A,,disease_model_collision,,Brugada,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_88,1480008,KCNJ2,,disease_model_collision,,SQTS,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_89,842027,KCNQ1,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_90,2576605,ANK2,,disease_model_collision,,arrhythmia,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_91,4813695,KCNH2,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_92,3000119,KCNQ1,,penetrance_boundary,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_93,942279,CASQ2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_94,583099,TRDN,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_95,517279,SCN5A,,disease_model_collision,,cardiomyopathy_overlap,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_96,4077704,TRDN,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_97,405265,KCNQ1,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_98,924596,SCN5A,,disease_model_collision,,Brugada,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_99,1367739,CASQ2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_100,403974,KCNJ2,,disease_model_collision,,SQTS,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_101,1805845,RYR2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_102,2732852,TRDN,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_103,418270,KCNE1,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_104,649240,RYR2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_105,817280,KCNQ1,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_106,3575248,CASQ2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_107,488729,SCN5A,,disease_model_collision,,arrhythmia,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_108,547164,KCNE1,,ancestry_concentrated,,LQTS,False,True,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_109,2773478,KCNQ1,,disease_model_collision,,LQTS,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_110,1477795,KCNJ2,,disease_model_collision,,SQTS,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_111,915308,TRDN,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_112,1675066,HCN4,,disease_model_collision,,cardiomyopathy_overlap,True,True,False,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_113,404190,RYR2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_114,1746831,CASQ2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_115,408869,CASQ2,,disease_model_collision,,CPVT,True,True,True,True,3,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_116,430060,KCNE1,,penetrance_boundary,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_117,1208780,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_118,857501,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_119,1068919,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_120,519280,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_121,1802180,CACNA2D1,,unknown_or_insufficient,,Brugada,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_122,2104041,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_123,1787905,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_124,1306529,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_125,3645049,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_126,864600,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_127,532312,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_128,1074305,KCNH2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_129,3592999,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_130,2861576,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_131,917819,KCNH2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_132,519537,KCNQ1,,penetrance_boundary,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_133,837649,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_134,4537402,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_135,3385945,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_136,2988469,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_137,656121,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_138,523933,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_139,3076027,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_140,449221,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_141,1332487,SCN5A,,disease_model_collision,,arrhythmia,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_142,858435,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_143,411734,CACNA1C,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_144,1327132,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_145,3629463,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_146,1677487,TRDN,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_147,2009452,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_148,570614,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_149,1342783,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_150,405341,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_151,418689,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_152,810745,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_153,503760,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_154,2428920,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_155,3862980,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_156,3076068,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_157,1457672,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_158,635221,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_159,405258,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_160,4727450,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_161,4528252,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_162,3720792,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_163,3644294,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_164,3376533,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_165,3076044,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_166,3076029,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_167,2584422,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_168,1382290,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_169,1070517,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_170,653333,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_171,638156,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_172,523705,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_173,418247,KCNH2,,canonical_monogenic,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_174,1254662,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_175,1334090,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_176,1455253,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_177,2202832,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_178,2914975,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_179,1425730,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_180,427947,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_181,654552,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_182,2626900,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_183,419715,KCNH2,,penetrance_boundary,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_184,463523,KCNJ2,,disease_model_collision,,SQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_185,571947,HCN4,,penetrance_boundary,,Brugada,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_186,406420,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_187,1033372,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_188,372376,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_189,2997913,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_190,372313,CACNA1C,,disease_model_collision,,cardiomyopathy_overlap,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_191,4757644,SCN5A,,disease_model_collision,,arrhythmia,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_192,1739478,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_193,3376789,SCN5A,,disease_model_collision,,conduction,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_194,2505148,SCN5A,,disease_model_collision,,cardiomyopathy_overlap,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_195,2801649,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_196,488772,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_197,463294,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_198,2844180,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_199,3384908,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_200,2499833,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_201,3337797,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_202,3340202,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_203,2773480,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_204,985692,ANK2,,disease_model_collision,,arrhythmia,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_205,4800056,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_206,3780743,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_207,2434223,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_208,3253477,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_209,927383,KCNH2,,canonical_monogenic,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_210,3236407,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_211,1743359,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_212,3544410,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_213,1072847,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_214,2506125,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_215,2811031,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_216,1208559,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_217,4614939,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_218,4723996,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_219,3485292,CASQ2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_220,2794330,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_221,2203336,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_222,2865838,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_223,3225249,TRDN,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_224,3338801,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_225,3367171,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_226,2734486,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_227,3720794,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_228,573008,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_229,3338732,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_230,519257,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_231,3338339,SCN5A,,disease_model_collision,,arrhythmia,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_232,3720290,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_233,519533,RYR2,,disease_model_collision,,cardiomyopathy_overlap,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_234,1784131,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_235,1527872,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_236,2574853,CASQ2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_237,2631072,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_238,4747274,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_239,1009997,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_240,4689790,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_241,1791538,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_242,3376712,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_243,1415094,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_244,809661,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_245,638351,KCNJ2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_246,970883,HCN4,,disease_model_collision,,cardiomyopathy_overlap,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_247,2735505,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_248,1504964,HCN4,,canonical_monogenic,,Brugada,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_249,1405357,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_250,519476,KCNJ2,,disease_model_collision,,SQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_251,2049671,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_252,1076382,KCNH2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_253,4614411,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_254,4531894,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_255,4081467,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_256,2904944,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_257,1489978,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_258,965523,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_259,933168,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_260,869440,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_261,663623,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_262,637975,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_263,488859,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_264,488698,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_265,444879,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_266,431053,KCNQ1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_267,375455,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_268,4730168,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_269,4725502,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_270,3895444,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_271,3730888,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_272,3720789,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_273,3720786,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_274,3544414,KCNH2,,canonical_monogenic,,cardiomyopathy_overlap,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_275,3338695,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_276,3254535,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_277,2831712,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_278,2136630,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_279,1968021,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_280,1810619,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_281,1792370,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_282,1728012,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_283,1466419,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_284,1197726,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_285,1171507,KCNH2,,canonical_monogenic,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_286,1066606,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_287,560686,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_288,373026,KCNH2,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_289,4756584,SCN5A,,disease_model_collision,,arrhythmia,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_290,3950971,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_291,3717482,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_292,3662749,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_293,3662441,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_294,2910169,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_295,1965471,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_296,1684121,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_297,1375303,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_298,979202,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_299,858096,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_300,547163,KCNE1,,canonical_monogenic,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_301,4746934,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_302,2828493,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_303,2737123,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_304,2203008,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_305,1804987,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_306,1678118,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_307,1480581,RYR2,,disease_model_collision,,cardiomyopathy_overlap,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_308,1439521,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_309,1328938,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_310,1035886,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_311,1021015,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_312,869430,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_313,656670,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_314,581079,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_315,572162,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_316,463600,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_317,404183,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_318,2754358,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_319,2505552,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_320,1457736,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_321,3894738,TRDN,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_322,3717909,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_323,2762883,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_324,2434224,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_325,1799347,TRDN,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_326,1517713,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_327,1467722,CALM2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_328,3721367,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_329,2446019,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_330,3899523,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_331,3601972,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_332,3233417,CACNA1C,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_333,1707563,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_334,1218634,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_335,4811016,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_336,4750132,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_337,4732891,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_338,4719475,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_339,4714005,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_340,4709530,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_341,4688928,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_342,4278376,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_343,4090692,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_344,4084700,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_345,4084699,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_346,4076475,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_347,4070996,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_348,3901502,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_349,3898708,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_350,3895224,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_351,3895223,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_352,3894930,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_353,3894017,KCNQ1,,unanchored_assertion_state,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_354,3893245,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_355,3893242,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_356,3862988,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_357,3774956,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_358,3769591,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_359,3726879,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_360,3719869,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_361,3693769,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_362,3669101,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_363,3660922,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_364,3659274,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_365,3659247,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_366,3648787,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_367,3641656,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_368,3603667,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_369,3601179,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_370,3392793,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_371,3383201,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_372,3383071,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_373,3382790,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_374,3376696,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_375,3376665,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_376,3376650,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_377,3338779,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_378,3338330,KCNQ1,,unanchored_assertion_state,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_379,3337204,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_380,3335922,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_381,3235934,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_382,3235891,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_383,3075923,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_384,2982293,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_385,2971269,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_386,2837284,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_387,2836375,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_388,2828480,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_389,2814371,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_390,2811762,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_391,2807267,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_392,2773484,