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DESCRIPTION
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Package: GOcontext
Type: Package
Title: Context-Aware Restriction of the Gene Ontology for Enrichment Analysis
Version: 0.1.0
Authors@R: c(
person(
given = "Thomas",
family = "Rauter",
email = "rauterthomas0@gmail.com",
role = c("aut", "cre", "fnd"),
comment = c(ORCID = "0009-0004-5578-3628")
))
Description: GOcontext provides tools for constructing context-specific
subgraphs of the Gene Ontology (GO) prior to functional enrichment
analysis. The package allows users to load a GO ontology, attach
organism-specific GO annotations, and restrict the ontology to
biologically relevant terms. Branches of the GO hierarchy can be
interactively explored and selectively retained or excluded to define
a focused hypothesis space. The resulting GO subgraph can be exported
as TERM2GENE and TERM2NAME tables for enrichment workflows such as
clusterProfiler::enricher(). By restricting the ontology DAG itself
before downstream analysis, GOcontext enables reproducible curation
of the tested GO term universe while preserving the hierarchical
structure of the ontology.
License: MIT + file LICENSE
URL: https://thomas-rauter.github.io/GOcontext/,
https://github.com/Thomas-Rauter/GOcontext
BugReports: https://github.com/Thomas-Rauter/GOcontext/issues
Encoding: UTF-8
LazyData: false
RoxygenNote: 7.3.3
Depends:
R (>= 4.5)
Imports:
GO.db,
AnnotationDbi,
rlang,
methods,
utils
Suggests:
org.EcK12.eg.db,
testthat (>= 3.0.0),
knitr,
rmarkdown,
BiocStyle,
pkgdown,
stats,
mockery
VignetteBuilder: knitr
biocViews:
GO,
GeneSetEnrichment,
Annotation,
GraphAndNetwork,
SystemsBiology,
Software