about-reprogramming.html

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title: Reprogramming Biology - Biocompute Lab
section: about-reprogramming
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        <h1 class="display-5 fw-bold lh-1 mb-3 pagetitle">Reprogramming biology</h1>
        <p class="lead">Biology offers many capabilities that could address the global challenges we face as a society. The Biocompute Lab is attempting to understand how to effectively reprogram biology to co-opt and install new functionalities into living systems across scales; from networks of interacting molecules, to cellular collectives, and even entire ecosystems.</p>
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      <blockquote class="blockquote">
        <p>The only way to learn a new programming language is by writing programs in it.</p> &#8212; Dennis Ritchie
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    <h2 class="pb-2 border-bottom">Core strands</h2>
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        <h4>Adaptive genetic circuits</h4>
        <p>In the words of Darwin: "It is not the most intellectual of the species that survives; it is not the strongest that survives; but the species that survives is the one that is able to adapt to and to adjust". With this in mind, we are developing new types of genetic part and circuitry whose function can adapt as needed over time. This allows their function to be optimised and robustly maintained even when exposed to diverse and changing environments.</p>
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        <h4>Data-centric biological design</h4>
        <p>Modern experimental methods can collect vast amounts of information and provide a detailed window into the inner workings of cells. To make sense of these rich, multi-dimensional datasets, we are employing machine learning and artificial intelligence approaches to unravel the complex interactions and rules that guide the behavior of biological systems. Using this information we aim to create improved biological design workflows.</p>
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        <h4>Unconventional computing</h4>
        <p>Biology often stores and processes information in very different ways than the typical electronic computers we commonly use. The Biocompute Lab is interested in exploring this diversity in computational architecture for inspiration into new ways to build computers that function requiring less power, that are able to function in harsh environments, and that have the potential to outperform those in use today. We value the weirder and the wackier!</p>
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        <h4>Biodesign across scales</h4>
        <p>From collections of molecules within a cell to our planetary ecosystem, biology functions at many length and time scales. Understanding how these functions emerge at differing scales is challenging, but essential if we are to effectively reprogram biology. We are tackling this question using high-performance computing and advanced multi-agent simulation to guide experiments and explore the key ingredients for emergence across scales.</p>
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    <h2 class="pb-2 py-5 border-bottom">Selected publications</h2>
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    <h2 class="pb-2 py-5 border-bottom">Key people</h2>
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