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_393,2773474,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_394,2770494,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_395,2748943,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_396,2747611,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_397,2725492,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_398,2724418,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_399,2723186,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_400,2719407,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_401,2708573,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_402,2692770,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_403,2587406,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_404,2587403,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_405,2577445,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_406,2575074,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_407,2575071,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_408,2575070,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_409,2575068,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_410,2575067,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_411,2575066,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_412,2575065,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_413,2575064,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_414,2575063,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_415,2574107,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_416,2574106,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_417,2574013,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_418,2574002,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_419,2567545,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_420,2502702,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_421,2502315,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_422,2498480,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_423,2453279,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_424,2446426,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_425,2136962,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_426,2136957,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_427,2130527,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_428,2129901,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_429,2129108,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_430,2102490,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_431,2035007,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_432,2028871,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_433,2023188,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_434,2017757,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_435,2017498,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_436,2004187,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_437,2000331,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_438,1879152,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_439,1802109,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_440,1786030,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_441,1778018,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_442,1771701,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_443,1769838,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_444,1723453,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_445,1711271,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_446,1709048,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_447,1708065,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_448,1522663,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_449,1500718,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_450,1500707,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_451,1493047,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_452,1488375,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_453,1457098,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_454,1454915,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_455,1454509,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_456,1454382,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_457,1452627,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_458,1451451,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_459,1449449,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_460,1445000,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_461,1439097,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_462,1438413,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_463,1437397,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_464,1426804,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_465,1416082,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_466,1414164,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_467,1411474,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_468,1384067,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_469,1350731,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_470,1343361,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_471,1342782,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_472,1342708,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_473,1331817,KCNQ1,,unanchored_assertion_state,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_474,1212402,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_475,1185948,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_476,1179766,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_477,1171410,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_478,1076090,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_479,1075209,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_480,1074347,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_481,1072801,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_482,1069232,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_483,1067022,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_484,1066272,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_485,1056776,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_486,1038475,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_487,1037124,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_488,1018501,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_489,1004846,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_490,992394,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_491,983505,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_492,983047,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_493,983022,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_494,977320,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_495,977170,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_496,966649,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_497,960695,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_498,956049,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_499,939724,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_500,930315,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_501,926196,KCNQ1,,unanchored_assertion_state,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_502,925351,KCNQ1,,unanchored_assertion_state,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_503,922607,KCNQ1,,unanchored_assertion_state,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_504,919956,KCNQ1,,unanchored_assertion_state,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_505,869436,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_506,869435,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_507,869434,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_508,869433,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_509,861314,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_510,855976,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_511,844409,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_512,842276,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_513,817323,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_514,817016,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_515,812675,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_516,684802,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_517,684787,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_518,667007,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_519,665471,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_520,660595,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_521,651458,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_522,641597,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_523,620198,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_524,620103,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_525,587644,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_526,582668,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_527,581345,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_528,581004,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_529,576205,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_530,573523,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_531,570590,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_532,570319,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_533,560649,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_534,560359,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_535,526930,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_536,523769,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_537,522585,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_538,519369,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_539,519357,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_540,517664,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_541,496690,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_542,489011,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_543,456869,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_544,449302,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_545,449283,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_546,448975,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_547,438610,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_548,432149,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_549,431370,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_550,430941,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_551,421737,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_552,420658,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_553,420529,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_554,419579,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_555,405268,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_556,405264,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_557,405263,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_558,405262,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_559,405261,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_560,405255,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_561,405254,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_562,405253,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_563,379504,KCNQ1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_564,372568,KCNQ1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_565,4804554,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_566,4763986,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_567,4758983,KCNH2,,unanchored_assertion_state,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_568,4758579,KCNH2,,unanchored_assertion_state,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_569,4757905,KCNH2,,unanchored_assertion_state,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_570,4733133,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_571,4728357,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_572,4727073,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_573,4726900,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_574,4724072,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_575,4722731,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_576,4721201,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_577,4720344,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_578,4720342,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_579,4719590,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_580,4715748,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_581,4715444,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_582,4714508,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_583,4710895,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_584,4710749,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_585,4709557,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_586,4709556,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_587,4686179,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_588,4681926,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_589,4614356,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_590,4614351,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_591,4614346,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_592,4614344,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_593,4529668,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_594,4281328,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_595,4280330,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_596,4090314,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_597,4074744,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_598,4074721,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_599,4071954,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_600,3911914,KCNH2,,unanchored_assertion_state,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_601,3911046,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_602,3900638,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_603,3895127,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_604,3895051,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_605,3895040,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_606,3894984,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_607,3894466,KCNH2,,unanchored_assertion_state,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_608,3893973,KCNH2,,unanchored_assertion_state,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_609,3862757,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_610,3775096,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_611,3773804,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_612,3764662,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_613,3728256,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_614,3724054,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_615,3721525,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_616,3720793,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_617,3720791,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_618,3720787,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_619,3712259,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_620,3657287,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_621,3655448,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_622,3651645,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_623,3651113,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_624,3602222,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_625,3544416,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_626,3386898,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_627,3383250,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_628,3382540,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_629,3376960,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_630,3376939,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_631,3370336,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_632,3341931,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_633,3338328,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_634,3255227,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_635,3254651,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_636,3254536,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_637,3252026,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_638,3236854,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_639,3230731,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_640,3230730,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_641,3230725,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_642,3076042,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_643,3076025,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_644,3075307,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_645,3074111,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_646,3068475,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_647,3066169,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_648,3064233,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_649,2918473,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_650,2906537,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_651,2880265,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_652,2858211,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_653,2832789,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_654,2821739,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_655,2814358,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_656,2813131,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_657,2790199,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_658,2773436,KCNH2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_659,2773424,KCNH2,,unanchored_assertion_state,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_660,2772506,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_661,2770983,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_662,2763043,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_663,2760013,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_664,2758800,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_665,2758297,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_666,2754986,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_667,2753718,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_668,2748964,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_669,2748626,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_670,2746100,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_671,2745936,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_672,2744101,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_673,2735100,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_674,2735098,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_675,2735096,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_676,2727880,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_677,2725070,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_678,2698764,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_679,2694065,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_680,2687478,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_681,2665002,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_682,2664629,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_683,2637626,KCNH2,,unanchored_assertion_state,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_684,2579645,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_685,2575020,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_686,2574032,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_687,2571299,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_688,2567296,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_689,2452993,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_690,2442075,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_691,2429379,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_692,2227986,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_693,2136626,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_694,2136623,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_695,2133333,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_696,2130516,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_697,2128179,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_698,2125899,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_699,2121024,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_700,2120904,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_701,2095758,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_702,2088283,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_703,2085464,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_704,2078663,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_705,2071298,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_706,2062924,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_707,2055725,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_708,2042701,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_709,2033107,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_710,2032030,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_711,2023450,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_712,2016168,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_713,2012895,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_714,2002742,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_715,1994302,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_716,1994292,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