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---
title: About - Biocompute Lab
section: about
---
{% include header.html %}
<main>
<div class="container col-xxl-8 px-4 py-1">
<div class="row flex-lg-row-reverse align-items-center g-5 py-5">
<div class="col-10 col-sm-8 col-lg-6">
<img src="{{baseurl}}/images/about/biocompute-web.jpg" class="d-block mx-lg-auto img-fluid" width="500" height="300" loading="lazy">
</div>
<div class="col-lg-6">
<h1 class="display-5 fw-bold lh-1 mb-3 pagetitle">Biology computes</h1>
<p class="lead">From individual cells deciding how to differentiate during development, to social insects coordinating their actions when scavenging for food; the ability to perform complex computations and process information enables life across scales.</p>
<div class="d-grid gap-2 d-md-flex justify-content-md-start">
<span class="badge bg-light text-dark rounded-pill">synthetic biology</span>
<span class="badge bg-light text-dark rounded-pill">biocomputation</span>
<span class="badge bg-light text-dark rounded-pill">data-centric biodesign</span>
<span class="badge bg-light text-dark rounded-pill">evolution</span>
</div>
</div>
</div>
</div>
<div class="container px-4 py-1">
<p class="bcl-box">
The Biocompute Lab explores the molecular-scale mechanisms that
individual cells and groups of cells use to make sense of their world.
We apply tools and methods from the field of synthetic biology to create
new living systems from the ground-up. By studying these artificial
systems using novel techniques we are developing based on sequencing,
microfluidics and computational modelling, we aim to better understand
the rules governing how biological parts are best pieced together to
perform useful computations. Understanding the computational
architecture of cells opens new ways of reprogramming them to tackle
problems spanning the sustainable production of materials to novel
therapeutics. It also provides key insights into how biology controls
the complex processes and structures sustaining life.
</p>
</div>
<div class="container px-4 py-5">
<h2 class="pb-2 border-bottom">Research areas</h2>
<div class="row g-4 py-5 row-cols-1 row-cols-lg-3">
<div class="feature col">
<div class="feature-icon bg-primary">
<img width=100% src="{{baseurl}}/images/about/reprogramming-web.jpg"/>
</div>
<h3>Reprogramming biology</h3>
<p>Biology offers many capabilities that could address the global challenges we face as a society. The Biocompute Lab is attempting to understand how to effectively reprogram biology to co-opt and install new functionalities into living systems across scales; from networks of interacting molecules, to cellular collectives, and even entire ecosystems.</p>
<a class="btn btn-success" href="{{baseurl}}/about-reprogramming" role="button">Learn more</a>
</div>
<div class="feature col">
<div class="feature-icon bg-primary bg-gradient">
<img width=100% src="{{baseurl}}/images/about/analytics-web.jpg"/>
</div>
<h3>Advanced cellular analytics</h3>
<p>Inside every cell is a complex, dynamic and sometimes mysterious environment. The Biocompute Lab is developing advanced biometrology approaches based on emerging technologies like nanopore sequencing and high-throughput fluorescence activated cell sorting to "see" and "measure" the inner workings of this typically hidden world.</p>
<a class="btn btn-success" href="{{baseurl}}/about-analytics" role="button">Learn more</a>
</div>
<div class="feature col">
<div class="feature-icon bg-primary bg-gradient">
<img width=100% src="{{baseurl}}/images/about/evolution-web.jpg"/>
</div>
<h3>Engineering [with] evolution</h3>
<p>Evolution is the most powerful creative force on this planet. The Biocompute Lab is exploring ways to harness and integrate evolution into new biological design workflows, as well as searching for avenues to engineer evolutionary processes themselves to create a new generation of truly self-adaptive engineered living system.</p>
<a class="btn btn-success" href="{{baseurl}}/about-evolution" role="button">Learn more</a>
</div>
</div>
<h2 class="pb-2 border-bottom">Support</h2>
<div class="row">
<p>Our research is made possible by the generous support from funders, charities and other organisations that have believed in our vision for broadening our understanding of the computational architecture of biology and engineering living substrates in new and interesting ways.</p>
</div>
<div class="row px-3">
<ul class="funding-list">
<li><b>The Royal Society</b> – University Research Fellowship (UF160357, RGF\EA\180024, RGF\R1\180012, RGF\EA\201020), <a href="https://royalsociety.org/grants-schemes-awards/grants/public-engagement-fund/newly-funded-projects/2018/">Public Engagement Award</a> (PEF2\180019)</li>
<li><b>The Alan Turing Institute</b> – Turing Fellowship (2TF1\100241)</li>
<li><b>UKRI</b></span> – <a href="http://www.bristol.ac.uk/brissynbio/">BrisSynBio Fellowship</a> (BB/L01386X/1), Impact Acceleration Awards (EP/P511298/1)</li>
<li><b>EU H2020</b> – <a href="http://www.syncrop.org">SynCrop ETN</a> (#764591)</li>
<li><b>Leverhulme Trust</b> – Research Project Grant (RPG-2019-229)</li>
<li><b>NVIDIA</b> – GPU grant programme</li>
</ul>
</div>
</div>
</main>
{% include footer.html %}