diff --git a/long_example.md b/long_example.md index 6c82c0c..5eeaaa2 100644 --- a/long_example.md +++ b/long_example.md @@ -12,4 +12,4 @@ The source text comes from the abstract of PMID [18974824](https://www.ncbi.nlm. | [**replace_from_dictionary**](nlpre/replace_from_dictionary.py) | MeSH_N-Methylaspartate receptors are widely expressed in the brain and are critical for many forms of MeSH_Neuronal_Plasticity .
NMDA .
Subtypes of the NMDA receptor NR2 subunit are differentially expressed during development ; in the forebrain , the NR2B receptor is dominant early in development , and later both NR2A and NR2B are expressed .
In heterologous expression systems , NR2A-containing receptors open more reliably and show much faster opening and closing kinetics than do NR2B-containing receptors .
However , conflicting data , showing similar open probabilities , exist for receptors expressed in neurons .
Similarly , studies of MeSH_Neuronal_Plasticity have produced divergent results , with some showing that only NR2A-containing receptors can drive MeSH_Long-Term_Potentiation and others showing that either subtype is capable of driving potentiation .
In order to address these conflicting results as well as open questions about the number and location of functional receptors in the synapse , we constructed a Monte Carlo model of glutamate release , diffusion , and binding to MeSH_Receptors_N-Methyl-D-Aspartate and of receptor opening and closing as well as a model of the activation of calcium-MeSH_Calcium-Calmodulin-Dependent_Protein_Kinases II , an enzyme critical for induction of MeSH_Neuronal_Plasticity , by NMDA receptor-mediated calcium influx .
Our results suggest that the conflicting data concerning receptor open probabilities can be resolved , with NR2A - and NR2B-containing receptors having very different opening probabilities .
They also support the conclusion that receptors containing either subtype can drive MeSH_Long-Term_Potentiation .
We also are able to estimate the number of functional receptors at a synapse from experimental data .
Finally , in our models , the opening of NR2B-containing receptors is highly dependent on the location of the receptor relative to the site of glutamate release whereas the opening of NR2A-containing receptors is not .
These results help to clarify the previous findings and suggest future experiments to address open questions concerning NMDA receptor function . | | [**token_replacement**](nlpre/token_replacement.py) | MeSH_N-Methylaspartate receptors are widely expressed in the brain and are critical for many forms of MeSH_Neuronal_Plasticity .
NMDA .
Subtypes of the NMDA receptor NR2 subunit are differentially expressed during development ; in the forebrain , the NR2B receptor is dominant early in development , and later both NR2A and NR2B are expressed .
In heterologous expression systems , NR2A-containing receptors open more reliably and show much faster opening and closing kinetics than do NR2B-containing receptors .
However , conflicting data , showing similar open probabilities , exist for receptors expressed in neurons .
Similarly , studies of MeSH_Neuronal_Plasticity have produced divergent results , with some showing that only NR2A-containing receptors can drive MeSH_Long-Term_Potentiation and others showing that either subtype is capable of driving potentiation .
In order to address these conflicting results as well as open questions about the number and location of functional receptors in the synapse , we constructed a Monte Carlo model of glutamate release , diffusion , and binding to MeSH_Receptors_N-Methyl-D-Aspartate and of receptor opening and closing as well as a model of the activation of calcium-MeSH_Calcium-Calmodulin-Dependent_Protein_Kinases II , an enzyme critical for induction of MeSH_Neuronal_Plasticity , by NMDA receptor-mediated calcium influx .
Our results suggest that the conflicting data concerning receptor open probabilities can be resolved , with NR2A - and NR2B-containing receptors having very different opening probabilities .
They also support the conclusion that receptors containing either subtype can drive MeSH_Long-Term_Potentiation .
We also are able to estimate the number of functional receptors at a synapse from experimental data .
Finally , in our models , the opening of NR2B-containing receptors is highly dependent on the location of the receptor relative to the site of glutamate release whereas the opening of NR2A-containing receptors is not .
These results help to clarify the previous findings and suggest future experiments to address open questions concerning NMDA receptor function . | | [**decaps_text**](nlpre/decaps_text.py) | MeSH_N-Methylaspartate receptors are widely expressed in the brain and are critical for many forms of MeSH_Neuronal_Plasticity .