_717,1968946,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_718,1805233,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_719,1804945,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_720,1799488,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_721,1797445,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_722,1797337,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_723,1795706,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_724,1795334,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_725,1795320,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_726,1795256,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_727,1794263,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_728,1793177,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_729,1790360,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_730,1789092,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_731,1786650,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_732,1785054,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_733,1783287,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_734,1779222,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_735,1777473,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_736,1771379,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_737,1766052,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_738,1765131,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_739,1764714,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_740,1762927,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_741,1758500,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_742,1748411,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_743,1742104,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_744,1742024,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_745,1736686,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_746,1727478,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_747,1713142,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_748,1711664,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_749,1711663,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_750,1701539,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_751,1698966,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_752,1683771,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_753,1683770,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_754,1676088,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_755,1675096,KCNH2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_756,1527874,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_757,1527873,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_758,1524546,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_759,1521307,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_760,1499958,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_761,1488212,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_762,1473108,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_763,1467197,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_764,1458718,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_765,1458716,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_766,1457690,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_767,1456278,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_768,1456173,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_769,1455507,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_770,1455493,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_771,1453664,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_772,1452777,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_773,1452601,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_774,1452025,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_775,1439179,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_776,1434518,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_777,1424837,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_778,1422891,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_779,1414553,KCNH2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_780,1410227,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_781,1406991,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_782,1398420,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_783,1397577,KCNH2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_784,1338861,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_785,1335697,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_786,1334904,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_787,1331098,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_788,1323136,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_789,1284270,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_790,1219815,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_791,1215035,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_792,1213540,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_793,1211558,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_794,1202184,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_795,1201653,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_796,1191999,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_797,1189275,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_798,1178326,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_799,1163877,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_800,1098796,KCNH2,,unanchored_assertion_state,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_801,1076538,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_802,1076264,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_803,1074304,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_804,1073738,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_805,1072804,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_806,1072580,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_807,1072040,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_808,1070567,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_809,1070541,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_810,1070208,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_811,1069329,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_812,1069284,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_813,1068978,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_814,1066309,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_815,1064627,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_816,1064605,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_817,1058879,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_818,1001814,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_819,992792,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_820,983076,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_821,979201,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_822,977169,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_823,977166,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_824,972695,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_825,972694,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_826,968402,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_827,960485,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_828,958799,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_829,956361,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_830,955885,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_831,949692,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_832,947666,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_833,943648,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_834,943351,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_835,943187,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_836,941189,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_837,939419,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_838,937320,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_839,937182,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_840,936138,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_841,934348,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_842,928528,KCNH2,,unanchored_assertion_state,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_843,871784,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_844,869439,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_845,869431,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_846,863419,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_847,858246,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_848,853484,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_849,851169,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_850,850821,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_851,846538,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_852,835590,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_853,818076,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_854,817961,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_855,817602,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_856,811073,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_857,695023,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_858,692260,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_859,692259,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_860,692257,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_861,667408,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_862,663923,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_863,663471,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_864,660047,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_865,657779,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_866,652241,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_867,648088,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_868,645394,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_869,641517,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_870,640022,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_871,637977,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_872,632866,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_873,620172,KCNH2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_874,620154,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_875,618184,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_876,598783,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_877,582292,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_878,581669,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_879,579489,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_880,572344,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_881,570715,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_882,570494,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_883,568003,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_884,565724,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_885,560696,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_886,545950,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_887,526969,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_888,526968,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_889,526939,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_890,526932,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_891,526925,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_892,526908,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_893,524038,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_894,523953,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_895,523712,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_896,523697,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_897,520423,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_898,519551,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_899,519524,KCNH2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_900,519509,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_901,519501,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_902,519473,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_903,519399,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_904,519378,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_905,519348,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_906,519330,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_907,519329,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_908,519327,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_909,519255,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_910,519237,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_911,519234,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_912,519217,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_913,519204,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_914,503778,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_915,503735,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_916,503674,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_917,503672,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_918,503659,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_919,495746,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_920,489342,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_921,488895,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_922,488692,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_923,456935,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_924,456921,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_925,456919,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_926,456918,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_927,456904,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_928,456903,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_929,456902,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_930,456901,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_931,456886,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_932,456876,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_933,446417,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_934,439845,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_935,431374,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_936,431036,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_937,430730,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_938,427945,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_939,427944,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_940,427076,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_941,426429,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_942,423753,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_943,423696,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_944,423015,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_945,421672,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_946,420923,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_947,420585,KCNH2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_948,420260,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_949,419410,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_950,419379,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_951,419311,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_952,418919,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_953,418815,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_954,418787,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_955,418670,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_956,418597,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_957,405358,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_958,405355,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_959,405345,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_960,405342,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_961,392690,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_962,392341,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_963,391858,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_964,387850,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_965,379451,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_966,379293,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_967,372942,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_968,372589,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_969,372571,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_970,372378,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_971,372377,KCNH2,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_972,4814196,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_973,4814157,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_974,4814013,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_975,4757059,SCN5A,,disease_model_collision,,arrhythmia,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_976,4733790,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_977,4731428,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_978,4730817,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_979,4727300,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_980,4723344,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_981,4722126,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_982,4721301,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_983,4720439,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_984,4717480,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_985,4716661,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_986,4716468,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_987,4714862,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_988,4712144,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_989,4681217,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_990,4614942,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_991,4614940,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_992,4614936,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_993,4537605,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_994,4536358,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_995,4531893,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_996,4530664,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_997,4526988,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_998,4160653,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_999,4160651,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1000,4084973,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1001,4082128,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1002,4071999,SCN5A,,disease_model_collision,,conduction,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1003,3898691,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1004,3895188,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1005,3894898,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1006,3894008,SCN5A,,disease_model_collision,,arrhythmia,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1007,3893711,SCN5A,,disease_model_collision,,arrhythmia,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1008,3793221,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1009,3793218,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1010,3778738,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1011,3773853,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1012,3772281,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1013,3766453,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1014,3730868,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1015,3729291,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1016,3727847,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1017,3723601,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1018,3723452,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1019,3722844,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1020,3722003,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1021,3721680,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1022,3720482,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1023,3699241,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1024,3668098,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1025,3663041,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1026,3662552,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1027,3661184,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1028,3660495,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1029,3653975,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1030,3649069,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1031,3645763,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1032,3644710,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1033,3642736,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1034,3639026,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1035,3633347,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1036,3600631,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1037,3544406,SCN5A,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1038,3438263,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1039,3385944,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1040,3385918,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1041,3383167,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1042,3381870,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1043,3376929,SCN5A,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1044,3367173,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1045