I've been using ProjecTILs and the CD4/CD8 human T cell reference atlases in some scRNA-seq work lately and it has been very useful for us. I wonder whether you or @ncborcherding (via https://github.com/ncborcherding/utility) have any plans to make any scATAC-seq-based references?
I know that I could use promoter accessibility as a proxy for gene activity and then perhaps perform the projections based on that, but I'd imagine this would lose/ignore a lot of distal regulatory elements important for cell-type-specific activity. It would be great if there was a way to project directly in the regulatory element space to enable an analysis like this!
I've been using
ProjecTILsand the CD4/CD8 human T cell reference atlases in some scRNA-seq work lately and it has been very useful for us. I wonder whether you or @ncborcherding (via https://github.com/ncborcherding/utility) have any plans to make any scATAC-seq-based references?I know that I could use promoter accessibility as a proxy for gene activity and then perhaps perform the projections based on that, but I'd imagine this would lose/ignore a lot of distal regulatory elements important for cell-type-specific activity. It would be great if there was a way to project directly in the regulatory element space to enable an analysis like this!