diff --git a/cli/rt/run.rs b/cli/rt/run.rs
index 68f7b95a448546..00306b3086b5b9 100644
--- a/cli/rt/run.rs
+++ b/cli/rt/run.rs
@@ -1075,6 +1075,27 @@ pub async fn run(
     }
     checker
   });
+  let (storage_key_resolver, origin_data_folder_path) =
+    match metadata.location.as_ref() {
+      Some(location) => {
+        let deno_dir = deno_resolver::cache::DenoDir::new(
+          sys_traits::impls::RealSys,
+          deno_cache_dir::resolve_deno_dir(
+            &sys_traits::impls::RealSys,
+            deno_cache_dir::ResolveDenoDirOptions {
+              maybe_initial_cwd: None,
+              maybe_custom_root: None,
+            },
+          )?
+          .into_owned(),
+        );
+        (
+          StorageKeyResolver::from_flag(location),
+          Some(deno_dir.compile_origin_data_folder_path()),
+        )
+      }
+      None => (StorageKeyResolver::empty(), None),
+    };
   let lib_main_worker_options = LibMainWorkerOptions {
     argv: metadata.argv,
     log_level: WorkerLogLevel::Info,
@@ -1095,7 +1116,7 @@ pub async fn run(
     node_debug: std::env::var("NODE_DEBUG").ok(),
     node_cluster_unique_id: std::env::var("NODE_UNIQUE_ID").ok(),
     node_cluster_sched_policy: std::env::var("NODE_CLUSTER_SCHED_POLICY").ok(),
-    origin_data_folder_path: None,
+    origin_data_folder_path,
     seed: metadata.seed,
     unsafely_ignore_certificate_errors: metadata
       .unsafely_ignore_certificate_errors,
@@ -1123,7 +1144,7 @@ pub async fn run(
     create_npm_process_state_provider(&npm_resolver),
     pkg_json_resolver,
     root_cert_store_provider,
-    StorageKeyResolver::empty(),
+    storage_key_resolver,
     sys.clone(),
     lib_main_worker_options,
     Default::default(),
diff --git a/libs/resolver/cache/deno_dir.rs b/libs/resolver/cache/deno_dir.rs
index 0a54581ced3469..d99ec25a63f9b4 100644
--- a/libs/resolver/cache/deno_dir.rs
+++ b/libs/resolver/cache/deno_dir.rs
@@ -140,6 +140,11 @@ impl<TSys: DiskCacheSys> DenoDir<TSys> {
     self.root.join("location_data")
   }
 
+  /// Path to the origin data folder used by `deno compile` binaries.
+  pub fn compile_origin_data_folder_path(&self) -> PathBuf {
+    self.root.join("origin_data")
+  }
+
   /// File used for the upgrade checker.
   pub fn upgrade_check_file_path(&self) -> PathBuf {
     self.root.join("latest.txt")
diff --git a/tests/specs/compile/storage_apis/__test__.jsonc b/tests/specs/compile/storage_apis/__test__.jsonc
new file mode 100644
index 00000000000000..8f050f3f338bdf
--- /dev/null
+++ b/tests/specs/compile/storage_apis/__test__.jsonc
@@ -0,0 +1,31 @@
+{
+  "tempDir": true,
+  "tests": {
+    "with_location": {
+      "steps": [
+        {
+          "if": "unix",
+          "args": "compile --location https://example.com/main --output main main.ts",
+          "output": "[WILDCARD]"
+        },
+        {
+          "if": "unix",
+          "commandName": "main",
+          "args": [],
+          "output": "A\nB\n"
+        },
+        {
+          "if": "windows",
+          "args": "compile --location https://example.com/main --output main.exe main.ts",
+          "output": "[WILDCARD]"
+        },
+        {
+          "if": "windows",
+          "commandName": "./main.exe",
+          "args": [],
+          "output": "A\nB\n"
+        }
+      ]
+    }
+  }
+}
diff --git a/tests/specs/compile/storage_apis/main.ts b/tests/specs/compile/storage_apis/main.ts
new file mode 100644
index 00000000000000..03ee409723d1ca
--- /dev/null
+++ b/tests/specs/compile/storage_apis/main.ts
@@ -0,0 +1,11 @@
+localStorage.setItem("a", "A");
+console.log(localStorage.getItem("a"));
+
+const cache = await caches.open("v1");
+await cache.put(
+  new Request("https://example.com/b"),
+  new Response("B"),
+);
+const res = await cache.match(new Request("https://example.com/b"));
+if (!res) throw new Error("unreachable: cache entry was just set");
+console.log(await res.text());