,3345326,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1046,3337556,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1047,3337555,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1048,3337551,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1049,3316598,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1050,3316597,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1051,3316593,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1052,3252620,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1053,3252218,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1054,3251141,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1055,3251122,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1056,3248566,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1057,3238947,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1058,3236392,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1059,3229479,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1060,3076028,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1061,3075937,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1062,3075757,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1063,3075755,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1064,3075752,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1065,3074416,SCN5A,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1066,3073663,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1067,3073053,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1068,3071701,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1069,3067128,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1070,3062283,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1071,3027437,SCN5A,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1072,3024479,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1073,3001404,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1074,2910170,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1075,2862415,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1076,2861983,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1077,2850091,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1078,2846167,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1079,2834047,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1080,2831276,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1081,2829409,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1082,2820677,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1083,2818735,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1084,2817837,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1085,2798618,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1086,2774482,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1087,2774480,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1088,2774462,SCN5A,,disease_model_collision,,arrhythmia,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1089,2774456,SCN5A,,disease_model_collision,,arrhythmia,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1090,2774447,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1091,2767841,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1092,2767035,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1093,2764562,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1094,2764009,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1095,2754673,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1096,2750658,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1097,2749678,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1098,2739542,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1099,2733575,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1100,2728351,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1101,2719420,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1102,2713386,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1103,2708294,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1104,2705691,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1105,2587163,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1106,2582527,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1107,2574114,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1108,2574113,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1109,2567176,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1110,2567171,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1111,2567167,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1112,2506126,SCN5A,,disease_model_collision,,arrhythmia,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1113,2505150,SCN5A,,disease_model_collision,,cardiomyopathy_overlap,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1114,2498925,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1115,2444515,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1116,2203341,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1117,2203340,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1118,2203339,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1119,2203338,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1120,2203337,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1121,2203335,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1122,2126186,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1123,2124520,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1124,2114785,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1125,2113775,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1126,2107269,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1127,2107170,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1128,2106626,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1129,2100770,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1130,2094285,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1131,2088946,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1132,2069900,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1133,2057896,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1134,2039747,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1135,2036709,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1136,2031437,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1137,2027600,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1138,2027105,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1139,2026498,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1140,2016715,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1141,2016359,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1142,2011754,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1143,1937049,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1144,1803812,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1145,1798592,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1146,1795999,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1147,1792542,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1148,1788496,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1149,1777850,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1150,1773144,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1151,1767167,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1152,1755450,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1153,1737836,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1154,1733997,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1155,1730458,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1156,1729777,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1157,1691761,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1158,1691220,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1159,1678156,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1160,1678123,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1161,1527869,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1162,1521971,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1163,1510225,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1164,1502792,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1165,1502060,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1166,1460043,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1167,1458577,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1168,1458575,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1169,1455926,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1170,1455755,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1171,1455694,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1172,1454071,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1173,1452285,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1174,1451878,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1175,1449654,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1176,1434817,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1177,1408176,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1178,1406093,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1179,1392890,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1180,1386100,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1181,1374462,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1182,1361908,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1183,1348900,SCN5A,,disease_model_collision,,conduction,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1184,1345786,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1185,1326912,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1186,1326908,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1187,1326907,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1188,1299249,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1189,1285130,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1190,1188516,SCN5A,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1191,1187556,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1192,1185878,SCN5A,,disease_model_collision,,arrhythmia,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1193,1184975,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1194,1076640,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1195,1076635,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1196,1076515,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1197,1076513,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1198,1075437,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1199,1073809,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1200,1073629,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1201,1072446,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1202,1071777,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1203,1069115,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1204,1068181,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1205,1067586,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1206,1066010,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1207,1012143,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1208,988404,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1209,987436,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1210,984516,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1211,984492,SCN5A,,disease_model_collision,,arrhythmia,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1212,979203,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1213,979075,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1214,978725,SCN5A,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1215,972696,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1216,972691,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1217,970218,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1218,961103,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1219,956404,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1220,952177,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1221,944678,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1222,942054,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1223,940929,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1224,937538,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1225,936474,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1226,928434,SCN5A,,disease_model_collision,,arrhythmia,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1227,927104,SCN5A,,disease_model_collision,,arrhythmia,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1228,927012,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1229,917995,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1230,863801,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1231,858385,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1232,856890,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1233,853346,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1234,851951,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1235,851217,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1236,850294,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1237,848941,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1238,848007,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1239,847226,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1240,845474,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1241,844438,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1242,830371,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1243,817608,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1244,811838,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1245,801959,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1246,691966,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1247,691705,SCN5A,,disease_model_collision,,arrhythmia,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1248,689494,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1249,667016,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1250,660776,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1251,654856,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1252,641344,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1253,637991,SCN5A,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1254,637989,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1255,633410,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1256,632980,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1257,598785,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1258,598784,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1259,583354,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1260,582177,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1261,581866,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1262,579734,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1263,572957,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1264,572252,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1265,572011,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1266,571408,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1267,560692,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1268,523568,SCN5A,,disease_model_collision,,conduction,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1269,520461,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1270,519554,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1271,519464,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1272,519460,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1273,519429,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1274,519384,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1275,505895,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1276,505834,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1277,496573,SCN5A,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1278,463332,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1279,463318,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1280,463308,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1281,463292,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1282,452184,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1283,448976,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1284,446418,SCN5A,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1285,432733,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1286,432148,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1287,431948,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1288,429979,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1289,426612,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1290,426254,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1291,423108,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1292,422443,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1293,421358,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1294,420342,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1295,419109,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1296,406440,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1297,406435,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1298,406434,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1299,406427,SCN5A,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1300,406426,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1301,406419,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1302,406418,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1303,406415,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1304,406396,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1305,403732,SCN5A,,disease_model_collision,,cardiomyopathy_overlap,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1306,392337,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1307,389150,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1308,374130,SCN5A,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1309,4724223,KCNE1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1310,3601178,KCNE1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1311,1415503,KCNE1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1312,1343372,KCNE1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1313,1065921,KCNE1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1314,812588,KCNE1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1315,620398,KCNE1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1316,527017,KCNE1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1317,441101,KCNE1,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1318,4814200,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1319,4800130,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1320,4800118,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1321,4800115,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1322,4800104,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1323,4800083,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1324,4697937,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1325,4614849,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1326,4542511,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1327,4537880,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1328,4531406,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1329,4291726,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1330,4071994,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1331,3949071,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1332,3901845,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1333,3895065,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1334,3894941,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1335,3894655,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1336,3776659,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1337,3766443,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1338,3633845,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1339,3633837,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1340,3633806,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1341,3572967,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1342,3544417,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1343,3544409,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1344,3391121,RYR2,,unanchored_assertion_state,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1345,3383138,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1346,3382069,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1347,3338338,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1348,3337537,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1349,3065287,RYR2,,unanchored_assertion_state,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1350,2920176,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1351,2883988,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1352,2865610,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1353,2840453,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1354,2806184,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1355,2758112,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1356,2747580,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1357,2734117,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1358,2727021,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1359,2719667,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1360,2707246,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1361,2587823,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1362,2575972,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1363,2500749,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1364,2441802,RYR2,,disease_model_collision,,cardiomyopathy_overlap,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1365,2435632,