NMDA .
Subtypes of the NMDA receptor NR2 subunit are differentially expressed during development ; in the forebrain , the NR2B receptor is dominant early in development , and later both NR2A and NR2B are expressed .
In heterologous expression systems , NR2A-containing receptors open more reliably and show much faster opening and closing kinetics than do NR2B-containing receptors .
However , conflicting data , showing similar open probabilities , exist for receptors expressed in neurons .
Similarly , studies of MeSH_Neuronal_Plasticity have produced divergent results , with some showing that only NR2A-containing receptors can drive MeSH_Long-Term_Potentiation and others showing that either subtype is capable of driving potentiation .
In order to address these conflicting results as well as open questions about the number and location of functional receptors in the synapse , we constructed a Monte Carlo model of glutamate release , diffusion , and binding to MeSH_Receptors_N-Methyl-D-Aspartate and of receptor opening and closing as well as a model of the activation of calcium-MeSH_Calcium-Calmodulin-Dependent_Protein_Kinases II , an enzyme critical for induction of MeSH_Neuronal_Plasticity , by NMDA receptor-mediated calcium influx .
Our results suggest that the conflicting data concerning receptor open probabilities can be resolved , with NR2A - and NR2B-containing receptors having very different opening probabilities .
They also support the conclusion that receptors containing either subtype can drive MeSH_Long-Term_Potentiation .
We also are able to estimate the number of functional receptors at a synapse from experimental data .
Finally , in our models , the opening of NR2B-containing receptors is highly dependent on the location of the receptor relative to the site of glutamate release whereas the opening of NR2A-containing receptors is not .
These results help to clarify the previous findings and suggest future experiments to address open questions concerning NMDA receptor function . | -| [**pos_tokenizer**](nlpre/pos_tokenizer.py) | MeSH_N-Methylaspartate receptor brain critical many form MeSH_Neuronal_Plasticity
NMDA
subtype NMDA receptor NR2 subunit development forebrain NR2B receptor dominant development NR2A NR2B
heterologou expression system receptor faster open kinetic NR2B-containing receptor
datum similar open probability receptor neuron
study MeSH_Neuronal_Plasticity divergent result show NR2A-containing receptor MeSH_Long-Term_Potentiation other subtype capable potentiation
order result open question number location functional receptor synapse monte carlo model glutamate release diffusion bound MeSH_Receptors_N-Methyl-D-Aspartate receptor open close model activation calcium-MeSH_Calcium-Calmodulin-Dependent_Protein_Kinases Ius enzyme critical induction MeSH_Neuronal_Plasticity NMDA receptor-mediated calcium influx
result datum receptor open probability NR2A NR2B-containing receptor different open probability
conclusion receptor subtype MeSH_Long-Term_Potentiation
able number functional receptor synapse experimental datum
model open NR2B-containing receptor dependent location receptor relative site glutamate release open NR2A-containing receptor
result previou find future experiment open question NMDA receptor function | \ No newline at end of file +| [**pos_tokenizer**](nlpre/pos_tokenizer.py) | MeSH_N-Methylaspartate receptor brain critical many form MeSH_Neuronal_Plasticity
NMDA
subtype NMDA receptor NR2 subunit development forebrain NR2B receptor dominant development NR2A NR2B
heterologous expression system receptor faster open kinetic NR2B-containing receptor
datum similar open probability receptor neuron
study MeSH_Neuronal_Plasticity divergent result show NR2A-containing receptor MeSH_Long-Term_Potentiation other subtype capable potentiation
order result open question number location functional receptor synapse monte carlo model glutamate release diffusion bound MeSH_Receptors_N-Methyl-D-Aspartate receptor open close model activation calcium-MeSH_Calcium-Calmodulin-Dependent_Protein_Kinases Ius enzyme critical induction MeSH_Neuronal_Plasticity NMDA receptor-mediated calcium influx
result datum receptor open probability NR2A NR2B-containing receptor different open probability
conclusion receptor subtype MeSH_Long-Term_Potentiation
able number functional receptor synapse experimental datum
model open NR2B-containing receptor dependent location receptor relative site glutamate release open NR2A-containing receptor
result previou find future experiment open question NMDA receptor function |