diff --git a/CHANGELOG.md b/CHANGELOG.md
index 2ab4491..6b57b80 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -27,6 +27,8 @@ adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0.html).
   `:param` strings in `openapi_json()`).
 - JWT hot path reuses prebuilt `DecodingKey` and `Validation` per route (no per-request
   rebuild) ([#109](https://github.com/QueryaHub/OxyRoute/issues/109)).
+- CORS response merge skips the Python `response_header_pairs` call when the request has
+  no `Origin` header ([#108](https://github.com/QueryaHub/OxyRoute/issues/108)).
 
 ## [0.3.0] - 2026-04-27
 
diff --git a/oxyroute/cors.py b/oxyroute/cors.py
index a77d200..c119cea 100644
--- a/oxyroute/cors.py
+++ b/oxyroute/cors.py
@@ -22,7 +22,8 @@ class CORSConfig:
     response header merging without the built-in ``OPTIONS`` handler.
 
     ``response_header_pairs`` is called from Rust to merge CORS headers into normal responses
-    (after a route or middleware that returns a body).
+    (after a route or middleware that returns a body). The native layer skips this call when
+    the request has no ``Origin`` header (same outcome as an empty pair list).
     """
 
     allow_origins: list[str] = field(default_factory=lambda: ["*"])
diff --git a/src/dispatch.rs b/src/dispatch.rs
index 95929bd..15e3502 100644
--- a/src/dispatch.rs
+++ b/src/dispatch.rs
@@ -1502,6 +1502,9 @@ fn send_handler_map_inline(
 
 /// `if_absent`: only add a header if no same-name (case-insensitive) header is already present
 /// (``security`` preset). `false` replaces/merges like CORS (``replace`` / duplicate header names).
+///
+/// For CORS (`if_absent == false`), skip the Python `response_header_pairs` call when the
+/// request has no ``Origin`` header (issue #108) — same outcome as an empty pair list.
 fn merge_config_response_headers(
     py: Python<'_>,
     config: &Option<Py<PyAny>>,
@@ -1512,6 +1515,12 @@ fn merge_config_response_headers(
     let Some(c) = config else {
         return Ok(mapped);
     };
+    if !if_absent {
+        let headers = scope.getattr("headers")?;
+        if header_get_lax(&headers, "origin").is_none() {
+            return Ok(mapped);
+        }
+    }
     let pairs: Vec<(String, String)> = c
         .call_method1(py, "response_header_pairs", (&scope,))?
         .extract(py)?;
diff --git a/tests/test_cors.py b/tests/test_cors.py
index 3089e6e..739168b 100644
--- a/tests/test_cors.py
+++ b/tests/test_cors.py
@@ -57,3 +57,86 @@ async def _run() -> None:
         assert r.headers.get("access-control-allow-origin") == "https://a.example"
 
     asyncio.run(_run())
+
+
+class _CountingCors(CORSConfig):
+    """Tracks ``response_header_pairs`` calls from the native layer (issue #108)."""
+
+    pairs_calls: int
+
+    def __init__(self, **kwargs: object) -> None:
+        super().__init__(**kwargs)  # type: ignore[arg-type]
+        self.pairs_calls = 0
+
+    def response_header_pairs(self, scope: object) -> list[tuple[str, str]]:
+        self.pairs_calls += 1
+        return super().response_header_pairs(scope)
+
+
+def test_cors_without_origin_skips_python_pairs_call() -> None:
+    cfg = _CountingCors(allow_origins=["https://app.example"])
+    app = App()
+    apply_cors(app, cfg)
+
+    @app.get("/n")
+    def _n() -> str:
+        return "ok"
+
+    async def _run() -> None:
+        transport = httpx.ASGITransport(app=asgi_test_app(app))
+        async with httpx.AsyncClient(transport=transport, base_url="http://test") as c:
+            r = await c.get("/n")
+        assert r.status_code == 200
+        assert r.text == "ok"
+        assert r.headers.get("access-control-allow-origin") is None
+
+    asyncio.run(_run())
+    assert cfg.pairs_calls == 0
+
+
+def test_cors_wildcard_without_origin_skips_pairs_with_origin_calls() -> None:
+    cfg = _CountingCors(allow_origins=["*"], allow_credentials=False)
+    app = App()
+    apply_cors(app, cfg)
+
+    @app.get("/w")
+    def _w() -> str:
+        return "w"
+
+    async def _run() -> None:
+        transport = httpx.ASGITransport(app=asgi_test_app(app))
+        async with httpx.AsyncClient(transport=transport, base_url="http://test") as c:
+            bare = await c.get("/w")
+            starred = await c.get("/w", headers={"origin": "https://any.example"})
+        assert bare.status_code == 200
+        assert bare.headers.get("access-control-allow-origin") is None
+        assert starred.status_code == 200
+        assert starred.headers.get("access-control-allow-origin") == "*"
+
+    asyncio.run(_run())
+    assert cfg.pairs_calls == 1
+
+
+def test_cors_credentials_with_origin_still_merges() -> None:
+    cfg = _CountingCors(
+        allow_origins=["https://app.example"],
+        allow_credentials=True,
+    )
+    app = App()
+    apply_cors(app, cfg)
+
+    @app.get("/c")
+    def _c() -> str:
+        return "c"
+
+    async def _run() -> None:
+        transport = httpx.ASGITransport(app=asgi_test_app(app))
+        async with httpx.AsyncClient(transport=transport, base_url="http://test") as c:
+            no_o = await c.get("/c")
+            with_o = await c.get("/c", headers={"origin": "https://app.example"})
+        assert no_o.headers.get("access-control-allow-origin") is None
+        assert with_o.headers.get("access-control-allow-origin") == "https://app.example"
+        assert with_o.headers.get("access-control-allow-credentials") == "true"
+
+    asyncio.run(_run())
+    assert cfg.pairs_calls == 1