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1366,2433112,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1367,2203006,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1368,2169498,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1369,2151921,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1370,2125455,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1371,2120716,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1372,2105630,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1373,2101383,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1374,2075220,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1375,2018903,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1376,1997174,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1377,1932217,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1378,1805497,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1379,1805396,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1380,1773663,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1381,1745086,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1382,1710227,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1383,1693182,RYR2,,unanchored_assertion_state,,cardiomyopathy_overlap,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1384,1527876,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1385,1527868,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1386,1524904,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1387,1499030,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1388,1496297,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1389,1480185,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1390,1479669,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1391,1474443,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1392,1472640,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1393,1467901,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1394,1451617,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1395,1441921,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1396,1441891,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1397,1410932,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1398,1384586,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1399,1383749,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1400,1363823,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1401,1346560,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1402,1342890,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1403,1330215,RYR2,,disease_model_collision,,cardiomyopathy_overlap,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1404,1213111,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1405,1119951,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1406,1119950,RYR2,,unanchored_assertion_state,,arrhythmia,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1407,1072928,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1408,1072597,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1409,1070571,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1410,1069130,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1411,1067931,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1412,1067138,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1413,1066599,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1414,1051501,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1415,1013805,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1416,1007679,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1417,982634,RYR2,,unanchored_assertion_state,,cardiomyopathy_overlap,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1418,979205,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1419,979204,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1420,978366,RYR2,,unanchored_assertion_state,,conduction,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1421,957942,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1422,954202,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1423,947851,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1424,947702,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1425,940323,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1426,933804,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1427,931781,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1428,915531,RYR2,,unanchored_assertion_state,,cardiomyopathy_overlap,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1429,870975,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1430,869428,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1431,861770,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1432,840374,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1433,692253,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1434,665174,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1435,656745,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1436,654791,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1437,654125,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1438,651491,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1439,649923,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1440,644207,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1441,637985,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1442,580536,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1443,578246,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1444,575682,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1445,575059,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1446,571532,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1447,570194,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1448,568135,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1449,566084,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1450,560709,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1451,532366,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1452,532324,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1453,520467,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1454,519356,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1455,463624,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1456,463608,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1457,463605,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1458,463579,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1459,463577,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1460,463549,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1461,452065,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1462,450836,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1463,449306,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1464,427948,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1465,427184,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1466,427164,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1467,423597,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1468,420865,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1469,418465,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1470,404218,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1471,404208,RYR2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1472,372588,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1473,372582,RYR2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1474,4798117,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1475,4281696,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1476,4219483,CASQ2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1477,3722584,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1478,3722580,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1479,3688556,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1480,3676998,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1481,3638681,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1482,3623127,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1483,3575736,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1484,3575685,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1485,3575384,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1486,3338342,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1487,3263466,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1488,2822271,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1489,2806492,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1490,2770074,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1491,2744443,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1492,2717451,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1493,2704628,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1494,2506578,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1495,2438853,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1496,2089290,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1497,1793918,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1498,1324014,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1499,452250,CASQ2,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1500,4782180,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1501,4714700,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1502,4712099,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1503,4077705,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1504,3721374,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1505,3669900,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1506,3593000,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1507,2920531,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1508,2818604,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1509,2730579,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1510,2634568,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1511,2018973,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1512,1798674,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1513,1797791,TRDN,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1514,1746830,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1515,1708485,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1516,1458047,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1517,463677,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1518,408740,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1519,408737,TRDN,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1520,4787824,CALM1,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1521,4785412,CALM1,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1522,3338336,CALM1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1523,2100843,CALM1,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1524,1362982,CALM1,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1525,974613,CALM1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1526,974612,CALM1,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1527,961658,CALM1,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1528,948239,CALM1,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1529,639902,CALM1,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1530,542137,CALM1,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1531,426161,CALM1,,disease_model_collision,,CPVT,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1532,418107,CALM1,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1533,388500,CALM1,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1534,384090,CALM1,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1535,2734184,CALM2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1536,2500174,CALM2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1537,1456260,CALM2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1538,1398892,CALM2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1539,1327459,CALM2,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1540,1067140,CALM2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1541,955533,CALM2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1542,812710,CALM2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1543,641544,CALM2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1544,576319,CALM2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1545,488476,CALM2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1546,448971,CALM2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1547,2138308,CALM3,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1548,1358003,CALM3,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1549,812678,CALM3,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1550,812676,CALM3,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1551,458198,CALM3,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1552,409871,CALM3,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1553,409870,CALM3,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1554,389576,CALM3,,disease_model_collision,,SADS,True,False,True,True,2,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1555,4796659,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1556,4732021,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1557,4725226,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1558,4721538,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1559,4708265,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1560,4683080,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1561,4613600,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1562,4613598,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1563,4531921,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1564,4293673,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1565,4292238,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1566,4097147,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1567,4097146,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1568,4088107,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1569,4075802,ANK2,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1570,4075490,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1571,4071961,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1572,4071958,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1573,4051668,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1574,3898990,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1575,3897593,ANK2,,disease_model_collision,,arrhythmia,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1576,3772520,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1577,3729667,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1578,3654249,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1579,3632705,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1580,3540989,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1581,3540979,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1582,3390615,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1583,3383192,ANK2,,disease_model_collision,,arrhythmia,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1584,3377103,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1585,3376714,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1586,3376713,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1587,3376711,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1588,3365181,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1589,3344952,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1590,3340753,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1591,3338731,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1592,3337796,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1593,3119609,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1594,3068471,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1595,3030812,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1596,2861152,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1597,2672177,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1598,2576797,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1599,2575852,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1600,2565317,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1601,2544521,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1602,2506786,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1603,2499788,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1604,2430081,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1605,2228433,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1606,2121821,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1607,2029441,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1608,1729746,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1609,1695772,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1610,1678114,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1611,1678112,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1612,1483377,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1613,1334346,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1614,1317290,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1615,985758,ANK2,,disease_model_collision,,arrhythmia,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1616,985336,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1617,985206,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1618,954568,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1619,818077,ANK2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1620,4788797,KCNJ2,,disease_model_collision,,SQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1621,4784294,KCNJ2,,disease_model_collision,,SQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1622,4783746,KCNJ2,,disease_model_collision,,SQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1623,3755832,KCNJ2,,disease_model_collision,,SQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1624,3220886,KCNJ2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1625,2682647,KCNJ2,,disease_model_collision,,SQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1626,2036326,KCNJ2,,disease_model_collision,,SQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1627,2020840,KCNJ2,,disease_model_collision,,SQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1628,1739158,KCNJ2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1629,1496231,KCNJ2,,disease_model_collision,,SQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1630,995608,KCNJ2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1631,981438,KCNJ2,,disease_model_collision,,SQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1632,960380,KCNJ2,,disease_model_collision,,SQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1633,946743,KCNJ2,,disease_model_collision,,SQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1634,858285,KCNJ2,,disease_model_collision,,SQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1635,801410,KCNJ2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1636,689769,KCNJ2,,disease_model_collision,,SQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1637,652820,KCNJ2,,disease_model_collision,,SQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1638,569363,KCNJ2,,disease_model_collision,,SQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1639,546134,KCNJ2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1640,523694,KCNJ2,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1641,430545,KCNJ2,,disease_model_collision,,SQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1642,429589,KCNJ2,,disease_model_collision,,SQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1643,4755562,HCN4,,unanchored_assertion_state,,conduction,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1644,2636206,HCN4,,disease_model_collision,,arrhythmia,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1645,2028837,HCN4,,unanchored_assertion_state,,Brugada,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1646,1697968,HCN4,,unanchored_assertion_state,,cardiomyopathy_overlap,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1647,1675065,HCN4,,unanchored_assertion_state,,cardiomyopathy_overlap,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1648,1359536,HCN4,,unanchored_assertion_state,,Brugada,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1649,666148,HCN4,,unanchored_assertion_state,,Brugada,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1650,470654,HCN4,,unanchored_assertion_state,,Brugada,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1651,374861,HCN4,,unanchored_assertion_state,,conduction,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1652,374860,HCN4,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1653,374859,HCN4,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1654,374858,HCN4,,unanchored_assertion_state,,conduction,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1655,4689845,CACNA1C,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1656,4613766,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1657,4536255,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1658,4531394,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1659,4531392,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1660,4530641,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1661,4292479,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1662,4278773,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1663,4086502,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1664,3897582,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1665,3894932,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1666,3775665,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1667,3718454,CACNA1C,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1668,3600410,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1669,3573697,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1670,3483968,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1671,3483966,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1672,3393691,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1673,3392514,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1674,3382973,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1675,3382740,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1676,3377227,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1677,3375805,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1678,3370332,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1679,3252305,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1680,3069192,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1681,3066281,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1682,3027509,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1683,2921274,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1684,2626971,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1685,2626927,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1686,2584438,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1687,2578446,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1688,2577479,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1689,2575833,CACNA1C,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1690,2506866,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1691,2504611,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1692,2504609,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1693,2501348,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1694,2452672,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1695,2251969,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1696,1803055,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1697,1744618,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1698,1712194,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1699,1705745,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1700,1705744,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1701,1700075,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1702,1699326,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1703,1699036,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1704,1695801,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1705,1685597,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1706,1685596,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1707,1344837,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1708,1325838,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1709,1313855,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1710,1309258,CACNA1C,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1711,1303511,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1712,1302971,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1713,1302480,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1714,1214422,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1715,1164022,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1716,981247,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1717,978295,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1718,978276,CACNA1C,,disease_model_collision,,conduction,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1719,973262,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1720,802809,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1721,633648,CACNA1C,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1722,633647,CACNA1C,,disease_model_collision,,LQTS,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1723,522828,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1724,521136,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1725,450908,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1726,450063,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1727,432248,CACNA1C,,disease_model_collision,,Brugada,True,False,False,True,1,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1728,4277370,CACNA2D1,,unanchored_assertion_state,,Brugada,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1729,1802181,CACNA2D1,,unanchored_assertion_state,,Brugada,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1730,1802179,CACNA2D1,,unanchored_assertion_state,,Brugada,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. +row_1731,4687971,AKAP9,,unanchored_assertion_state,,LQTS,False,False,False,False,0,src/31_rebuild_failure_membership_from_available_tables.py conservative field rules,Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied. diff --git a/data/processed/cab_patch_clamp_functional_overlay.csv b/data/processed/cab_patch_clamp_functional_overlay.csv new file mode 100644 index 0000000..8b13789 --- /dev/null +++ b/data/processed/cab_patch_clamp_functional_overlay.csv @@ -0,0 +1 @@ + diff --git a/data/processed/patch_clamp_source_inventory.csv b/data/processed/patch_clamp_source_inventory.csv new file mode 100644 index 0000000..99a5b0c --- /dev/null +++ b/data/processed/patch_clamp_source_inventory.csv @@ -0,0 +1,2 @@ +status,reason,genes_prioritized +manual_download_required,Patch-clamp supplementary tables require source-by-source license/manual review; no copyrighted full-text scraping is performed.,KCNQ1|KCNH2|SCN5A|RYR2|CACNA1C|KCNE1|CASQ2 diff --git a/data/processed/patch_clamp_variant_scores_normalized.csv b/data/processed/patch_clamp_variant_scores_normalized.csv new file mode 100644 index 0000000..8b13789 --- /dev/null +++ b/data/processed/patch_clamp_variant_scores_normalized.csv @@ -0,0 +1 @@ + diff --git a/reports/failures/temporal_alignment_failures.csv b/reports/failures/temporal_alignment_failures.csv new file mode 100644 index 0000000..2b71ea6 --- /dev/null +++ b/reports/failures/temporal_alignment_failures.csv @@ -0,0 +1,790 @@ +variation_id,reason +440850,missing_baseline +4535537,missing_baseline +3774534,missing_baseline +2565185,missing_baseline +2635811,missing_baseline +3076015,missing_baseline +2682850,missing_baseline +3075756,missing_baseline +2051520,missing_baseline +2632714,missing_baseline +4756593,missing_baseline +2744490,missing_baseline +4081881,missing_baseline +2452890,missing_baseline +3673082,missing_baseline +3023363,missing_baseline 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+2626927,missing_baseline +2584438,missing_baseline +2578446,missing_baseline +2577479,missing_baseline +2575833,missing_baseline +2506866,missing_baseline +2504611,missing_baseline +2504609,missing_baseline +2501348,missing_baseline +2452672,missing_baseline +2251969,missing_baseline +4277370,missing_baseline +4687971,missing_baseline diff --git a/reports/final_external_rebuild_audit_report.md b/reports/final_external_rebuild_audit_report.md new file mode 100644 index 0000000..f77c2f3 --- /dev/null +++ b/reports/final_external_rebuild_audit_report.md @@ -0,0 +1,3 @@ +# CAB external rebuild audit report + +Claims remain publication-safe only where raw downloads, checksums, parsed overlays, and recomputed tables exist. Deprecated claims are not restored by default. diff --git a/reports/qc/external_resource_discovery_report.md b/reports/qc/external_resource_discovery_report.md new file mode 100644 index 0000000..60cb6df --- /dev/null +++ b/reports/qc/external_resource_discovery_report.md @@ -0,0 +1,16 @@ +# External resource discovery report + +Status: scaffolded for local external rebuild. + +This runtime cannot resolve external domains, so resources were not downloaded here. The provided scripts download and checksum resources locally. + +Official/public discovery anchors: + +- ClinVar FTP primer: variant_summary is a tab-delimited file released monthly; complete ClinVar XML files are posted monthly, and VCV XML is recommended for all data for a variant. +- ClinGen downloads page: Gene-Disease Validity download files are available as CSV and are built in real time. +- ClinGen VCI/ERepo documentation: approved VCEP interpretations are disseminated through the Evidence Repository and ClinVar. +- gnomAD downloads page: use v4.1.1/latest v4 documentation and local/BigQuery/API-backed extraction. +- MaveDB API: public data can be searched and score tables downloaded without authentication; base URL is https://api.mavedb.org/api/v1/. +- GA4GH VRS: optional normalization/variant identity layer. + +No external-resource claim is rebuilt until `data/raw/external_manifest.csv` contains downloaded resources with checksums and downstream parsed tables exist. diff --git a/reports/qc/patch_clamp_integration_qc_report.md b/reports/qc/patch_clamp_integration_qc_report.md new file mode 100644 index 0000000..0252ec9 --- /dev/null +++ b/reports/qc/patch_clamp_integration_qc_report.md @@ -0,0 +1,3 @@ +# Patch-clamp integration QC + +Manual source inventory is required. No copyrighted article text is scraped. Sparse/gene-level coverage must not be called validation. diff --git a/reports/qc/temporal_rebuilt_qc_report.md b/reports/qc/temporal_rebuilt_qc_report.md new file mode 100644 index 0000000..259f156 --- /dev/null +++ b/reports/qc/temporal_rebuilt_qc_report.md @@ -0,0 +1,5 @@ +# Temporal rebuilt QC + +Aligned rows: 942 +Failed mappings: 789 +Deprecated temporal chi2/OR remains deprecated unless exact contingency is reproduced. diff --git a/reports/tables/blocked_claims_after_external_rebuild.csv b/reports/tables/blocked_claims_after_external_rebuild.csv new file mode 100644 index 0000000..0123ada --- /dev/null +++ b/reports/tables/blocked_claims_after_external_rebuild.csv @@ -0,0 +1,4 @@ +claim,status,why +VCEP 57.5%,blocked,Blocked unless actual variant-level VCEP/CSpec coverage file supports it. +gnomAD raw rebuild,blocked_or_pending,Requires local gnomAD extracted sites table or API-backed lookup. +patch-clamp validation,blocked_or_feasibility_only,Requires manually reviewed public supplementary tables; sparse coverage is not validation. diff --git a/reports/tables/deprecated_claims_after_external_rebuild.csv b/reports/tables/deprecated_claims_after_external_rebuild.csv new file mode 100644 index 0000000..80032fe --- /dev/null +++ b/reports/tables/deprecated_claims_after_external_rebuild.csv @@ -0,0 +1,4 @@ +claim,status,why +combined exposure = 741/42.8%,deprecated,Not restored unless true union equals 741. +temporal chi2=39.79 / OR=5.14,deprecated,Not restored unless exact raw snapshot contingency reproduces it. +ClinGen chi2=127.98,deprecated,Not restored unless exact contingency reproduces it. diff --git a/reports/tables/failure_class_counts_final.csv b/reports/tables/failure_class_counts_final.csv new file mode 100644 index 0000000..7dfc435 --- /dev/null +++ b/reports/tables/failure_class_counts_final.csv @@ -0,0 +1,7 @@ +class,n,percent +A_disease_model_transfer,963,0.5563258232235702 +B_population_frequency,104,0.06008087810514154 +C_phenotype_environment,568,0.32813402657423457 +class_membership_events_total,1635, +unique_union,995,0.5748122472559214 +multiple_memberships,600,0.3466204506065858 diff --git a/reports/tables/failure_overlap_final.csv b/reports/tables/failure_overlap_final.csv new file mode 100644 index 0000000..9729de6 --- /dev/null +++ b/reports/tables/failure_overlap_final.csv @@ -0,0 +1,5 @@ +overlap,n +A&B,72 +A&C,568 +B&C,40 +A&B&C,40 diff --git a/reports/tables/failure_union_final.csv b/reports/tables/failure_union_final.csv new file mode 100644 index 0000000..eb1be0c --- /dev/null +++ b/reports/tables/failure_union_final.csv @@ -0,0 +1,2 @@ +N,A,B,C,class_membership_events_total,true_union,true_union_percent,multiple_failure_membership_assertions +1731,963,104,568,1635,995,0.5748122472559214,600 diff --git a/reports/tables/patch_clamp_coverage_by_architecture.csv b/reports/tables/patch_clamp_coverage_by_architecture.csv new file mode 100644 index 0000000..8b13789 --- /dev/null +++ b/reports/tables/patch_clamp_coverage_by_architecture.csv @@ -0,0 +1 @@ + diff --git a/reports/tables/patch_clamp_coverage_by_gene.csv b/reports/tables/patch_clamp_coverage_by_gene.csv new file mode 100644 index 0000000..8b13789 --- /dev/null +++ b/reports/tables/patch_clamp_coverage_by_gene.csv @@ -0,0 +1 @@ + diff --git a/reports/tables/publication_safe_numbers_rebuilt_external.csv b/reports/tables/publication_safe_numbers_rebuilt_external.csv new file mode 100644 index 0000000..2a5feea --- /dev/null +++ b/reports/tables/publication_safe_numbers_rebuilt_external.csv @@ -0,0 +1,4 @@ +claim,value,status,source,publication_use +failure unique union,995,recomputed_by_current_repository_script,reports/tables/failure_union_final.csv,Allowed only with explicit membership-table definition. +failure class-membership events,1635,recomputed_by_current_repository_script,reports/tables/failure_union_final.csv,"Allowed as events, not unique exposure." +ClinVar temporal endpoint counts,see table,reproduced_from_raw_external_if_manifest_contains_snapshots,reports/tables/temporal_rebuilt_endpoint_counts.csv,Allowed only with exact snapshot dates and manifest checksums. diff --git a/reports/tables/temporal_deprecated_claim_retest.csv b/reports/tables/temporal_deprecated_claim_retest.csv new file mode 100644 index 0000000..de19fce --- /dev/null +++ b/reports/tables/temporal_deprecated_claim_retest.csv @@ -0,0 +1,2 @@ +claim,status,reason +temporal chi2=39.79 / OR=5.14,not_restored_by_default,Exact endpoint/contingency must be reproduced by explicit downstream pairwise test. diff --git a/reports/tables/temporal_rebuilt_endpoint_counts.csv b/reports/tables/temporal_rebuilt_endpoint_counts.csv new file mode 100644 index 0000000..fce576e --- /dev/null +++ b/reports/tables/temporal_rebuilt_endpoint_counts.csv @@ -0,0 +1,7 @@ +endpoint,N,changed,rate +classification_change,942,94,0.09978768577494693 +P_LP_to_VUS_or_conflicting,942,0,0.0 +P_LP_to_lower_confidence,942,0,0.0 +condition_label_change,942,386,0.40976645435244163 +review_status_change,942,158,0.16772823779193205 +submitter_count_change,942,215,0.22823779193205945 diff --git a/reports/tables/temporal_rebuilt_overlap_bias.csv b/reports/tables/temporal_rebuilt_overlap_bias.csv new file mode 100644 index 0000000..45e28b6 --- /dev/null +++ b/reports/tables/temporal_rebuilt_overlap_bias.csv @@ -0,0 +1,2 @@ +aligned,failed,failure_rate +942,789,0.4558058925476603 diff --git a/reports/tables/temporal_rebuilt_pairwise_tests.csv b/reports/tables/temporal_rebuilt_pairwise_tests.csv new file mode 100644 index 0000000..8b13789 --- /dev/null +++ b/reports/tables/temporal_rebuilt_pairwise_tests.csv @@ -0,0 +1 @@ + diff --git a/run_external_rebuild.ps1 b/run_external_rebuild.ps1 new file mode 100644 index 0000000..2afe378 --- /dev/null +++ b/run_external_rebuild.ps1 @@ -0,0 +1,30 @@ +$ErrorActionPreference = "Stop" + +python src/20_download_external_resources.py --config config/external_resources.yaml +python src/21_parse_clinvar_snapshots.py --config config/external_resources.yaml +python src/22_rebuild_temporal_endpoints.py --config config/external_resources.yaml +python src/23_fetch_parse_clingen_resources.py --config config/external_resources.yaml +python src/24_rebuild_clingen_vcep_cspec_overlay.py --config config/external_resources.yaml + +python - <<'PY' +import yaml, sys +cfg = yaml.safe_load(open("config/external_resources.yaml", encoding="utf-8")) +sys.exit(0 if (cfg.get("gnomad") or {}).get("local_sites_table") else 1) +PY +if ($LASTEXITCODE -eq 0) { + python src/25_rebuild_gnomad_af_lookup.py --config config/external_resources.yaml +} else { + Write-Host "Skipping gnomAD rebuild: no local sites table configured." +} + +python src/26_fetch_parse_mavedb.py --config config/external_resources.yaml +python src/27_search_patch_clamp_supplementary_tables.py --config config/external_resources.yaml +python src/28_integrate_functional_evidence.py --config config/external_resources.yaml + +if (Test-Path "data/processed/cab_failure_membership_explicit.csv") { + python src/29_recompute_failure_union.py --config config/external_resources.yaml +} else { + Write-Host "Skipping failure union: explicit membership table missing." +} + +python src/30_rebuild_publication_safe_claims.py --config config/external_resources.yaml diff --git a/run_external_rebuild.sh b/run_external_rebuild.sh new file mode 100644 index 0000000..d7270c9 --- /dev/null +++ b/run_external_rebuild.sh @@ -0,0 +1,32 @@ +#!/usr/bin/env bash +set -euo pipefail + +python src/20_download_external_resources.py --config config/external_resources.yaml +python src/21_parse_clinvar_snapshots.py --config config/external_resources.yaml +python src/22_rebuild_temporal_endpoints.py --config config/external_resources.yaml +python src/23_fetch_parse_clingen_resources.py --config config/external_resources.yaml +python src/24_rebuild_clingen_vcep_cspec_overlay.py --config config/external_resources.yaml + +if python - <<'PY' +import yaml +cfg = yaml.safe_load(open("config/external_resources.yaml", encoding="utf-8")) +p = (cfg.get("gnomad") or {}).get("local_sites_table") or "" +raise SystemExit(0 if p else 1) +PY +then + python src/25_rebuild_gnomad_af_lookup.py --config config/external_resources.yaml +else + echo "Skipping gnomAD rebuild: no local sites table configured." >&2 +fi + +python src/26_fetch_parse_mavedb.py --config config/external_resources.yaml || true +python src/27_search_patch_clamp_supplementary_tables.py --config config/external_resources.yaml +python src/28_integrate_functional_evidence.py --config config/external_resources.yaml + +if [ -f data/processed/cab_failure_membership_explicit.csv ]; then + python src/29_recompute_failure_union.py --config config/external_resources.yaml +else + echo "Skipping failure union: explicit membership table missing." >&2 +fi + +python src/30_rebuild_publication_safe_claims.py --config config/external_resources.yaml diff --git a/src/20_download_external_resources.py b/src/20_download_external_resources.py new file mode 100644 index 0000000..a483415 --- /dev/null +++ b/src/20_download_external_resources.py @@ -0,0 +1,59 @@ +#!/usr/bin/env python3 +from pathlib import Path +from cab_external_utils import basic_arg_parser, load_yaml, setup_logging, atomic_download, sha256_file, file_size, append_manifest, utc_now + +def iter_resources(cfg): + for group in ("clinvar", "clingen"): + for key, item in (cfg.get(group, {}) or {}).items(): + if isinstance(item, dict) and item.get("url") and item.get("output"): + yield group, key, item + +def main(): + ap = basic_arg_parser("Download configured external CAB resources and write checksum manifest.") + args = ap.parse_args() + log = setup_logging("20_download_external_resources") + cfg = load_yaml(args.config) + downloaded = 0 + for group, key, item in iter_resources(cfg): + out = Path(item["output"]) + try: + p = atomic_download(item["url"], out, log, overwrite=args.overwrite) + append_manifest({ + "resource_name": item.get("resource_name", f"{group}:{key}"), + "version": item.get("version", ""), + "release_date": item.get("release_date", ""), + "download_date": utc_now(), + "source_url": item["url"], + "local_path": str(p), + "checksum_sha256": sha256_file(p), + "file_size": file_size(p), + "license_or_terms": item.get("license_or_terms", "verify at access time"), + "parser_script": "", + "parse_status": "downloaded_not_parsed", + "row_count_raw": "", + "row_count_parsed": "", + "notes": "Downloaded by 20_download_external_resources.py" + }, args.manifest) + downloaded += 1 + except Exception as e: + log.exception("Download failed for %s:%s", group, key) + append_manifest({ + "resource_name": item.get("resource_name", f"{group}:{key}"), + "version": item.get("version", ""), + "release_date": item.get("release_date", ""), + "download_date": utc_now(), + "source_url": item["url"], + "local_path": str(out), + "checksum_sha256": "", + "file_size": "", + "license_or_terms": item.get("license_or_terms", "verify at access time"), + "parser_script": "", + "parse_status": "download_failed", + "row_count_raw": "", + "row_count_parsed": "", + "notes": repr(e) + }, args.manifest) + log.info("Configured downloads completed: %s successful", downloaded) + +if __name__ == "__main__": + main() diff --git a/src/21_parse_clinvar_snapshots.py b/src/21_parse_clinvar_snapshots.py new file mode 100644 index 0000000..28b5f41 --- /dev/null +++ b/src/21_parse_clinvar_snapshots.py @@ -0,0 +1,130 @@ +#!/usr/bin/env python3 +import csv +import gzip +import sys +from pathlib import Path + +from cab_external_utils import ( + basic_arg_parser, + load_yaml, + setup_logging, + append_manifest, + sha256_file, + file_size, + utc_now, + ensure_dir, +) + +try: + csv.field_size_limit(sys.maxsize) +except OverflowError: + csv.field_size_limit(2**31 - 1) + +KEEP = [ + "VariationID", "AlleleID", "Type", "Name", "GeneID", "GeneSymbol", "HGNC_ID", + "ClinicalSignificance", "ClinSigSimple", "LastEvaluated", "RS# (dbSNP)", + "nsv/esv (dbVar)", "RCVaccession", "PhenotypeIDS", "PhenotypeList", + "Origin", "OriginSimple", "Assembly", "ChromosomeAccession", "Chromosome", + "Start", "Stop", "ReferenceAllele", "AlternateAllele", "ReviewStatus", + "NumberSubmitters", "Guidelines", "TestedInGTR", "OtherIDs", "SubmitterCategories" +] + +REQUIRED = ["VariationID", "GeneSymbol", "ClinicalSignificance", "ReviewStatus"] + + +def open_text(path): + path = Path(path) + if path.suffix == ".gz": + return gzip.open(path, "rt", encoding="utf-8", errors="replace", newline="") + return open(path, "r", encoding="utf-8", errors="replace", newline="") + + +def parse_one(path, out, version, manifest, log): + path = Path(path) + out = Path(out) + ensure_dir(out.parent) + + raw_count = 0 + parsed_count = 0 + + log.info("Parsing %s -> %s", path, out) + + with open_text(path) as fin: + reader = csv.DictReader(fin, delimiter="\t") + + if reader.fieldnames is None: + raise ValueError(f"No header found in {path}") + + missing = [c for c in REQUIRED if c not in reader.fieldnames] + if missing: + raise ValueError( + f"{path}: missing required columns {missing}; " + f"available={reader.fieldnames[:80]}" + ) + + with open(out, "w", newline="", encoding="utf-8") as fout: + writer = csv.DictWriter(fout, fieldnames=KEEP) + writer.writeheader() + + for row in reader: + raw_count += 1 + writer.writerow({k: row.get(k, "") for k in KEEP}) + parsed_count += 1 + + if parsed_count % 250000 == 0: + log.info("Parsed %s rows from %s", parsed_count, path.name) + + append_manifest({ + "resource_name": "ClinVar parsed variant_summary", + "version": version, + "release_date": version, + "download_date": utc_now(), + "source_url": "", + "local_path": str(out), + "checksum_sha256": sha256_file(out), + "file_size": file_size(out), + "license_or_terms": "Derived from ClinVar public FTP variant_summary.", + "parser_script": "src/21_parse_clinvar_snapshots.py", + "parse_status": "parsed_streaming", + "row_count_raw": raw_count, + "row_count_parsed": parsed_count, + "notes": f"source={path}" + }, manifest) + + log.info("Finished %s: raw=%s parsed=%s", path.name, raw_count, parsed_count) + return parsed_count + + +def main(): + ap = basic_arg_parser("Parse ClinVar baseline/followup variant_summary snapshots using streaming IO.") + ap.add_argument("--baseline", default=None) + ap.add_argument("--followup", default=None) + ap.add_argument("--skip-existing", action="store_true") + args = ap.parse_args() + + log = setup_logging("21_parse_clinvar_snapshots") + cfg = load_yaml(args.config) + + baseline = args.baseline or cfg["clinvar"]["baseline_variant_summary"]["output"] + followup = args.followup or cfg["clinvar"]["followup_variant_summary"]["output"] + + b_out = Path("data/processed/clinvar_snapshot_baseline_202301.csv") + f_out = Path("data/processed/clinvar_snapshot_followup_202604.csv") + + for pth in [baseline, followup]: + if not Path(pth).exists(): + raise FileNotFoundError(f"Required ClinVar snapshot missing: {pth}") + + if args.skip_existing and b_out.exists(): + log.info("Skipping existing baseline output: %s", b_out) + else: + parse_one(baseline, b_out, "2023-01", args.manifest, log) + + if args.skip_existing and f_out.exists(): + log.info("Skipping existing followup output: %s", f_out) + else: + parse_one(followup, f_out, "2026-04", args.manifest, log) + + +if __name__ == "__main__": + main() diff --git a/src/22_rebuild_temporal_endpoints.py b/src/22_rebuild_temporal_endpoints.py new file mode 100644 index 0000000..198b225 --- /dev/null +++ b/src/22_rebuild_temporal_endpoints.py @@ -0,0 +1,82 @@ +#!/usr/bin/env python3 +from pathlib import Path +from cab_external_utils import basic_arg_parser, setup_logging, read_csv_any, require_columns, write_csv + +def norm_class(s): + s = (s or "").lower() + if "pathogenic" in s and "conflict" not in s: + return "P_LP" + if "uncertain" in s or "vus" in s: + return "VUS" + if "benign" in s: + return "B_LB" + if "conflict" in s or "conflicting" in s: + return "conflicting" + return s or "missing" + +def main(): + ap = basic_arg_parser("Rebuild ClinVar temporal endpoints from parsed raw snapshots.") + ap.add_argument("--cab-master", default="data/processed/cab_causal_architecture_assignments.csv") + ap.add_argument("--baseline", default="data/processed/clinvar_snapshot_baseline_202301.csv") + ap.add_argument("--followup", default="data/processed/clinvar_snapshot_followup_202604.csv") + args = ap.parse_args() + log = setup_logging("22_rebuild_temporal_endpoints") + for p in [args.cab_master, args.baseline, args.followup]: + if not Path(p).exists(): + raise FileNotFoundError(p) + cab = read_csv_any(args.cab_master) + base = read_csv_any(args.baseline) + foll = read_csv_any(args.followup) + require_columns(cab, ["variation_id"], args.cab_master) + require_columns(base, ["VariationID", "ClinicalSignificance", "ReviewStatus", "PhenotypeList"], args.baseline) + require_columns(foll, ["VariationID", "ClinicalSignificance", "ReviewStatus", "PhenotypeList"], args.followup) + b = {str(r["VariationID"]): r for r in base} + f = {str(r["VariationID"]): r for r in foll} + rows, failures = [], [] + for r in cab: + vid = str(r.get("variation_id", "")).strip() + br, fr = b.get(vid), f.get(vid) + if not br or not fr: + failures.append({"variation_id": vid, "reason": "missing_baseline" if not br else "missing_followup"}) + continue + bc, fc = norm_class(br.get("ClinicalSignificance")), norm_class(fr.get("ClinicalSignificance")) + row = dict(r) + row.update({ + "baseline_clinvar_class": bc, + "followup_clinvar_class": fc, + "classification_change": str(bc != fc).lower(), + "P_LP_to_VUS_or_conflicting": str(bc == "P_LP" and fc in {"VUS", "conflicting"}).lower(), + "P_LP_to_lower_confidence": str(bc == "P_LP" and fc in {"VUS", "B_LB", "conflicting"}).lower(), + "condition_label_change": str((br.get("PhenotypeList") or "") != (fr.get("PhenotypeList") or "")).lower(), + "review_status_change": str((br.get("ReviewStatus") or "") != (fr.get("ReviewStatus") or "")).lower(), + "submitter_count_change": str((br.get("NumberSubmitters") or "") != (fr.get("NumberSubmitters") or "")).lower(), + "record_removed_or_merged": "false", + "baseline_snapshot": "2023-01", + "followup_snapshot": "2026-04" + }) + rows.append(row) + write_csv("data/processed/cab_clinvar_temporal_alignment_raw_rebuilt.csv", rows) + write_csv("data/processed/cab_clinvar_temporal_endpoints_rebuilt.csv", rows) + write_csv("reports/failures/temporal_alignment_failures.csv", failures) + counts = [] + endpoints = ["classification_change","P_LP_to_VUS_or_conflicting","P_LP_to_lower_confidence","condition_label_change","review_status_change","submitter_count_change"] + for endpoint in endpoints: + n = len(rows) + changed = sum(1 for x in rows if x.get(endpoint) == "true") + counts.append({"endpoint": endpoint, "N": n, "changed": changed, "rate": changed/n if n else ""}) + write_csv("reports/tables/temporal_rebuilt_endpoint_counts.csv", counts) + write_csv("reports/tables/temporal_rebuilt_pairwise_tests.csv", []) + write_csv("reports/tables/temporal_rebuilt_overlap_bias.csv", [{"aligned": len(rows), "failed": len(failures), "failure_rate": len(failures)/(len(rows)+len(failures)) if (rows or failures) else ""}]) + write_csv("reports/tables/temporal_deprecated_claim_retest.csv", [{ + "claim": "temporal chi2=39.79 / OR=5.14", + "status": "not_restored_by_default", + "reason": "Exact endpoint/contingency must be reproduced by explicit downstream pairwise test." + }]) + Path("reports/qc/temporal_rebuilt_qc_report.md").write_text( + f"# Temporal rebuilt QC\n\nAligned rows: {len(rows)}\nFailed mappings: {len(failures)}\nDeprecated temporal chi2/OR remains deprecated unless exact contingency is reproduced.\n", + encoding="utf-8" + ) + log.info("Temporal alignment rows=%s failures=%s", len(rows), len(failures)) + +if __name__ == "__main__": + main() diff --git a/src/23_fetch_parse_clingen_resources.py b/src/23_fetch_parse_clingen_resources.py new file mode 100644 index 0000000..aca8dd7 --- /dev/null +++ b/src/23_fetch_parse_clingen_resources.py @@ -0,0 +1,55 @@ +#!/usr/bin/env python3 +from pathlib import Path +from cab_external_utils import basic_arg_parser, load_yaml, setup_logging, read_csv_any, write_csv, append_manifest, sha256_file, file_size, utc_now + +def pick(r, *names): + lower = {k.lower().strip(): k for k in r.keys()} + for n in names: + k = lower.get(n.lower()) + if k is not None: + return r.get(k, "") + return "" + +def main(): + ap = basic_arg_parser("Parse ClinGen Gene-Disease Validity.") + ap.add_argument("--validity", default=None) + args = ap.parse_args() + log = setup_logging("23_fetch_parse_clingen_resources") + cfg = load_yaml(args.config) + validity = args.validity or cfg["clingen"]["gene_disease_validity"]["output"] + if not Path(validity).exists(): + raise FileNotFoundError(f"ClinGen validity file missing: {validity}") + rows = read_csv_any(validity) + parsed = [] + for r in rows: + parsed.append({ + "gene_symbol": pick(r, "Gene Symbol", "Gene", "HGNC Symbol"), + "disease_label": pick(r, "Disease", "Disease Label", "Disease Entity"), + "disease_id": pick(r, "Disease ID", "MONDO ID", "MONDO"), + "validity_classification": pick(r, "Classification", "Validity Classification", "Classification Title"), + "mode_of_inheritance": pick(r, "Mode of Inheritance", "MOI"), + "expert_panel": pick(r, "Expert Panel", "GCEP"), + "report_date": pick(r, "Report Date", "Classification Date", "Date"), + "source_columns_json": "|".join(r.keys()) + }) + n = write_csv("data/processed/clingen_gene_disease_validity_rebuilt.csv", parsed) + append_manifest({ + "resource_name": "ClinGen Gene-Disease Validity parsed", + "version": "current", + "release_date": "current", + "download_date": utc_now(), + "source_url": cfg["clingen"]["gene_disease_validity"].get("url", ""), + "local_path": "data/processed/clingen_gene_disease_validity_rebuilt.csv", + "checksum_sha256": sha256_file("data/processed/clingen_gene_disease_validity_rebuilt.csv"), + "file_size": file_size("data/processed/clingen_gene_disease_validity_rebuilt.csv"), + "license_or_terms": "Derived from ClinGen public resource; verify terms.", + "parser_script": "src/23_fetch_parse_clingen_resources.py", + "parse_status": "parsed", + "row_count_raw": len(rows), + "row_count_parsed": n, + "notes": f"source={validity}" + }, args.manifest) + log.info("Parsed ClinGen validity rows=%s", n) + +if __name__ == "__main__": + main() diff --git a/src/24_rebuild_clingen_vcep_cspec_overlay.py b/src/24_rebuild_clingen_vcep_cspec_overlay.py new file mode 100644 index 0000000..5a3a6d3 --- /dev/null +++ b/src/24_rebuild_clingen_vcep_cspec_overlay.py @@ -0,0 +1,68 @@ +#!/usr/bin/env python3 +from pathlib import Path +from cab_external_utils import basic_arg_parser, setup_logging, read_csv_any, require_columns, write_csv + +HIGH = {"definitive", "strong"} + +def main(): + ap = basic_arg_parser("Rebuild CAB ClinGen/VCEP/CSpec overlay.") + ap.add_argument("--cab-master", default="data/processed/cab_causal_architecture_assignments.csv") + ap.add_argument("--validity", default="data/processed/clingen_gene_disease_validity_rebuilt.csv") + args = ap.parse_args() + log = setup_logging("24_rebuild_clingen_vcep_cspec_overlay") + for p in [args.cab_master, args.validity]: + if not Path(p).exists(): + raise FileNotFoundError(p) + cab = read_csv_any(args.cab_master) + val = read_csv_any(args.validity) + require_columns(cab, ["gene"], args.cab_master) + require_columns(val, ["gene_symbol", "validity_classification"], args.validity) + by_gene = {} + for r in val: + g = (r.get("gene_symbol") or "").upper().strip() + if g: + by_gene.setdefault(g, []).append(r) + overlay = [] + for r in cab: + g = (r.get("gene") or "").upper().strip() + hits = by_gene.get(g, []) + classes = sorted(set((h.get("validity_classification") or "").strip() for h in hits if h.get("validity_classification"))) + high = any(c.lower() in HIGH for c in classes) + row = dict(r) + row.update({ + "clingen_validity_level": "gene_only" if hits else "unavailable", + "clingen_validity_classes": "|".join(classes), + "clingen_high_validity": str(high).lower(), + "vcep_level": "unavailable", + "cspec_level": "unavailable", + "usable_for_variant_level_claim": "false" + }) + overlay.append(row) + write_csv("data/processed/cab_clingen_overlay_rebuilt.csv", overlay) + counts = {} + for r in overlay: + key = r["clingen_validity_classes"] or "unavailable" + counts[key] = counts.get(key, 0) + 1 + write_csv("reports/tables/clingen_rebuilt_counts.csv", [{"validity_classes": k, "n": v} for k, v in counts.items()]) + write_csv("reports/tables/clingen_rebuilt_enrichment_tests.csv", []) + write_csv("data/processed/clingen_vcep_variant_overlay_rebuilt.csv", []) + write_csv("data/processed/clingen_cspec_overlay_rebuilt.csv", []) + write_csv("reports/tables/clingen_vcep_cspec_real_coverage.csv", [{ + "resource": "VCEP/CSpec", + "status": "blocked_or_unavailable", + "variant_level_count": 0, + "reason": "No structured variant-level VCEP/CSpec records parsed." + }]) + write_csv("reports/tables/clingen_deprecated_claim_retest.csv", [{ + "claim": "ClinGen chi-square=127.98 / OR=6.94", + "status": "not_restored", + "reason": "Exact contingency not reproduced by this gene-level overlay." + }]) + Path("reports/qc/clingen_rebuilt_qc_report.md").write_text( + f"# ClinGen rebuilt QC\n\nCAB rows overlaid: {len(overlay)}\nValidity genes parsed: {len(by_gene)}\nVCEP/CSpec variant-level claims remain blocked unless structured variant-level files are supplied.\n", + encoding="utf-8" + ) + log.info("CAB ClinGen overlay rows=%s", len(overlay)) + +if __name__ == "__main__": + main() diff --git a/src/25_rebuild_gnomad_af_lookup.py b/src/25_rebuild_gnomad_af_lookup.py new file mode 100644 index 0000000..49adac4 --- /dev/null +++ b/src/25_rebuild_gnomad_af_lookup.py @@ -0,0 +1,59 @@ +#!/usr/bin/env python3 +from pathlib import Path +from cab_external_utils import basic_arg_parser, load_yaml, setup_logging, read_csv_any, write_csv + +def main(): + ap = basic_arg_parser("Rebuild gnomAD AF lookup from supplied local/API-backed table.") + ap.add_argument("--cab-master", default="data/processed/cab_causal_architecture_assignments.csv") + ap.add_argument("--gnomad-sites-table", default=None) + args = ap.parse_args() + log = setup_logging("25_rebuild_gnomad_af_lookup") + cfg = load_yaml(args.config) + sites = args.gnomad_sites_table or cfg.get("gnomad", {}).get("local_sites_table", "") + if not sites: + raise RuntimeError("No gnomAD local sites table configured. Supply --gnomad-sites-table or config.gnomad.local_sites_table.") + if not Path(sites).exists(): + raise FileNotFoundError(sites) + cab = read_csv_any(args.cab_master) + gnomad = read_csv_any(sites) + needed = set(cfg.get("gnomad", {}).get("required_columns", [])) + got = set(gnomad[0].keys()) if gnomad else set() + missing = needed - got + if missing: + raise ValueError(f"gnomAD sites table missing required columns: {sorted(missing)}") + idx = {(r["chr"], str(r["pos"]), r["ref"], r["alt"]): r for r in gnomad} + out, failures = [], [] + for r in cab: + key = (r.get("chr", ""), str(r.get("pos", "")), r.get("ref", ""), r.get("alt", "")) + hit = idx.get(key) + row = dict(r) + if hit: + for k in needed: + row[f"gnomad_{k}"] = hit.get(k, "") + row["lookup_status"] = "exact" + row["gnomAD_source_release"] = cfg.get("gnomad", {}).get("release", "") + else: + row["lookup_status"] = "no_match" + row["failure_reason"] = "no exact chr-pos-ref-alt match" + failures.append({"assertion_id": r.get("assertion_id", ""), "variation_id": r.get("variation_id", ""), "reason": "no_match"}) + out.append(row) + write_csv("data/processed/gnomad_lookup_rebuilt_per_assertion.csv", out) + write_csv("reports/failures/gnomad_lookup_failures.csv", failures) + write_csv("reports/tables/gnomad_rebuilt_lookup_status.csv", [ + {"lookup_status": "exact", "n": sum(1 for r in out if r.get("lookup_status") == "exact")}, + {"lookup_status": "no_match", "n": sum(1 for r in out if r.get("lookup_status") == "no_match")} + ]) + write_csv("reports/tables/gnomad_rebuilt_threshold_grid.csv", []) + write_csv("reports/tables/gnomad_rebuilt_vs_cached_claims.csv", [{ + "claim": "gnomAD threshold grid cached claims", + "status": "requires_threshold_recompute_after_lookup", + "source": sites + }]) + Path("reports/qc/gnomad_rebuilt_qc_report.md").write_text( + f"# gnomAD rebuilt QC\n\nCAB rows: {len(cab)}\nLookup table rows: {len(gnomad)}\nFailures: {len(failures)}\n", + encoding="utf-8" + ) + log.info("gnomAD lookup rows=%s failures=%s", len(out), len(failures)) + +if __name__ == "__main__": + main() diff --git a/src/26_fetch_parse_mavedb.py b/src/26_fetch_parse_mavedb.py new file mode 100644 index 0000000..cc19d51 --- /dev/null +++ b/src/26_fetch_parse_mavedb.py @@ -0,0 +1,65 @@ +#!/usr/bin/env python3 +import json +from pathlib import Path +from urllib.parse import quote +import urllib.request +from cab_external_utils import basic_arg_parser, load_yaml, setup_logging, ensure_dir, sha256_file, file_size, write_csv, append_manifest, utc_now + +def post_json(url, payload): + data = json.dumps(payload).encode("utf-8") + req = urllib.request.Request(url, data=data, headers={"Content-Type": "application/json", "User-Agent": "CAB-external-rebuild/1.0"}) + with urllib.request.urlopen(req, timeout=120) as r: + return r.read() + +def main(): + ap = basic_arg_parser("Fetch MaveDB metadata for relevant genes.") + args = ap.parse_args() + log = setup_logging("26_fetch_parse_mavedb") + cfg = load_yaml(args.config) + base = cfg.get("mavedb", {}).get("api_base_url", "https://api.mavedb.org/api/v1").rstrip("/") + genes = cfg.get("mavedb", {}).get("genes", []) + ensure_dir("data/raw/mavedb/current") + inv = [] + for gene in genes: + url = f"{base}/score-sets/search" + out = Path(f"data/raw/mavedb/current/{gene}_score_sets_search.json") + try: + raw = post_json(url, {"text": gene, "limit": 100, "offset": 0}) + out.write_bytes(raw) + checksum = sha256_file(out) + inv.append({"gene": gene, "query_url": url, "local_path": str(out), "checksum_sha256": checksum, "parse_status": "downloaded_metadata"}) + append_manifest({ + "resource_name": f"MaveDB score-set search {gene}", + "version": "current", + "release_date": "current", + "download_date": utc_now(), + "source_url": url, + "local_path": str(out), + "checksum_sha256": checksum, + "file_size": file_size(out), + "license_or_terms": "Verify MaveDB and score-set-specific license.", + "parser_script": "src/26_fetch_parse_mavedb.py", + "parse_status": "downloaded_metadata", + "row_count_raw": "", + "row_count_parsed": "", + "notes": "Public metadata only; score tables require per-score-set license checks." + }, args.manifest) + except Exception as e: + log.exception("MaveDB query failed for %s", gene) + inv.append({"gene": gene, "query_url": url, "local_path": str(out), "checksum_sha256": "", "parse_status": "failed", "notes": repr(e)}) + write_csv("data/processed/mavedb_score_sets_relevant_genes.csv", inv) + write_csv("reports/tables/mavedb_score_set_inventory.csv", inv) + write_csv("data/processed/mavedb_variant_scores_normalized.csv", []) + write_csv("data/processed/cab_mavedb_functional_overlay.csv", []) + write_csv("reports/tables/mavedb_variant_match_counts.csv", [{"status": "pending_score_table_download", "n": 0}]) + write_csv("reports/tables/mavedb_functional_coverage_by_gene.csv", []) + write_csv("reports/tables/mavedb_functional_coverage_by_architecture.csv", []) + write_csv("reports/tables/mavedb_functional_tests.csv", []) + Path("reports/qc/mavedb_integration_qc_report.md").write_text( + "# MaveDB integration QC\n\nMetadata queries attempted. Variant-level score integration is not validation and remains unavailable until score tables are downloaded, licensed, normalized, and joined.\n", + encoding="utf-8" + ) + log.info("MaveDB metadata inventory rows=%s", len(inv)) + +if __name__ == "__main__": + main() diff --git a/src/27_search_patch_clamp_supplementary_tables.py b/src/27_search_patch_clamp_supplementary_tables.py new file mode 100644 index 0000000..a001123 --- /dev/null +++ b/src/27_search_patch_clamp_supplementary_tables.py @@ -0,0 +1,34 @@ +#!/usr/bin/env python3 +from pathlib import Path +from cab_external_utils import basic_arg_parser, load_yaml, setup_logging, read_csv_any, write_csv + +def main(): + ap = basic_arg_parser("Ingest manually curated patch-clamp supplementary source inventory.") + ap.add_argument("--manual-inventory", default=None) + args = ap.parse_args() + log = setup_logging("27_search_patch_clamp_supplementary_tables") + cfg = load_yaml(args.config) + inv_path = args.manual_inventory or cfg.get("patch_clamp", {}).get("manual_inventory_csv", "") + if not inv_path or not Path(inv_path).exists(): + rows = [{ + "status": "manual_download_required", + "reason": "Patch-clamp supplementary tables require source-by-source license/manual review; no copyrighted full-text scraping is performed.", + "genes_prioritized": "|".join(cfg.get("patch_clamp", {}).get("priority_genes", [])) + }] + write_csv("data/processed/patch_clamp_source_inventory.csv", rows) + write_csv("data/processed/patch_clamp_variant_scores_normalized.csv", []) + write_csv("data/processed/cab_patch_clamp_functional_overlay.csv", []) + write_csv("reports/tables/patch_clamp_coverage_by_gene.csv", []) + write_csv("reports/tables/patch_clamp_coverage_by_architecture.csv", []) + Path("reports/qc/patch_clamp_integration_qc_report.md").write_text( + "# Patch-clamp integration QC\n\nManual source inventory is required. No copyrighted article text is scraped. Sparse/gene-level coverage must not be called validation.\n", + encoding="utf-8" + ) + log.info("Manual patch-clamp inventory missing; wrote manual-required status.") + return + rows = read_csv_any(inv_path) + write_csv("data/processed/patch_clamp_source_inventory.csv", rows) + log.info("Loaded manual patch-clamp inventory rows=%s", len(rows)) + +if __name__ == "__main__": + main() diff --git a/src/28_integrate_functional_evidence.py b/src/28_integrate_functional_evidence.py new file mode 100644 index 0000000..3284bb6 --- /dev/null +++ b/src/28_integrate_functional_evidence.py @@ -0,0 +1,29 @@ +#!/usr/bin/env python3 +from pathlib import Path +from cab_external_utils import basic_arg_parser, setup_logging, read_csv_any, write_csv + +def main(): + ap = basic_arg_parser("Integrate MaveDB and patch-clamp functional evidence overlays.") + args = ap.parse_args() + log = setup_logging("28_integrate_functional_evidence") + combined = [] + for path, source in [ + ("data/processed/cab_mavedb_functional_overlay.csv", "mavedb"), + ("data/processed/cab_patch_clamp_functional_overlay.csv", "patch_clamp") + ]: + if Path(path).exists(): + for r in read_csv_any(path): + rr = dict(r) + rr["functional_source"] = source + combined.append(rr) + write_csv("data/processed/cab_functional_evidence_overlay_combined.csv", combined) + write_csv("reports/tables/functional_evidence_combined_coverage.csv", [{ + "functional_overlay_rows": len(combined), + "claim_strength": "feasibility_only" if not combined else "as_labeled_variant_or_gene_level", + "not_validation": "true" + }]) + write_csv("reports/tables/functional_evidence_combined_tests.csv", []) + log.info("Combined functional evidence rows=%s", len(combined)) + +if __name__ == "__main__": + main() diff --git a/src/29_recompute_failure_union.py b/src/29_recompute_failure_union.py new file mode 100644 index 0000000..ef53065 --- /dev/null +++ b/src/29_recompute_failure_union.py @@ -0,0 +1,55 @@ +#!/usr/bin/env python3 +from pathlib import Path +from cab_external_utils import basic_arg_parser, setup_logging, read_csv_any, require_columns, write_csv, truth + +def main(): + ap = basic_arg_parser("Recompute final failure unique union from explicit membership.") + ap.add_argument("--membership", default="data/processed/cab_failure_membership_explicit.csv") + args = ap.parse_args() + log = setup_logging("29_recompute_failure_union") + if not Path(args.membership).exists(): + raise FileNotFoundError(f"Explicit membership missing: {args.membership}") + rows = read_csv_any(args.membership) + cols = [ + "failure_A_disease_model_transfer", + "failure_B_population_frequency", + "failure_C_phenotype_environment" + ] + require_columns(rows, cols, args.membership) + n = len(rows) + A = sum(truth(r[cols[0]]) for r in rows) + B = sum(truth(r[cols[1]]) for r in rows) + C = sum(truth(r[cols[2]]) for r in rows) + events = sum(sum(truth(r[c]) for c in cols) for r in rows) + union = sum(any(truth(r[c]) for c in cols) for r in rows) + multi = sum(sum(truth(r[c]) for c in cols) > 1 for r in rows) + def both(c1, c2): return sum(truth(r[c1]) and truth(r[c2]) for r in rows) + triple = sum(all(truth(r[c]) for c in cols) for r in rows) + write_csv("reports/tables/failure_class_counts_final.csv", [ + {"class": "A_disease_model_transfer", "n": A, "percent": A/n if n else ""}, + {"class": "B_population_frequency", "n": B, "percent": B/n if n else ""}, + {"class": "C_phenotype_environment", "n": C, "percent": C/n if n else ""}, + {"class": "class_membership_events_total", "n": events, "percent": ""}, + {"class": "unique_union", "n": union, "percent": union/n if n else ""}, + {"class": "multiple_memberships", "n": multi, "percent": multi/n if n else ""} + ]) + write_csv("reports/tables/failure_overlap_final.csv", [ + {"overlap": "A&B", "n": both(cols[0], cols[1])}, + {"overlap": "A&C", "n": both(cols[0], cols[2])}, + {"overlap": "B&C", "n": both(cols[1], cols[2])}, + {"overlap": "A&B&C", "n": triple} + ]) + write_csv("reports/tables/failure_union_final.csv", [{ + "N": n, + "A": A, + "B": B, + "C": C, + "class_membership_events_total": events, + "true_union": union, + "true_union_percent": union/n if n else "", + "multiple_failure_membership_assertions": multi + }]) + log.info("Failure union=%s events=%s rows=%s", union, events, n) + +if __name__ == "__main__": + main() diff --git a/src/30_rebuild_publication_safe_claims.py b/src/30_rebuild_publication_safe_claims.py new file mode 100644 index 0000000..5914c3a --- /dev/null +++ b/src/30_rebuild_publication_safe_claims.py @@ -0,0 +1,72 @@ +#!/usr/bin/env python3 +from pathlib import Path +from cab_external_utils import basic_arg_parser, setup_logging, read_csv_any, write_csv + +def main(): + ap = basic_arg_parser("Rebuild publication-safe claim tables after external rebuild.") + args = ap.parse_args() + log = setup_logging("30_rebuild_publication_safe_claims") + safe = [] + if Path("reports/tables/failure_union_final.csv").exists(): + fu = read_csv_any("reports/tables/failure_union_final.csv")[0] + safe.extend([ + { + "claim": "failure unique union", + "value": fu.get("true_union", ""), + "status": "recomputed_by_current_repository_script", + "source": "reports/tables/failure_union_final.csv", + "publication_use": "Allowed only with explicit membership-table definition." + }, + { + "claim": "failure class-membership events", + "value": fu.get("class_membership_events_total", ""), + "status": "recomputed_by_current_repository_script", + "source": "reports/tables/failure_union_final.csv", + "publication_use": "Allowed as events, not unique exposure." + } + ]) + else: + safe.append({ + "claim": "failure unique union", + "value": "", + "status": "blocked", + "source": "", + "publication_use": "Do not use until explicit membership exists." + }) + if Path("reports/tables/temporal_rebuilt_endpoint_counts.csv").exists(): + safe.append({ + "claim": "ClinVar temporal endpoint counts", + "value": "see table", + "status": "reproduced_from_raw_external_if_manifest_contains_snapshots", + "source": "reports/tables/temporal_rebuilt_endpoint_counts.csv", + "publication_use": "Allowed only with exact snapshot dates and manifest checksums." + }) + if Path("data/processed/cab_clingen_overlay_rebuilt.csv").exists(): + safe.append({ + "claim": "ClinGen gene-level overlay", + "value": "see clingen_rebuilt_counts.csv", + "status": "external_constraint_gene_level", + "source": "reports/tables/clingen_rebuilt_counts.csv", + "publication_use": "Allowed as gene-level/gene-condition constraint only; not variant-level VCEP." + }) + deprecated = [ + {"claim": "combined exposure = 741/42.8%", "status": "deprecated", "why": "Not restored unless true union equals 741."}, + {"claim": "temporal chi2=39.79 / OR=5.14", "status": "deprecated", "why": "Not restored unless exact raw snapshot contingency reproduces it."}, + {"claim": "ClinGen chi2=127.98", "status": "deprecated", "why": "Not restored unless exact contingency reproduces it."} + ] + blocked = [ + {"claim": "VCEP 57.5%", "status": "blocked", "why": "Blocked unless actual variant-level VCEP/CSpec coverage file supports it."}, + {"claim": "gnomAD raw rebuild", "status": "blocked_or_pending", "why": "Requires local gnomAD extracted sites table or API-backed lookup."}, + {"claim": "patch-clamp validation", "status": "blocked_or_feasibility_only", "why": "Requires manually reviewed public supplementary tables; sparse coverage is not validation."} + ] + write_csv("reports/tables/publication_safe_numbers_rebuilt_external.csv", safe) + write_csv("reports/tables/deprecated_claims_after_external_rebuild.csv", deprecated) + write_csv("reports/tables/blocked_claims_after_external_rebuild.csv", blocked) + Path("reports/final_external_rebuild_audit_report.md").write_text( + "# CAB external rebuild audit report\n\nClaims remain publication-safe only where raw downloads, checksums, parsed overlays, and recomputed tables exist. Deprecated claims are not restored by default.\n", + encoding="utf-8" + ) + log.info("Wrote rebuilt claim tables.") + +if __name__ == "__main__": + main() diff --git a/src/31_rebuild_failure_membership_from_available_tables.py b/src/31_rebuild_failure_membership_from_available_tables.py new file mode 100644 index 0000000..e38594e --- /dev/null +++ b/src/31_rebuild_failure_membership_from_available_tables.py @@ -0,0 +1,225 @@ +#!/usr/bin/env python3 +from __future__ import annotations + +import argparse +import csv +import re +from pathlib import Path + +MULTI_MODEL_HUBS = {"SCN5A", "CACNA1C", "RYR2"} + +def ensure_dir(path): + Path(path).mkdir(parents=True, exist_ok=True) + +def read_csv(path): + with open(path, "r", encoding="utf-8", errors="replace", newline="") as f: + return list(csv.DictReader(f)) + +def write_csv(path, rows, fieldnames=None): + rows = list(rows) + ensure_dir(Path(path).parent) + if fieldnames is None: + keys, seen = [], set() + for r in rows: + for k in r.keys(): + if k not in seen: + keys.append(k) + seen.add(k) + fieldnames = keys + with open(path, "w", encoding="utf-8", newline="") as f: + w = csv.DictWriter(f, fieldnames=fieldnames) + w.writeheader() + for r in rows: + w.writerow({k: r.get(k, "") for k in fieldnames}) + return len(rows) + +def norm_key(s): + return re.sub(r"[^a-z0-9]+", "_", str(s).lower()).strip("_") + +def normalized_row(row): + out = dict(row) + for k, v in row.items(): + nk = norm_key(k) + if nk not in out: + out[nk] = v + return out + +def get_any(row, names, default=""): + for n in names: + for key in [n, norm_key(n)]: + if key in row and row.get(key) not in (None, ""): + return row.get(key) + return default + +def as_float(x, default=None): + try: + if x in ("", None): + return default + return float(x) + except Exception: + return default + +def as_bool(x): + return str(x).strip().lower() in {"true", "1", "yes", "y"} + +def contains_any(text, terms): + t = str(text or "").lower() + return any(term in t for term in terms) + +def first_existing(paths): + for p in paths: + if Path(p).exists(): + return p + return None + +def main(): + ap = argparse.ArgumentParser() + ap.add_argument("--architecture", default=None) + ap.add_argument("--routing", default=None) + ap.add_argument("--gnomad", default=None) + ap.add_argument("--output", default="data/processed/cab_failure_membership_explicit.csv") + ap.add_argument("--counts-output", default="reports/tables/failure_class_counts_final.csv") + ap.add_argument("--overlap-output", default="reports/tables/failure_overlap_final.csv") + ap.add_argument("--union-output", default="reports/tables/failure_union_final.csv") + args = ap.parse_args() + + arch_path = args.architecture or first_existing([ + "reports/tables/cab_causal_architecture_assignments.csv", + "data/processed/cab_causal_architecture_assignments.csv", + "reports/tables/cab_routing_assignments.csv", + "data/processed/cab_routing_assignments.csv", + ]) + if not arch_path: + raise FileNotFoundError("No CAB architecture/routing assignment table found.") + + rows = [normalized_row(r) for r in read_csv(arch_path)] + if not rows: + raise ValueError(f"No rows read from {arch_path}") + + gnomad = {} + gnomad_path = args.gnomad or first_existing([ + "data/processed/gnomad_lookup_rebuilt_per_assertion.csv", + "reports/tables/gnomad_lookup_rebuilt_per_assertion.csv", + ]) + if gnomad_path: + for r in read_csv(gnomad_path): + rr = normalized_row(r) + vid = str(get_any(rr, ["variation_id", "VariationID"])).strip() + aid = str(get_any(rr, ["assertion_id"])).strip() + key = vid or aid + if key: + gnomad[key] = rr + + out = [] + for i, r in enumerate(rows, start=1): + assertion_id = str(get_any(r, ["assertion_id"], f"row_{i}")).strip() or f"row_{i}" + variation_id = str(get_any(r, ["variation_id", "VariationID", "clinvar_variation_id"])).strip() + gene = str(get_any(r, ["gene", "GeneSymbol", "gene_symbol"])).strip().upper() + condition = str(get_any(r, ["condition_label_normalized", "condition", "phenotype", "PhenotypeList", "condition_label"])).strip() + primary = str(get_any(r, ["primary_regime", "cab_regime", "regime"])).strip() + arch = str(get_any(r, ["causal_architecture", "architecture"])).strip() + env = str(get_any(r, ["clinical_inference_environment", "environment", "phenotype_inference_mode"])).strip() + + joined_text = " | ".join(str(x) for x in [condition, primary, arch, env, get_any(r, ["failure_rule_notes"], "")]).lower() + + disease_model_collision = as_bool(get_any(r, ["disease_model_collision"])) + entropy = as_float(get_any(r, ["condition_entropy", "phenotype_entropy"]), None) + multi_family = as_float(get_any(r, ["normalized_disease_model_family_count", "disease_model_family_count"]), 0) or 0 + A = ( + disease_model_collision + or primary == "disease_model_collision" + or contains_any(joined_text, ["disease_model_collision", "disease model collision", "model collision", "mixed", "collision-prone"]) + or (entropy is not None and entropy >= 1.0) + or multi_family > 1 + or (gene in MULTI_MODEL_HUBS and contains_any(joined_text, ["mixed", "collision", "sads", "postmortem", "cpvt"])) + ) + + g = gnomad.get(variation_id) or gnomad.get(assertion_id) or {} + global_af = as_float(get_any(g, ["gnomad_global_af", "global_af", "af"]), as_float(get_any(r, ["gnomad_global_af", "global_af", "af"]), None)) + popmax_af = as_float(get_any(g, ["gnomad_popmax_af", "popmax_af"]), as_float(get_any(r, ["gnomad_popmax_af", "popmax_af"]), None)) + popmax_ratio = as_float(get_any(r, ["popmax_global_ratio", "rank_median_popmax_global_ratio"]), None) + af_flag = str(get_any(r, ["AF_compatibility_flag", "af_compatibility_flag", "VITAL_flag", "vital_flag", "route", "VITAL_route"])).lower() + B = ( + primary == "ancestry_concentrated" + or arch == "population_localized_susceptibility" + or contains_any(joined_text, ["ancestry_concentrated", "population_localized_susceptibility", "population frequency", "popmax", "frequency tension"]) + or ("check_popmax" in af_flag or "popmax" in af_flag or "tension" in af_flag) + or (popmax_af is not None and popmax_af >= 1e-5 and (global_af is None or global_af < 1e-5)) + or (popmax_ratio is not None and popmax_ratio >= 10) + ) + + C = ( + arch in {"genotype_first_postmortem", "provocation_dependent_instability", "underresolved_contextual"} + or contains_any(env, ["sads", "cpvt", "postmortem", "autopsy", "death", "exercise", "stress", "provocation"]) + or contains_any(condition, ["sads", "sudden", "postmortem", "death", "exercise", "stress", "provocation", "cpvt"]) + or contains_any(joined_text, ["genotype_first_postmortem", "provocation_dependent_instability", "phenotype environment"]) + ) + + count = int(A) + int(B) + int(C) + out.append({ + "assertion_id": assertion_id, + "variation_id": variation_id, + "gene": gene, + "condition_label_normalized": condition, + "primary_regime": primary, + "causal_architecture": arch, + "clinical_inference_environment": env, + "failure_A_disease_model_transfer": str(bool(A)), + "failure_B_population_frequency": str(bool(B)), + "failure_C_phenotype_environment": str(bool(C)), + "failure_any_union": str(count > 0), + "failure_class_count_per_assertion": count, + "failure_rule_source": "src/31_rebuild_failure_membership_from_available_tables.py conservative field rules", + "failure_rule_notes": "Rebuilt from available CAB assignment/routing tables; external gnomAD used only if supplied." + }) + + fieldnames = [ + "assertion_id", "variation_id", "gene", "condition_label_normalized", "primary_regime", + "causal_architecture", "clinical_inference_environment", + "failure_A_disease_model_transfer", "failure_B_population_frequency", + "failure_C_phenotype_environment", "failure_any_union", + "failure_class_count_per_assertion", "failure_rule_source", "failure_rule_notes" + ] + write_csv(args.output, out, fieldnames) + + def truth(x): return str(x).lower() == "true" + n = len(out) + A = sum(truth(r["failure_A_disease_model_transfer"]) for r in out) + B = sum(truth(r["failure_B_population_frequency"]) for r in out) + C = sum(truth(r["failure_C_phenotype_environment"]) for r in out) + union = sum(truth(r["failure_any_union"]) for r in out) + events = sum(int(r["failure_class_count_per_assertion"]) for r in out) + multi = sum(int(r["failure_class_count_per_assertion"]) > 1 for r in out) + + write_csv(args.counts_output, [ + {"class": "A_disease_model_transfer", "n": A, "percent": A/n if n else ""}, + {"class": "B_population_frequency", "n": B, "percent": B/n if n else ""}, + {"class": "C_phenotype_environment", "n": C, "percent": C/n if n else ""}, + {"class": "class_membership_events_total", "n": events, "percent": ""}, + {"class": "unique_union", "n": union, "percent": union/n if n else ""}, + {"class": "multiple_memberships", "n": multi, "percent": multi/n if n else ""}, + ]) + write_csv(args.overlap_output, [ + {"overlap": "A&B", "n": sum(truth(r["failure_A_disease_model_transfer"]) and truth(r["failure_B_population_frequency"]) for r in out)}, + {"overlap": "A&C", "n": sum(truth(r["failure_A_disease_model_transfer"]) and truth(r["failure_C_phenotype_environment"]) for r in out)}, + {"overlap": "B&C", "n": sum(truth(r["failure_B_population_frequency"]) and truth(r["failure_C_phenotype_environment"]) for r in out)}, + {"overlap": "A&B&C", "n": sum(truth(r["failure_A_disease_model_transfer"]) and truth(r["failure_B_population_frequency"]) and truth(r["failure_C_phenotype_environment"]) for r in out)}, + ]) + write_csv(args.union_output, [{ + "N": n, + "A": A, + "B": B, + "C": C, + "class_membership_events_total": events, + "true_union": union, + "true_union_percent": union/n if n else "", + "multiple_failure_membership_assertions": multi, + "source_table": arch_path, + "gnomad_overlay": gnomad_path or "" + }]) + + print(f"Wrote {args.output}") + print(f"N={n} A={A} B={B} C={C} events={events} union={union} multi={multi}") + +if __name__ == "__main__": + main() diff --git a/src/cab_external_utils.py b/src/cab_external_utils.py new file mode 100644 index 0000000..5c64bf4 --- /dev/null +++ b/src/cab_external_utils.py @@ -0,0 +1,162 @@ +#!/usr/bin/env python3 +from __future__ import annotations + +import argparse +import csv +import datetime as dt +import gzip +import hashlib +import json +import logging +from pathlib import Path +import sys +import urllib.request + +try: + csv.field_size_limit(sys.maxsize) +except OverflowError: + csv.field_size_limit(2**31 - 1) +from typing import Iterable, Mapping, Sequence + +try: + import yaml +except ImportError: + yaml = None + + +def utc_now() -> str: + return dt.datetime.now(dt.timezone.utc).isoformat(timespec="seconds") + + +def ensure_dir(path: str | Path) -> Path: + p = Path(path) + p.mkdir(parents=True, exist_ok=True) + return p + + +def setup_logging(name: str, log_dir: str | Path = "logs") -> logging.Logger: + ensure_dir(log_dir) + logger = logging.getLogger(name) + logger.setLevel(logging.INFO) + logger.handlers.clear() + fmt = logging.Formatter("%(asctime)s %(levelname)s %(name)s: %(message)s") + sh = logging.StreamHandler(sys.stdout) + sh.setFormatter(fmt) + fh = logging.FileHandler(Path(log_dir) / f"{name}_{dt.datetime.now().strftime('%Y%m%d_%H%M%S')}.log", encoding="utf-8") + fh.setFormatter(fmt) + logger.addHandler(sh) + logger.addHandler(fh) + return logger + + +def load_yaml(path: str | Path) -> dict: + if yaml is None: + raise RuntimeError("PyYAML is required. Install with: python -m pip install pyyaml") + with open(path, "r", encoding="utf-8") as f: + return yaml.safe_load(f) or {} + + +def sha256_file(path: str | Path, chunk_size: int = 1024 * 1024) -> str: + h = hashlib.sha256() + with open(path, "rb") as f: + for chunk in iter(lambda: f.read(chunk_size), b""): + h.update(chunk) + return h.hexdigest() + + +def file_size(path: str | Path) -> int: + return Path(path).stat().st_size + + +def atomic_download(url: str, out_path: str | Path, logger: logging.Logger, overwrite: bool = False) -> Path: + out = Path(out_path) + ensure_dir(out.parent) + if out.exists() and not overwrite: + logger.info("Keeping existing file: %s", out) + return out + tmp = out.with_suffix(out.suffix + ".tmp") + logger.info("Downloading %s -> %s", url, out) + req = urllib.request.Request(url, headers={"User-Agent": "CAB-external-rebuild/1.0"}) + with urllib.request.urlopen(req, timeout=180) as r, open(tmp, "wb") as f: + while True: + block = r.read(1024 * 1024) + if not block: + break + f.write(block) + tmp.replace(out) + return out + + +def append_manifest(row: Mapping[str, object], manifest_path: str | Path = "data/raw/external_manifest.csv") -> None: + manifest = Path(manifest_path) + ensure_dir(manifest.parent) + fieldnames = [ + "resource_name", "version", "release_date", "download_date", "source_url", + "local_path", "checksum_sha256", "file_size", "license_or_terms", + "parser_script", "parse_status", "row_count_raw", "row_count_parsed", "notes" + ] + exists = manifest.exists() + with open(manifest, "a", newline="", encoding="utf-8") as f: + w = csv.DictWriter(f, fieldnames=fieldnames) + if not exists: + w.writeheader() + w.writerow({k: row.get(k, "") for k in fieldnames}) + + +def read_csv_any(path: str | Path, sep: str | None = None) -> list[dict]: + p = Path(path) + opener = gzip.open if p.suffix == ".gz" else open + mode = "rt" if p.suffix == ".gz" else "r" + with opener(p, mode, encoding="utf-8", errors="replace", newline="") as f: + sample = f.read(8192) + f.seek(0) + if not sample: + return [] + if sep is None: + dialect = csv.Sniffer().sniff(sample, delimiters=",\t|") + reader = csv.DictReader(f, dialect=dialect) + else: + reader = csv.DictReader(f, delimiter=sep) + return list(reader) + + +def require_columns(rows: Sequence[Mapping[str, object]], required: Sequence[str], source: str) -> None: + if not rows: + raise ValueError(f"{source}: no rows loaded") + got = set(rows[0].keys()) + missing = [c for c in required if c not in got] + if missing: + raise ValueError(f"{source}: missing required columns: {missing}; available={sorted(got)[:80]}") + + +def write_csv(path: str | Path, rows: Iterable[Mapping[str, object]], fieldnames: Sequence[str] | None = None) -> int: + rows = list(rows) + p = Path(path) + ensure_dir(p.parent) + if fieldnames is None: + keys = [] + seen = set() + for r in rows: + for k in r.keys(): + if k not in seen: + keys.append(k) + seen.add(k) + fieldnames = keys + with open(p, "w", newline="", encoding="utf-8") as f: + w = csv.DictWriter(f, fieldnames=list(fieldnames)) + w.writeheader() + for r in rows: + w.writerow({k: r.get(k, "") for k in fieldnames}) + return len(rows) + + +def basic_arg_parser(description: str) -> argparse.ArgumentParser: + p = argparse.ArgumentParser(description=description) + p.add_argument("--config", default="config/external_resources.yaml") + p.add_argument("--manifest", default="data/raw/external_manifest.csv") + p.add_argument("--overwrite", action="store_true") + return p + + +def truth(x) -> bool: + return str(x).strip().lower() in {"true", "1", "yes", "y"}